메뉴 건너뛰기




Volumn 5, Issue 7, 2007, Pages 705-711

Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR; DOUBLE STRANDED DNA; MYC PROTEIN; PROTEIN P27; PROTEIN P53;

EID: 34547129356     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-07-0058     Document Type: Article
Times cited : (37)

References (51)
  • 2
    • 0029743372 scopus 로고    scopus 로고
    • Conditional expression of N-myc in human neuroblastoma cells increases expression of α-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells
    • Lutz W, Stohr M, Schurmann J, Wenzel A, Lohr A, Schwab M. Conditional expression of N-myc in human neuroblastoma cells increases expression of α-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells. Oncogene 1996;13:803-12.
    • (1996) Oncogene , vol.13 , pp. 803-812
    • Lutz, W.1    Stohr, M.2    Schurmann, J.3    Wenzel, A.4    Lohr, A.5    Schwab, M.6
  • 3
    • 0038298900 scopus 로고    scopus 로고
    • Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss
    • Baudino TA., Maclean KH, Brennan J, et al. Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Mol Cell 2003;11:905-14.
    • (2003) Mol Cell , vol.11 , pp. 905-914
    • Baudino, T.A.1    Maclean, K.H.2    Brennan, J.3
  • 4
    • 21144448938 scopus 로고    scopus 로고
    • Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation
    • Nilsson JA, Keller UB, Baudino TA, et al. Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Cancer Cell 2005;7:433-44.
    • (2005) Cancer Cell , vol.7 , pp. 433-444
    • Nilsson, J.A.1    Keller, U.B.2    Baudino, T.A.3
  • 5
    • 34249097128 scopus 로고    scopus 로고
    • Myc targets Cks1to provoke the suppression of p27Kip1, proliferation and lymphomagenesis
    • Keller UB, Old JB, Dorsey FC, et al. Myc targets Cks1to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J 2007;26:2562-74.
    • (2007) EMBO J , vol.26 , pp. 2562-2574
    • Keller, U.B.1    Old, J.B.2    Dorsey, F.C.3
  • 6
    • 0036285034 scopus 로고    scopus 로고
    • c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
    • Vafa O, Wade M, Kern S, et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell 2002;9:1031-44.
    • (2002) Mol Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1    Wade, M.2    Kern, S.3
  • 7
    • 0033569422 scopus 로고    scopus 로고
    • Disruption of the ARF-Mdm2-53 tumor suppressor pathway in Myc-induced lymphomagenesis
    • Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. Disruption of the ARF-Mdm2-53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 1999;13:2658-69.
    • (1999) Genes Dev , vol.13 , pp. 2658-2669
    • Eischen, C.M.1    Weber, J.D.2    Roussel, M.F.3    Sherr, C.J.4    Cleveland, J.L.5
  • 9
    • 0037099496 scopus 로고    scopus 로고
    • Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis
    • Martins CP, Berns A. Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis. EMBO J 2002;21:3739-48.
    • (2002) EMBO J , vol.21 , pp. 3739-3748
    • Martins, C.P.1    Berns, A.2
  • 10
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • Sherr CJ. Principles of tumor suppression. Cell 2004;116:235-46.
    • (2004) Cell , vol.116 , pp. 235-246
    • Sherr, C.J.1
  • 11
    • 33746803213 scopus 로고    scopus 로고
    • Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms
    • Finch A, Prescott J, Shchors K, et al. Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms. Cancer Cell 2006;10:113-20.
    • (2006) Cancer Cell , vol.10 , pp. 113-120
    • Finch, A.1    Prescott, J.2    Shchors, K.3
  • 12
    • 0029742122 scopus 로고    scopus 로고
    • Genomic instability in MycER-activated Rat1A-MycER cells
    • Mai S, Fluri M, Siwarski D, Huppi K. Genomic instability in MycER-activated Rat1A-MycER cells. Chromosome Res 1996;4:365-71.
    • (1996) Chromosome Res , vol.4 , pp. 365-371
    • Mai, S.1    Fluri, M.2    Siwarski, D.3    Huppi, K.4
  • 13
    • 0033616602 scopus 로고    scopus 로고
    • Transient excess of MYC activity can elicit genomic instability and tumorigenesis
    • Felsher DW, Bishop JM. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. Proc Natl Acad Sci U S A 1999;96:3940-4.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3940-3944
    • Felsher, D.W.1    Bishop, J.M.2
  • 14
    • 0029822745 scopus 로고    scopus 로고
    • Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc
    • Vlach J, Hennecke S, Alevizopoulos K, Conti D, Amati B. Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J 1996;15:6595-604.
    • (1996) EMBO J , vol.15 , pp. 6595-6604
    • Vlach, J.1    Hennecke, S.2    Alevizopoulos, K.3    Conti, D.4    Amati, B.5
  • 16
    • 22144453538 scopus 로고    scopus 로고
    • c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus
    • Louis SF, Vermolen BJ, Garini Y, et al. c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus. Proc Natl Acad Sci U S A 2005;102:9613-8.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9613-9618
    • Louis, S.F.1    Vermolen, B.J.2    Garini, Y.3
  • 17
    • 9244251125 scopus 로고    scopus 로고
    • Cell cycle checkpoints and cancer
    • Kastan MB, Bartek J. Cell cycle checkpoints and cancer. Nature 2004;432:316-23.
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 18
    • 0034798285 scopus 로고    scopus 로고
    • ATM: Genome stability, neuronal development, and cancer cross paths
    • Shiloh Y, Kastan MB. ATM: genome stability, neuronal development, and cancer cross paths. Adv Cancer Res 2001;83:209-54.
    • (2001) Adv Cancer Res , vol.83 , pp. 209-254
    • Shiloh, Y.1    Kastan, M.B.2
  • 19
    • 0034946243 scopus 로고    scopus 로고
    • Ataxia telangiectasia gene mutations in leukaemia and lymphoma
    • Boultwood J. Ataxia telangiectasia gene mutations in leukaemia and lymphoma. J Clin Pathol 2001;54:512-6.
    • (2001) J Clin Pathol , vol.54 , pp. 512-516
    • Boultwood, J.1
  • 20
    • 15844426692 scopus 로고    scopus 로고
    • Atm-deficient mice: A paradigm of ataxia telangiectasia
    • Barlow C, Hirotsune S, Paylor R, et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 1996;86:159-71.
    • (1996) Cell , vol.86 , pp. 159-171
    • Barlow, C.1    Hirotsune, S.2    Paylor, R.3
  • 21
    • 0034284341 scopus 로고    scopus 로고
    • Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice
    • Liyanage M, Weaver Z, Barlow C, et al. Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice. Blood 2000;96:1940-6.
    • (2000) Blood , vol.96 , pp. 1940-1946
    • Liyanage, M.1    Weaver, Z.2    Barlow, C.3
  • 22
    • 0028171968 scopus 로고
    • Mediation of c-Myc-induced apoptosis by p53
    • Hermeking H, Eick D. Mediation of c-Myc-induced apoptosis by p53. Science 1994;265:2091-3.
    • (1994) Science , vol.265 , pp. 2091-2093
    • Hermeking, H.1    Eick, D.2
  • 23
    • 0028034199 scopus 로고
    • Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1
    • Wagner AJ, Kokontis JM, Hay N. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. Genes Dev 1994;8:2817-30.
    • (1994) Genes Dev , vol.8 , pp. 2817-2830
    • Wagner, A.J.1    Kokontis, J.M.2    Hay, N.3
  • 24
    • 0032145569 scopus 로고    scopus 로고
    • Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
    • Zindy F, Eischen CM, Randle DH, et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 1998;12:2424-33.
    • (1998) Genes Dev , vol.12 , pp. 2424-2433
    • Zindy, F.1    Eischen, C.M.2    Randle, D.H.3
  • 25
    • 31944451363 scopus 로고    scopus 로고
    • ATM promotes apoptosis and suppresses tumorigenesis in response to Myc
    • Pusapati RV, Rounbehler RJ, Hong S, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A 2006;103:1446-51.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1446-1451
    • Pusapati, R.V.1    Rounbehler, R.J.2    Hong, S.3
  • 26
    • 0029002136 scopus 로고
    • A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
    • Littlewood TD, Hancock DC, Danielian PS, Parker MG, Evan GI. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res 1995;23:1686-90.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1686-1690
    • Littlewood, T.D.1    Hancock, D.C.2    Danielian, P.S.3    Parker, M.G.4    Evan, G.I.5
  • 27
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003;421:499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 29
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • Canman CE, Lim DS, Cimprich KA, et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998;281:1677-9.
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1    Lim, D.S.2    Cimprich, K.A.3
  • 30
    • 0035265686 scopus 로고    scopus 로고
    • Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001;7:683-94.
    • Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 2001;7:683-94.
  • 32
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003;4:321-8.
    • (2003) Cancer Cell , vol.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3
  • 33
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 2000;10:886-95.
    • (2000) Curr Biol , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 34
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams JM, Harris AW, Pinkert CA, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985;318:533-8.
    • (1985) Nature , vol.318 , pp. 533-538
    • Adams, J.M.1    Harris, A.W.2    Pinkert, C.A.3
  • 35
    • 0029819493 scopus 로고    scopus 로고
    • Mutations associated with variant phenotypes in ataxia-telangiectasia
    • McConville CM, Stankovic T, Byrd PJ, et al. Mutations associated with variant phenotypes in ataxia-telangiectasia. Am J Hum Genet 1996;59:320-30.
    • (1996) Am J Hum Genet , vol.59 , pp. 320-330
    • McConville, C.M.1    Stankovic, T.2    Byrd, P.J.3
  • 36
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova J, Horejsi Z, Koed K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005;434:864-70.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3
  • 37
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis VG, Vassiliou LV, Karakaidos P, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005;434:907-13.
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1    Vassiliou, L.V.2    Karakaidos, P.3
  • 38
    • 0028046245 scopus 로고
    • Apoptosis and macrophage-mediated deletion of precursor B cells in the bone marrow of Eμ-myc transgenic mice
    • Jacobsen KA, Prasad VS, Sidman CL, Osmond DG. Apoptosis and macrophage-mediated deletion of precursor B cells in the bone marrow of Eμ-myc transgenic mice. Blood 1994;84:2784-94.
    • (1994) Blood , vol.84 , pp. 2784-2794
    • Jacobsen, K.A.1    Prasad, V.S.2    Sidman, C.L.3    Osmond, D.G.4
  • 39
    • 0023102883 scopus 로고
    • A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis
    • Collins LS, Dorshkind K. A stromal cell line from myeloid long-term bone marrow cultures can support myelopoiesis and B lymphopoiesis. J Immunol 1987;138:1082-7.
    • (1987) J Immunol , vol.138 , pp. 1082-1087
    • Collins, L.S.1    Dorshkind, K.2
  • 40
    • 0034953712 scopus 로고    scopus 로고
    • Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis
    • Eischen CM, Woo D, Roussel MF, Cleveland JL. Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol Cell Biol 2001;21:5063-70.
    • (2001) Mol Cell Biol , vol.21 , pp. 5063-5070
    • Eischen, C.M.1    Woo, D.2    Roussel, M.F.3    Cleveland, J.L.4
  • 41
    • 33746106937 scopus 로고    scopus 로고
    • MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species
    • Ray S, Atkuri KR, Deb-Basu D, et al. MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species. Cancer Res 2006;66:6598-605.
    • (2006) Cancer Res , vol.66 , pp. 6598-6605
    • Ray, S.1    Atkuri, K.R.2    Deb-Basu, D.3
  • 42
    • 22144493320 scopus 로고    scopus 로고
    • ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress
    • Pauklin S, Kristjuhan A, Maimets T, Jaks V. ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress. Biochem Biophys Res Commun 2005;334:386-94.
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 386-394
    • Pauklin, S.1    Kristjuhan, A.2    Maimets, T.3    Jaks, V.4
  • 43
    • 0030584727 scopus 로고    scopus 로고
    • Cytokines suppress apoptosis independent of increases in reactive oxygen levels
    • Packham G, Ashmun RA, Cleveland JL. Cytokines suppress apoptosis independent of increases in reactive oxygen levels. J Immunol 1996;156:2792-800.
    • (1996) J Immunol , vol.156 , pp. 2792-2800
    • Packham, G.1    Ashmun, R.A.2    Cleveland, J.L.3
  • 44
    • 0025251664 scopus 로고
    • Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    • Strasser A, Harris AW, Cory S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990;348:331-3.
    • (1990) Nature , vol.348 , pp. 331-333
    • Strasser, A.1    Harris, A.W.2    Cory, S.3
  • 47
    • 23844469503 scopus 로고    scopus 로고
    • Evasion of the p53 tumor surveillance network by tumor-derived myc mutants
    • Hemann MT, Bric A, Teruya-Feldstein J, et al. Evasion of the p53 tumor surveillance network by tumor-derived myc mutants. Nature 2005;436:807-11.
    • (2005) Nature , vol.436 , pp. 807-811
    • Hemann, M.T.1    Bric, A.2    Teruya-Feldstein, J.3
  • 48
    • 0032524070 scopus 로고    scopus 로고
    • Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
    • Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 1998;280:1089-91.
    • (1998) Science , vol.280 , pp. 1089-1091
    • Herzog, K.H.1    Chong, M.J.2    Kapsetaki, M.3    Morgan, J.I.4    McKinnon, P.J.5
  • 49
    • 33845893896 scopus 로고    scopus 로고
    • Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase
    • Shreeram S, Hee WK, Demidov ON, et al. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med 2006;203:2793-9.
    • (2006) J Exp Med , vol.203 , pp. 2793-2799
    • Shreeram, S.1    Hee, W.K.2    Demidov, O.N.3
  • 51
    • 0346455759 scopus 로고    scopus 로고
    • Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
    • Liu G, Parant JM, Lang G, et al. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet 2004;36:63-8.
    • (2004) Nat Genet , vol.36 , pp. 63-68
    • Liu, G.1    Parant, J.M.2    Lang, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.