Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: Its orientation impacts cGMP but not cAMP affinity

Journal of Biological Chemistry

Volumn 281, Issue 9, 2006, Pages 5553-5558

  Zoraghi, Roya ^a   Corbin, Jackie D ^a   Francis, Sharron H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL IMMOBILIZATION; CHEMICAL BONDS; PROTEINS;

ADENINE; CYCLIC NUCLEOTIDE; GUANINE; MOLECULAR MASS;

AMINO ACIDS;

CYCLIC AMP; CYCLIC GMP; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE V; SILDENAFIL; VARDENAFIL; CGMP BINDING, CGMP SPECIFIC 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CGMP-BINDING, CGMP-SPECIFIC 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC GMP PHOSPHODIESTERASE; GLUTAMINE; IMIDAZOLE DERIVATIVE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PIPERAZINE DERIVATIVE; SULFONE; TRIAZINE DERIVATIVE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; CYCLIC AMP; CYCLIC GMP; GLUTAMINE; HUMANS; IMIDAZOLES; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; SULFONES; TRIAZINES;

EID: 33646847852     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510372200     Document Type: Article

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