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Volumn 11, Issue 7, 2007, Pages 861-867

Targeting pleiotropin to treat osteoarthritis

Author keywords

Cartilage; Chondrocyte; Growth factor; Midkine; Osteoarthritis; Pleiotropin; Signal transduction

Indexed keywords

ANTIOXIDANT; CAPSAICIN; COLLAGEN TYPE 1; CYCLOOXYGENASE 2 INHIBITOR; GROWTH FACTOR; HYDROCORTISONE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LIDOCAINE; MESSENGER RNA; OPIATE; PARACETAMOL; PLEIOTROPHIN; SALICYLIC ACID DERIVATIVE; TRAMADOL;

EID: 34447309030     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.11.7.861     Document Type: Review
Times cited : (17)

References (59)
  • 1
    • 0035076295 scopus 로고    scopus 로고
    • Articular cartilage and changes in arthritis. An introduction: Cell biology of osteoarthritis
    • SANDELL LJ, AIGNER T: Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res. (2001) 3:107-113.
    • (2001) Arthritis Res , vol.3 , pp. 107-113
    • SANDELL, L.J.1    AIGNER, T.2
  • 2
    • 0035460852 scopus 로고    scopus 로고
    • Anticytokine therapy for osteoarthritis
    • GOLDRING MB. Anticytokine therapy for osteoarthritis. Expert Opin. Biol. Ther. (2001) 1:817-829.
    • (2001) Expert Opin. Biol. Ther , vol.1 , pp. 817-829
    • GOLDRING, M.B.1
  • 3
    • 0034744284 scopus 로고    scopus 로고
    • The splice variants VEGF 121 and VEGF 189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage
    • PUFE T, PETERSEN W, TILLMANN B, MENTLEIN R: The splice variants VEGF 121 and VEGF 189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage. Arthritis Rheum. (2001) 44:1082-1088.
    • (2001) Arthritis Rheum , vol.44 , pp. 1082-1088
    • PUFE, T.1    PETERSEN, W.2    TILLMANN, B.3    MENTLEIN, R.4
  • 4
    • 1542323197 scopus 로고    scopus 로고
    • Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor
    • PUFE T, LEMKE A, KURZ B et al.: Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am. J. Pathol. (2004) 164:185-192.
    • (2004) Am. J. Pathol , vol.164 , pp. 185-192
    • PUFE, T.1    LEMKE, A.2    KURZ, B.3
  • 5
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • GERBER HP, VU TH, RYAN AM, KOWALSKI J, WERB Z, FERRARA N: VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med. (1999) 5:623-628.
    • (1999) Nat. Med , vol.5 , pp. 623-628
    • GERBER, H.P.1    VU, T.H.2    RYAN, A.M.3    KOWALSKI, J.4    WERB, Z.5    FERRARA, N.6
  • 6
    • 0029548635 scopus 로고
    • Pleiotrophin and midkine in normal development and tumor biology
    • KURTZ A, SCHULTE AM, WELLSTEIN A: Pleiotrophin and midkine in normal development and tumor biology. Crit. Rev. Oncog. (1995) 6:151-177.
    • (1995) Crit. Rev. Oncog , vol.6 , pp. 151-177
    • KURTZ, A.1    SCHULTE, A.M.2    WELLSTEIN, A.3
  • 7
    • 0032951527 scopus 로고    scopus 로고
    • Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors
    • ZHANG N, DEUEL TF: Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors. Curr. Opin. Hematol. (1999) 6:44-50.
    • (1999) Curr. Opin. Hematol , vol.6 , pp. 44-50
    • ZHANG, N.1    DEUEL, T.F.2
  • 8
    • 0035783495 scopus 로고    scopus 로고
    • The pleiotropin/midkine family of cytokines: Role in glial-neuronal signalling
    • HAYNES L, RUMSBY M: The pleiotropin/midkine family of cytokines: role in glial-neuronal signalling. Prog. Brain Res. (2001) 132:313-324.
    • (2001) Prog. Brain Res , vol.132 , pp. 313-324
    • HAYNES, L.1    RUMSBY, M.2
  • 10
    • 0036739307 scopus 로고    scopus 로고
    • Midkine and pleiotrophin: Two related proteins involved in development, survival, inflammation and tumorigenesis
    • MURAMATSU T: Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. J. Biochem. (Tokyo) (2002) 132:359-371.
    • (2002) J. Biochem. (Tokyo) , vol.132 , pp. 359-371
    • MURAMATSU, T.1
  • 11
    • 0842265835 scopus 로고    scopus 로고
    • Midkine and pleiotrophin in neural development and cancer
    • KADOMATSU K, MURAMATSU T: Midkine and pleiotrophin in neural development and cancer. Cancer Lett. (2004) 204:127-143.
    • (2004) Cancer Lett , vol.204 , pp. 127-143
    • KADOMATSU, K.1    MURAMATSU, T.2
  • 12
    • 0026728088 scopus 로고
    • Cellular distribution of the new growth factor pleiotrophin (HB-GAM) mRNA in developing and adult rat tissues
    • VANDERWINDEN JM, MAILLEUX P, SCHIFFMANN SN, VANDERHAEGHEN JJ: Cellular distribution of the new growth factor pleiotrophin (HB-GAM) mRNA in developing and adult rat tissues. Anat. Embryol. (Berl) (1992) 186:387-406.
    • (1992) Anat. Embryol. (Berl) , vol.186 , pp. 387-406
    • VANDERWINDEN, J.M.1    MAILLEUX, P.2    SCHIFFMANN, S.N.3    VANDERHAEGHEN, J.J.4
  • 13
    • 0027628233 scopus 로고
    • Pleiotrophin is an abundant protein in dissociative extracts of bovine fetal epiphyseal cartilage and nasal cartilage from newborns
    • NEAME PJ, YOUNG CN, BROCK CW et al.: Pleiotrophin is an abundant protein in dissociative extracts of bovine fetal epiphyseal cartilage and nasal cartilage from newborns. J. Orthop. Res. (1993) 11:479-491.
    • (1993) J. Orthop. Res , vol.11 , pp. 479-491
    • NEAME, P.J.1    YOUNG, C.N.2    BROCK, C.W.3
  • 14
    • 0031935293 scopus 로고    scopus 로고
    • HB-GAM/ pleiotrophin: Localization of mRNA and protein in the chicken developing leg
    • DREYFUS J, BRUNET-DE CARVALHO N, DUPREZ D, RAULAIS D, VIGNY M: HB-GAM/ pleiotrophin: localization of mRNA and protein in the chicken developing leg. Int. J. Dev. Biol. (1998) 42:189-198.
    • (1998) Int. J. Dev. Biol , vol.42 , pp. 189-198
    • DREYFUS, J.1    BRUNET-DE, C.N.2    DUPREZ, D.3    RAULAIS, D.4    VIGNY, M.5
  • 15
    • 0033787773 scopus 로고    scopus 로고
    • Chondromodulin I and pleiotrophin gene expression in bovine cartilage and epiphysis
    • AZIZAN A, GAW JU, GOVINDRAJ P, TAPP H, NEAME PJ: Chondromodulin I and pleiotrophin gene expression in bovine cartilage and epiphysis. Matrix Biol. (2000) 19:521-531.
    • (2000) Matrix Biol , vol.19 , pp. 521-531
    • AZIZAN, A.1    GAW, J.U.2    GOVINDRAJ, P.3    TAPP, H.4    NEAME, P.J.5
  • 16
    • 0034915786 scopus 로고    scopus 로고
    • Immunolocalization of the angiogenetic factor pleiotrophin (PTN) in the growth plate of mice
    • PETERSEN W, RAFII M: Immunolocalization of the angiogenetic factor pleiotrophin (PTN) in the growth plate of mice. Arch. Orthop. Trauma Surg. (2001) 121:414-416.
    • (2001) Arch. Orthop. Trauma Surg , vol.121 , pp. 414-416
    • PETERSEN, W.1    RAFII, M.2
  • 17
    • 0037384990 scopus 로고    scopus 로고
    • Pleiotrophin, an embryonic differentiation and growth factor, is expressed in osteoarthritis
    • PUFE T, BARTSCHER M, PETERSEN W, TILLMANN B, MENTLEIN R: Pleiotrophin, an embryonic differentiation and growth factor, is expressed in osteoarthritis. Osteoarthritis Cartilage (2003) 11:260-264.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 260-264
    • PUFE, T.1    BARTSCHER, M.2    PETERSEN, W.3    TILLMANN, B.4    MENTLEIN, R.5
  • 18
    • 34447306802 scopus 로고    scopus 로고
    • New functions of angiogenic peptides in osteoarthritic cartilage
    • MENTLEIN R, PUFE T: New functions of angiogenic peptides in osteoarthritic cartilage. Curr. Rheumatol. Rev. (2005) 1:37-43.
    • (2005) Curr. Rheumatol. Rev , vol.1 , pp. 37-43
    • MENTLEIN, R.1    PUFE, T.2
  • 19
    • 33846365629 scopus 로고    scopus 로고
    • Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes
    • PUFET, GROTH G, GOLDRING MB, TILLMANN B, MENTLEIN R: Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes. Osteoarthritis Cartilage (2006) 15:155-162.
    • (2006) Osteoarthritis Cartilage , vol.15 , pp. 155-162
    • PUFET, G.G.1    GOLDRING, M.B.2    TILLMANN, B.3    MENTLEIN, R.4
  • 20
    • 0030777346 scopus 로고    scopus 로고
    • Transformation by Ras suppresses expression of the neurotrophic growth factor pleiotrophin
    • CORBLEY MJ: Transformation by Ras suppresses expression of the neurotrophic growth factor pleiotrophin. J. Biol. Chem. (1997) 272:24696-24702.
    • (1997) J. Biol. Chem , vol.272 , pp. 24696-24702
    • CORBLEY, M.J.1
  • 21
    • 0034646459 scopus 로고    scopus 로고
    • Pleiotrophin signals increased tyrosine phosphorylation of ß-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase ß/ζ
    • MENG K, RODRIGUEZ-PEÑA A, DIMITROV T et al.: Pleiotrophin signals increased tyrosine phosphorylation of ß-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase ß/ζ. Proc. Natl. Acad. Sci. USA (2000) 97:2603-2608.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2603-2608
    • MENG, K.1    RODRIGUEZ-PEÑA, A.2    DIMITROV, T.3
  • 22
    • 0035907231 scopus 로고    scopus 로고
    • Identification of ALK (anaplastic lymphoma kinase) as a receptor for the growth factor pleiotrophin
    • STOICA GE, KUO A, AIGNER A et al.: Identification of ALK (anaplastic lymphoma kinase) as a receptor for the growth factor pleiotrophin. J. Biol. Chem. (2001) 276:16772-16779.
    • (2001) J. Biol. Chem , vol.276 , pp. 16772-16779
    • STOICA, G.E.1    KUO, A.2    AIGNER, A.3
  • 23
    • 0037134490 scopus 로고    scopus 로고
    • Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth
    • POWERS C, AIGNERA, STOICA GE, MCDONNELL K, WELLSTEIN A: Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth. J. Biol. Chem. (2002) 277:14153-14158.
    • (2002) J. Biol. Chem , vol.277 , pp. 14153-14158
    • POWERS, C.1    AIGNERA, S.G.2    MCDONNELL, K.3    WELLSTEIN, A.4
  • 24
    • 22544440004 scopus 로고    scopus 로고
    • Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin
    • MOOG-LUTZ C, DEGOUTIN J, GOUZI JY et al.: Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin. J. Biol. Chem. (2005) 280:26039-26048.
    • (2005) J. Biol. Chem , vol.280 , pp. 26039-26048
    • MOOG-LUTZ, C.1    DEGOUTIN, J.2    GOUZI, J.Y.3
  • 25
    • 33746876351 scopus 로고    scopus 로고
    • RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo
    • ULBRICHT U, ECKERICH C, FILLBRANDT R, WESTPHAL M, LAMSZUS K: RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo. J. Neurochem. (2006) 98:1497-1506.
    • (2006) J. Neurochem , vol.98 , pp. 1497-1506
    • ULBRICHT, U.1    ECKERICH, C.2    FILLBRANDT, R.3    WESTPHAL, M.4    LAMSZUS, K.5
  • 26
    • 33845188730 scopus 로고    scopus 로고
    • Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition
    • PEREZ-PINERA P, ALCANTARA S, DIMITROV T, VEGA JA, DEUEL TF: Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition. Proc. Natl. Acad. Sci. USA (2006) 103:17795-17800.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17795-17800
    • PEREZ-PINERA, P.1    ALCANTARA, S.2    DIMITROV, T.3    VEGA, J.A.4    DEUEL, T.F.5
  • 27
    • 0030836664 scopus 로고    scopus 로고
    • Signal transduction pathways involved in the mitogenic activity of pleiotrophin
    • SOUTTAU B, AHMAND S, RIEGEL AT, WELLSTEIN A: Signal transduction pathways involved in the mitogenic activity of pleiotrophin. J. Biol. Chem. (1997) 272:19588-19593.
    • (1997) J. Biol. Chem , vol.272 , pp. 19588-19593
    • SOUTTAU, B.1    AHMAND, S.2    RIEGEL, A.T.3    WELLSTEIN, A.4
  • 28
    • 0026679749 scopus 로고
    • Expression of the HBNF (heparin-binding neurite-promoting factor) gene in the brain of fetal, neonatal and adult rat: An in situ hybridization study
    • BLOCH B, NORMAND E, KOVESDI I, BOHLEN P: Expression of the HBNF (heparin-binding neurite-promoting factor) gene in the brain of fetal, neonatal and adult rat: an in situ hybridization study. Brain Res. Dev. Brain Res. (1992) 70:267-278.
    • (1992) Brain Res. Dev. Brain Res , vol.70 , pp. 267-278
    • BLOCH, B.1    NORMAND, E.2    KOVESDI, I.3    BOHLEN, P.4
  • 29
    • 33846830012 scopus 로고    scopus 로고
    • Overexpression of midkine contributes to anti-apoptotic effects in human meningiomas
    • TONG Y, MENTLEIN R, BUHL R, HUGO H-H, MEHDORN HM, HELD-FEINDT J: Overexpression of midkine contributes to anti-apoptotic effects in human meningiomas. J. Neurochem. (2007) 100:1097-1107.
    • (2007) J. Neurochem , vol.100 , pp. 1097-1107
    • TONG, Y.1    MENTLEIN, R.2    BUHL, R.3    HUGO, H.-H.4    MEHDORN, H.M.5    HELD-FEINDT, J.6
  • 30
    • 0036846123 scopus 로고    scopus 로고
    • Pleiotrophin, an angiogenic and mitogenic growth factor, is expressed in human gliomas
    • MENTLEIN R, HELD-FEINDT J: Pleiotrophin, an angiogenic and mitogenic growth factor, is expressed in human gliomas. J. Neurochem. (2002) 83:747-753.
    • (2002) J. Neurochem , vol.83 , pp. 747-753
    • MENTLEIN, R.1    HELD-FEINDT, J.2
  • 31
    • 0030878183 scopus 로고    scopus 로고
    • Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant
    • ZHANG N, ZHONG R, WANG ZY, DEUEL TF: Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant. J. Biol. Chem. (1997) 272:16733-16736.
    • (1997) J. Biol. Chem , vol.272 , pp. 16733-16736
    • ZHANG, N.1    ZHONG, R.2    WANG, Z.Y.3    DEUEL, T.F.4
  • 32
    • 0034665583 scopus 로고    scopus 로고
    • Pleiotrophin can be rate-limiting for pancreatic cancer cell growth
    • WEBER D, KLOMP H-J, CZUBAYKO F, WELLSTEIN A, JUHL A: Pleiotrophin can be rate-limiting for pancreatic cancer cell growth. Cancer Res. (2000) 60:5284-5286.
    • (2000) Cancer Res , vol.60 , pp. 5284-5286
    • WEBER, D.1    KLOMP, H.-J.2    CZUBAYKO, F.3    WELLSTEIN, A.4    JUHL, A.5
  • 33
    • 0141958798 scopus 로고    scopus 로고
    • Angiogenesis factors in gliomas - a new key to tumour therapy?
    • MENTLEIN R, HELD-FEINDT J: Angiogenesis factors in gliomas - a new key to tumour therapy? Naturwissenschaften (2003) 90:385-394.
    • (2003) Naturwissenschaften , vol.90 , pp. 385-394
    • MENTLEIN, R.1    HELD-FEINDT, J.2
  • 35
    • 0032539011 scopus 로고    scopus 로고
    • Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM)
    • IMAI S, KAKSONEN M, RAULO E et al.: Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM). J. Cell Biol. (1998) 143:1113-1128.
    • (1998) J. Cell Biol , vol.143 , pp. 1113-1128
    • IMAI, S.1    KAKSONEN, M.2    RAULO, E.3
  • 36
    • 0036830216 scopus 로고    scopus 로고
    • Pleiotrophin/ osteoblast-stimulating factor 1: Dissecting its diverse functions in bone formation
    • TARE RS, OREFFO RO, CLARKE NM, ROACH HI: Pleiotrophin/ osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation. J. Bone Miner. Res. (2002) 17:2009-2020.
    • (2002) J. Bone Miner. Res , vol.17 , pp. 2009-2020
    • TARE, R.S.1    OREFFO, R.O.2    CLARKE, N.M.3    ROACH, H.I.4
  • 37
    • 7744237621 scopus 로고    scopus 로고
    • The angiogenic peptide pleiotrophin (PTN/HB-GAM) is expressed in fracture healing: An immunohistochemical study in rats
    • PETERSEN W, WILDEMANN B, PUFE T, RASCHKE M, SCHMIDMAIER G: The angiogenic peptide pleiotrophin (PTN/HB-GAM) is expressed in fracture healing: an immunohistochemical study in rats. Arch. Orthop. Trauma Surg. (2003) 124:603-607.
    • (2003) Arch. Orthop. Trauma Surg , vol.124 , pp. 603-607
    • PETERSEN, W.1    WILDEMANN, B.2    PUFE, T.3    RASCHKE, M.4    SCHMIDMAIER, G.5
  • 38
    • 18244364350 scopus 로고    scopus 로고
    • LI G, CUI Y, MCILMURRAY L, ALLEN WE, WANG H: rhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells. J. Orthop. Res. (2005) 23:680-685.
    • LI G, CUI Y, MCILMURRAY L, ALLEN WE, WANG H: rhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells. J. Orthop. Res. (2005) 23:680-685.
  • 40
    • 0037215657 scopus 로고    scopus 로고
    • Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: Osteoconductive biomimetic scaffolds for tissue engineering
    • YANG X, TARE RS, PARTRIDGE KA et al.: Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering. J. Bone Miner. Res. (2003) 18:47-57.
    • (2003) J. Bone Miner. Res , vol.18 , pp. 47-57
    • YANG, X.1    TARE, R.S.2    PARTRIDGE, K.A.3
  • 41
    • 20444432055 scopus 로고    scopus 로고
    • Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair
    • LI G, BUNN JR, MUSHIPE MT, HE Q, CHEN X: Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair. Calcif. Tissue Int. (2005) 76:299-306.
    • (2005) Calcif. Tissue Int , vol.76 , pp. 299-306
    • LI, G.1    BUNN, J.R.2    MUSHIPE, M.T.3    HE, Q.4    CHEN, X.5
  • 42
    • 3042539594 scopus 로고    scopus 로고
    • Growth factors for skeletal reconstruction and fracture repair
    • OREFFO RO: Growth factors for skeletal reconstruction and fracture repair. Curr. Opin. Investig. Drugs (2004) 5:419-423.
    • (2004) Curr. Opin. Investig. Drugs , vol.5 , pp. 419-423
    • OREFFO, R.O.1
  • 43
    • 0031577598 scopus 로고    scopus 로고
    • Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1
    • MASUDA H, TSUJIMURA A, YOSHIOKA M et al.: Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1. Biochem. Biophys. Res. Commun. (1997) 238:528-533.
    • (1997) Biochem. Biophys. Res. Commun , vol.238 , pp. 528-533
    • MASUDA, H.1    TSUJIMURA, A.2    YOSHIOKA, M.3
  • 44
    • 2442701291 scopus 로고    scopus 로고
    • Bone mass increase specific to the female in a line of transgenic mice overexpressing human osteoblast stimulating factor-1
    • HASHIMOTO-GOTOH T, OHNISHI H, TSUJIMURA A et al.: Bone mass increase specific to the female in a line of transgenic mice overexpressing human osteoblast stimulating factor-1. J. Bone Miner. Metab. (2004) 22:278-282.
    • (2004) J. Bone Miner. Metab , vol.22 , pp. 278-282
    • HASHIMOTO-GOTOH, T.1    OHNISHI, H.2    TSUJIMURA, A.3
  • 45
    • 0037333961 scopus 로고    scopus 로고
    • Pleiotrophin, an embryonic growth and differentiation factor, is expressed in rheumatoid arthritis
    • PUFE T, BARTSCHER M, PETERSEN W, TILLMANN B, MENTLEIN R: Pleiotrophin, an embryonic growth and differentiation factor, is expressed in rheumatoid arthritis. Arthritis Rheum. (2003) 48:660-667.
    • (2003) Arthritis Rheum , vol.48 , pp. 660-667
    • PUFE, T.1    BARTSCHER, M.2    PETERSEN, W.3    TILLMANN, B.4    MENTLEIN, R.5
  • 46
    • 0030824409 scopus 로고    scopus 로고
    • Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: Chemotactic activity to neutrophils and association with inflammatory synovitis
    • TAKADA T, TORIYAMA K, MURAMATSU H, SONG XJ, TORII S, MURAMATSU T: Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis. J. Biochem. (Tokyo) (1997) 122:453-458.
    • (1997) J. Biochem. (Tokyo) , vol.122 , pp. 453-458
    • TAKADA, T.1    TORIYAMA, K.2    MURAMATSU, H.3    SONG, X.J.4    TORII, S.5    MURAMATSU, T.6
  • 47
    • 2342606952 scopus 로고    scopus 로고
    • Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis
    • MARUYAMA K, MURAMATSU H, ISHIGURO N, MURAMATSU T: Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. (2004) 50:1420-1429.
    • (2004) Arthritis Rheum , vol.50 , pp. 1420-1429
    • MARUYAMA, K.1    MURAMATSU, H.2    ISHIGURO, N.3    MURAMATSU, T.4
  • 48
    • 0029047764 scopus 로고
    • Retinoic acid-induced heparin binding protein (RIHB) binds to embryonal chondrocytes and cartilage primarily via proteoglycans
    • BEAU I, COCKSHUTT AM, REGNIER F, CHANY-FOURNIER F, RAULAIS D: Retinoic acid-induced heparin binding protein (RIHB) binds to embryonal chondrocytes and cartilage primarily via proteoglycans. Exp. Cell Res. (1995) 218:531-539.
    • (1995) Exp. Cell Res , vol.218 , pp. 531-539
    • BEAU, I.1    COCKSHUTT, A.M.2    REGNIER, F.3    CHANY-FOURNIER, F.4    RAULAIS, D.5
  • 49
    • 0031867649 scopus 로고    scopus 로고
    • HB-GAM/ pleiotrophin but not RIHB/midkine enhances chondrogenesis in micromass culture
    • DREYFUS J, BRUNET-DE CARVALHO N, DUPREZ D, RAULAIS D, VIGNY M: HB-GAM/ pleiotrophin but not RIHB/midkine enhances chondrogenesis in micromass culture. Exp. Cell Res. (1998) 241:171-180.
    • (1998) Exp. Cell Res , vol.241 , pp. 171-180
    • DREYFUS, J.1    BRUNET-DE, C.N.2    DUPREZ, D.3    RAULAIS, D.4    VIGNY, M.5
  • 50
    • 0032757274 scopus 로고    scopus 로고
    • Pleiotrophin inhibits chondrocyte proliferation and stimulates proteoglycan synthesis in mature bovine cartilage
    • TAPP H, HERNANDEZ DJ, NEAME PJ, KOOB TJ: Pleiotrophin inhibits chondrocyte proliferation and stimulates proteoglycan synthesis in mature bovine cartilage. Matrix Biol. (1999) 18:543-556.
    • (1999) Matrix Biol , vol.18 , pp. 543-556
    • TAPP, H.1    HERNANDEZ, D.J.2    NEAME, P.J.3    KOOB, T.J.4
  • 51
    • 0036898973 scopus 로고    scopus 로고
    • Articular cartilage degradation and de-differentiation of chondrocytes by the systemic administration of retinyl acetate-ectopic production of osteoblast stimulating factor-1 by chondrocytes in mice
    • KUBO M, TAKASE T, MATSUSUE Y, RAUVALA H, IMAI S: Articular cartilage degradation and de-differentiation of chondrocytes by the systemic administration of retinyl acetate-ectopic production of osteoblast stimulating factor-1 by chondrocytes in mice. Osteoarthritis Cartilage (2002) 10:968-976.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 968-976
    • KUBO, M.1    TAKASE, T.2    MATSUSUE, Y.3    RAUVALA, H.4    IMAI, S.5
  • 52
    • 27544466756 scopus 로고    scopus 로고
    • Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6,-1 beta and oncostatin M pre-treated non-sclerotic osteoblasts
    • SANCHEZ C, DEBERG MA, PICCARDI N, MSIKA P, REGINSTER JY, HENROTIN YE: Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6,-1 beta and oncostatin M pre-treated non-sclerotic osteoblasts. Osteoarthritis Cartilage (2005) 13:979-987.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 979-987
    • SANCHEZ, C.1    DEBERG, M.A.2    PICCARDI, N.3    MSIKA, P.4    REGINSTER, J.Y.5    HENROTIN, Y.E.6
  • 54
    • 33646476551 scopus 로고    scopus 로고
    • Osteoarthritis: Pathobiology-targets and ways for therapeutic intervention
    • AIGNER T, SACHSE A, GEBHARD PM, ROACH HI: Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. Adv. Drug Deliv. Rev. (2006) 58:128-149.
    • (2006) Adv. Drug Deliv. Rev , vol.58 , pp. 128-149
    • AIGNER, T.1    SACHSE, A.2    GEBHARD, P.M.3    ROACH, H.I.4
  • 55
    • 33847242563 scopus 로고    scopus 로고
    • Pathobiology of osteoarthritis: Pathomechanisms and potential therapeutic targets
    • ROACH HI, AIGNERT, SODER S, HAAG J, WELKERLING H: Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets. Curr. Drug Targets (2007) 8:271-282.
    • (2007) Curr. Drug Targets , vol.8 , pp. 271-282
    • ROACH, H.I.1    AIGNERT, S.S.2    HAAG, J.3    WELKERLING, H.4
  • 56
    • 33847191703 scopus 로고    scopus 로고
    • Antioxidant to treat osteoarthritis: Dream or reality?
    • HENROTIN Y, KURZ B: Antioxidant to treat osteoarthritis: dream or reality? Curr. Drug Targets (2007) 8:347-357.
    • (2007) Curr. Drug Targets , vol.8 , pp. 347-357
    • HENROTIN, Y.1    KURZ, B.2
  • 57
    • 0034885826 scopus 로고    scopus 로고
    • Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer
    • GELSE K, JIANG QJ, AIGNER T et al.: Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer. Arthritis Rheum. (2001) 44:1943-1953.
    • (2001) Arthritis Rheum , vol.44 , pp. 1943-1953
    • GELSE, K.1    JIANG, Q.J.2    AIGNER, T.3
  • 58
    • 0032168880 scopus 로고    scopus 로고
    • Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation
    • VAN BEUNINGEN HM, GLANSBEEK HL, VAN DER KRAAN PM, VAN DEN BERG WB: Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. Osteoarthritis Cartilage (1998) 6:306-317.
    • (1998) Osteoarthritis Cartilage , vol.6 , pp. 306-317
    • VAN BEUNINGEN, H.M.1    GLANSBEEK, H.L.2    VAN DER KRAAN PM, V.D.B.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.