Specific binding of Hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: Calorimetric and spectroscopic studies

Journal of Molecular Biology

Volumn 271, Issue 2, 1997, Pages 244-257

  Haq, Ihtshamul ^a,b   Ladbury, John E ^b   Chowdhry, Babur Z ^a   Jenkins, Terence C ^c   Chaires, Jonathan B ^d  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Calorimetry; DNA drug interactions; Hoechst 33258; Solvent accessible surface; Thermodynamics

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; DOUBLE STRANDED DNA; SODIUM ION;

AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CALORIMETRY; CONTROLLED STUDY; DNA DENATURATION; DRUG DNA BINDING; ENTHALPY; ENTROPY; FLUORESCENCE SPECTROSCOPY; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; LIGAND BINDING; PRIORITY JOURNAL; STOICHIOMETRY; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

EID: 0031571628     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1170     Document Type: Article

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