3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 9, 2006, Pages 3144-3152

  Athri, Prashanth ^a   Wenzler, Tanja ^b   Ruiz, Patricia ^a   Brun, Reto ^b   Boykin, David W ^a   Tidwell, Richard ^c   Wilson, W David ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

3D QSAR; Anti parasitic; CoMFA CoMSIA; Heterocyclic diamidines

Indexed keywords

DIAMIDINE DERIVATIVE; FURAMIDINE; HETEROCYCLIC COMPOUND; KINETOPLAST DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; ELECTRICITY; HYDROPHOBICITY; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STEREOSPECIFICITY; TRYPANOSOMA;

ANIMALS; ANTIPARASITIC AGENTS; CYCLIZATION; DATABASES, FACTUAL; ELECTROSTATICS; HYDROGEN BONDING; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PENTAMIDINE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI BRUCEI;

ANIMALIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 33644980902     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.029     Document Type: Article

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