Characterization of a novel Kv1.5 channel blocker in Xenopus oocytes, CHO cells, human and rat cardiomyocytes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 364, Issue 5, 2001, Pages 472-478

  Bachmann, Alexander ^a   Gutcher, Ilona ^a   Kopp, Karin ^a   Brendel, Joachim ^a   Bosch, Ralph F ^b   Busch, Andreas E ^a   Gögelein, Heinz ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Action potential; Atrial fibrillation; Cardiac potassium currents; IKur; Kv1.5; S9947

Indexed keywords

2' (BENZYLOXYCARBONYLAMINOMETHYL)BIPHENYL 2 CARBOXYLIC ACID 2 (2 PYRIDYL)ETHYLAMIDE; POTASSIUM CHANNEL BLOCKING AGENT; S 9947; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; FEMALE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IC 50; MALE; NONHUMAN; OOCYTE; PATCH CLAMP; POTASSIUM CURRENT; RAT; VOLTAGE CLAMP; XENOPUS LAEVIS;

ACTION POTENTIALS; ANIMALS; BIPHENYL COMPOUNDS; CHO CELLS; CRICETINAE; ELECTRIC STIMULATION; FEMALE; HEART; HUMANS; KV1.5 POTASSIUM CHANNEL; MALE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; XENOPUS;

EID: 0034751048     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100100474     Document Type: Article

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