The unified hypothesis of interactions among the bone, adipose and vascular systems: 'Osteo-lipo-vascular interactions'

Medical Hypotheses

Volumn 66, Issue 5, 2006, Pages 960-963

  Koshiyama, Hiroyuki ^a,b   Ogawa, Yoshihiro ^c   Tanaka, Kiyoshi ^b,d   Tanaka, Issei ^e  

^a Kitano Hospital   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d KYOTO WOMEN'S UNIVERSITY   (Japan)

^e Keihanna Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; HUMORAL ANTIBODY; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; TRANSCRIPTION FACTOR;

ADIPOCYTE; ADIPOSE TISSUE; ARTICLE; ATHEROSCLEROSIS; BONE; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; HUMAN; HYPERLIPIDEMIA; HYPOTHESIS; INFLAMMATION; MACROPHAGE; MESENCHYMAL STEM CELL; MOLECULAR INTERACTION; OBESITY; OSTEOBLAST; OSTEOCLAST; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VASCULAR TISSUE;

ADIPOSE TISSUE; ANIMALS; BLOOD VESSELS; BONE AND BONES; CARDIOVASCULAR DISEASES; HUMANS; HYPERLIPIDEMIAS; MODELS, BIOLOGICAL; OBESITY; OSTEOPOROSIS;

EID: 32244442769     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2005.11.024     Document Type: Article

References (26)

1. N.J. Stone, S. Bilek, and S. Rosenbaum Recent national cholesterol education program adult treatment panel III update: adjustments and options Am J Cardiol 96 2005 53E 59E
2. H. Koshiyama, Y. Wada, and Y. Nakamura Hypercholesterolemia as a possible risk factor for osteopenia in type 2 diabetes (letter) Arch Intern Med 161 2001 1678
3. J.R. Burnett, and S.D. Vasikaran Cardiovascular disease and osteoporosis: is there a link between lipids and bone? Ann Clin Biochem 39 2002 203 210
4. H. Koshiyama Current topics in endocrinology: blood vessels and bones Nippon Naika Gakkai Zasshi 92 2003 629 634
5. Y. Matsuzawa Adipocytokines and metabolic syndrome Semin Vasc Med 5 2005 34 39
6. M. Abedin, Y. Tintut, and L.L. Demer Vascular calcification: mechanisms and clinical ramifications Arterioscl Thromb Vasc Biol 24 2004 1161 1170
7. M. Suda, Y. Komatsu, and K. Tanaka C-Type natriuretic peptide/guanylate cyclase B system in rat osteogenic ROB-C26 cells and its down-regulation by dexamethazone Calcified Tissue Int 65 1999 472 478
8. S. Takeda, F. Elefteriou, and R. Levasseur Leptin regulates bone formation via the sympathetic nervous system Cell 111 2002 305 317
9. T.A. Cock, and J. Auwerx Leptin: cutting the fat off the bone Lancet 362 2003 1572 1574
10. P.W. Ingham Hedgehog signaling: a tale of two lipids Science 294 2001 1879 1881
11. Y. Sakuma, K. Tanaka, and M. Suda Crucial involvement of the EP4 subtype of prostaglandin E receptor in osteoclast formation by proinflammatory cytokines and lipopolysaccharide J Bone Miner Res 15 2000 218 227
12. L.M. Boyden, J. Mao, and J. Belsy High bone density due to a mutation in LDL-receptor-related protein 5 New Engl J Med 346 20 2002 1513 1521
13. J. Plutzky Medicine. PPARs as therapeutic targets: reverse cardiology? Science 302 2003 406 407
14. J.H. Hong, E.S. Hwang, and M.T. McManus TAZ, a transcriptional modulator of mesenchymal stem cell differentiation Science 309 2005 1074 1078
15. F. Parhami, Y. Tintut, W.G. Beamer, N. Gharavi, W. Goodman, and L.L. Demer Atherogenic high-fat diet reduces bone mineralization in mice J Bone Miner Res 16 2001 182 188
16. H. Koshiyama, D. Shimono, N. Kuwamura, J. Minamikawa, and Y. Nakamura Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes J Clin Endocrinol Metab 86 2001 3452 3456
17. G.P. Chrousos, and P.W. Gold Editorial: a healthy body in a healthy mind-and vice versa-the damaging power of "uncontrollable" stress J Clin Endocrinol Metab 83 1998 1842 1845
18. H. Masuzaki, J. Paterson, and H. Shinyama A transgenic model of visceral obesity and the metabolic syndrome Science 294 2001 2166 2170
19. I.J. Bujalska, S. Kumar, and P.M. Stewart Does central obesity reflect "Cushing's disease of the omentum? Lancet 349 1997 1210 1213
20. H. Xu, G.T. Barnes, and Q. Yang Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J Clin Invest 112 2003 1821 1830
21. T. Suganami, J. Nishida, and Y. Ogawa A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor alpha Arterioscl Thromb Vasc Biol 25 2005 2062 2068
22. Koshiyama H, Honjo S, HamamotoY, Ikeda H, Wada Y. Drugs share antidiabetic and antiathersclerotic actions through "the common soil". Med Hypotheses [in press].
23. H. Koshiyama The impact of statin treatment on diabetic patients Curr Opin Investig Drugs 4 2003 395 400
24. H. Koshiyama, Y. Nakamura, S. Tanaka, and J. Minamikawa Decrease in carotid intima-media thickness after one-year therapy with etidronate for osteopenia associated with type 2 diabetes J Clin Endocrinol Metab 85 2000 2793 2796
25. R. Ylitalo Bisphosphonate and atherosclerosis General Pharmacol 35 2002 287 296
26. Y. Wada, Y. Nakamura, and H. Koshiyama Lack of positive correlation between stain use and bone mineral density in Japanese subjects with type 2 diabetes Arch Intern Med 160 2000 2865