Unusually strong binding to the DNA minor groove by a highly twisted benzimidazole diphenylether: Induced fit and bound water

Biochemistry

Volumn 46, Issue 23, 2007, Pages 6944-6956

  Tanious, Farial A ^a   Laine, William ^b   Peixoto, Paul ^b   Bailly, Christian ^b,c   Goodwin, Kristie D ^d   Lewis, Mark A ^e   Long, Eric C ^e   Georgiadis, Millie M ^d   Tidwell, Richard R ^f   Wilson, W David ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^c INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e INDIANA UNIVERSITY   (United States)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DIPHENYLETHER; COMPOUND-DNA INTERFACE; DIAMIDINE;

AROMATIC POLYMERS; BINDING ENERGY; BIOSENSORS; CRYSTALLOGRAPHY; DERIVATIVES; DICHROISM;

DNA;

ADENINE; BENZIMIDAZOLE; CATION; DIAMIDINE DERIVATIVE; DIPHENYL ETHER; DNA; FUNCTIONAL GROUP; RT 29; THYMIDINE; UNCLASSIFIED DRUG; WATER;

ARTICLE; BIOSENSOR; CIRCULAR DICHROISM; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTALLOGRAPHY; DNA BINDING; DNA CONFORMATION; DNA FOOTPRINTING; DNA SEQUENCE; ENTHALPY; FLUORESCENCE; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE;

BASE SEQUENCE; BENZAMIDINES; BENZIMIDAZOLES; DEOXYRIBONUCLEASE I; DNA; DNA FOOTPRINTING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; WATER;

EID: 34250156358     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700288g     Document Type: Article

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