Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors

Current Opinion in Hematology

Volumn 6, Issue 1, 1999, Pages 44-50

  Zhang, Nan ^a   Deuel, Thomas F ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH FACTOR; CYTOKINE; HEPARIN BINDING PROTEIN; MIDKINE; PLEIOTROPHIN; POLYPEPTIDE;

ANGIOGENESIS; ANIMAL MODEL; CARCINOGENESIS; CELL MIGRATION; DIFFERENTIATION; EPITHELIUM; GENETIC CONSERVATION; HUMAN; MESODERM; METASTASIS; MITOGENESIS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CYTOKINES; FIBROBLAST GROWTH FACTORS; HUMANS; MITOGENS; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION;

EID: 0032951527     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199901000-00008     Document Type: Review

References (79)

1. d heparin-binding growth factor (BGF-8) in bovine uterus: purification and N-terminal amino acid sequence. Biochem Biophys Res Commun 1989, 165:1096-1103.
2. d heparin-binding protein of developing brain that is distinct from fibroblast growth factors. EMBO J 1989, 8:2933-2941.
3. 3 Li YS, Milner PG, Chauhan AK, Watson MA, Hoffman RM, Kodner CM, et al.: Cloning and expression of a developmental regulated protein that induces mitogenic and neurite outgrowth activity. Science 1990, 250:1690-1694.
4. 4 Li YS, Hoffman RH, Deuel TF: Murine PTN CDNA. 1991. [European Molecular Biology Laboratory Accession no. 58637.]
5. 5 Merenmies J, Rauvala H: Molecular cloning of the 18-kDa growth associated protein of developing brain. J Biol Chem 1990, 265:16721-16724.
6. 6 Hampton BS, Marshak DR, Burgess WH: Structural and functional characterization of full-length heparin-binding associated molecule. Mol Biol Cell 1992, 3:85-93.
7. 7 Goldfarb M: The fibroblast growth factor family. Cell Growth Differ 1990, 1:439-445.
8. 8 Kadomatsu K, Tomomura M, Muramatsu T: CDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun 1988, 151:1312-1318.
9. 9 Kinnunen T, Raulo E, Nolo R, Maccarana M, Lindahl U, Rauvala H: Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparin sulfate at the cell surface. J Biol Chem 1996, 27(4):2243-2248.
10. 10 Kuo MD, Oda Y, Huang JS, Huang SS: Amino acid sequence and characterization of a heparin-binding neurite-promoting factor (p18) from bovine brain. J Biol Chem 1990, 265:18749-18752.
11. 11 Fabri L, Nice EC, Ward LD, Merata H, Burgess AW, Simpson RL: Characterization of bovine heparin-binding neurotrophic factor (HBNF): assignment of disulphide bonds. Biochem Int 1992, 1:1-9.
12. 12 Hulmes JD, Seddon AP, Decker MM, Bohlen P: Comparison of the disulfide bond arrangements of human recombinant and bovine brain heparin-binding neurite-promoting factors. Biochem Biophys Res Commun 1993, 192:738-746.
13. 13 Muramatsu H, Inui T, Kimura T, Sakakibara S, Song X, Murta H, Muramatsu T: Localization of heparin-binding neurite outgrowth and antigenic regions in midkine molecule. Biochem Biophys Res Commun 1994, 203:1131-1139.
14. 14 Kuo MD, Huang SS, Huang JS: Characterization of heparin-binding growth-associated factor receptor on NIH 3T3 cells. Biochem Biophys Res Commun 1992, 182:188-194.
15. 15 Seddon AP, Hulmes JD, Decker MM, Kovesdi I, Fairhurst JL, Backer J, et al.: Refolding and characterization of human recombinant heparin-binding neurite-promoting factor. Protein Exp Purif 1994, 5:14-21.
16. 16 Silos-Santiago I, Yeh HJ, Gurrieri MA, Guillerman RP, Li YS, Wolf J, et al.: Localization of pleiotrophin and its mRNA in subpopulations of neurons and their corresponding axonal tracts suggests important roles in neural-glial interactions during development and in maturity. J Neurobiol 1996, 32:283-296.
17. 17 Vanderwinden JM, Mailleux P, Schiffmann SN, Vanderhaeghen JJ: Cellular distribution of the new growth factor pleiotrophin (HB-GAM) mRNA in developing and adult rat tissue. Anat Embryol 1992, 186:387-406.
18. 18 Yeh HJ, He YY, Xu J, Hsu CY, Deuel TF: Upregulation of pleiotrophin gene expression in developing microvasculature, macrophages, and astrocytes after acute ischemic brain injury. J Neurosci 1998, 18:3699-3707.
19. 19 Li YS, Gurrieri M, Deuel TF: Pleiotrophin gene expression is highly restricted and is regulated by platelet-derived growth factor. Biochem Biophys Res Commun 1992, 184:427-432.
20. 20 Laaroubi K, Vacherot F, Delbe J, Caruelle D, Barritault D, Courty J: Biochemical and mitogenic properties of the heparin-binding growth factor HARP. Prog Growth Factor Research 1995, 6:25-34.
21. 21 Vacherot F, Laaroubi K, Caruelle D, Delbe J, Barritault D, Courty J: Upregulalion of heparin-affin regulatory peptide by androgen in vitro cell. Dev Biol Anim 1995, 31:647-648.
22. 22 Courty J, Danchel MC, Caruelle DN, Guye T, Barrifault D: Purification and characterization of a new endothelial cell growth factor named HARP (Heparin Affin Regulatory Peptide). J Cell Biochem 1991, 15F(suppl):221.
23. 23 Laaruoubi K, Delbe J, Vacherote F, Desgranges P, Tardieu M, Jaye M, et al.: Mitogenic and in vitro angiogenic activity of human recombinant heparin affin regulatory peptide. Growth Factors 1994, 10:89-98.
24. 24 Fang W, Hartmann N, Chow DT, Riegel AT, Wellstein A: Pleiotrophin stimulates fibroblasts and endothelial cells and is expressed in human cancer. J Biol Chem 1992, 262:25889-25897.
25. 25 Delbei J, Vacherot F, Laaroubi K, Barritault D, Courty J: Effect of heparin on bovine epithelial lens cells proliferation induced by heparin affin regulatory peptide. J Cell Physiol 1995, 164:47-54.
26. 26 Raulo E, Julkume I, Merenmies J, Pihlaskari R, Rauvala H: Secretion and biological activities of heparin-binding growth-associated molecule neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein. J Biol Chem 1992, 267:11408-11416.
27. 27 Bohlen P, Kovesdi I: HBNF and Mk members of a novel gene family of heparin-binding proteins with potential roles in embryogenesis and brain function. Prog Growth Factor Res 1991, 6:25-34.
28. 28 Takamatsu H, Itoh M, Kimura M, Gospodarowicz D, Amann E: Expression and purification of biologically active OSF-1 in Escherechia coli. Biochem Biophys Res Commun 1992, 185:224-230.
29. 29 Cahuhan AK, Li YS, Deuel TF: Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice. Proc Natl Acad Sci U S A 1993, 90:679-682.
30. 30 Chernousov MA, Carey DJ: N-syndecan 3 (syndecan 3) from neonatal rat brain binds basic fibroblast growth factor. J Biol Chem 1993, 68:16810-16814.
31. 31 Wellstein A, Fang W, Khatri A, Lu Y, Swain SS, Dickson RB, et al.: A heparin-binding growth factor secreted from breast cancer cells homolgous to a developmentally regulated cytokine. J Biol Chem 1992, 267:2582-2587.
32. 32 Kurtz A, Schulte AM, Wellstein A: Pleiotrophin and midkine in normal development and tumor biology. Crit Rev Oncog 1995, 6:151-177.
33. 33 Tsutsui J, Kadomatsu K, Matsubrara S, Nakagawara A, Hamnoue M, Takao S, et al.: A new family of heparine-binding growth/differentiation factors: increased midkine expression in Wilms' tumor and other human carcinomas. Cancer Res 1993, 53:1281-1285.
34. 34 Garver RI, Radford DM, Donis-Keller H, Wick MR, Milner PG: Midkine and pleiotrophin expression in normal and malignant breast tissue. Cancer 1994, 74:1584-1590.
35. 35 Nakagawara A, Milbrandt J, Muramatsu T, Deuel TF, Zhao H, Cnaan A, Brodeur GM: Differential expression of pleiotrophin and midkine in advanced neuroblastoma. Cancer Res 1995, 55:1792-1797.
36. 36 Schulte AM, Lai S, Kurtz A, Czubayko F, Riegel AT, Wellstein A: Human trophoblast and choriocarcinoman expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus. Proc Natl Acad Sci U S A 1996, 93:14759-14764.
37. 37 Nakanishi T, Kadomatsu K, Okamoto T, Tomoda Y, Muramatsu T: Expression of midkine and pleiotrophin in ovarian tumors. Obstet Gynecol 1997, 90:285-290.
38. 38 Cross M, Dexter TM: Growth factors in development, transformation and tumorigenesis. Cell 1991, 64:271-280.
39. 39 Rodeck U, Herlyn M: Growth factors in melanoma. Cancer Metastasis Rev 1991, 10:89-101.
40. 40 Zhang N, Zhong R, Wang ZY, Deuel TF: Human breast cancer growth inhibited in vivo by a dominant negative pleiotrophin mutant. J Biol Chem 1998, 272:16730-16736.
41. 41 Czubayko F, Riegel AT, Wellstein A: Ribozyme-targeting elucidates a direct role of pleiotrophin in tumor growth. J Biol Chem 1994, 269:21358-21363.
42. 42 Czubayko F, Schute AM, Berchem GJ, Wellstein A: Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin. Proc Natl Acad Sci U S A 1996, 33:14753-14758.
43. 43 Li YS, Deuel TF: Pleiotrophin stimulates tyrosine phosphorylation in NIH 3T3 and NB41A3 cells. Biochem Biophys Res Commun 1993, 195:1089-1095.
44. 44 Raulo E, Chernousov MA, Carey DJ, Nolo RJ, Rauvala H: Isolation of a neuronal cell surface receptor of Heparin Binding Growth-Associated Molecule (HB-GAM). J Biol Chem 1994, 269:12999-13004.
45. 45 Maeda N, Nishiwaki T, Shintani T, Hamanaka H, Noda M: 6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase/RPTBβ/ζ binds pleiotrophin/heparin-binding growth-associated molecular (HB-GAM). J Biol Chem 1996, 272:21446-21452.
46. 46 Kadomatsu K, Tomomura M, Muramatsu T: cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Biochem Biophys Res Commun 1988, 151:1312-1318.
47. 47 Kadomatsu K, Huang RP, Suganuma T, Murata F, Muramatsu T: A retinoic acid-responsive gene, Mk, found in the teratocarcinoma system is expressed in spatially and temporally control manner during mouse embryogenesis. J Cell Biol 1990a, 110:607-616.
48. 48 Tomomura M, Kadomatsu K, Matsubara S, Muramatsu T: A retionoic acid responsive gene mk found in the teratocarcinoma sys heterogeneity of the transcript and the nature of the translation product. J Biol Chem 1990a, 265:10765-10770.
49. 49 Vigny M, Raulais D, Puzenat N, Duprez D, Hartman MP, Jeanny JC, Courtois Y: Identification of a new heparin-binding protein localized within chick basement membranes. Eur J Biochem 1989, 186:733-740.
50. 50 Tsutsui J, Uehara K, Kadomatsu K, Matsubara S, Muramatsu T: A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse. Biochem Biophys Res Commun 1991, 176:792-297.
51. 51 Nakamoto M, Matsubara S, Miyauchi T, Obama H, Ozawa M, Muramatsu T: A new family of heparin-binding growth/differentiation factors: differential expression of the midkine (MK) and HB-GAM genes during mouse development. J Biochem (Tokyo) 1992, 112:346-349.
52. 52 Muramatsu H, Shirahama H, Yonezawa S, Maruta H, Muramatsu T: Midkine, a retinoic acid inducable growth/differentiation factor: immunochemical evidence for the function and distribution. Dev Biol 1993, 159:392-402.
53. 53 Matsumoto K, Wanaka A, Mori T, Taguchi A, Ishii N, Muramatsu H, et al.: Localization of pleotrophin and midkine in the postnatal developing cerebellum. Neurosci Lett 1994a, 178:216-220.
54. 54 Matsumoto K, Wanaka A, Takatsuji K, Muramatsu H, Muramatsu T, Tohyama M: A novel family heparin-binding growth factors, pleiotrophin and midkine, is expressed in the developing rat cerebral cortex. Brain Res Dev Brain Res 1994b, 79:229-241.
55. 55 Yoshida Y, Goto M, Tsutui J, Ozawa M, Sato E, Osame M, Muramatsu T: Midkine is present in the early stage of cerebral infarction. Brain Res Dev Brain Res 1995, 85:25-30.
56. 56 Wang S, Yoshida Y, Goto M, Moritoyo T, Tsutsui J, Izumo S, et al.: Midkine exists in astrocytes in the early stage of cerebral infarction. Brain Res Dev Brain Res 1998, 106:205-209.
57. 57 Miyashiro M, Kadomatsu K, Ogata N, Yamamoto C, Takahashi K, Uyama M, et al.: Midkine expression intransient retinal ischemia in the rat. Curr Eye Res 1998, 17:9-13.
58. 58 Mochizuki R, Takeda A, Sato N, Kimpara T, Onodera H, Itoyama Y, Muramatsu T: Induction of midkine expression in reactive astrocytes following rat transient forebrain ischemia. Exp Neurol 1998, 149:73-78.
59. 59 Yasuhara D, Muramatsu H, Kim SU, Muramatsu T, Maruta H, McGeer PL: Midkine, a novel neurotrophic factor, is present in senile plagues of Alzheimer's disease. Biochem Biophys Res Commun 1993, 192:246-251.
60. 60 Unoki K, Ohba N, Arimura H, Muramatsu H, Muramatsu T: Rescue of photo receptors from the damaging effects of constant light by midkine, a retinoic acid-responsive gene product. Invest Ophthmol Vis Sci 1994, 35:4063-4068.
61. 61 Takada T, Kinkori T, Muramatsu H, Hayakawa A, Torii S, Muramatsu T: Midkine, a retinoic acid-inducible heparin-binding cytokine, is a novel regulator of intracellular calcium in human neutrophils. Biochem Biophys Res Commun 1997, 241:756-761.
62. 62 Hiramatsu K, Yoshida H, Kimura T, Takagi K: Midkine induces histamine release from mast cells and the immediate cutaneous response. Biochem Mol Biol Int 1998, 44:453-462.
63. 63 Koyima S, Inui T, Muramatsu H, Kimura T, Sakakibara S, Muramatsu T: Biochem Biophys Res Commun 1995, 216:574-581.
64. 64 Michikawa M, Kikuchi S, Muramatsu H, Muramatsu T, Kim SU: A retinoic acid responsive gene product, midkine, has neurotrophic functions for mouse spinal cord and dorsal root ganglion neurons in culture. J Neurosci Res 1993a, 35:530-539.
65. 65 Muramatsu H, Muramatsu T: Purification of recombinant midkine and examination of its biological activities: functional comparison of new heparin-binding factors. Biochem Biophys Res Commun 1991, 177:652-658.
66. 66 Nurcombe V, Fraser N, Herlaar E, Heath K: MK: a pluripotent embryonic stem-cell-derived neuroregulatory factor. Development 1992, 116:1175-1183.
67. 67 Kikuchi S, Muramatsu H, Muramatsu T, Kim SU: Midkine, a novel neurotrophic factor, promotes survival of mesencephalic neurons in culture. Neurosci Lett 1993, 160:9-12.
68. 68 Michkawa M, Xu RV, Muramatsu H, Muramatsu T, Kim SU: Midkine is a mediator of retinoid acid induced neuronal differentiation of embryonal carcinoma cells. Biochem Biophys Res Commun 1993b, 192:1312-1318.
69. 69 Tomomura M, Kadomtsu K, Nakamoto M, Muramatsu H, Kondoh H, Imagawa K, Muramatsu T: A retinoic acid responsive gene, Mk, produces a secreted protein with heparin-binding activity. Biochem Biophys Res Commun 1990b, 171:603-609.
70. 70 Kurtz A, Schult AM, Wellstein A: Pleiotrophin and midkine in normal development and tumor biology. Crit Rev Oncog 1995, 6:151-177.
71. 71 Kadomatsu K, Hagihara M, Akhter S, Fan QW, Muramatsu H, Muramatsu T: Midkine induces the transformation of NIH 3T3 cells. Br J Cancer 1997, 75:354-359.
72. 72 Choudhuri R, Zhang HT, Domini S, Ziche M, Bicknell B: An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis. Cancer Res 1997, 57:1814-1819.
73. 73 Garver RI, Chan CS, Milner PG: Reciprocal expression of pleiotrophin and midkine in normal versus malignant lung tissues. Am J Respir Cell Mol Biol 1993, 9:463-466.
74. 74 O'Brien T, Cranston D, Fuggle S, Bicknell R, Harris AL: The angiogenic factor midkine is expressed in bladder cancer, and overexpression correlates with a poor outcome in patients with invasion cancer. Cancer Res 1996, 56:2515-2518.
75. 75 Nakanishi T, Kadomatsu K, Okamoto T, Tomoda Y, Muramatsu T: Expression of midkine and pleiotrophin in ovarian tumors. Obstet Gynecol 1997, 90:285-290.
76. 76 Kaname T, Kadomatsu K, Aridome K, Yamashita S, Sakamoto K, Ogawa M, et al.: The expression of truncated mk in human tumors. Biochem Biophys Res Commun 1996, 219:256-260.
77. 77 Miyashiro I, Kaname T, Nakayama T, Nakamori S, Yagyu T, Monden T, et al.: Expression of truncated midkine in human colorectal cancers. Cancer Lett 1996, 106:287-291.
78. 78 Miyashiro I, Kaname T, Shin E, Wakasugi E, Monden T, Takatsuka Y, et al.: Midkine expression in human breast cancers: expression of truncated form. Breast Cancer Res Treat 1997, 43:1-6.
79. 79 Aridome K, Takao S, Kaname T, Kadomatsu K, Natsugoe S, Kiyima F, et al.: Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas. Br J Cancer 1998, 78:472-477.