Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis

Cancer Research

Volumn 64, Issue 24, 2004, Pages 8804-8807

  Vitale Cross, Lynn ^a   Amornphimoltham, Panomwat ^a   Fisher, Galen ^b   Molinolo, Alfredo A ^a   Gutkind, J Silvio ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b LASER AND SKIN SURGERY CENTER OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; K RAS PROTEIN; TETRACYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DYSPLASIA; EPITHELIUM HYPERPLASIA; ESOPHAGUS; FORESTOMACH; GENE MUTATION; IMMUNOHISTOCHEMISTRY; METASTASIS; MITOSIS INHIBITION; MOUSE; MOUTH MUCOSA; NONHUMAN; ONCOGENE RAS; PAPILLOMA; PRIORITY JOURNAL; SKIN; SQUAMOUS CELL CARCINOMA; TONGUE; TRANSGENE;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; EPIDERMIS; FEMALE; GENE EXPRESSION; GENES, RAS; MALE; MICE; MICE, TRANSGENIC; RAS PROTEINS; SKIN NEOPLASMS; STEM CELLS; TRANSGENES;

EID: 10844223748     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-2623     Document Type: Article

References (19)

1. Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-9.
2. Das N, Majumder J, DasGupta UB. ras gene mutations in oral cancer in eastern India. Oral Oncol 2000;36:76-80.
3. Perez-Losada J, Balmain A. Stem-cell hierarchy in skin cancer. Nat Rev Cancer 2003;3:434-43.
4. Serrano M, Lin AW, McCurrach ME, et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
5. Joneson T, Bar-Sagi D. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol Cell Biol 1999;19:5892-901.
6. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
7. Owens DM, Watt FM. Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer 2003;3:444-51.
8. Tumbar T, Guasch G, Greco V, et al. Defining the epithelial stem cell niche in skin. Science 2004;303:359-63.
9. Gossen M, Freundlieb S, Bender G, et al. Transcriptional activation by tetracyclines in mammalian cells. Science 1995;268:1766-9.
10. Ramirez A, Bravo A, Jorcano JL, Vidal M. Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development. Differentiation 1994;58:53-64.
11. Fisher GH, Wellen SL, Klimstra D, et al. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 2001;15:3249-62.
12. Brown K, Strathdee D, Bryson S, et al. The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr Biol 1998;8:516-24.
13. Bailleul B, Surani MA, White S, et al. Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell 1990;62:697-708.
14. Tuveson DA, Shaw AT, Willis NA, et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 2004;5:375-87.
15. Hingorani SR, Petricoin EF, Maitra A, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003;4:437-50.
16. Land H, Parada LF, Weinberg RA. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1983;304:596-602.
17. Blasco MA, Hahn WC. Evolving views of telomerase and cancer. Trends Cell Biol 2003;13:289-94.
18. Cairns J. Somatic stem cells and the kinetics of mutagenesis and carcinogenesis. Proc Natl Acad Sci USA 2002;99:10567-70.
19. Frank SA, Nowak MA, Cell biology: developmental predisposition to cancer. Nature 2003;422:494.