Haplotypes at the DRD2 locus and severe alcoholism

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 5, 2000, Pages 622-631

  Noble, Ernest P ^a   Zhang, Xuxian ^a   Ritchie, Terry L ^a   Sparkes, Robert S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

D2 dopamine receptor gene; Dopamine; DRD2 haplotypes; Reward; Severe alcoholism

Indexed keywords

DOPAMINE 2 RECEPTOR;

ADULT; ALCOHOLISM; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DISEASE SEVERITY; EXON; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE; SCREENING; SUBSTANCE ABUSE; UNTRANSLATED REGION;

ADULT; AGED; ALCOHOLISM; ALLELES; DATA INTERPRETATION, STATISTICAL; DNA; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; RECEPTORS, DOPAMINE D2;

EID: 0034626376     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/1096-8628(20001009)96:5<622::AID-AJMG7>3.0.CO;2-5     Document Type: Article

References (95)

1. 2 dopamine receptor gene and alcoholism
2. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia
3. 2 receptor gene TaqI A RFLP in Japanese
4. Types of alcoholics: I. evidence for an empirically derived typology based on indicators of vulnerability and severity
5. 2 receptor locus
6. Good genes in bad neighbourhoods
7. Going the distance: A current view of enhancer action
8. 2 receptor gene in alcoholism
9. 2 dopamine receptor TaqI B RFLP in severe alcoholics
10. 2 receptor gene variants: Association and linkage studies in impulsive-addictive-compulsive behavior
11. 2 receptor gene and alcoholism
12. Efficiency of utilization of the simian virus 40 late polyadenylation site: Effects of upstream sequences
13. Evolution of haplotypes at the DRD2 locus
14. Neurogenetic adaptive mechanisms in alcoholism
15. 2 dopamine receptor gene is associated but not linked with alcoholism
16. 2 receptor locus as a modifying gene in neuropsychiatric disorders
17. 2 receptor (DRD2) gene: A genetic risk factor in smoking
18. 2 receptor as a major gene in obesity and weight
19. 2 receptor gene: A genetic risk factor in substance abuse
20. Polygenic inheritance of Tourette syndrome, stuttering, attention deficit-hyperactivity, conduct and oppositional defiant disorder: The additive and subtractive effect of the three dopaminergic genes - DRD2, DβH and DAT1
21. 2 dopamine receptor locus in heavy drinking and alcoholism
22. 2 dopamine receptor locus in heavy drinking and alcoholism
23. Regulatory mutations and human genetic disease
24. Model-free linkage analysis using likelihoods
25. Comparison of GENEHUNTER and MFLINK for analysis of COGA linkage data
26. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats
27. 2 receptor (DRD2) with alcoholism
28. 2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23
29. 311Cys with alcoholism
30. 2A receptor gene
31. Common quantitative trait loci for alcohol-related behaviors and CNS neurotensin measures: Voluntary ethanol consumption
32. No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis
33. 2 dopamine receptor gene and alcoholism
34. DRD2 allele frequencies and linkage disequilibria, including the -141C Ins/Del promoter polymorphism, in European-American, African-American and Japanese subjects
35. Genetic transmission
36. A functionally deficient DRD2 variant (Ser 311 Cys) is not linked to alcoholism and substance abuse
37. Are genes coding for dopamine receptors implicated in alcoholism?
38. 2 receptor gene is located on chromosome 11 at q22-q23 and identifies a Taq1 RFLP
39. PCR detection of the TaqI A RFLP at the DRD2 locus
40. 2 receptor gene
41. 1 dopamine receptor gene and alcoholism in Finland
42. 2 receptor gene and alcoholism
43. Alternative strategies for uncovering genes contributing to alcoholism risk: Unpredictable findings in a genetic wonderland
44. 4 receptor genes and alcoholism
45. 2 receptor gene and alcoholism
46. Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
47. 2 receptor gene
48. Drug abuse: Hedonic homeostatic dysregulation
49. Faster multipoint linkage analysis using Fourier transforms
50. 2 dopamine receptor A1 allele with alcoholism: Medical severity of alcoholism and type of controls
51. Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
52. Novel polymorphisms in the 5' region of the LEP gene: Association with leptin levels and response to low-calorie diet in human obesity
53. 2 receptor gene in samples of female and male alcoholics
54. An editorial: What can the DRD2/alcoholism stow teach us about association studies in psychiatric genetics?
55. Alcoholism and the dopaminergic system: A review
56. 2 dopamine receptor gene: A review of association studies in alcoholism and phenotypes
57. DRD2 gene and alcoholism
58. 2 receptor gene
59. 2 dopamine receptor gene with cocaine dependence
60. 2 dopamine receptor gene with receptor-binding characteristics in alcoholism
61. 2 dopamine receptor polymorphism and brain regional glucose metabolism
62. 2 dopamine receptor (DRD2) gene and methadone treatment outcome of opioid-dependent patients
63. 2 dopamine receptor gene and obesity
64. 4 dopamine receptor polymorphisms and personality
65. 2 dopamine receptor gene and cigarette smoking: A reward gene?
66. 2 dopamine receptor TaqI A alleles in medically ill alcoholic and nonalcoholic patients
67. Haplotypes at the DRD2 locus and severe alcoholism
68. 2 receptor RFLPs, haplotypes and their association with substance use in black and caucasian research volunteers
69. 2 dopamine receptor locus: Studies of association and linkage
70. 2 receptor and alcoholism. A meta-analysis
71. 2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphism: Enhanced frequencies in psychostimulant-preferring polysubstance abusers
72. 2 receptors
73. Localization of genes affecting alcohol drinking in mice
74. 2 receptor in vivo and in vitro
75. 2 receptor availability in healthy volunteers
76. Comorbidity of mental disorders with alcohol and other drug abuse
77. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. I. DNA pooling
78. Alcohol disorders in the community: A report from the epidemiologic catchment area
79. Efficacy of different viral promoters in directing gene expression in mammalian cells: Effect of 3'-untranslated sequences
80. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
81. Haplotyping by double PCR amplification of specific alleles
82. The dopamine D2 receptor gene and alcoholism
83. 2 dopamine receptor TaqI B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers
84. 2 dopamine receptor gene and smoking status in lung cancer patients
85. 2 dopamine receptor locus (DRD2) in alcoholics and controls
86. Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common μ1 opioid receptor mechanism
87. Confirmation of quantitative trait loci for alcohol preference in mice
88. 2 receptor binding in the human striatum associated with the A1 allele
89. Members of the rel/NF-(χ) B family of transcriptional regulatory proteins bind the HRAS1 minisatellite DNA sequence
90. 2 dopamine receptor (DRD2) gene in a British, Caucasian control group screened to exclude alcoholism and heavy drinking
91. 2 receptor gene
92. A logistic regression extension of the transmission disequilibrium test for continuous traits: Application to linkage disequilibrium between alcoholism and the candidate genes DRD2 and ADH3
93. Complete characterization of disequilibrium at two loci
94. Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens. Genetic and motivational determinants