Human topoisomerase I C-terminal domain fragment containing the active site tyrosine is a molten globule: Implication for the formation of competent productive complex

Journal of Structural Biology

Volumn 159, Issue 1, 2007, Pages 111-121

  Punchihewa, Chandanamali ^a   Dai, Jixun ^a   Carver, Megan ^a   Yang, Danzhou ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

CD; Fluorescence; Human topoisomerase I C terminal domain; Molten globule; NMR

Indexed keywords

DNA FRAGMENT; DNA TOPOISOMERASE; TYROSINE;

ALPHA HELIX; ARTICLE; CONTROLLED STUDY; ENZYME CONFORMATION; ENZYME MECHANISM; HUMAN; HYDROPHOBICITY; MOLTING; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE;

BINDING SITES; DNA TOPOISOMERASES, TYPE I; HUMANS; HYDROPHOBICITY; PEPTIDE FRAGMENTS; PLIABILITY; PROTEIN STRUCTURE, TERTIARY; TYROSINE;

EID: 34249931428     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2007.03.001     Document Type: Article

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