Biochemistry: Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region

Science

Volumn 309, Issue 5731, 2005, Pages 142-145

  Pufall, Miles A ^a   Lee, Gregory M ^b   Nelson, Mary L ^a   Kang, Hyun Seo ^b   Velyvis, Algirdas ^c   Kay, Lewis E ^c   McIntosh, Lawrence P ^b   Graves, Barbara J ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL IMMOBILIZATION; CHEMICAL BONDS; CONFORMATIONS; DNA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHATES; PROTEINS;

DNA BINDING AFFINITY; PHOSPHORYLATION; PROTEIN ACTIVITY; TRANSCRIPTION ACTIVATORS;

BIOCHEMISTRY;

PHOSPHATE; TRANSCRIPTION FACTOR ETS 1; CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN-DEPENDENT PROTEIN KINASE II; DNA; ETS1 PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN); TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS;

BIOCHEMISTRY;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELL CONTACT; DNA BINDING; DNA TRANSCRIPTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HYDROPHOBICITY; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTATION; NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DNA; HYDROPHOBICITY; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 21744436606     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1111915     Document Type: Article

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35. We acknowledge support from NIH grant R01 GM38663 (B.J.G.); NIH grants T32-CA93247 and -GM08537 (M.A.P.); P01-CA24014 (Huntsman Cancer Institute) and the U.S. Department of Energy and the Huntsman Cancer Foundation (B.J.G.); the National Cancer Institute of Canada with funds from the Canadian Cancer Society (L.P.M.); the Government of Canada's Network of Centres of Excellence Program supported by the Canadian Institutes of Health Research (CIHR); the Natural Sciences and Engineering Research Council through the Protein Engineering Network of Centres of Excellence (L.P.M. and L.E.K.); and the CIHR for a Scientist Award (L.P.M.) and funding (L.E.K.). L.E.K. holds a Canada Research Chair in Biochemistry.