The CXC chemokine GCP-2/CXCL6 is predominantly induced in mesenchymal cells by interleukin-1β and is down-regulated by interferon-γ: Comparison with interleukin-8/CXCL8

Laboratory Investigation

Volumn 83, Issue 1, 2003, Pages 23-34

  Wuyts, Anja ^a   Struyf, Sofie ^a   Gijsbers, Klara ^a   Schutyser, Evemie ^a   Put, Willy ^a   Conings, René ^a   Lenaerts, Jean Pierre ^a   Geboes, Karel ^b   Opdenakker, Ghislain ^a   Menten, Patricia ^a   Proost, Paul ^a   Van Damme, Jo ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; CHEMOKINE CXCL6; CHEMOKINE RECEPTOR; DOUBLE STRANDED RNA; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CELL STRUCTURE; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENDOTHELIUM CELL; FIBROBLAST; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; LEUKOCYTE; LUNG ALVEOLUS MACROPHAGE; MEASLES VIRUS; MESENCHYME CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; QUANTITATIVE DIAGNOSIS; SARCOMA;

EID: 0037241927     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000048719.53282.00     Document Type: Article

References (56)

1. Abu El-Asrar AM, Struyf S, Al-Kharashi SA, Missotten L, Van Damme J, and Geboes K (2000). Chemokines in the limbal form of vernal keratoconjunctivitis. Br J Ophthalmol 84:1360-1366.
2. + CXC chemokine-induced angiogenic activity. J Immunol 165:5269-5277.
3. Arenberg DA, Keane MP, DiGiovine B, Kunkel SL, Morris SB, Xue Y-Y, Burdick MD, Glass MC, lannettoni MD, and Strieter RM (1998). Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer. J Clin Invest 102:465-472.
4. Arenberg DA, Kunkel SL, Polverini PJ, Glass M, Burdick MD, and Strieter RM (1996). Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice. J Clin Invest 97:2792-2802.
5. Austin KJ, King CP, Vierk JE, Sasser RG, and Hansen TR (1999). Pregnancy-specific protein B induces release of an alpha chemokine in bovine endometrium. Endocrinology 140:542-545.
6. Baggiolini M (1998). Chemokines and leukocyte traffic. Nature 392:565-568.
7. Baggiolini M, Dewald B, and Moser B (1994). Interleukin-8 and related chemotactic cytokines: CXC and CC chemokines. Adv Immunol 55:97-179.
8. Brandt E, Ludwig A, and Flad H-D (2000). CTAP-III, βTG, and NAP-2. In: Oppenheim JJ and Feldmann M, editors. Cytokine reference: A compendium of cytokines and other mediators of host defense. London, UK: Academic Press, 1077-1094.
9. Cassatella MA (1999). Neutrophil-derived proteins: Selling cytokines by the pound. Adv Immunol 73:369-509.
10. D'Haens GR, Geboes K, Peeters M, Baert F, Penninckx F, and Rutgeerts P (1998). Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 114:262-267.
11. Fathi M, Johansson A, Lundborg M, Orre L, Sköld CM, and Camner P (2001). Functional and morphological differences between human alveolar and interstitial macrophages. Exp Mol Pathol 70:77-82.
12. Froyen G, Proost P, Ronsse I, Mitera T, Haelens A, Wuyts A, Opdenakker G, Van Damme J, and Billiau A (1997). Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs. Eur J Biochem 243:762-769.
13. Galy AHM and Spits H (1991). IL-1, IL-4, and IFN-γ differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells. J Immunol 147:3823-3830.
14. Goodman RB, Strieter RM, Frevert CW, Cummings CJ, Tekamp-Olson P, Kunkel SL, Walz A, and Martin TR (1998). Quantitative comparison of C-X-C chemokines produced by endotoxin-stimulated human alveolar macrophages. Am J Physiol 275:L87-L95.
15. Grimm MC, Elsbury SKO, Pavli P, and Doe WF (1996). Interleukin 8: Cells of origin in inflammatory bowel disease. Gut 38:90-98.
16. Hoet PH, Gilissen LP, Leyva M, and Nemery B (1999). In vitro cytotoxicity of textile paint components linked to the "Ardystil syndrome." Toxicol Sci 52:209-216.
17. Imaizumi T-A, Albertine KH, Jicha DL, McIntyre TM, Prescott SM, and Zimmerman GA (1997). Human endothelial cells synthesize ENA-78: Relationship to IL-8 and to signaling of PMN adhesion. Am J Respir Cell Mol Biol 17:181-192.
18. King AG, Horowitz D, Dillon SB, Levin R, Farese AM, MacVittie TJ, and Pelus LM (2001). Rapid mobilization of murine hematopoietic stem cells with enhanced engraftment properties and evaluation of hematopoietic progenitor cell mobilization in rhesus monkeys by a single injection of SB-251353, a specific truncated form of the human CXC chemokine GROβ. Blood 97:1534-1542.
19. King AG, Johanson K, Frey CL, DeMarsh PL, White JR, McDevitt P, McNulty D, Balcarek J, Jonak ZL, Bhatnagar PK, and Pelus LM (2000). Identification of unique truncated KC/GROβ chemokines with potent hematopoietic and antiinfective activities. J Immunol 164:3774-3782.
20. Lee TH, Lee GW, Ziff EB, and Vilcek J (1990). Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts. Mol Cell Biol 10:1982-1988.
21. Lukacs NW, Kunkel SL, Allen R, Evanoff HL, Shaklee CL, Sherman JS, Burdick MD, and Strieter RM (1995). Stimulus and cell-specific expression of C-X-C and C-C chemokines by pulmonary stromal cell populations. Am J Physiol 268: L856-L861.
22. Luster AD (1998). Chemokines: Chemotactic cytokines that mediate inflammation. N Engl J Med 338:436-445.
23. Mantovani A (1999). The chemokine system: Redundancy for robust outputs. Immunol Today 20:254-257.
24. Mazzucchelli L, Hauser C, Z'graggen K, Wagner H, Hess M, Laissue JA, and Mueller C (1994). Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. Am J Pathol 144:997-1007.
25. Menten P, Proost P, Struyf S, Van Coillie E, Put W, Lenaerts J-P, Conings R, Jaspar J-M, De Groote D, Billiau A, Opdenakker G, and Van Damme J (1999). Differential induction of monocyte chemotactic protein-3 in mononuclear leukocytes and fibroblasts by interferon-α/β and interferon-γ reveals MCP-3 heterogeneity. Eur J Immunol 29:678-685.
26. Murphy PM, Baggiolini M, Charo IF, Hébert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, and Power CA (2000). International union of pharmacology. XXII Nomenclature for chemokine receptors. Pharmacol Rev 52:145-176.
27. Nyhlén K, Linden M, Andersson R, and Uppugunduri S (2000). Corticosteroids and interferons inhibit cytokine-induced production of IL-8 by human endothelial cells. Cytokine 12:355-360.
28. Oliveira IC, Sciavolino PJ, Lee TH, and Vilcek J (1992). Downregulation of interieukin 8 gene expression in human fibroblasts: Unique mechanism of transcriptional inhibition by interferon. Proc Natl Acad Sci USA 89:9049-9053.
29. Opdenakker G and Van Damme J (1992). Chemotactic factors, passive invasion and metastasis of cancer cells. Immunol Today 13:463-464.
30. Proost P, De Wolf-Peeters C, Conings R, Opdenakker G, Billiau A, and Van Damme J (1993). Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells: In vitro and in vivo comparison with natural forms of GRO, IP-10 and IL-8. J Immunol 150:1000-1010.
31. Proost P, Van Leuven P, Wuyts A, Ebberink R, Opdenakker G, and Van Damme J (1995). Chemical synthesis, purification and folding of the human monocyte chemotactic proteins MCP-2 and MCP-3 into biologically active chemokines. Cytokine 7:97-104.
32. Rampart M, Herman AG, Grillet B, Opdenakker G, and Van Damme J (1992). Development and application of a radioimmunoassay for interleukin-8: Detection of interleukin-8 in synovial fluids from patients with inflammatory joint disease. Lab Invest 66:512-518.
33. Schnyder-Candrian S, Strieter RM, Kunkel SL, and Walz A (1995). Interferon-a and interferon-γ down-regulate the production of interleukin-8 and ENA-78 in human monocytes. J Leukoc Biol 57:929-935.
34. Schnyder-Candrian S and Walz A (1997). Neutrophil-activating protein ENA-78 and IL-8 exhibit different patterns of expression in lipopolysaccharide- and cytokine-stimulated human monocytes. J Immunol 158:3888-3894.
35. Smith JB and Herschman HR (1995). Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokine. J Biol Chem 270:16756-16765.
36. Strieter RM, Kunkel SL, Burdick MD, Lincoln PM, and Walz A (1992). The detection of a novel neutrophil-activating peptide (ENA-78) using a sensitive ELISA. Immunol Invest 21:589-596.
37. Strieter RM, Polverini PJ, Kunkel SL, Arenberg DA, Burdick MD, Kasper J, Dzuiba J, Van Damme J, Walz A, Marriott D, Chan S-Y, Roczniak S, and Shanafelt AB (1995). The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 270:27348-27357.
38. Struyf S, Van Coillie E, Paemen L, Put W, Lenaerts J-P, Proost P, Opdenakker G, and Van Damme J (1998). Synergistic induction of MCP-1 and -2 by IL-1β and interferons in fibroblasts and epithelial cells. J Leukoc Biol 63:364-372.
39. Teixeira MG, Austin KJ, Perry DJ, Dooley VD, Johnson GA, Francis BR, and Hansen TR (1997). Bovine granulocyte chemotactic protein-2 is secreted by the endometrium in response to interferon-tau (IFN-τ. Endocrine 6:31-37.
40. Theys J, Nuyts S, Landuyt W, Van Mellaert L, Dillen C, Böhringer M, Dürre P, Lambin P, and Anné J (1999). Stable Escherichia coli-Clostridium acetobutylicum shuttle vector for secretion of murine tumor necrosis factor alpha. Appl Environ Microbiol 65:4295-4300.
41. Van Coillie E, Van Aelst I, Wuyts A, Vercauteren R, Devos R, De Wolf-Peeters C, Van Damme J, and Opdenakker G (2001). Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle. Am J Pathol 159:1405-1414.
42. Van Damme J, Bunning RAD, Conings R, Graham R, Russell G, and Opdenakker G (1990). Characterization of granulocyte chemotactic activity from human cytokine-stimulated chondrocytes as interleukin 8. Cytokine 2:106-111.
43. Van Damme J, Van Beeumen J, Decock B, Van Snick J, De Ley M, and Billiau A (1988). Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1β and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6. J Immunol 140:1534-1541.
44. Walz A (2000). ENA-78. In: Oppenheim JJ and Feldmann M, editors. Cytokine reference: A compendium of cytokines and other mediators of host defense. London, UK: Academic Press, 1049-1059.
45. Walz A, Burgener R, Car B, Baggiolini M, Kunkel SL, and Strieter RM (1991). Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8. J Exp Med 174:1355-1362.
46. Walz A, Schmutz P, Mueller C, and Schnyder-Candrian S (1997). Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease. J Leukoc Biol 62:604-611.
47. Wang D and Richmond A (2000). MGSA/GRO. In: Oppenhelm JJ and Feldmann M, editors. Cytokine reference: A compendium of cytokines and other mediators of host defense. London, UK: Academic Press, 1023-1048.
48. Wolf M, Delgado MB, Jones SA, Dewald B, Clark-Lewis I, and Baggiolini M (1998). Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2. Eur J Immunol 28:164-170.
49. 2-terminal heterogeneity: Functional comparison of different natural isoforms. Eur J Biochem 260:421-429.
50. Wuyts A, Proost P, Froyen G, Haelens A, Billiau A, Opdenakker G, and Van Damme J (1997a). Purification and identification of human and mouse granulocyte chemotactic protein-2 isoforms. Methods Enzymol 287:13-33.
51. Wuyts A, Proost P, Lenaerts J-P, Ben-Baruch A, Van Damme J, and Wang JM (1998a). Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78. Eur J Biochem 255:67-73.
52. Wuyts A, Proost P, and Van Damme J (1998b). Interleukin-8 and other CXC chemokines, 3rd ed. In: Thomson AW, editor. The cytokine handbook. London, UK: Academic Press, 271-311.
53. Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim JJ, Proost P, and Van Damme J (1997b). Characterization of synthetic human granulocyte chemotactic protein 2: Usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. Biochemistry 36:2716-2723.
54. Zlotnik A, Morales J, and Hedrick JA (1999). Recent advances in chemokines and chemokine receptors. Crit Rev Immunol 19:1-47.
55. Zlotnik A and Yoshie O (2000). Chemokines: A new classification system and their role in immunity. Immunity 12:121-127.
56. Z'graggen K, Walz A, Mazzucchelli L, Strieter RM, and Mueller C (1997). The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease. Gastroenterology 113:808-816.