Crystal structure of human phosphodiesterase 3B: Atomic basis for substrate and inhibitor specificity

Biochemistry

Volumn 43, Issue 20, 2004, Pages 6091-6100

  Scapin, Giovanna ^a   Patel, Sangita B ^a   Chung, Christine ^a   Varnerin, Jeffrey P ^a   Edmondson, Scott D ^a   Mastracchio, Anthony ^a   Parmee, Emma R ^a   Singh, Suresh B ^a   Becker, Joseph W ^a   Van Der Ploeg, Lex H T ^b   Tota, Michael R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MRL San Diego Neuroscience Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; ENZYMES; METABOLISM; MOLECULAR BIOLOGY;

ERECTILE DYSFUNCTION; METABOLIC RATE;

BIOCHEMISTRY;

CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; PHOSPHODIESTERASE 3B; PHOSPHODIESTERASE 3B INHIBITOR; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; CONGESTIVE HEART FAILURE; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME SPECIFICITY; ERECTILE DYSFUNCTION; INFLAMMATION; LIPOLYSIS; METABOLIC RATE; OBESITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIC GMP; DIMERIZATION; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PHOSPHODIESTERASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 2442700405     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049868i     Document Type: Article

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