The inflammatory process in aging

Reviews in Clinical Gerontology

Volumn 16, Issue 3, 2006, Pages 179-187

  Pal Yu, Byung ^a,b,c   Young Chung, Hae ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Pusan National University   (South Korea)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 14; NONSTEROID ANTIINFLAMMATORY AGENT; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

AGING; ALZHEIMER DISEASE; CALORIC RESTRICTION; CHRONIC INFLAMMATION; DEMENTIA; EXERCISE; HUMAN; IMMUNE SYSTEM; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGE; METABOLIC SYNDROME X; OBESITY; OSTEOPOROSIS; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; REVIEW; SIGNAL TRANSDUCTION;

EID: 34547539154     PISSN: 09592598     EISSN: 14699036     Source Type: Journal    
DOI: 10.1017/S0959259807002110     Document Type: Review

References (75)

1. Licastro F, Candore G, Lio D et al. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 2005; 2: 8-22.
2. Hanson PM. Dampening inflammation. Nature Immunol 2005; 6: 1189-81.
3. Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases and frailty. Annu Rev Med 2000; 51: 245-70.
4. Krabbe KS, Pedersen M, Bruunsgaard H. Inflammatory mediators in the elderly. Exp Gerontol 2004; 39: 687-99.
5. Chung HY, Zou Y, Sung BK et al. The molecular inflammatory process in aging. Anti-oxidants, Redox, Signaling 2006; 8: 572-81.
6. Roubenoff R. Catabolism of aging: is it an inflammatory process? Curr Opin Clin Nutr Metab Care 2003; 6: 295-99.
7. Medzhitov R. Innate immunity N Engl J Med 2000; 343: 338-44.
8. Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nature Immunol 2005; 5: 1119-205.
9. Yu BP. Aging and oxidative stress: modulation by dietary restriction. Free Rad Biol Med 1996; 21; 651-68.
10. Yu BP, Yang R. Critical evaluation of free radical theory of aging: a proposal of oxidative stress hypothesis. Ann NY Acad Sci 1996; 786: 1-11.
11. Droge W. Redox regulation in anabolic and catabolic processes. Curr Opin Clin Metab Care 2006; 9; 190-95.
12. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 1998; 78: 547-81.
13. Caruso C, Candore G, Colonna-Romana G, Lio D, Franceshi C. Inflammation and lifespan. Science 2004; 305: 1736-39.
14. Chung HY, Kim HJ, Kim WJ, Yu BP. The inflammatory hypothesis of aging: molecular modulation by calorie restriction. Ann NY Acad Sci 2001; 928;327-35.
15. Kim HJ, Jung KJ, Yu BP, Cho CG, Choi JS, Chung HY. Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech Ageing Dev 2002; 123; 1589-95.
16. Franceschi C, Bonafe M. Centenarians as a model for healthy aging. Biochem Soc Trans 2003; 2: 457-61.
17. Hirose N, Arai Y, Gondoh Y et al. Tokyo centenarian study: aging inflammation hypothesis. Geriatr Gerontol Int 2004; 14: S182-S185.
18. Pes GM, Lio D, Carru C et al. Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians. Aging Clin Exp Res 2004; 16: 244-48.
19. Caruso C, Lio D, Cavallone L, Franceschi C. Aging, longevity inflammation, and cancer. Ann N Y Acad Sci 2004; 1028: 1-13.
20. Aggarwal BB, Shishodia S, Sandur SK, Pandey M, Sethi G. Inflammation and cancer: how hot is the link? Biochem Pharmacol 2006; 72: 1605-21.
21. Chatterjee B, Clark RA, Roy AK. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol 2000; 5: 521-32.
22. Im JA, Kim SH, Lee JW, Shim JY, Lee HR, Lee DC. Association between hypoadiponectinemia and cardiovascular risk factors in non-obese healthy adults. Metab Clin Exp 2006; 55: 1546-50.
23. Fantuzzi G. Adipose tissue, adiopkines, and inflammation. J Allergy Clin Immunol 2005; 115: 911-19.
24. Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol 2001; 280: C719-C741.
25. Brandes R, Fleming I, Busse R. Endothelial aging. Cardiovasc Res 2005; 566: 286-94.
26. Zou Y, Jung KJ, Kim JW, Yu BP, Chung HY. Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction. FASEB J 2004; 18; 320-22.
27. Zou Y, Yoon S, Jung KJ et al. Up-regulation of aortic adhesion molecules during aging. J Geront 2006; 61: 244-48.
28. Vlassara H, Cai W, Crabdall J et al. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci USA 2002; 99: 15596-601.
29. Chung HY, Jung KJ, Yu BP. Molecular inflammation as an underlying mechanism of aging: the anti-inflammatory action of calorie restriction. In: Surh YJ, Packer L ed. Oxidative stress, inflammation, and health. Boca Raton: CRC Press, 2005; 389-421.
30. Kim HJ, Jung KJ, Yu BP, Cho CG, Choi JS, Chung HY. Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech Ageing Dev 2002; 123: 1589-95.
31. Shishodia S, Aggarwal BB. Nuclear factor-kappaB activation: a question of life or death. J Biochem Mol Biol. 2002; 35: 28-40.
32. Luo JL, Kamata H, Karin M. IKK/NF-κB signaling: balancing life and death - a new approach to cancer therapy. J Clin Invest 2005; 115: 2625-32.
33. Je JH, Lee JY, Jung KJ et al. NF-κB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway. FEBS Letters 2004; 566: 183-89.
34. Minghetti BA. PPAR-gamma agonists are regulators of microglial activation and brain inflammation. Curr Pharm Des 2006; 12: 93-109.
35. Sung BK, Park S, Yu BP, Chung HY. Amelioration of age-related inflammation and oxidative stress by PPARγ activator: suppression of NF-κB by 2,4-thiazolidinedione. Exp Geront 2006; 41: 590-99.
36. Sung BK, Park S, Yu BP, Chung HY. Modulation of PPAR in aging, inflammation and calorie restriction. J Geront 2004; 59: B997-B1006.
37. Glass CK. Going nuclear in metabolic and cardiovascular disease. J Clin Invest 2006; 116: 556-560.
38. Rios-Vazquez R, Marzoa-Rivas R, Gil-Ortega I, Kaski JC. Peroxisome proliferator-activated receptor-gamma agonists for management and prevention of vascular disease in patients with and without diabetes mellitus. Am J Cardiovasc Drugs 2006; 6: 233-42.
39. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005; 115: 1111-19.
40. Ross R. Atherosclerosis - an inflammatory disease. New Engl J Med 1999; 340: 115-126.
41. Koh JM, Khang YH, Jung CH et al. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int 2005; 10: 1263-71.
42. Kobayashi K, Takahashi N, Jimi E et al. Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med 2000; 91: 275-28
43. Goldberg SR. Inflammatory mediators as essential elements in bone remodeling. Calcif Tissue Int 2003; 73: 97-100.
44. Ginaldi L, Di Benedetto MC, Di Martinis M. Osteoporosis, inflammation and ageing. Immunity Ageing 2005; 2: 14-19.
45. Zwerina J, Hayer S, Redlich K et al. Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destruction. Arthritis Rheum 2006; 54: 463-72.
46. Kumar S, Votta BJ, Rieman DJ, Badger AM, Gowen M, Lee JC. CIL-1-and TNF-induced bone resorption is mediated by p38 mitogen-activated protein kinase. J Cell Physiol 2001; 187: 294-303.
47. Risner ME, Saunders AM, Altman JFB et al. Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease Pharmacogenomics J 2006; 6: 246-54.
48. Klegeris A, McGeer PL. Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Curr Alzheimer Res 2005; 3: 355-65.
49. McGeer PL, Rogers J, McGeer EG. Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. Alzheimer's Dis 2006; 9: 271-76.
50. Sastre M, Klockgether T, Heneka MT. Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. Int J Dev Neurosci 2006; 24: 167-76.
51. McGeer PL, McGeer EG. Inflammation and the degenerative diseases of aging. Ann N Y Acad Sci 2004; 1035: 104-16.
52. Sastre M, Dewachter I, Rossner S. Non-steroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci USA 2006; 103: 443-48.
53. Yaffe K, Lindquist K, Penninx BW et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003; 61: 76-80.
54. Engelhart MJ, Geerlings MI, Meijer J. Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study. Arch Neurol 2004; 61: 668-72.
55. Borkan GA, Hults DE, Gerzof SG, Robbins AH, Silbert CK. Age-changes in body composition revealed by computed tomography. J Gerontol 1983; 38: 673-77.
56. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005; 111: 1448-54.
57. Dandona P, Aljada A, Branyopadhyay A. Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004; 25: 4-7.
58. Ferroni P, Basili S, Falco A, Davì G. Inflammation, insulin resistance and obesity. Current Atherosclerosis Rep 2004; 6: 424-431.
59. Tracy RP. Is visceral adiposity the 'enemy within'? Arteriosclerosis Thromb Vasc Biol 2001; 21: 881-90.
60. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796-808.
61. Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000; 21: 697-738.
62. Bastard JP, Maachi M, Lagathu C et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006; 17: 4-12.
63. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005; 115: 1111-19.
64. Arkan MC, Hevener AL, Greten FR. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005; 11: 191-98.
65. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insuli-receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996; 271: 665-68.
66. Hotamisligil GS, Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 2003; 3: S53-S55.
67. Chavakis T, Bierhaus A, Nawroth PP. RAGE (receptor for advanced glycation endproducts): a central player in the inflammatory response. Microb Infect 2004; 6: 1219-25.
68. Yu BP. Why calorie restriction would work for human longevity. Biogerontology 2006; 7:179-82.
69. Pertynska-Marczewska M, Kiriakidis S, Wait R, Beech J, Feldmann M, Paleolog EM. Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages. Cytokine 2004; 28: 35-47.
70. Zhang X, Dong F, Ren J, Driscoll MJ, Culver B. High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex. Exp Neurol 2005; 191: 318-25.
71. Serhan CN. Lipoxins and aspirin-triggered 15-spi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins, Leuko Essent Fatty Acids 2005; 73: 141-62.
72. Gangemi S, Luciotti G, D'Urbano E. Physical exercise increases urinary excretion of lipoxin A4 and related compounds. J Appl Physiol 2003; 94: 2237-2240.
73. Radak Z, Chung HY, Naito H, Takahashi R, Jung KJ, Kim HJ, Goto S. Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise. FASEB J 2004; 18: 749-50.
74. Kalani R, Judge S, Carter C, Pahor M, Leeuwenburgh C. Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6. J Gerontol 2006; 61: 211-17.
75. Koshiyama H, Ogawa Y, Tanaka K, Tanaka I. The unified hypothesis of interactions among the bone, adipose and vascular systems: osteolipovascular interactions. Med Hypotheses 2006; 66: 960-63.