D2 dopamine receptor gene haplotypes and their influence on alcohol and tobacco consumption magnitude in alcohol-dependent individuals

Alcohol and Alcoholism

Volumn 42, Issue 3, 2007, Pages 258-266

  Preuss, Ulrich W ^a,b   Zill, P ^a   Koller, G ^a   Bondy, B ^a   Sokya, M ^a,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c Private Hospital Meiringen   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; NICOTINE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTERNATIONAL CLASSIFICATION OF DISEASES; INTRON; MAJOR CLINICAL STUDY; MALE; MARKER GENE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TOBACCO DEPENDENCE;

ADULT; ALCOHOL DRINKING; ALCOHOL-RELATED DISORDERS; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; RECEPTORS, DOPAMINE D2; SMOKING;

NICOTIANA TABACUM;

EID: 34447549206     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agm030     Document Type: Article

References (82)

1. Anthony, J. C. and Echeagaray-Wagner, F. (2000) Epidemiologic analysis of alcohol and tobacco use. Alcohol Research and Health 24, 201-208.
2. Arinami, T., Gao, M., Hamaguchi, H. et al. (1997) A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Human Molecular Genetics 6, 577-582.
3. Audrain-McGovern, J., Lerman, C., Wileyto, E. P. et al. (2004) Interacting effects of genetic predisposition and depression on adolescent smoking progression. American Journal of Psychiatry 161, 1224-1230.
4. Bader, J. S. (2001) The relative power of SNPs and haplotype as genetic markers for association tests. Pharmacogenomics 2, 11-24.
5. Balfour, D. J. K., Benwell, M. E. M., Birrell, C. E. et al. (1998) Sensitization of the mesoaccumbens dopamine response to nicotine. Pharmacology Biochemistry and Behavior 59, 1021-1030.
6. Berggren, U., Fahlke, C., Aronsson, E. et al. (2006) The taqi D2 dopamine receptor gene A1 allele is associated with alcohol-dependence although its effect size is small. Alcohol Alcoholism 41, 479-485.
7. Bien, T. H. and Burge, R. (1990) Smoking and drinking: A review of the literature. International Journal of Addiction 25, 1429-1454.
8. Bierut, L., Rice, J. and Edenberg, H. (2000a) Family-based study of the association of the dopamine D2 receptor gene (D2 dopamine receptor gene) with habitual smoking. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 90, 299-302.
9. Bierut, L., Schuckit, M. A., Hesselbrock, V. et al. (2000b) Co-Occurring risk factors for alcohol dependence and habitual smoking. Alcohol Research and Health 24, 233-241.
10. Blomqvist, O., Ericson, M., Engel, J. A. et al. (1997) Accumbal dopamine overflow after ethanol: Localization of the antagonizing effect of mecamylamine. European Journal of Pharmacology 334, 149-156.
11. Bowirrat, A. and Oscar-Berman, M. (2005) Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 132, 29-37.
12. Breen, G., Brown, J., Maude, S. et al. (1999).) 141 C del/ins polymorphism of the dopamine receptor 2 gene is associated with schizophrenia in a British population. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 88, 407-410.
13. Bucholz, K. K., Cadoret, R., Cloninger, C. R. et al. (1994) A new, semi-structured psychiatric interview for use in genetic linkage studies, a report on the reliability of the SSAGA. Journal of Studies on Alcohol 55, 149-158.
14. Collins, A. C. (1990) Interactions of ethanol and nicotine at the receptor level. Recent Developments in Alcoholism 8, 221-231.
15. Comings, D. E. and Blum, K. (2000) Reward deficiency syndrome: Genetic aspects of behavioral disorders. Progress in Brain Research 126 325-341.
16. Comings, D. E., Ferry, L., Bradshaw-Robinson, S. et al. (1996) The dopamine D2 receptor (DRD2) gene: A genetic risk factor in smoking. Pharmacogenetics 6, 73-79.
17. Drummond, D. C. (2000) What does cue-reactivity have to offer clinical research? Addiction 95 (Suppl 2), S129-S144.
18. Edwards, R. (2004) The problem of tobacco smoking. British Medical Journal 328, 217-219.
19. Erblich, J., Lerman, C., Self, D. W. et al. (2004) Stress-induced cigarette craving: Effects of the D2 Dopamine receptor gene TaqI RFLP and SLC6A3 VNTR polymorphisms. Pharmacogenomics Journal 4, 102-109.
20. Fan, R. and Knapp, M. (2003) Genome association studies of complex diseases by case-control designs. American Journal of Human Genetics 72, 850-868.
21. Gelernter, J. and Kranzler, H. (1999) D2 dopamine receptor gene (D2 Dopamine receptor genes) allele and haplotype frequencies in alcohol dependent and control subjects, no association with phenotype or severity of phenotype. Neuropsychopharmacology 20, 640-649.
22. Gilbert, D., McClernon, J., Rabinovich, N. et al. (2004) Effects of quitting smoking on EEG activation and attention last for more than 31 days and are more severe with stress, dependence, D2 dopamine receptor gene A1 allele, and depressive traits. Nicotine and Tobacco Research 6, 249-267.
23. Glass, J. M., Adams, K. M., Nigg, J. T. et al. (2006) Smoking is associated with neurocognitive deficits in alcoholism. Drug and Alcohol Dependence 82, 119-126.
24. Goode, E. L., Badzioch, M. D., Kim, H. et al. (2003) Framingham Heart Study. Multiple genome-wide analyses of smoking behavior in the Framingham Heart Study. BMC Genetics 4 (Suppl 1), S102.
25. Gorrod, J. W., Aislaitner, G. (1998) Preliminary Indication of a Genetic Influence on Nicotine Metabolism in Smokers. Society for Research on Nicotine and Tobacco. Annual conference in New Orleans.
26. Gorwood, P., Limosin, F., Batel, P. et al. (2003) The A9 allele of the dopamine transporter gene is associated with delirium tremens and alcohol-withdrawal seizure. Biological Psychiatry 53, 85-92.
27. Grandy, D. K., Zhang, Y. and Civelli, O. (1993) PCR detection of the Taq1A RFLP at the D2 dopamine receptor gene locus. Human Molecular Genetics 2, 2197.
28. Guo, S. W. and Thompson, E. A. (1992) Performing the exact test of Hardy Weinberg proportion for multiple alleles. Biometrics 48, 361-372.
29. Hallikainen, T., Hietala, J., Kauhanen, J. et al. (2003) Ethanol consumption and D2 dopamine receptor gene TaqI A polymorphism among socially drinking males. American Journal of Medical Genetics Part A 119, 152-155.
30. Heath, A. C., Bucholz, K. K., Madden, P. A. F. et al. (1997) Genetic and environmental contributions to alcohol dependence risk in a national twin sample consistency of findings in men and women. Psychological Medicine 27, 1381-1396.
31. Hesselbrock, M., Easton, C., Bucholz, K. K. et al. (1999) A validity study of the SSAGA-a comparison with the SCAN. Addiction 94, 1361-1370.
32. Hurt, R. D. and Patten, C. A. (2003) Treatment of tobacco dependence in alcoholics. Recent Developments in Alcoholism 16, 335-359.
33. Jonsson, E. G., Nothen, M. M., Grunhage, F. et al. (1999) Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Molecular Psychiatry 4, 290-296.
34. Koob, G. F., Roberts, A. J., Schilteis, G. et al. (1998) Neurocircuitry targets in ethanol reward and dependence. Alcoholism Clinical and Experimental Research 22, 3-9.
35. Koopmans, J. R., Slutske, W. S., Heath, A. C. et al. (1999) The genetics of smoking initiation and quantity smoked in Dutch adolescent and young adult twins. Behavior Genetics 29, 383-393.
36. Kreek, M. J. and Koob, G. F. (1998) Drug dependence: Stress and dysregulation of brain reward pathways. Drug and Alcohol Dependence 51, 23-47.
37. Laruelle, M., Gelernter, J. and Innis, R. B. (1998) D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene. Molecular Psychiatry 3, 261-265.
38. Lawford, B. R., Young, R., Noble, E. P. et al. (2006) The D2 dopamine receptor (D2 dopamine receptor gene) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder. European Psychiatry 21, 180-185.
39. Lerman, C., Caporaso, N. E., Audrain, J. et al. (1999) Evidence suggesting the role of specific genetic factors in cigarette smoking. Health Psychology 18, 14-20.
40. Lerman, C. and Swan, G. E. (2002) Non-replication of genetic association studies is DAT all folks? Nicotine and Tobacco Research 4, 247-251.
41. Li, M. D., Ma, J. Z. and Beuten, J. (2004) Progress in searching for susceptibility loci and genes for smoking-related behaviour. Clinical Genetics 66, 382-392.
42. Li, M. D., Ma, J. Z., Cheng, R. et al. (2003) Framingham Heart Study. A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population. BMC Genetics 4 (Suppl 1 , S103.
43. Lu, R. B., Lee, F., Ko, H. C. et al. (2001) Dopamine D2 receptor gene (D2 dopamine receptor gene) is associated with alcoholism with conduct disorder. Alcoholism Clinical and Experimental Research 25, 177-184.
44. Munafo, M. R., Johnstone, E. C., Welsh, K. I. et al. (2005) Association between the D2 dopamine receptor gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers. Pharmacogenomics Journal 2, 96-101.
45. Noble, E. P. (1998) The D2 dopamine receptor gene: A review of association studies in alcoholism and phenotypes. Alcoholism 16 33-45.
46. Noble, E. P. (2000) Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene a review. European Psychiatry 15, 79-89.
47. Noble, E. P. (2003) D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Journal of Medical Genetics Part B Neuropsychiatric Genetics 116, 103-125.
48. Noble, E. P., Jeor, S. T., Ritchie T. et al. (1994) D2 dopamine receptor gene and cigarette smoking: A reward gene? Medical Hypotheses 42, 257-260.
49. Noble, E. P., Zhang, X., Ritchie, T. L. et al. (2000) Haplotypes at the DRD2 locus and severe alcoholism. Journal of Medical Genetics Part B Neuropsychiatric Genetics 96, 622-631.
50. Pergadia, M. L., Heath, A. C., Martin, N. G. et al. (2006) Genetic analyses of DSM-IV nicotine withdrawal in adult twins. Psychological Medicine 36, 963-972.
51. Phillips, T. J. and Shen, E. H. (1996) Neurochemical bases of locomotion and ethanol stimulant effects. International Review of Neurobiology 39, 243-282.
52. Pohjalainen, T., Nagren, K., Syvalahti, E. K. et al. (1999) The dopamine D2 receptor 5- flanking variant, -141C Ins/Del, is not associated with reduced dopamine D2 receptor density in vivo. Pharmacogenetics 9, 505-509.
53. Pohjalainen, T., Rinne, J. O., Nagren, K. et al. (1998) The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Molecular Psychiatry 3, 256-260.
54. Preuss, U. W., Koller, G., Soyka, M. et al. (2001) Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects further evidence from a German alcohol-dependent inpatient sample. Biological Psychiatry 50, 636-639.
55. Preuss, U. W., Soyka, M., Bahlmann, M. et al. (2000) Serotonin transporter gene regulatory region polymorphism (5- HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity. Psychiatry Research 96, 51-61.
56. Ritchie, T. and Noble, E. P. (2003) Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochemical Research 28, 73-82.
57. Sabol, S., Nelson, M., Fisher, C. et al. (1999) A genetic association for cigarette smoking behavior. Health Psychology 18, 7-13.
58. Saccone, N. L., Kwon, J. M., Corbett, J. et al. (2000) A genome screen of maximum number of drinks as a alcoholism phenotype. Journal of Medical Genetics Part B Neuropsychiatric Genetics 96, 632-637.
59. Saccone, N. L., Neuman, R. J., Saccone, S. F. et al. (2003) Genetic analysis of maximum cigarette-use phenotypes. BMC Genetics 4 (Suppl. 1), S105.
60. Samson, H. H., Tolliver, G. A., Haraguchi, M. et al. (1992) Alcohol self-administration: Role of mesolimbic dopamine. Annales of the New York Academy of Science 654, 242-253.
61. Sander, T., Harms, H., Podschus, J. et al. (1997) Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium. Biological Psychiatry 41, 299-304.
62. Sano, A., Kondoh, K., Hakimoto, Y. et al. (1993) A 40-nucleotide repeat polymorphism in the human dopamine transporter gene. Human Genetics 91, 405-406.
63. Schmidt, L. G., Harms, H., Kuhn, S. et al. (1998) Modification of alcohol withdrawal by the A9 allele of the dopamine transporter gene. American Journal of Psychiatry 155, 474-478.
64. Soyka, M., Preuss, U. W., Koller, G. et al. (2002) Dopamine D 4 receptor gene polymorphism and extraversion revisited results from the Munich gene bank project for alcoholism. Journal of Psychiatric Research 36, 429-435.
65. Spitz, M. R., Shi, H., Yang, F. et al. (1998) Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients. Journal of the National Cancer Institut 90, 358-361.
66. Straub, R. E., Sullivan, P. F., Ma, Y. et al. (1999) Susceptibility genes for nicotine dependence: A genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study. Molecular Psychiatry 4, 129-144.
67. Thanos, P. K., Rivera, S. N., Weaver, K. et al. (2005) Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice effects on ethanol drinking. Life Sciences 77, 130-139.
68. Thanos, P. K., Taintor, N. B., Rivera, S. N. et al. (2004) D2 dopamine receptor gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking. Alcoholism Clinical and Experimental Research 28, 720-728.
69. Thanos, P. K., Volkow, N. D., Freimuth, P. et al. (2001) Overexpression of dopamine D2 receptors reduces alcohol self-administration. Journal of Neurochemistry 78, 1094-1103.
70. Thompson, J., Thomas, N., Singleton, A. et al. (1997) D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: Reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 7, 479-484.
71. Tiihonen, J., Kuikka, J., Bergstrom, K. et al. (1995) Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics. Nature Medicine 7, 654-657.
72. Tregouet, D. A., Barbaux, S., Escolano, S., et al. (2002) Specific haplotypes of the P-selectin gene are associated with myocardial infarction. Human Molecular Genetics 11, 2015-2023.
73. True, W. R., Heath, A. C., Scherrer, J. F. et al. (1997) Genetic and environmental contributions to smoking. Addiction 92, 1277-1287.
74. True, W. R., Xian, H., Scherrer, J. F. et al. (1999) Common genetic vulnerability for nicotine and alcohol dependence in men. Archives of General Psychiatry 56, 655-661.
75. Vandenbergh, D. J., Bennett, C. J., Grant, M. D. et al. (2002) Smoking status and the human dopamine transporter variable number of tandem repeats (VNTR) polymorphism: Failure to replicate and finding that never-smokers may be different. Nicotine and Tobacco Research 4, 333-340.
76. VanNess, S. H., Owens, M. J. and Kilts, C. D. (2005) The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. BMC Genetics 6, 55.
77. Volkow, N. D., Chang, L., Wang, G. J. et al. (2001) Low level of brain dopamine D2 receptors in methamphetamine abusers association with metabolism in the orbitofrontal cortex. American Journal of Psychiatry 158, 2015-2021.
78. Volkow, N. D., Fowler, J. S. and Wang, G. J. (2002) Role of dopamine in drug reinforcement and addiction in humans results from imaging studies. Behavioural Pharmacology 13, 355-366.
79. Volkow, N. D., Fowler, J. S., Wang, G. J. et al. (2004) Dopamine in drug abuse and addiction: Results from imaging studies and treatment implications. Molecular Psychiatry 6, 557-569.
80. Volkow, N. D., Wang, G. J., Begleiter, H. et al. (2006) High levels of dopamine D2 receptors in unaffected members of alcoholic families: Possible protective factors. Archives of General Psychiatry 63, 999-1008.
81. Wigginton, J. E., Cutler, D. J. and Abecasis, G. R. (2005) A note on exact tests of Hardy-Weinberg equilibrium. American Journal of Human Genetics 76, 887-893.
82. Zacny, J. P. (1990) Behavioral aspects of alcohol-tobacco interactions. Recent Developments in Alcoholism 8, 205-219.