Potent Nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

Tetrahedron Letters

Volumn 39, Issue 19, 1998, Pages 2895-2898

  Goetz, Michael A ^a   Hensens, Otto D ^a   Zink, Deborah L ^a   Borris, Robert P ^a   Morales, Francisco ^b   Tamayo Castillo, Giselle ^b   Slaughter, Robert S ^a   Felix, John ^a   Ball, Richard G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b INSTITUTO NACIONAL DE BIODIVERSIDAD   (Costa Rica)

Author keywords

[No Author keywords available]

Indexed keywords

CORREOLIDE; DEHYDROCORREOLIDE; PLANT EXTRACT; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COSTA RICA; DRUG ISOLATION; DRUG STRUCTURE; IMMUNOSUPPRESSIVE TREATMENT; MEMBRANE POTENTIAL; NONHUMAN; PHYTOCHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; T LYMPHOCYTE ACTIVATION; TREE;

SPACHEA CORREAE;

EID: 0032492930     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00427-4     Document Type: Article

References (7)

1. 1. Lin, C. S.; Boltz, R. C.; Blake, J. T.; Nguyen, M.; Talento, A.; Fischer, P. A. J. Exp. Med. 1993, 177, 637-645.
2. 2. Knaus, H. G.; Koch, R. O. A.; Eberhart, A.; Kaczorowski, G. J.; Garcia, M. L.; Slaughter, R. S. Biochemistry 1995, 34, 13627-13634.
3. 3. Leonard, R. J.; Garcia, M. L.; Slaughter, R. S.; Reuben, J. P. Proc. Natl. Acad. Sci. USA 1992, 89, 10094-10098.
4. 4. Slaughter, R. S. et al. manuscript in preparation.
5. 3).
6. 6. Abreu, H. D., Fo, R. B.; Gottlieb, H. E.; and Shoolery, J. N. Phytochemistry 1990, 29, 2257-2261.
7. -3. The authors have deposited the atomic coordinates for this structure with the Cambridge Crystallographic Data Centre. The coordinates can be obtained on request from the Director, Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK.