Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes

Osteoarthritis and Cartilage

Volumn 15, Issue 2, 2007, Pages 155-162

  Pufe, T ^a   Groth, G ^a   Goldring, M B ^b   Tillmann, B ^a   Mentlein, R ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Cartilage; Chemotaxis; Chondrocytes; Gene expression; Growth factor; Osteoarthritis; Pleiotrophin; Signal transduction

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; COLLAGENASE 3; FIBROBLAST GROWTH FACTOR; INTERSTITIAL COLLAGENASE; LIGAND; MESSENGER RNA; NITRIC OXIDE; PLEIOTROPHIN; PROTEIN TYROSINE PHOSPHATASE; SYNDECAN 3; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1; VASCULOTROPIN;

ARTICLE; CARTILAGE; CARTILAGE CELL; CELL IMMORTALIZATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENT; FETUS (ANATOMY); GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MESODERM; NEUROECTODERM; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CARRIER PROTEINS; CARTILAGE, ARTICULAR; CATTLE; CHONDROCYTES; CYTOKINES; GROWTH SUBSTANCES; HUMANS; OSTEOARTHRITIS; SIGNAL TRANSDUCTION;

EID: 33846365629     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2006.07.005     Document Type: Article

References (36)

1. Kurtz A., Schulte A.M., and Wellstein A. Pleiotrophin and midkine in normal development and tumor biology. Crit Rev Oncog 6 (1995) 151-177
2. Zhang N., and Deuel T.F. Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin-binding growth and differentiation factors. Curr Opin Hematol 6 (1999) 44-50
3. Muramatsu T. Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. J Biochem (Tokyo) 132 (2002) 359-371
4. Kadomatsu K., and Muramatsu T. Midkine and pleiotrophin in neural development and cancer. Cancer Lett 204 (2004) 127-143
5. Souttau B., Ahmand S., Riegel A.T., and Wellstein A. Signal transduction pathways involved in the mitogenic activity of pleiotrophin. J Biol Chem 272 (1997) 19588-19593
6. Meng K., Rodriguez-Peña A., Dimitrov T., Chen W., Yamin M., Noda M., et al. Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ. Proc Natl Acad Sci U S A 97 (2000) 2603-2608
7. Stoica G.E., Kuo A., Aigner A., Sunitha I., Souttou B., Malerczyk C., et al. Identification of ALK (anaplastic lymphoma kinase) as a receptor for the growth factor pleiotrophin. J Biol Chem 276 (2001) 16772-16779
8. Bowden E.T., Stoica G.E., and Wellstein A. Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase. J Biol Chem 277 (2002) 35862-35868
9. Pufe T., Bartscher M., Petersen W., Tillmann B., and Mentlein R. Expression of pleiotrophin, an embryonic growth and differentiation factor, in rheumatoid arthritis. Arthritis Rheum 48 (2003) 660-667
10. Tare R.S., Oreffo R.O., Clarke N.M., and Roach H.I. Pleiotrophin/osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation. J Bone Miner Res 17 (2002) 2009-2020
11. Neame P.J., Young C.N., Brock C.W., Treep J.T., Ganey T.M., Sasse J., et al. Pleiotrophin is an abundant protein in dissociative extracts of bovine fetal epiphyseal cartilage and nasal cartilage from newborns. J Orthop Res 11 (1993) 479-491
12. Azizan A., Gaw J.U., Govindraj P., Tapp H., and Neame P.J. Chondromodulin I and pleiotrophin gene expression in bovine cartilage and epiphysis. Matrix Biol 19 (2000) 521-531
13. Petersen W., and Rafii M. Immunolocalization of the angiogenetic factor pleiotrophin (PTN) in the growth plate of mice. Arch Orthop Trauma Surg 121 (2001) 414-416
14. Pufe T., Bartscher M., Petersen W., Tillmann B., and Mentlein R. Pleiotrophin, an embryonic differentiation and growth factor, is expressed in osteoarthritis. Osteoarthritis Cartilage 11 (2003) 260-264
15. Loeser R., Sadiev S., Tan L., and Goldring M.B. Integrin expression by primary and immortalized human chondrocytes: evidence of a differential role for α1β1 and α2β1 integrins mediating chondrocyte adhesion to types II and VI collagen. Osteoarthritis Cartilage 8 (2000) 96-105
16. Osaki M., Tan L., Choy B.K., Yoshida Y., Auron P.E., Cheah K.S.E., et al. The TATA-containing core promoter of the type II collagen gene (COL2A1) is the target of interferon-γ-mediated inhibition in human chondrocytes: requirement for Stat1α, Jak1, and Jak2. Biochem J 369 (2003) 103-115
17. Parker W.L., Goldring M.B., and Philip A. Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGF-β receptor independent manner. J Bone Miner Res 18 (2003) 289-302
18. Pufe T., Harde V., Petersen W., Goldring M.B., Tillmann B., and Mentlein R. Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes. J Pathol 202 (2004) 367-374
19. Mentlein R., and Held-Feindt J. Pleiotrophin, an angiogenic and mitogenic growth factor, is expressed in human gliomas. J Neurochem 83 (2002) 747-753
20. Varoga D., Pufe T., Harder J., Meyer-Hoffert U., Mentlein R., Schröder J.-M., et al. Production of endogenous antibiotics in articular cartilage. Arthritis Rheum 50 (2004) 3526-3534
21. Held-Feindt J., Dörner L., Gülcan S., Mehdorn H.M., and Mentlein R. Cannabinoid receptors in human gliomas. J Neurochem 98 (2006) 886-893
22. Mentlein R., Forstreuter F., Mehdorn H.M., and Held-Feindt J. Functional significance of vascular endothelial growth factor receptor expression on human glioma cells. J Neurooncol 67 (2004) 9-18
23. Pufe T., Petersen W., Tillmann B., and Mentlein R. The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage. Arthritis Rheum 44 (2001) 1082-1088
24. Pufe T., Lemke A., Kurz B., Petersen W., Tillmann B., Grodzinsky A.J., et al. Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol 164 (2004) 185-192
25. Sandell L.J., and Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res 3 (2001) 107-113
26. Goldring M.B. Anticytokine therapy for osteoarthritis. Expert Opin Biol Ther 1 (2001) 817-829
27. Powers C., Aigner A., Stoica G.E., McDonnell K., and Wellstein A. Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth. J Biol Chem 277 (2002) 14153-14158
28. Morris S.W., Naeve C., Mathew P., James P.L., Kirstein M.N., Cui X., et al. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14 (1997) 2175-2188
29. Moog-Lutz C., Degoutin J., Gouzi J.Y., Frobert Y., Brunet-de Carvalho N., Bureau J., et al. Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin. J Biol Chem 280 (2005) 26039-26048
30. Miyake I., Hakomori Y., Shinohara A., Gamou T., Saito M., Iwamatsu A., et al. Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines. Oncogene 21 (2002) 5823-5834
31. Tare R.S., Oreffo R.O., Sato K., Rauvala H., Clarke N.M., and Roach H.I. Effects of targeted overexpression of pleiotrophin on postnatal bone development. Biochem Biophys Res Commun 298 (2002) 324-332
32. Kubo M., Takase T., Matsusue Y., Rauvala H., and Imai S. Articular cartilage degradation and de-differentiation of chondrocytes by the systemic administration of retinyl acetate-ectopic production of osteoblast stimulating factor-1 by chondrocytes in mice. Osteoarthritis Cartilage 10 (2002) 968-976
33. Yang X., Tare R.S., Partridge K.A., Roach H.I., Clarke N.M., Howdle S.M., et al. Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering. J Bone Miner Res 18 (2003) 47-57
34. Imai S., Kaksonen M., Raulo E., Kinnunen T., Fages C., Meng X., et al. Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM). J Cell Biol 143 (1998) 1113-1128
35. Fang W., Hartmann N., Chow D.T., Riegel A.T., and Wellstein A. Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer. J Biol Chem 267 (1992) 25889-25897
36. Tapp H., Hernandez D.J., Neame P.J., and Koob T.J. Pleiotrophin inhibits chondrocyte proliferation and stimulates proteoglycan synthesis in mature bovine cartilage. Matrix Biol 18 (1999) 543-556