-
1
-
-
0035064546
-
Therapy-related leukemia associated with alkylating agents
-
Davies, S.M. (2001) Therapy-related leukemia associated with alkylating agents. Med. Pediatr. Oncol., 36, 536-540.
-
(2001)
Med. Pediatr. Oncol
, vol.36
, pp. 536-540
-
-
Davies, S.M.1
-
2
-
-
0034028030
-
6-alkylguanine by alkyltransferases
-
6-alkylguanine by alkyltransferases. Mutat. Res., 462, 83-100.
-
(2000)
Mutat. Res
, vol.462
, pp. 83-100
-
-
Pegg, A.E.1
-
4
-
-
0029670679
-
6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O 6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea
-
6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O 6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea. Biochemistry, 35, 1328-1334.
-
(1996)
Biochemistry
, vol.35
, pp. 1328-1334
-
-
Srivenugopal, K.S.1
-
5
-
-
0036262190
-
6-alkylguanine-DNA alkyltransferase
-
6-alkylguanine-DNA alkyltransferase. Carcinogenesis, 23, 823-830.
-
(2002)
Carcinogenesis
, vol.23
, pp. 823-830
-
-
Xu-Welliver, M.1
-
6
-
-
2642574948
-
Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: A long road traveled and still a far way to go
-
Kaina, B. (2004) Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: A long road traveled and still a far way to go. Cytogenet. Genome Res., 104, 77-86.
-
(2004)
Cytogenet. Genome Res
, vol.104
, pp. 77-86
-
-
Kaina, B.1
-
7
-
-
0019957212
-
Formation of the cross-link 1-[N3-deoxycytidyl], 2-[Nl-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea
-
Tong, W.P. et al. (1982) Formation of the cross-link 1-[N3-deoxycytidyl], 2-[Nl-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea. Cancer Res., 42, 3102-3105.
-
(1982)
Cancer Res
, vol.42
, pp. 3102-3105
-
-
Tong, W.P.1
-
8
-
-
0023678302
-
6-alkylguanine-DNA alkyltransferase and BCNU-treated defined length synthetic oligodeoxynucleotides
-
6-alkylguanine-DNA alkyltransferase and BCNU-treated defined length synthetic oligodeoxynucleotides. Nucleic Acids Res. 16, 6779-6788.
-
(1988)
Nucleic Acids Res
, vol.16
, pp. 6779-6788
-
-
Brent, T.P.1
-
9
-
-
0021112746
-
6-methylguanine-DNA methyltransferase
-
6-methylguanine-DNA methyltransferase. Nucleic Acids Res., 11, 7743-7758.
-
(1983)
Nucleic Acids Res
, vol.11
, pp. 7743-7758
-
-
Robins, P.1
-
10
-
-
13344282752
-
Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine
-
Belanich, M. et al. (1996) Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. Cancer Res., 56, 783-788.
-
(1996)
Cancer Res
, vol.56
, pp. 783-788
-
-
Belanich, M.1
-
11
-
-
0025196019
-
Depletion of mammalian O 6-alkylguanine-DNA alkyltransferase activity by O 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
-
Dolan, M.E. et al. (1990) Depletion of mammalian O 6-alkylguanine-DNA alkyltransferase activity by O 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc. Natl Acad Sci. USA, 87, 5368-5372.
-
(1990)
Proc. Natl Acad Sci. USA
, vol.87
, pp. 5368-5372
-
-
Dolan, M.E.1
-
12
-
-
0025924488
-
6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents
-
6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. Cancer Res., 51, 3367-3372.
-
(1991)
Cancer Res
, vol.51
, pp. 3367-3372
-
-
Dolan, M.E.1
-
13
-
-
0028858706
-
Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O 6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea
-
Pegg, A.E. et al. (1995) Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O 6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea. Biochem. Pharmacol., 50 1141-1148.
-
(1995)
Biochem. Pharmacol
, vol.50
, pp. 1141-1148
-
-
Pegg, A.E.1
-
14
-
-
27744480123
-
6-benzylguanine and 1,3-bis(2-chloroethyl -l-nitrosourea in advanced melanoma
-
6-benzylguanine and 1,3-bis(2-chloroethyl -l-nitrosourea in advanced melanoma. Clin. Cancer Res., 11, 7861-7865.
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 7861-7865
-
-
Gajewski, T.F.1
-
15
-
-
27244442921
-
Phase I trial of temozolomide plus O 6-benzylguanine for patients with recurrent or progressive malignant glioma
-
Quinn, J.A. et al. (2005) Phase I trial of temozolomide plus O 6-benzylguanine for patients with recurrent or progressive malignant glioma. J. Clin. Oncol., 23, 7178-7187.
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 7178-7187
-
-
Quinn, J.A.1
-
16
-
-
0036570292
-
Phase II trial of carmustine plus O 6-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma
-
Quinn, J.A. et al. (2002) Phase II trial of carmustine plus O 6-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J. Clin. Oncol., 30, 2277-2283.
-
(2002)
J. Clin. Oncol
, vol.30
, pp. 2277-2283
-
-
Quinn, J.A.1
-
17
-
-
34447580788
-
6-benzylguanine in patients with recurrent malignant glioma abstract from the Society for Neuro-Oncology Eighth Annual
-
6-benzylguanine in patients with recurrent malignant glioma abstract from the Society for Neuro-Oncology Eighth Annual Meeting. Neuro-oncol., 5, 279-360.
-
(2003)
Meeting. Neuro-oncol
, vol.5
, pp. 279-360
-
-
Weingart, J.1
-
18
-
-
0032826199
-
An overview of cyclophosphamide development and clinical applications
-
Colvin, O.M. (1999) An overview of cyclophosphamide development and clinical applications. Curr. Pharm. Des., 5, 555-560.
-
(1999)
Curr. Pharm. Des
, vol.5
, pp. 555-560
-
-
Colvin, O.M.1
-
19
-
-
0032849465
-
The chemistry of the metabolites of cyclophosphamide
-
Ludeman, S.M. (1999) The chemistry of the metabolites of cyclophosphamide. Curr. Pharm. Des., 5, 627-643.
-
(1999)
Curr. Pharm. Des
, vol.5
, pp. 627-643
-
-
Ludeman, S.M.1
-
20
-
-
0033153762
-
6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity
-
6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity. Cancer Res., 59, 3059-3063.
-
(1999)
Cancer Res
, vol.59
, pp. 3059-3063
-
-
Cai, Y.1
-
22
-
-
0033600130
-
Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea
-
Allay, E. et al. (1999) Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea. Oncogene, 18, 3783-3787.
-
(1999)
Oncogene
, vol.18
, pp. 3783-3787
-
-
Allay, E.1
-
23
-
-
0027473747
-
6-alkylguanine-DNA alkyltransferase
-
6-alkylguanine-DNA alkyltransferase. Science, 259, 219-222.
-
(1993)
Science
, vol.259
, pp. 219-222
-
-
Dumenco, L.L.1
-
24
-
-
0028169360
-
6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas
-
6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas. Cancer Res., 54, 4648-4652.
-
(1994)
Cancer Res
, vol.54
, pp. 4648-4652
-
-
Liu, L.1
-
25
-
-
0028904619
-
Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon
-
Zaidi, N.H. et al. (1995) Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis, 16, 451-456.
-
(1995)
Carcinogenesis
, vol.16
, pp. 451-456
-
-
Zaidi, N.H.1
-
26
-
-
0030749230
-
The DNA repair protein O 6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineo-plastic chloroethylnitrosourea
-
Becker, K. et al. (1997) The DNA repair protein O 6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineo-plastic chloroethylnitrosourea. Cancer Res., 57, 3335-3338.
-
(1997)
Cancer Res
, vol.57
, pp. 3335-3338
-
-
Becker, K.1
-
27
-
-
0032892044
-
DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents
-
Glassner, B.J. et al. (1999) DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents. Mutagenesis, 14, 339-347.
-
(1999)
Mutagenesis
, vol.14
, pp. 339-347
-
-
Glassner, B.J.1
-
28
-
-
27744592647
-
6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-l-nitrosourea (BCNU)-induced long-term toxicities
-
6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-l-nitrosourea (BCNU)-induced long-term toxicities. J. Pharmacol. Exp. Ther., 315, 1247-1255.
-
(2005)
J. Pharmacol. Exp. Ther
, vol.315
, pp. 1247-1255
-
-
Hansen, R.J.1
-
29
-
-
0021857850
-
A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes
-
Jones, I.M. et al. (1985) A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes. Mutat. Res., 147, 97-105.
-
(1985)
Mutat. Res
, vol.147
, pp. 97-105
-
-
Jones, I.M.1
-
30
-
-
0033782928
-
Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase
-
Shiraishi, A. et al. (2000) Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase. Carcinogenesis, 21, 1879-1883.
-
(2000)
Carcinogenesis
, vol.21
, pp. 1879-1883
-
-
Shiraishi, A.1
-
31
-
-
8944258921
-
Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent
-
Tsuzuki, T. et al. (1996) Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent. Carcinogenesis, 17, 1215-1220.
-
(1996)
Carcinogenesis
, vol.17
, pp. 1215-1220
-
-
Tsuzuki, T.1
-
32
-
-
0034287446
-
6-alkylguanine-DNA alkyltransferases
-
6-alkylguanine-DNA alkyltransferases. Cancer Res., 60, 5464-5469.
-
(2000)
Cancer Res
, vol.60
, pp. 5464-5469
-
-
Cai, Y.1
-
33
-
-
0027403796
-
6-alkylguanine-DNA alkyltransferase
-
6-alkylguanine-DNA alkyltransferase. Cancer Res., 53, 997-1003.
-
(1993)
Cancer Res
, vol.53
, pp. 997-1003
-
-
Minnick, D.T.1
-
34
-
-
0035032231
-
Biology and therapy of secondary leukaemias
-
Dann, E.J. et al. (2001) Biology and therapy of secondary leukaemias. Best Pract. Res. Clin. Haematol., 14, 119-137.
-
(2001)
Best Pract. Res. Clin. Haematol
, vol.14
, pp. 119-137
-
-
Dann, E.J.1
-
35
-
-
0031792320
-
Acute leukemia following treatment of malignant glioma
-
Perry J.R. et al. (1998) Acute leukemia following treatment of malignant glioma. J. Neuro-oncol., 40, 39--46.
-
(1998)
J. Neuro-oncol
, vol.40
, pp. 39-46
-
-
Perry, J.R.1
-
36
-
-
26844477930
-
Secondary Ph+ acute lymphoblastic leukemia after temozolomide
-
De Vita, S. et al. (2005) Secondary Ph+ acute lymphoblastic leukemia after temozolomide. Ann. Hematol., 84, 760-762.
-
(2005)
Ann. Hematol
, vol.84
, pp. 760-762
-
-
De Vita, S.1
-
37
-
-
14944377007
-
Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma
-
Su, Y.W. et al. (2005) Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma. J. Neuro-oncol. 71, 315-318.
-
(2005)
J. Neuro-oncol
, vol.71
, pp. 315-318
-
-
Su, Y.W.1
-
38
-
-
33645509873
-
Mutagenic potential of temozolomide in bone marrow cells in vivo
-
Geiger, H. et al. (2006) Mutagenic potential of temozolomide in bone marrow cells in vivo. Blood, 107, 3010-3011.
-
(2006)
Blood
, vol.107
, pp. 3010-3011
-
-
Geiger, H.1
-
39
-
-
0033941733
-
Temozolomide and treatment of malignant glioma
-
Friedman, H.S. et al. (2000) Temozolomide and treatment of malignant glioma. Clin. Cancer Res., 6, 2585-2597.
-
(2000)
Clin. Cancer Res
, vol.6
, pp. 2585-2597
-
-
Friedman, H.S.1
-
40
-
-
0030972856
-
Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice
-
Sakumi, K. et al. (1997) Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice. Cancer Res., 57, 2415-2418.
-
(1997)
Cancer Res
, vol.57
, pp. 2415-2418
-
-
Sakumi, K.1
-
41
-
-
33746762861
-
A phase II trial of O 6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma
-
Ryan, C.W. et al. (2006) A phase II trial of O 6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma. Cancer Chemother. Pharmacol, 58, 634-639.
-
(2006)
Cancer Chemother. Pharmacol
, vol.58
, pp. 634-639
-
-
Ryan, C.W.1
-
42
-
-
0022273478
-
6-(2-chloroethyl) guanine mediates the biological effects of chloroethylnitrosoureas
-
6-(2-chloroethyl) guanine mediates the biological effects of chloroethylnitrosoureas. Environ. Health Perspect., 62, 119-126.
-
(1985)
Environ. Health Perspect
, vol.62
, pp. 119-126
-
-
Bodell, W.J.1
-
44
-
-
0032170023
-
Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents
-
Allan J.M. et al. (1998) Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents. Cancer Res., 58, 3965-3973.
-
(1998)
Cancer Res
, vol.58
, pp. 3965-3973
-
-
Allan, J.M.1
-
45
-
-
0030730579
-
6-methylguanine-DNA methyltransferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines
-
6-methylguanine-DNA methyltransferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines. Mol. Pharmacol., 52, 815-820.
-
(1997)
Mol. Pharmacol
, vol.52
, pp. 815-820
-
-
Chen, Z.P.1
-
46
-
-
0032698083
-
Tissue-specific mutant frequencies and mutational spectra in cyclophosphamide-treated lacl transgenic mice
-
Gorelick, N.J. et al. (1999) Tissue-specific mutant frequencies and mutational spectra in cyclophosphamide-treated lacl transgenic mice. Environ. Mol. Mutagen., 34, 154-166.
-
(1999)
Environ. Mol. Mutagen
, vol.34
, pp. 154-166
-
-
Gorelick, N.J.1
-
47
-
-
0032825953
-
Mechanisms of resistance to the toxicity of cyclophosphamide
-
Gamcsik, M.P. et al. (1999) Mechanisms of resistance to the toxicity of cyclophosphamide. Curr. Pharm. Des., 5, 587-605.
-
(1999)
Curr. Pharm. Des
, vol.5
, pp. 587-605
-
-
Gamcsik, M.P.1
-
48
-
-
0035523959
-
6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells
-
6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells. Mol. Cancer Ther., 1, 21-28.
-
(2001)
Mol. Cancer Ther
, vol.1
, pp. 21-28
-
-
Cai, Y.1
-
49
-
-
0242330251
-
Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells
-
Smith, S.M. et al. (2003) Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells. Cancer Chemother. Pharmacol., 52, 291-302.
-
(2003)
Cancer Chemother. Pharmacol
, vol.52
, pp. 291-302
-
-
Smith, S.M.1
|