Structural insight into substrate specificity of phosphodiesterase 10

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 14, 2007, Pages 5782-5787

  Wang, Huanchen ^a   Liu, Yudong ^a   Hou, Jing ^a,c   Zheng, Meiyan ^a   Robinson, Howard ^b   Ke, Hengming ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Crystal structure; Cyclic nucleotides cAMP and cGMP

Indexed keywords

AMINO ACID; CYCLIC AMP; CYCLIC GMP; GLUTAMINE; METAL DERIVATIVE; MUTANT PROTEIN; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10; PHOSPHODIESTERASE 10A2; UNCLASSIFIED DRUG; DIVALENT CATION; HEAVY METAL; PDE10A PROTEIN, HUMAN;

ARTICLE; COMPLEX FORMATION; CONFORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN FAMILY; SECOND MESSENGER; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CATIONS, DIVALENT; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC GMP; GLUTAMINE; HUMANS; HYDROGEN BONDING; KINETICS; METALS, HEAVY; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORIC DIESTER HYDROLASES; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 34347240412     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700279104     Document Type: Article

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