Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity

Psychiatry Research

Volumn 96, Issue 1, 2000, Pages 51-61

  Preuss, Ulrich W ^a   Soyka, Michael ^a   Bahlmann, Miriam ^a   Wenzel, Karin ^a   Behrens, Stefanie ^a   de Jonge, Sylvia ^a   Krüger, Marc ^a   Bondy, Brigitta ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alcohol dependence; Healthy control subjects; Impulsivity; Serotonin transporter polymorphism; 3H paroxetine binding

Indexed keywords

PAROXETINE; SEROTONIN TRANSPORTER;

ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA POLYMORPHISM; DRUG RECEPTOR BINDING; FEMALE; GENOTYPE; HUMAN; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; ONSET AGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; THROMBOCYTE;

ADULT; AGED; ALCOHOLISM; BLOOD PLATELETS; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; GENOTYPE; HUMANS; IMPULSIVE BEHAVIOR; MALE; MIDDLE AGED; PAROXETINE; PHENOTYPE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 0034715152     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(00)00190-6     Document Type: Article

References (39)

1. Ballenger J.C., Goodwin F.K., Major L.F., Brown G.L. Alcohol and central serotonin metabolism in man. Archives of General Psychiatry. 36:1979;224-227.
2. Barratt E.S. Factor analysis of some psychometric measures of impulsiveness and anxiety. Psychological Reports. 16:1965;547-554.
3. Bucholz K.K., Cadoret R., Cloninger C.R., Dinwiddie S.H., Hesselbrock V.M., Nurnberger J.I., Reich T., Schmidt I., Schuckit M.A. A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. Journal of Studies in Alcohol. 55:1995;149-158.
4. Chen H.T., Casanova M.F., Kleinman J.E., Zito M., Goldman D., Linnoila M. H-paroxetine binding in brains of alcoholics. Psychiatry Research. 38:1991;293-299.
5. Coccaro E.F., Harvey P.D., Kupsaw-Lawrence E., Herbert J.L., Bernstein D.P. Development of neuropharmacologically based behavioral assessments of impulsive aggressive behavior. Journal of Neuropsychiatry and Clinical Neuroscience. 3:1991;44-51.
6. Coccaro E.F., Kavoussi R.J., Sheline Y.I., Lish J.D., Csernansky J.G. Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Archives of General Psychiatry. 53:1996;531-536.
7. Collier D.A., Arranz M.J., Sham P., Battersby S., Vallada H., Gill P., Aitchison K.J., Sodhi M., Li T., Roberts G.W., Smith B., Morton J., Murray R.M., Smith D., Kirov G. The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuroreport. 7:1996;1675-1679.
8. Cook E.H., Courchesne R., Lord R., Cox N.J., Yan S., Lincoln A., Haas R., Courchesne E., Leventhal B.L. Evidence of linkage between the serotonin transporter and autistic disorder. Molecular Psychiatry. 2:1997;247-250.
9. 3H-paroxetine binding. Life Sciences. 48:1991;1977-1983.
10. Edenberg H.J., Reynolds J., Koller D.L., Begleiter H., Bucholz K.K., Conneally P.M., Crowe R., Goate A., Hesselbrock V., Li T.K., Nurnberger J.I., Porjesz B., Reich T., Rice J.P., Schuckit M., Tischfield J.A., Foroud T. A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence. Alcohol: Clinical and Experimental Research. 22:1998;1080-1085.
11. Endler N.S., Parker J.D.A., Butcher J.N. A factor analytic study of coping styles and the MMPI-2 content scales. Journal of Clinical Psychology. 49:1993;523-527.
12. Fils-Aime M.L., Eckhardt M.J., George D.T., Brown G.L., Mefford I., Linnoila M. Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics. Archives of General Psychiatry. 53:1996;211-216.
13. Greenberg B.D., Tolliver T.J., Huang S.J., Li Q., Bengel D., Murphy D.L. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. American Journal of Medical Genetics. 88:1999;83-97.
14. Gurrera R.J. Some biological and behavioral features with clinical personality types. Journal of Nervous and Mental Disease. 178:1990;556-566.
15. Heils A., Teufel A., Petri S., Stöber G., Riederer P., Bengel D., Lesch K.P. Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry. 66:1996;2621-2624.
16. Heinz A., Higley J.D., Gorey J.G., Saunders R.C., Jones D.W., Hommer D., Zajicek K., Suomi S.J., Lesch K.P., Weinberger D.R., Linnoila M. In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. American Journal of Psychiatry. 155:1998;1023-1028.
17. LeMarquand D., Pihl R.O., Benkelfat C. Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biological Psychiatry. 36:1994;395-421.
18. LeMarquand D., Pihl R.O., Benkelfat C. Serotonin and alcohol intake, abuse and dependence: clinical evidence. Biological Psychiatry. 36:1994;326-337.
19. Lesch K.P., Beckmann H. Neurotransporter: Neue Aspekte zum Wirkmechanismus psychotropher Substanzen. Nervenarzt. 64:1993;75-79.
20. Lesch K.P., Gross J., Franzek E., Wolozin B.L., Riederer P., Murphy D.L. Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biological Psychiatry. 37:1995;215-223.
21. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Müller C.R., Hamer D.H., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274:1996;1527-1531.
22. Lesch K.P., Moessner R. Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental and neurodegenerative disorders? Biological Psychiatry. 44:1998;179-192.
23. 3H-paroxetine binding to platelets from healthy volunteers. Biological Psychiatry. 34:1993;356-360.
24. 3H]-paroxetine binding to human platelets. Journal of Affective Disorders. 50:1998;11-15.
25. McBride W.J., Murphy J.M., Lumeng L., Li T.K. Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats. Alcohol. 7:1990;199-205.
26. Mellerup E.T., Bech P., Lauritzen L., Lunde M., Plenge P. Platelet paroxetine binding in alcoholics. Alcohol and Alcoholism. 27:1992;603-606.
27. Murphy D.L. Neuropsychiatric disorders and the multiple human brain serotonin receptor subtypes and subsystems. Neuropsychopharmacology. 3:1990;457-471.
28. Nagoshi C.T., Wilson J.R., Rodriguez L.A. Impulsivity, sensation seeking, and behavioral and emotional responses to alcohol. Alcohol: Clinical and Experimental Research. 15:1991;661-667.
29. 3H-paroxetine binding in control subjects and depressed patients: relationship to serotonin uptake and age. Psychiatry Research. 51:1994;147-155.
30. Ramamoorthy S., Bauman A.L., Moore K.R., Han H., Yang-Feng T., Chang A.S., Ganapathy V., Blakely R.D. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization, Proceedings of the National Academy of Sciences of the United States of America. 90:1993;2542-2546.
31. Rausch J.L., Fei Y., Li J., Ganapythy V., Leibach F.H. Linkage disequilibrium between SERT VNTR and promoter region base pair deletion: relevance to alcoholism risk. World Congress on Psychiatric Genetics, Santa Fe, NM. 1997.
32. Sander T., Harms H., Lesch K.P., Dufeu P., Kuhn S., Hoehe M., Rommelspacher H., Schmidt L.G. Possible genotypic association of a regulatory variant of the serotonin transporter gene with severe alcohol dependence. Alcohol: Clinical and Experimental Research. 21:1997;1356-1359.
33. Sander T., Harms H., Dufeu P., Kuhn S., Hoehe M., Lesch K.P., Rommelspacher H., Schmidt L.G. Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biological Psychiatry. 43:1998;908-912.
34. 123/125I] RTI-55, an in vivo label for the serotonin transporter. Synapse. 11(2):1992;134-139.
35. 3H]paroxetine binding related to impulsive suicide attempts and borderline personality disorder. Biological Psychiatry. 43:1998;730-746.
36. Virkkunen M., Rawlings R., Tokola R., Poland R.E., Guidotti A., Nemeroff C., Bissette G., Kalogeras K., Karonen S.L., Linnoila M. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Archives of General Psychiatry. 51:1994;20-27.
37. Virkkunen M., Goldman D., Nielsen D.A., Linnoila M. Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence. Journal of Psychiatry and Neuroscience. 20:1995;271-275.
38. Virkkunen M., Linnoila M. Serotonin in early-onset alcoholism. Recent Developments in Alcoholism. 13:1997;173-189.
39. Wittchen H.U., Zaudig M., Fydrich T. SKID-I/II: Strukturieres klinisches Interview für DSM-IV. 1997;Hogrefe, Goettingen.