Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair

Calcified Tissue International

Volumn 76, Issue 4, 2005, Pages 299-306

  Li, G ^a   Bunn, J R ^a   Mushipe, M T ^a   He, Q ^a   Chen, X ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Bone development; Fracture repair; Over expression; Pleiotrophin; rhBMP 2.

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; PLEIOTROPHIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BODY HEIGHT; BONE DEVELOPMENT; BONE GROWTH; BONE MATURATION; BONE RADIOGRAPHY; BONE REMODELING; CALLUS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DRILL; FEMUR; FEMUR FRACTURE; FRACTURE HEALING; HISTOLOGY; IMPLANTATION; LONG BONE; MALE; MATURATION; MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; STANDARD; TIBIA; TRABECULAR BONE; TRANSGENIC MOUSE; WILD TYPE; X RAY;

ANIMALS; BONE DEVELOPMENT; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; CARRIER PROTEINS; COMPRESSIVE STRENGTH; CYTOKINES; DISEASE MODELS, ANIMAL; FEMUR; FRACTURE HEALING; HUMANS; MALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; RECOMBINANT PROTEINS; TIBIA; TRANSFORMING GROWTH FACTOR BETA;

EID: 20444432055     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-004-0145-6     Document Type: Article

References (15)

1. YS Li PG Milner AK Chauhan 1990 Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity Science 250 1690 1694
2. H Rauvala 1989 An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors EMBO J 8 2933 2941
3. F Vacherot J Delbe M Heroult D Barritault DG Fernig J Courty 1999 Glycosaminoglycans differentially bind HARP and modulate its biological activity J Biol Chem 274 7741 7747
4. K Tezuka S Takeshita Y Hakeda M Kumegawa R Kikuno T Hashimoto-Gotoh 1990 Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues Biochem Biophys Res Commun 173 246 251
5. BS Hampton DR Marshak WH Burgess 1992 Structural and functional characterization of full-length heparin-binding growth associated molecule Mol Biol Cell 3 85 93
6. TF Deuel N Zhang HJ Yeh I Silos-Santiago ZY Wang 2002 Pleiotrophin: a cytokine with diverse functions and a novel signaling pathway Arch Biochem Biophys 397 162 171
7. S Imai M Kaksonen E Raulo 1998 Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM) J Cell Biol 143 1113 1128
8. RS Tare RO Oreffo NM Clarke HI Roach 2002 Pleiotrophin/Osteoblast- stimulating factor 1: dissecting its diverse functions in bone formation J Bone Miner Res 17 2009 2020
9. H Masuda A Tsujimura M Yoshioka 1997 Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1 Biochem Biophys Res Commun 238 528 533
10. RS Tare RO Oreffo K Sato H Rauvala NM Clarke HI Roach 2002 Effects of targeted overexpression of pleiotrophin on postnatal bone development Biochem Biophys Res Commun 298 324 332
11. CK Connolly G Li JR Bunn M Mushipe GR Dickson DR Marsh 2003 A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animals J Orthop Res 21 843 849
12. G Li G White C Connolly D Marsh 2002 Cell proliferation and apoptosis during fracture healing J Bone Miner Res 17 791 799
13. E Raulo MA Chernousov DJ Carey R Nolo H Rauvala 1994 Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3) J Biol Chem 269 12999 13004
14. X Yang RS Tare KA Partridge 2003 Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering J Bone Miner Res 18 47 57
15. H Rauvala HJ Huttunen C Hages 2000 Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility Matrix Biol 19 377 387