Genomic instability in MycER-activated Rat1A-MycER cells

Chromosome Research

Volumn 4, Issue 5, 1996, Pages 365-371

  Mai, Sabine ^a   Fluri, Monika ^b   Siwarski, David ^c   Huppi, Konrad ^c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; ESTROGEN; EXTRACHROMOSOMAL DNA; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHROMOSOME ABERRATION; CHROMOSOME BREAKAGE; CHROMOSOME STRUCTURE; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENETIC STABILITY; NONHUMAN; NUMERICAL CHROMOSOME ABERRATION; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALIA;

EID: 0029742122     PISSN: 09673849     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02257272     Document Type: Article

References (32)

1. Baker PE (1982) Double minutes in human tumor cells. Cancer Genet Cytogenet 5: 81-94.
2. Bello-Fernandez C, Packham G, Cleveland JL (1993) The ornithine decarboxylase is a transcriptional target of c-Myc. Proc Natl Acad Sci USA 90: 9804-9808.
3. Daksis JI, Lu RY, Facchini LM, Marhin WW, Penn LJZ (1994) Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle. Oncogene 9: 3635-3645.
4. Eilers M, Picard D, Yamamoto KR, Bishop JM (1989) Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature 340: 66-68.
5. Gaubatz S, Meichele A, Eilers M (1994) An E-box element localized in the first intron mediates regulation of the prothymosin α gene by c-myc. Mol Cell Biol 14: 3853-3862.
6. Hanson KD, Shichiri M, Follansbee MR, Sedivy JM (1994) Effects of c-myc expression on cell cycle progression. Mol Cell Biol 14: 5748-5755.
7. 1. Nature 328: 445-449.
8. Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253: 49-53.
9. Karn J, Watson JV, Lowe AD, Green SM, Vedeckis W (1989) Regulation of cell cycle duration by c-myc levels. Oncogene 4: 4773-4787.
10. INK4 deletion with monosomy 5 in kidney epithelial cell lines but not primary renal tumors. Cancer Res 55: 1607-1612.
11. Livingstone LR, White A, Sprouse J et al. (1992) Altered cell cycle arrest and gene amplification potential accompanying loss of wild-type p53. Cell 70: 923-935.
12. Luecke-Huhle C (1989) Review: gene amplification-a cellular response to genotoxic stress. Mol Toxicol 2: 237-253.
13. Mai S (1994) Overexpression of c-myc precedes amplification of the gene encoding dihydrofolate reductase. Gene 148: 253-260.
14. Mai S, Jalava A (1994) C-Myc binds to 5′ flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation. Nucleic Acids Res 22: 2264-2273.
15. Mai S, Hanley-Hyde J, Fluri M (1996) C-Myc overexpression associated DHFR gene amplification in mouse, hamster, rat and human cell lines. Oncogene 12: 277-288.
16. Marcu KB, Boggone SA, Patel AJ (1992) Myc function and regulation. Annu Rev Biochem 61: 809-860.
17. Phillip A, Schneider A, Vastrik I et al. (1994) Repression of cyclin D1: A novel function of MYC. Mol Cell Biol 14: 4032-4043.
18. Otto E, McCord S, Tlsty TD (1989) Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability in neoplastic cells. J Biol Chem 264: 3390-3396.
19. Potter M, Wiener F (1992) Plasmacytomagenesis in mice: model of neoplastic development upon chromosomal translocation. Carcinogenesis 13: 1681-1697.
20. Rabbitts TH (1994) Chromosomal translocations in human cancer. Nature 372: 143-149.
21. Schimke RT (1984) Gene amplification, drug resistance, and cancer. Cancer Res 44: 1735-1742.
22. Smith KA, Gorman PA, Stark MB, Groves RP, Stark GR (1990) Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells. Cell 63: 1219-1227.
23. Smith KA, Stark MB, Gorman PA, Stark GR (1992) Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells. Proc Natl Acad Sci USA 89: 5427-5431.
24. Soussi T, Caron de Fromentel C, Breugnot C, May E (1988) Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein. Nucleic Acids Res 16: 11384.
25. Stark GR (1993) Regulation and mechanisms of mammalian gene amplification. Adv Cancer Res 61: 87-113.
26. Tlsty TD (1990) Normal diploid human and rodent cells lack a detectable frequency of gene amplification. Proc Natl Acad Sci USA 87: 3132-3136.
27. Wahl GM (1989) The importance of circular DNA in mammalian gene amplification. Cancer Res 49: 1333-1340.
28. Waters CM, Littlewood TD, Hancock DC, Moore JP, Evan GT (1991) C-Myc protein expression in untransformed fibroblasts. Oncogene 6: 797-805.
29. Wright JA, Smith HS, Watt FM et al. (1990) DNA amplification is rare in normal human cells. Proc Natl Acad Sci USA 87: 1791-1795.
30. Yin Y, Tainsky MA, Bischoff FZ, Strong L, Wahl GM (1992) Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70: 937-948.
31. Yokota J, Tsunetsuga-Yokota Y, Battifora H, Lefevre C, Cline MJ (1986) Alterations in myc, myb and ras Ha protooncogenes in cancers are frequent and show clinical correlation. Science 231: 261-265.
32. 1 enhances gene amplification. Cancer Res 56: 36-39.