PAR-2 activation regulates IL-8 and GRO-α synthesis by NF-κB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium

Clinical and Experimental Allergy

Volumn 37, Issue 7, 2007, Pages 1009-1022

  Rudack, C ^a,b   Steinhoff, M ^a   Mooren, F ^b   Buddenkotte, J ^a   Becker, K ^b   Von Eiff, C ^b   Sachse, F ^a  

^a Boltzmann Institute for Immunobiology of the Skin   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

CC chemokine rhinosinusitis; CXC chemokine; G protein coupled receptor; PAR 2; Protease

Indexed keywords

ALPHA CHEMOKINE; BAY 11 7085; BETA CHEMOKINE; CALCIUM; CORTISONE; CYTOKINE; EOTAXIN; GROWTH RELATED ONCOPROTEIN ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; ONCOPROTEIN; PEPTIDE; PERTUSSIS TOXIN; PROTEIN INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 2 ACTIVATING PEPTIDE; RANTES; SERINE PROTEINASE INHIBITOR; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRYPSIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; DEVICE; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NOSE MUCOSA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SYNTHESIS INHIBITION; RHINOSINUSITIS; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS; SUPERNATANT;

ACUTE DISEASE; ADULT; AGED; BACTERIAL PROTEINS; CALCIUM; CASE-CONTROL STUDIES; CELLS, CULTURED; CHEMOKINES, CC; CHEMOKINES, CXC; CHRONIC DISEASE; CULTURE MEDIA, CONDITIONED; FEMALE; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; NASAL MUCOSA; NASAL POLYPS; NF-KAPPA B; NITRILES; PEPTIDES; PERTUSSIS TOXIN; RANTES; RECEPTOR, PAR-2; RHINITIS; RNA, MESSENGER; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SIGNAL TRANSDUCTION; SINUSITIS; STAPHYLOCOCCUS AUREUS; SULFONES; TRYPSIN;

EID: 34250754475     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2007.02686.x     Document Type: Article

References (48)

1. Fokkens W, Lund V, Bachert C et al. EAACI position paper on rhinosinusitis and nasal polyps executive summary. Allergy 2005 60 : 583 601.
2. Ponikau JU, Sherris DA, Kern EB et al. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc 1999 74 : 877 84.
3. Bachert C, Gevaert P, Van Cauwenberge P. Staphylococcus aureus superantigens and airway disease. Curr Allergy Asthma Rep 2002 2 : 252 8.
4. Bachert C, Watelet JB, Gevaert P, Van Cauwenberge P. Pharmacological management of nasal polyposis. Drugs 2005 65 : 1537 52.
5. Bachert C, Wagenmann M, Hauser U, Rudack C. IL-5 synthesis is upregulated in human nasal polyp tissue. J Allergy Clin Immunol 1997 99 : 837 42.
6. Rudack C, Sachse F, Alberty J. Primary role of growth-related oncogene-alpha and granulocyte chemotactic protein-2 as neutrophil chemoattractants in chronic rhinosinusitis. Clin Exp Allergy 2006 36 : 748 59.
7. Rowe-Jones JM, Trendell-Smith N, Shembekar M, Mackay IS. Polypoid rhinosinusitis in patients with host defence deficiencies: cellular infiltration and disease severity. Rhinology 1997 35 : 113 7.
8. Steinhoff M, Buddenkotte J, Shpacovitch V et al. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 2005 26 : 1 43.
9. Dery O, Corvera CU, Steinhoff M, Bunnett NW. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases [Review] [167 refs]. Am J Physiol 1998 274 : t-52.
10. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R. Proteinase-activated receptors. Pharmacol Rev 2001 53 : 245 82.
11. Ossovskaya VS, Bunnett NW. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 2004 84 : 579 621.
12. Molino M, Barnathan ES, Numerof R et al. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 1997 272 : 4043 9.
13. Bohm SK, Grady EF, Bunnett NW. Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. Biochem J 1997 322 : 1 18.
14. Shpacovitch VM, Brzoska T, Buddenkotte J et al. Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells. J Invest Dermatol 2002 118 : 380 5.
15. Rudack C, Jorg S, Sachse F. Biologically active neutrophil chemokine pattern in tonsillitis. Clin Exp Immunol 2004 135 : 511 8.
16. Rudack C, Maune S, Eble J, Schroeder JM. The primary role in biologic activity of the neutrophil chemokines IL-8 and GRO-alpha in cultured nasal epithelial cells. J Interferon Cytokine Res 2003 23 : 113 23.
17. Rudack C, Bachert C, Stoll W. Effect of prednisolone on cytokine synthesis in nasal polyps. J Interferon Cytokine Res 1999 19 : 1031 5.
18. Pierce JW, Schoenleber R, Jesmok G et al. Novel inhibitors of cytokine-induced ikappa balpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 1997 272 : 21096 103.
19. Page K, Hughes VS, Odoms KK, Dunsmore KE, Hershenson MB. German cockroach proteases regulate interleukin-8 expression via nuclear factor for interleukin-6 in human bronchial epithelial cells. Am J Respir Cell Mol Biol 2005 32 : 225 31.
20. Shpacovitch VM, Varga G, Strey A et al. Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices. J Leukoc Biol 2004 76 : 388 98.
21. Steinhoff M, Corvera CU, Thoma MS et al. Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Experimental Dermatology 1999 8 : 282 94.
22. Buddenkotte J, Stroh C, Engels IH et al. Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B. J Invest Dermatol 2005 124 : 38 45.
23. Matsushima R, Takahashi A, Nakaya Y et al. Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent athway. Am J Physiol Lung Cell Mol Physiol 2006 290 : L385 95.
24. Sun G, Stacey MA, Schmidt M, Mori L, Mattoli S. Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J Immunol 2001 167 : 1014 21.
25. Page K, Strunk VS, Hershenson MB. Cockroach proteases increase IL-8 expression in human bronchial epithelial cells via activation of protease-activated receptor (PAR)-2 and extracellular-signal-regulated kinase. J Allergy Clin Immunol 2003 112 : 1112 8.
26. Dinh QT, Cryer A, Trevisani M et al. Gene and protein expression of protease-activated receptor 2 in structural and inflammatory cells in the nasal mucosa in seasonal allergic rhinitis. Clin Exp Allergy 2006 36 : 1039 48.
27. Knight DA, Lim S, Scaffidi AK et al. Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. J Allergy Clin Immunol 2001 108 : 797 803.
28. Iwakiri K, Ghazizadeh M, Jin E et al. Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris. J Invest Dermatol 2004 122 : 937 44.
29. Akers IA, Parsons M, Hill MR et al. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol - Lung Cellular Mol Physiol 2000 278 : L193 201.
30. Cocks TM, Moffatt JD. Protease-activated receptor-2 (PAR2) in the airways. Pulm Pharmacol Ther 2001 14 : 183 91.
31. Nystedt S, Ramakrishnan V, Sundelin J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem 1996 271 : 14910 5.
32. Cocks TM, Fong B, Chow JM et al. A protective role for protease-activated receptors in the airways. Nature 1999 398 : 156 60.
33. Borger P, Koeter GH, Timmerman JA, Vellenga E, Tomee JF, Kauffman HF. Proteases from Aspergillus fumigatus induce interleukin (IL)-6 and IL-8 production in airway epithelial cell lines by transcriptional mechanisms. J Infect Dis 1999 180 : 1267 74.
34. Kauffman HF, Tomee JF, van de Riet MA, Timmerman AJ, Borger P. Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production. J Allergy Clin Immunol 2000 105 : 1185 93.
35. Wuyts A, Struyf S, Gijsbers K et al. The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma: comparison with interleukin-8/CXCL8. Lab Invest 2003 83 : 23 34.
36. Froyen G, Proost P, Ronsse I et al. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs 30. Eur J Biochem 1997 243 : 762 9.
37. Gijsbers K, Van Assche G, Joossens S et al. CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue. Eur J Immunol 2004 34 : 1992 2000.
38. Arvidson S, Tegmark K. Regulation of virulence determinants in Staphylococcus aureus. Int J Med Microbiol 2001 291 : 159 70.
39. Berger P, Tunon-De-Lara JM, Savineau JP, Marthan R. Selected contribution: tryptase-induced PAR-2-mediated Ca(2+) signaling in human airway smooth muscle cells. J Appl Physiol 2001 91 : 995 1003.
40. Okamoto T, Nishibori M, Sawada K et al. The effects of stimulating protease-activated receptor-1 and -2 in A172 human glioblastoma. J Neural Transm 2001 108 : 125 40.
41. Rahman A, True AL, Anwar KN, Ye RD, Voyno-Yasenetskaya TA, Malik AB. Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells. Circ Res 2002 91 : 398 405.
42. Bohm SK, Khitin LM, Grady EF, Aponte G, Payan DG, Bunnett NW. Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J Biol Chem 1996 271 : 22003 16.
43. Stein B, Baldwin AS Jr. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B. Mol Cell Biol 1993 13 : 7191 8.
44. Weber C, Erl W, Pietsch A, Weber PC. Aspirin inhibits nuclear factorû{kappa}B mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation 1995 91 : 1914 7.
45. Pierce JW, Read MA, Ding H, Luscinskas FW, Collins T. Salicylates inhibit I kappa B-alpha phosphorylation, endothelial- leukocyte adhesion molecule expression, and neutrophil transmigration. J Immunol 1996 156 : 3961 9.
46. Kopp E, Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 1994 265 : 956 9.
47. De Caterina R, Libby P, Peng HB et al. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 1995 96 : 60 8.
48. Homma T, Kato A, Hashimoto N et al. Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells. Am J Respir Cell Mol Biol 2004 31 : 463 9.