Growth factors and the regulation of fetal growth

Diabetes Care

Volumn 21, Issue SUPPL.2, 1998, Pages

  Hill, David J ^a,b   Petrik, Jim ^c   Arany, Edith ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN;

CONFERENCE PAPER; FETOPLACENTAL UNIT; FETUS GROWTH; HUMAN; INSULIN RELEASE; INTRAUTERINE GROWTH RETARDATION; PANCREAS ISLET BETA CELL; PREGNANCY DIABETES MELLITUS;

ANIMALS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL MACROSOMIA; GROWTH SUBSTANCES; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; ISLETS OF LANGERHANS; PREGNANCY; PREGNANCY IN DIABETICS;

EID: 0031849328     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (109)

1. Naeye RL: Infants of diabetic mothers: a quantitative morphological study Pediatrics 35:980-988, 1965
2. Susa JB, Neave C, Sehgal P, Singer DB, Zeller WP, Schwartz R. Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiological hyperinsulinemia on fetal growth and composition. Diabetes 33:656-660, 1984
3. Newfeld ND, Scott M, Kaplan SA: Ontogeny of the mammalian insulin receptor. Dev Biol 78:151-160, 1980
4. Freemark M, D'Ercole AJ, Handwerger S: Somatomedin-C stimulates glycogen synthesis in fetal rat hepatocytes. Endocrinology 112:402-404, 1985
5. Carson BS, Phillips AF, Simmons MA, Battaglia FC, Meschia G: Effects of a sustained insulin infusion upon glucose uptake and oxygenation in the ovine fetus. Pea Res 14:147-152, 1980
6. Girbau M, Gomez JA, Lesniak MA, De Pablo F: Insulin and insulin-like growth factor I both stimulate metabolism, growth and differentiation in the post-neurula chick embryo. Endocrinology 121:1477-1482, 1987
7. Raynor MJ, Graham CF: Clonal analysis of the change in growth phenotype during embryonal carcinoma differentiation. J Cell Sci 58:331-334, 1982
8. Hill DJ, De Sousa D: Insulin is a mitogen for isolated epiphyseal growth plate chondrocytes from the fetal lamb. Endocrinology 126:2661-2670, 1990
9. Brown AL, Graham DE, Nissley SP, Hill DJ, Strain AJ, Rechler MM: Developmental regulation of insulin-like growth factor II mRNA in different rat tissues. J Biol Chem 261:13144-13150, 1986
10. Han VKM, Lund PK, Lee DC, D'Ercole AJ: Expression of somatomedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: identification, characterization and tissue distribution. J Clin Endocrinol Metab 66:422-429, 1988
11. McCusker RH, Clemmons DR: The insulin-like growth factor binding proteins: structure and biological functions. In The Insulin-Like Growth Factors, Structure and Biological Functions. Schofield PN, Ed. Oxford, U.K., Oxford University Press, 1992, p. 110-150
12. Brice AL, Cheetham JE, Bolton VN, Hill NCW, Schofield PN: Temporal changes in the expression of the insulin-like growth factor II gene associated with tissue maturation in the human fetus. Development 106:543-554, 1989
13. Han VKM, Hill DJ, Strain AJ, Towle AC, Lauder JM, Underwood LE, D'Ercole AJ: Identification of somatomedin/insulin-like growth factor immunoreactive cells in the human fetus. Ped Res 22:245-249, 1987
14. Hill DJ, Clemmons DR: Similar immunological distribution of insulin-like growth factor binding proteins -1, -2, and -3 in human fetal tissues. Growth Factors 6:315-326, 1992
15. Liu J-P, Baker J, Perkins AS, Robertson EJ, Efstratiadis A: Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75:59-72, 1993
16. Baker J, Liu J-P, Robertson EJ, Efstratiadis A: Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75:73-82, 1993
17. Lassarre C, Hardouin S, Daffos F, Forestier F, Frankenne F, Binoux M: Serum insulin-like growth factor binding proteins in the human fetus: relationships with growth in normal subjects and in subjects with intrauterine growth retardation. Ped Res 29:219-226, 1991
18. Delmis J, Drazancic A, Ivanisevic M, Suchanek E: Glucose, insulin, HGH and IGF-I levels in maternal serum, amniotic fluid and umbilical venous serum: a comparison between late normal pregnancy and pregnancies complicated with diabetes and fetal growth retardation. J Perinat Med 20:47-56, 1992
19. Wang HS, Lim J, English J, Irvine L, Chard T: The concentration of insulin-like growth factor-I and insulin-like growth factor binding protein-1 in human umbilical cord serum at delivery: relationship to birth weight. J Endocrinel 129:459-464, 1991
20. Price WA, Rong L, Stiles AD, D'Ercole AJ: Changes in IGF-I and -II, IGF binding protein, and IGF receptor transcript abundance after uterine artery ligation. Ped Res 32:291-295, 1992
21. Straus DS, Ooi GT, Orlowski CC, Rechler MM: Expression of the genes for insulin-like growth factor-I (IGF-I), IGF-II, and IGF-binding proteins-1 and -2 in fetal rat under conditions of intrauterine growth retardation caused by maternal fasting. Endocrinology 128:518-525, 1991
22. Hill DJ, Hubner C, Rashid P, Strain AJ, Clemmons DR: Insulin-like growth factor (IGF) binding protein release by human fetal fibroblasts: dependency on cell density and IGF peptides. J Endocrinol 122:87-98, 1989
23. Fowden AL: The role of insulin in prenatal growth. J Dev Physiol 12:173-182, 1989
24. Swenne I, Eriksson U: Diabetes in pregnancy: islet cell proliferation in fetal rat pancreas. Diabetologia 23:525-528, 1982
25. Dudek RW, Lawrence IE: Morphologic evidence of interaction between adult ductal epithelium of pancreas and fetal foregut mesenchyme. Diabetes 37:891-900, 1988
26. Yderstraede KB, Flindt-Egebak P: Neonatal rat islets of Langerhans and fetal rat pancreas: isolation, immunohistochemical, functional, and autoradiographic evaluation. Acta Diabetol 32:95-101, 1995
27. Finegood DT, Scaglia L, Bonner-Weir S: Dynamics of β-cell mass in the growing rat pancreas. Diabetes 44:249-256, 1995
28. Cantenys D, Portha B: Histogenesis of the endocrine pancreas in newborn rats after destruction by streptozotocin. Virchows Arch (Cell Pathol) 35:109-122, 1981
29. Bencosme SA: Cytology of the islet cells in alloxan diabetic rabbits. Am J Pathol 31:1149-1164, 1955
30. Brockenbrough JS, Weir GC, Bonner-Weir S: Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes 37:232-236, 1988
31. Gu D, Sarvetnick N: Epithelial cell proliferation and islet neogenesis in IFN-gamma transgenic mice. Development 118:33-46, 1993
32. Wilander E, Boquist L, Rerup C, Falkmer S: Functional and morphological studies of islet B-cell regeneration in endogenous and exogenous diabetes. Acta Pathol Microbiol Scand 78:496-504, 1970
33. Scaglia L, Cahill CJ, Finegood DT, Bonner-Weir S: Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology 138:1736-1741, 1997
34. Suarez-Pinzon WL, Strynadka K, Schulz R, Rabinovitch A: Mechanisms of cytokine-induced destruction of rat insulinoma cells: the role of nitric oxide. Endocrinology 134:1006-1010, 1994
35. Holemans K, Verhaeghe J, Dequeker J, Van Assche A: Insulin sensitivity in adult female rats subjected to malnutrition during the perinatal period. J Soc Gynecol Invest 3:71-77, 1996
36. Barker DJP: The fetal origins of adult disease. Fetal Mat Med Rev 6:71-80, 1994
37. Swenne I. Bone A-J, Howell S-L, Hellerstrom C: Effects of glucose and amino acids on the biosynthesis of DNA and insulin in fetal rat islets maintained in tissue culture. Diabetes 29:686-692, 1980
38. King DL, Kitchen KC, Chick WL: Pancreatic β-cell replication: relation to insulin secretion. Endocrinology 103:1321-1327, 1978
39. Pictet R, Rutter WJ: Development of the embryonic endocrine pancreas. In Handbook of Physiology. Sect. 7. Vol. 1. Steines DF, Freinkell N, Eds. Baltimore, MD, American Physiological Society, 1972, p. 25-66
40. Asplund K: Dynamics of insulin release from the foetal and neonatal rat pancreas. Eur J Clin Invest 3:338-344, 1973
41. De Gasparo M, Milner GR, Norris PD, Milner RDG: Effect of glucose and amino acids on foetal rat pancreatic growth and insulin secretion in vitro. J Endocrinol 77:241-248, 1978
42. Eriksson U, Hellerstrom C, Anderson A: Diabetes in pregnancy: effects of the maturation of (pro)insulin biosynthesis in foetal and neonatal rat islets. Diabetes Metabolisme 7:243-249, 1981
43. Dudek RW, Kawabe T, Brinn JE, O'Brien K, Poole MC, Morgan CR: Glucose effects in vitro maturation of fetal rat islets. Endocrinology 114:582-587, 1984
44. Milner RDG, Cser A, Cope GH: Effect of glucose on insulin biosynthesis and β-cell ultrastructure in cultured fetal rat pancreas. J Endocrinol 100:155-160, 1984
45. Swenne I: Glucose-stimulated DNA replication of the pancreatic islets during the development of the rat fetus: effects of nutrients, growth hormone and triiodothyroninc. Diabetes 34:803-807, 1985
46. Nielsen JH: Dissociation between insulin secretion and DNA synthesis in cultured pancreatic islets. Biomed Biochim Acta 44:161-166, 1985
47. Kakita K, Giddings SJ, Rotwein PS, Pernuitt MA: Insulin gene expression in the developing rat pancreas. Diabetes 32:691-696, 1983
48. Asplund K: The effect of glucose on the insulin secretion in foetal and newborn rats. In The Structure and Metabolism of the Pancreas Islets. Falkmer S, Hellman B, Taljedal I-B, Eds. Oxford, U.K., Pergamon Press, 1970, p. 477-484
49. Dudek RW, Kawabe T, Brinn JE, Poole M-C, Morgan CR: Effects of GH on the in vitro maturation of fetal islets. Proc Soc Exp Biol Med 177:69-76, 1984
50. Otonkoski T, Andersson S, Knip M, Simon O: Maturation of insulin response to glucose during human fetal and neonatal development studies with perfusion of pancreatic islet-like cell clusters. Diabetes 37:286-291, 1988
51. Otonkoski T, Hayek A: Constitution of a biphasic insulin response to glucose in human fetal pancreatic beta-cells with glucagon-like peptide 1. J Clin Endocrinol Metab 80:3779-3783, 1995
52. Sandler S. Andersson A, Schell A, Mellgren A, Tollemar J, Borg H, Petersson B, Groth CG, Hellerstrom C: Tissue culture of human fetal pancreas: development and function of β-cells in vitro and transplanation of explants to nude mice. Diabetes 34:1113-1119, 1985
53. Sandler S, Andersson A, Landstrom A, Tollemar J, Borg H, Petersson B, Groth CG, Hellerstrom C: Tissue culture of human fetal pancreas: effects of human serum on development and endocrine function of islet-like cell clusters. Diabetes 36:1401-1407, 1987
54. Andersson I, Billig H, Fryklund L, Hansson HA, Isaksson J, Nilsson A, Rozell B, Skottner A, Stemme S: Localization of IGF I in adult rats: immunohistochemical studies. Acta Physiol Scand 126:311-312, 1986
55. Hellerstrom C, Lewis NJ, Borg H, Johnson R, Freinkel N: Method for large scale isolation of pancreatic islets by tissue culture of fetal rat pancreas. Diabetes 28:769-776, 1979
56. Freinkel N, Lewis NJ, Johnson R, Hellerstrom C: Maturation of stimulus recognition and insulin secretion during tissue culture of fetal pancreas islets. Trans Am Clin Climatol Assoc 90:86-93, 1978
57. Swenne I, Heldin C-H, Hill DJ, Hellerstrom C: Effects of platelet-derived growth factor and somatomcdin-C/insulin-like growth factor I on the DNA replication of fetal rat islets of Langerhans in tissue culture. Endocrinology 122:214-218, 1988
58. 3H] thymidine incorporation in isolated pancreaticrat islets. Horm Metab Res 18:873-874, 1986
59. Sjoholm A, Hellerstrom C: TGFβ stimulates insulin secretion and blocks mitogenic response of pancreatic β-cells to glucose. Am J Physiol 260:C1046-C1051, 1991
60. Otonkoski T, Beattie GM, Rubin JS, Lopez AD, Baird A, Hayek A: Hepatocyte growth factor/scatter factor has insulinotropic activity in human fetal pancreatic cells. Diabetes 43:947-953, 1994
61. Otonkoski T, Mally MI, Hayek A: Opposite effects of β-cell differentiation and growth on Reg expression in human fetal pancreatic cells. Diabetes 43:1164-1166, 1994
62. Watanabe T, Yonemura Y, Yonekura H, Suzuki Y, Miyashita H, Sugiyama K, Moriizuma S, Unno M, Tanaka O, Kondo H: Pancreatic beta cell replication and amelioration of surgical diabetes by Reg protein. Proc Natl Acad Sci U S A 91:3589-3592, 1994
63. Hill DJ, Clemmons DR, Wilson S, Han VKM, Strain AJ, Milner RDG: Immunological distribution of one form of insulin-like growth factor (IGF) binding protein and IGF peptides in human fetal tissues. J Mol Endocrinol 2:31-38, 1989
64. Hogg J, Hill DJ, Han VKM: The ontogeny of insulin-like growth factor (IGF) and IGF binding protein gene expression in the rat pancreas. J Mol Endocrinol 13:49-58, 1994
65. Han VKM, Hill DJ, Strain AJ, Towle AC, Lauder JM, Underwood LE, D'Ercole AJ: Identification of somatomedin/insulin-like growth factor immunoreactive cells in the human fetus. Ped Res 22:245-249, 1987
66. Hill DJ, Frazer A, Swenne I, Wirdnam K, Milner RDG: Somatomedin-C in the human foetal pancreas: cellular localization and release during organ culture. Diabetes 36:465-471, 1987
67. Han VKM, Lund PK, Lee DC, D'Ercole AJ: Expression of somatomedin/ insulin-like growth factor in the human fetus: identification, characterization and tissue distribution. J Clin Endocr Metab 66:422-429, 1988
68. Hoog A, Grimelius L, Falkmer S, Sara VR: A high molecular weight IGF-2 immunoreactive peptide (pro-IGF-2?) in the insulin cells of the islets of Langerhans in pancreas of man and rat. Regul Pept 47:275-283, 1993
69. Maake C, Reinecke M: Immunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormones. Cell Tissue Res 273:249-259, 1993
70. Asfari M, Wei D, Noel M, Holthuizen PE, Czernichow P: IGF-II gene expression in a rat insulin-producing β-cell line (INS-1) is regulated by glucose. Diabetologia 38:927-935, 1995
71. Swenne I, Hill DJ, Strain AJ, Milner RDG: Growth hormone regulation of somatomedin-C/insulin-like growth factor-1 production and DNA replication in fetal rat islets in tissue culture. Diabetes 36:288-294, 1987
72. Hogg J, Han VKM, Clemmons DR, Hill DJ: Interactions of glucose, insulin-like growth factors (IGFs) and IGF binding proteins in the regulation of DNA synthesis by isolated fetal rat islets of Langerhans. J Endocrinol 138:401-412, 1993
73. Scharfmann R, Corvol M, Czernichow P: Characterization of insulinlike growth factor I produced by fetal rat pancreatic cells. Diabetes 38:686-690, 1989
74. Bryson JM, Tuch BE, Baxter RC: Production of insulin-like growth factor II by human fetal pancreas in culture. J Endocrinol 121:367-373, 1989
75. Rabinovitch A, Quigley C, Russel T, Patel Y, Mintz DH: Insulin and multiplication stimulating activity (an insulin-like growth factor) stimulate islet β-cell replication in neonatal rat pancreatic monolayer cultures. Diabetes 31:160-164, 1982
76. Romanus JA, Rabinovitch A, Rechler MM: Neonatal rat islet cell cultures synthesize insulin-like growth factor I. Diabetes 34:696-709, 1985
77. Otonkoski T, Knip M, Wong I, Simell O: Effects of growth hormone and insulin-like growth factor on endocrine function of human fetal islet-like cell clusters during long-term tissue culture. Diabetes 37:1678-1683, 1988
78. Leahy JL, Vandekerkhove KM: Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion. Endocrinology 126:1593-1598, 1990
79. Guler H-P, Schmid C, Zapf J, Froesch ER: Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects. Proc Natl Acad Sci U S A 86:2868-2872, 1989
80. Hill DJ, Sedran RJ, Brenner SL, McDonald TJ: Insulin-like growth factor-I (IGF-I) has a dual effect on insulin release from isolated, perifused adult rat islets of Langerhans. J Endocrinol 153:15-25, 1997
81. Van Schravendijk CF, Foriers A, Van Den Brande JL, Pipeleers DG: Evidence for the presence of type I insulin-like growth factor receptors on rat pancreatic A and B cells. Endocrinology 121:1784-1788, 1987
82. Sun FL, Dean WL, Kelsey G, Allen ND, Reik W: Transactivation of Igf2 in a mouse model of the Beckwith-Wiedemann syndrome. Nature 389:809-815, 1997
83. Dai Z, Xing Y, Boney CM, Clemmons DR, D'Ercole AJ: Human insulin-like growth factor-binding protein-1 (hIGFBP-1) in transgenic mice: characterization and insights into the regulation of IGFBP-1 expression. Endocrinology 135:1316-1327, 1994
84. Scaglia L, Smith FE, Bonner-Weir S: Apoptosis contributes to the involution of β-cell mass in the post partum rat pancreas. Endocrinology 136:5461-5468, 1995
85. Daughaday WH, Kapadia M: Maintenance of serum somatomedin activity in hypophysectomized pregnant rats. Endocrinology 102:1317-1320, 1978
86. Geier A, Haimshon M, Beery R, Lunenfeld B: Insulin-like growth factor-I inhibits cell death induced by cycloheximide in MCF-7 cells: a model system for analyzing control of cell death. In Vitro Cell Dev Biol-Animal 28A:725-729, 1992
87. Galli C, Meucci O, Scorziello A, Werge TM, Calissano P, Schettini G: Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-I through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J Neurosci 15:1172-1179, 1995
88. D'Mello SR, Galli C, Ciotti T, Calissano P: Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor-1 and cAMP Proc Natl Acad Sci U S A 90: 10989-10993, 1993
89. Chun SY, Billig H, Tilly JL, Furuta I, Tsafriri A, Hsueh AJW: Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I. Endocrinology 135: 1845-1853, 1994
90. Muta K, Krantz SB: Apoptosis of human erythroid colony-forming cells is decreased by stem cell factor and insulin-like growth factor I as well as erythropooetin. J Cell Physiol 156:264-271, 1993
91. Rodrigueztarduchy G, Collins MKL, Garcia I, Lopezrivas A: Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells. J Immunol 149:535-539, 1992
92. Schini VB, Catovsky S, Schray-Utz B, Busse R, Vanhoutte PM: Insulin-like growth factor I inhibits induction of nitric oxide synthase in vascular smooth muscle cells. Circ Res 74:24-32, 1994
93. Guan J, Williams C, Gunning M, Mallard C, Gluckman P: The effects of IGF-I treatment after hypoxic-ischaemic brain injury in adult rats. J Cerebr Blood Flow Metab 13:609-616, 1993
94. Hill DJ, Delovitch TL: Insulin-like growth factors protect isolated islets of Langerhans from the cytotoxic effects of cytokines. J Endocrinol 147 (Suppl.):O39, 1995
95. Baird A, Böhlen P: Fibroblast growth factors. In Peptide Growth Factors and Their Receptors. Sporn MB, Roberts AB, Eds. Berlin, Spring-Verlag, 1990, p. 369-418
96. Beattie GM, Lappi DA, Baird A, Hayek A: Selective elimination of fibroblasts from pancreatic islet monolayers by basic fibroblast growth factor-saporin mitotoxin. Diabetes 39:1002-1005, 1990
97. Gonzalez AM, Buscaglia M, Ong M, Baird A: Distribution of basic fibroblast growth factor in 18-day rat fetus: localization in the basement membranes of diverse tissues. J Cell Biol 110:753-765, 1990
98. Gonzalez AM, Hill DJ, Logan A, Maher P, Baird A: Complimentary distribution of fibroblast growth factor-2 (FGF-2) and FGF receptor-1 FGFR1 messenger RNA expression and protein presence in the mid-trimester human fetus. Ped Res 39:375-385, 1996
99. Hill DJ, Logan A, Ong M, De Sousa D, Gonzalez AM: Basic fibroblast growth factor is synthesized and released by isolated ovine fetal growth plate chondrocytes: potential role as an autocrine mitogen. Growth Factors 6:277-294, 1992
100. Flaumenhaft R, Moscatelli D, Saksela O, Rifkin D: Role of extracellular matrix in the action of basic fibroblast growth factor: matrix as a source of growth factor for long-term stimulation of plasminogen activator production and DNA synthesis. J Cell Physiol 140:75-81, 1989
101. Gauthier T, Maftouh M, Picard C: Rapid enzymatic degradation of (125I) (Tyr 10) FGF (1-10) by serum in vitro and involvement in the determination of circulating FGF by RIA. Biochem Biophys Res Comm 145:775-781, 1987
102. Zimering MB, Brandi ML, DeGrange DA, Marx SJ, Streeten E, Katsumata N, Murphy PR, Sato Y, Friesen HG, Aurbach GD: Circulating fibroblast growth factor-like substance in familial endocrine neoplasia type 1. J Clin Endocrinol Metab 70:149-154, 1990
103. Nguyen M, Watanabe H, Budson AE, Richie JP, Hayes DF, Folkman J: Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J Natl Cancer Inst 86:356-361, 1994
104. Cattini PA, Nickel B, Bock M, Kardami E: Immunolocalization of basic fibroblast growth factor (bFGF) in growing and growth-inhibited placental cells: a possible role for bFGF in placental cell development. Placenta 12:341-352, 1991
105. Gonzalez A-M, Hill DJ, Baird A: Anatomical distribution of basic fibroblast growth factor and its high affinity receptor, flg, in the human fetus. Proceedings of the 75th Annual Meeting of the Endocrine Society, Las Vegas, NV, 1993. The Endocrine Society, p. 85
106. Hill DJ, Tevaarwerk GJM, Arany E, Kilkenny D, Gregory M, Miell J: Fibroblast growth factor-2 (FGF-2) is present in maternal and cord serum, and in the mother is associated with a binding protein immunologically related to the FGF receptor-1. J Clin Endocrinol Metab 80:1822-1831, 1995
107. Hill DJ, Tevaarwerk GJM, Caddell C, Arany E, Kilkenny D, Gregory M: Fibroblast growth factor 2 is elevated in term maternal and cord serum and amniotic fluid in pregnancies complicated by diabetes: relationship to fetal and placental size. J Clin Endocrinol Metab 80:2626-2632, 1995
108. Hill DJ, Flyvbjerg A, Arany E, Lauszus F, Klebe JG: Serum fibroblast growth factor-2 (FGF-2) in pregnant women with type 1 diabetes: increased presence associated with retinopathy. J Clin Endocrinol Metab 82:1452-1457, 1997
109. Arany E, Hill DJ: Fibroblast growth factor-2 and fibroblast growth factor receptor-1 mRNA expression and peptide localization in placentae from normal and diabetic pregnancies. Placenta 19:133-142, 1998