Sequence-selective targeting of long stretches of the DNA minor groove by a novel dimeric bis-benzimidazole

Biochemistry

Volumn 42, Issue 20, 2003, Pages 5984-5992

  Joubert, Alexandra ^a   Sun, Xiao Wen ^b   Johansson, Eric ^c   Bailly, Christian ^a   Mann, John ^b   Neidle, Stephen ^c  

^a INSERM   (France)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; COMPUTER SIMULATION; DIMERS; DNA; HYDROGEN BONDS;

MINOR GROOVE;

BIOCHEMISTRY;

ADENINE; BENZIMIDAZOLE DERIVATIVE; CYTOSINE; DIMER; DNA B; GUANINE; HYDROGEN; METHYL GROUP; N METHYL N,N BIS 3,3 [4' [5'' [2''' (4 METHOXYPHENYL) 5''' 1H BENZIMIDAZOLYL] 2'' 1H BENZIMIDAZOLYL]PHENOXYPROPYLAMINE; NITROGEN; OXYGEN; THYMINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA SEQUENCE; DNA STRUCTURE; GENE TARGETING; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN MOTIF; SEQUENCE ANALYSIS;

BASE SEQUENCE; BENZIMIDAZOLES; BINDING SITES; COMPUTER SIMULATION; DIMERIZATION; DNA; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; THERMODYNAMICS;

PUFFINUS AURICULARIS;

EID: 0037508509     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026926w     Document Type: Article

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