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Volumn 7, Issue , 2007, Pages 649-665

WT1 peptide cancer vaccine for patients with hematopoietic malignancies and solid cancers

Author keywords

Cancer; Clinical trial; Immunotherapy; Vaccine; WT1

Indexed keywords

CANCER VACCINE; COMPLEMENTARY DNA; EPITOPE; GEMCITABINE; GENE PRODUCT; HLA ANTIGEN CLASS 1; IMATINIB; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; TUMOR ANTIGEN; WT1 PROTEIN;

EID: 34249817898     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2007.119     Document Type: Review
Times cited : (30)

References (84)
  • 2
    • 0025098654 scopus 로고
    • Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping
    • Gessler, M., Poustka, A., Cavenee, W., Neve, R.L., Orkin, S.H., and Bruns, G.A. (1990) Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 343, 774-778.
    • (1990) Nature , vol.343 , pp. 774-778
    • Gessler, M.1    Poustka, A.2    Cavenee, W.3    Neve, R.L.4    Orkin, S.H.5    Bruns, G.A.6
  • 5
    • 0028967215 scopus 로고
    • Repression of the retinoic acid receptoralpha gene by the Wilms' tumor suppressor gene product, wt1
    • Goodyer, P., Dehbi, M., Torban, E., Bruening, W., and Pelletier, J. (1995) Repression of the retinoic acid receptoralpha gene by the Wilms' tumor suppressor gene product, wt1. Oncogene 10, 1125-1129.
    • (1995) Oncogene , vol.10 , pp. 1125-1129
    • Goodyer, P.1    Dehbi, M.2    Torban, E.3    Bruening, W.4    Pelletier, J.5
  • 6
    • 0028844582 scopus 로고
    • Regulation of the protooncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1
    • Hewitt, S.M., Hamada, S., McDonnell, T.J., Rauscher, F.J., 3rd, and Saunders, G.F. (1995) Regulation of the protooncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res. 55, 5386-5389.
    • (1995) Cancer Res , vol.55 , pp. 5386-5389
    • Hewitt, S.M.1    Hamada, S.2    McDonnell, T.J.3    Rauscher 3rd, F.J.4    Saunders, G.F.5
  • 7
    • 0032981181 scopus 로고    scopus 로고
    • The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation
    • Kim, J., Prawitt, D., Bardeesy, N., Torban, E., Vicaner, C., Goodyer, P., Zabel, B., and Pelletier, J. (1999) The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation. Mol. Cell. Biol. 19, 2289-2299.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 2289-2299
    • Kim, J.1    Prawitt, D.2    Bardeesy, N.3    Torban, E.4    Vicaner, C.5    Goodyer, P.6    Zabel, B.7    Pelletier, J.8
  • 8
    • 0026751042 scopus 로고
    • Expression of the Wilms' tumor gene (WT1) in human leukemias
    • Miwa, H., Beran, M., and Saunders, G.F. (1992) Expression of the Wilms' tumor gene (WT1) in human leukemias. Leukemia 6, 405-409.
    • (1992) Leukemia , vol.6 , pp. 405-409
    • Miwa, H.1    Beran, M.2    Saunders, G.F.3
  • 9
    • 0027338058 scopus 로고
    • Expression of the candidate Wilm's tumor gene, WT1, in human leukemia cells
    • Miyagi, T., Ahuja, H., Kubota, T., Kubonishi, I., Koeffler, H.P., and Miyoshi, I. (1993) Expression of the candidate Wilm's tumor gene, WT1, in human leukemia cells. Leukemia 7, 970-977.
    • (1993) Leukemia , vol.7 , pp. 970-977
    • Miyagi, T.1    Ahuja, H.2    Kubota, T.3    Kubonishi, I.4    Koeffler, H.P.5    Miyoshi, I.6
  • 11
    • 0028606895 scopus 로고
    • The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells
    • Brieger, J., Weidmann, E., Fenchel, K., Mitrou, P.S., Hoelzer, D., and Bergmann, L. (1994) The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells. Leukemia 8, 2138-2143.
    • (1994) Leukemia , vol.8 , pp. 2138-2143
    • Brieger, J.1    Weidmann, E.2    Fenchel, K.3    Mitrou, P.S.4    Hoelzer, D.5    Bergmann, L.6
  • 12
    • 0029069227 scopus 로고
    • Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias
    • Menssen, H.D., Renkl, H.J., Rodeck, U., Maurer, J., Notter, M., Schwartz, S., Reinhardt, R., and Thiel, E. (1995) Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia 9, 1060-1067.
    • (1995) Leukemia , vol.9 , pp. 1060-1067
    • Menssen, H.D.1    Renkl, H.J.2    Rodeck, U.3    Maurer, J.4    Notter, M.5    Schwartz, S.6    Reinhardt, R.7    Thiel, E.8
  • 13
    • 0030737629 scopus 로고    scopus 로고
    • High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome
    • Bergmann, L., Miething, C., Maurer, U., Brieger, J., Karakas, T., Weidmann, E., and Hoelzer, D. (1997) High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome. Blood 90, 1217-1225.
    • (1997) Blood , vol.90 , pp. 1217-1225
    • Bergmann, L.1    Miething, C.2    Maurer, U.3    Brieger, J.4    Karakas, T.5    Weidmann, E.6    Hoelzer, D.7
  • 14
    • 0030997045 scopus 로고    scopus 로고
    • Detection by monoclonal antibodies of the Wilms' tumor (WT1) nuclear protein in patients with acute leukemia
    • Menssen, H.D., Renkl, H.J., Rodeck, U., Kari, C., Schwartz, S., and Thiel, E. (1997) Detection by monoclonal antibodies of the Wilms' tumor (WT1) nuclear protein in patients with acute leukemia. Int. J. Cancer 70, 518-523.
    • (1997) Int. J. Cancer , vol.70 , pp. 518-523
    • Menssen, H.D.1    Renkl, H.J.2    Rodeck, U.3    Kari, C.4    Schwartz, S.5    Thiel, E.6
  • 23
    • 13244292434 scopus 로고    scopus 로고
    • Expression of the Wilms' tumor gene product WT1 in glioblastomas and medulloblastomas
    • Nakahara, Y., Okamoto, H., Mineta, T., and Tabuchi, K. (2004) Expression of the Wilms' tumor gene product WT1 in glioblastomas and medulloblastomas. Brain Tumor Pathol. 21, 113-116.
    • (2004) Brain Tumor Pathol , vol.21 , pp. 113-116
    • Nakahara, Y.1    Okamoto, H.2    Mineta, T.3    Tabuchi, K.4
  • 26
    • 9244237089 scopus 로고    scopus 로고
    • Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: Implications for the involvement of WT1 in leukemogenesis
    • Yamagami, T., Sugiyama, H., Inoue, K., Ogawa, H., Tatekawa, T., Hirata, M., Kudoh, T., Akiyama, T., Murakami, A., and Maekawa, T. (1996) Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis. Blood 87, 2878-2884.
    • (1996) Blood , vol.87 , pp. 2878-2884
    • Yamagami, T.1    Sugiyama, H.2    Inoue, K.3    Ogawa, H.4    Tatekawa, T.5    Hirata, M.6    Kudoh, T.7    Akiyama, T.8    Murakami, A.9    Maekawa, T.10
  • 28
    • 0032944068 scopus 로고    scopus 로고
    • Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF)
    • Tsuboi, A., Oka, Y., Ogawa, H., Elisseeva, O.A., Tamaki, H., Oji, Y., Kim, E.H., Soma, T., Tatekawa, T., Kawakami, M., Kishimoto, T., and Sugiyama, H. (1999) Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF). Leuk. Res. 23, 499-505.
    • (1999) Leuk. Res , vol.23 , pp. 499-505
    • Tsuboi, A.1    Oka, Y.2    Ogawa, H.3    Elisseeva, O.A.4    Tamaki, H.5    Oji, Y.6    Kim, E.H.7    Soma, T.8    Tatekawa, T.9    Kawakami, M.10    Kishimoto, T.11    Sugiyama, H.12
  • 29
    • 0029310528 scopus 로고
    • T-cell immunotherapy of tumors by adoptive transfer of cytotoxic T lymphocytes and by vaccination with minimal essential epitopes
    • Melief, C.J. and Kast, W.M. (1995) T-cell immunotherapy of tumors by adoptive transfer of cytotoxic T lymphocytes and by vaccination with minimal essential epitopes. Immunol. Rev. 145, 167-177.
    • (1995) Immunol. Rev , vol.145 , pp. 167-177
    • Melief, C.J.1    Kast, W.M.2
  • 30
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumour immunology and immunotherapy
    • Rosenberg, S.A. (2001) Progress in human tumour immunology and immunotherapy. Nature 411, 380-384.
    • (2001) Nature , vol.411 , pp. 380-384
    • Rosenberg, S.A.1
  • 31
    • 0028040178 scopus 로고
    • Tumor immunity: Will new keys unlock the door?
    • Ritz, J. (1994) Tumor immunity: will new keys unlock the door? J. Clin. Oncol. 12, 237-238.
    • (1994) J. Clin. Oncol , vol.12 , pp. 237-238
    • Ritz, J.1
  • 35
    • 0012727860 scopus 로고    scopus 로고
    • Cancer immunotherapy targeting WT1 protein
    • Sugiyama, H. (2002) Cancer immunotherapy targeting WT1 protein. Int. J. Hematol. 76, 127-132.
    • (2002) Int. J. Hematol , vol.76 , pp. 127-132
    • Sugiyama, H.1
  • 36
    • 0034176750 scopus 로고    scopus 로고
    • Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1
    • Gao, L., Bellantuono, I., Elsasser, A., Marley, S.B., Gordon, M.Y., Goldman, J.M., and Stauss, H.J. (2000) Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood 95, 2198-2203.
    • (2000) Blood , vol.95 , pp. 2198-2203
    • Gao, L.1    Bellantuono, I.2    Elsasser, A.3    Marley, S.B.4    Gordon, M.Y.5    Goldman, J.M.6    Stauss, H.J.7
  • 37
    • 0033966369 scopus 로고    scopus 로고
    • HLA class I-restricted lysis of leukemia cells by a CD8(+) cytotoxic T-lymphocyte clone specific for WT1 peptide
    • Ohminami, H., Yasukawa, M., and Fujita, S. (2000) HLA class I-restricted lysis of leukemia cells by a CD8(+) cytotoxic T-lymphocyte clone specific for WT1 peptide. Blood 95, 286-293.
    • (2000) Blood , vol.95 , pp. 286-293
    • Ohminami, H.1    Yasukawa, M.2    Fujita, S.3
  • 39
    • 0037111734 scopus 로고    scopus 로고
    • Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL
    • Bellantuono, I., Gao, L., Parry, S., Marley, S., Dazzi, F., Apperley, J., Goldman, J.M., and Stauss, H.J. (2002) Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL. Blood 100, 3835-3837.
    • (2002) Blood , vol.100 , pp. 3835-3837
    • Bellantuono, I.1    Gao, L.2    Parry, S.3    Marley, S.4    Dazzi, F.5    Apperley, J.6    Goldman, J.M.7    Stauss, H.J.8
  • 41
    • 0036177505 scopus 로고    scopus 로고
    • Identification of a novel WT1-derived peptide which induces human leucocyte antigen-A24-restricted anti-leukaemia cytotoxic T lymphocytes
    • Azuma, T., Makita, M., Ninomiya, K., Fujita, S., Harada, M., and Yasukawa, M. (2002) Identification of a novel WT1-derived peptide which induces human leucocyte antigen-A24-restricted anti-leukaemia cytotoxic T lymphocytes. Br. J. Haematol. 116, 601-603.
    • (2002) Br. J. Haematol , vol.116 , pp. 601-603
    • Azuma, T.1    Makita, M.2    Ninomiya, K.3    Fujita, S.4    Harada, M.5    Yasukawa, M.6
  • 42
    • 2942561957 scopus 로고    scopus 로고
    • Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen
    • Savage, P., Gao, L., Vento, K., Cowburn, P., Man, S., Steven, N., Ogg, G., McMichael, A., Epenetos, A., Goulmy, E., and Stauss, H.J. (2004) Use of B cell-bound HLA-A2 class I monomers to generate high-avidity, allo-restricted CTLs against the leukemia-associated protein Wilms tumor antigen. Blood 103, 4613-4615.
    • (2004) Blood , vol.103 , pp. 4613-4615
    • Savage, P.1    Gao, L.2    Vento, K.3    Cowburn, P.4    Man, S.5    Steven, N.6    Ogg, G.7    McMichael, A.8    Epenetos, A.9    Goulmy, E.10    Stauss, H.J.11
  • 44
    • 43949158638 scopus 로고
    • Can antitumor immune responses discriminate between self and nonself?
    • Moudgil, K. and Sercarz, E. (1994) Can antitumor immune responses discriminate between self and nonself? Immunol. Today 15, 353-355.
    • (1994) Immunol. Today , vol.15 , pp. 353-355
    • Moudgil, K.1    Sercarz, E.2
  • 45
    • 0026591185 scopus 로고
    • How cytotoxic T cells manage to discriminate nonself from self at the nonapeptide level
    • Ohno, S. (1992) How cytotoxic T cells manage to discriminate nonself from self at the nonapeptide level. Proc. Natl. Acad. Sci. U. S. A. 89, 4643-4647.
    • (1992) Proc. Natl. Acad. Sci. U. S. A , vol.89 , pp. 4643-4647
    • Ohno, S.1
  • 47
    • 8444248183 scopus 로고    scopus 로고
    • In vitro stimulation with WT1 peptide-loaded Epstein-Barr virus-positive B cells elicits high frequencies of WT1 peptidespecific T cells with in vitro and in vivo tumoricidal activity
    • Doubrovina, E.S., Doubrovin, M.M., Lee, S., Shieh, J.H., Heller, G., Pamer, E., and O'Reilly, R.J. (2004) In vitro stimulation with WT1 peptide-loaded Epstein-Barr virus-positive B cells elicits high frequencies of WT1 peptidespecific T cells with in vitro and in vivo tumoricidal activity. Clin. Cancer Res. 10, 7207-7219.
    • (2004) Clin. Cancer Res , vol.10 , pp. 7207-7219
    • Doubrovina, E.S.1    Doubrovin, M.M.2    Lee, S.3    Shieh, J.H.4    Heller, G.5    Pamer, E.6    O'Reilly, R.J.7
  • 48
    • 0037572276 scopus 로고    scopus 로고
    • Human cytotoxic T lymphocytes specific for Wilms' tumor antigen-1 inhibit engraftment of leukemia-initiating stem cells in non-obese diabetic-severe combined immunodeficient recipients
    • Gao, L., Xue, S.A., Hasserjian, R., Cotter, F., Kaeda, J., Goldman, J.M., Dazzi, F., and Stauss, H.J. (2003) Human cytotoxic T lymphocytes specific for Wilms' tumor antigen-1 inhibit engraftment of leukemia-initiating stem cells in non-obese diabetic-severe combined immunodeficient recipients. Transplantation 75, 1429-1436.
    • (2003) Transplantation , vol.75 , pp. 1429-1436
    • Gao, L.1    Xue, S.A.2    Hasserjian, R.3    Cotter, F.4    Kaeda, J.5    Goldman, J.M.6    Dazzi, F.7    Stauss, H.J.8
  • 50
    • 0034663331 scopus 로고    scopus 로고
    • Immunity to WT1 in the animal model and in patients with acute myeloid leukemia
    • Gaiger, A., Reese, V., Disis, M.L., and Cheever, M.A. (2000) Immunity to WT1 in the animal model and in patients with acute myeloid leukemia. Blood 96, 1480-1489.
    • (2000) Blood , vol.96 , pp. 1480-1489
    • Gaiger, A.1    Reese, V.2    Disis, M.L.3    Cheever, M.A.4
  • 54
    • 0037105370 scopus 로고    scopus 로고
    • CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia
    • Scheibenbogen, C., Letsch, A., Thiel, E., Schmittel, A., Mailaender, V., Baerwolf, S., Nagorsen, D., and Keilholz, U. (2002) CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia. Blood 100, 2132-2137.
    • (2002) Blood , vol.100 , pp. 2132-2137
    • Scheibenbogen, C.1    Letsch, A.2    Thiel, E.3    Schmittel, A.4    Mailaender, V.5    Baerwolf, S.6    Nagorsen, D.7    Keilholz, U.8
  • 55
    • 0141889279 scopus 로고    scopus 로고
    • Functional leukemia-associated antigenspecific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation
    • Rezvani, K., Grube, M., Brenchley, J.M., Sconochia, G., Fujiwara, H., Price, D., Gostick, E., Yamada, K., Melenhorst, J., Childs, R., Hensel, N., Douek, D.C., and Barret, A.J. (2003) Functional leukemia-associated antigenspecific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation. Blood 102, 2892-2900.
    • (2003) Blood , vol.102 , pp. 2892-2900
    • Rezvani, K.1    Grube, M.2    Brenchley, J.M.3    Sconochia, G.4    Fujiwara, H.5    Price, D.6    Gostick, E.7    Yamada, K.8    Melenhorst, J.9    Childs, R.10    Hensel, N.11    Douek, D.C.12    Barret, A.J.13
  • 56
    • 29344436442 scopus 로고    scopus 로고
    • T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: Identification, quantification, and characterization
    • Rezvani, K., Brenchley, J.M., Price, D.A., Kilical, Y., Gostick, E., Sewell, A.K., Li, J., Mielke, S., Douek, D.C., and Barrett, A.J. (2005) T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization. Clin. Cancer. Res. 11, 8799-8807.
    • (2005) Clin. Cancer. Res , vol.11 , pp. 8799-8807
    • Rezvani, K.1    Brenchley, J.M.2    Price, D.A.3    Kilical, Y.4    Gostick, E.5    Sewell, A.K.6    Li, J.7    Mielke, S.8    Douek, D.C.9    Barrett, A.J.10
  • 58
    • 4644289323 scopus 로고    scopus 로고
    • Oka, Y., Tsuboi, A., Taguchi, T., Osaki, T., Kyo, T., Nakajima, H., Elisseeva, O.A., Oji, Y., Kawakami, M., Ikegame, K., Hosen, N., Yoshihara, S., Wu, F., Fujiki, H., Murakami, M., Masuda, T., Nishida, S., Shirakata, T., Nakatsuka, S., Sasaki, A., Udaka, K., Dohy, H., Aozasa, K., Noguchi, S., Kawase, I., and Sugiyama, H. (2004) Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc. Natl. Acad. Sci. U. S. A. 101, 13885-13890.
    • Oka, Y., Tsuboi, A., Taguchi, T., Osaki, T., Kyo, T., Nakajima, H., Elisseeva, O.A., Oji, Y., Kawakami, M., Ikegame, K., Hosen, N., Yoshihara, S., Wu, F., Fujiki, H., Murakami, M., Masuda, T., Nishida, S., Shirakata, T., Nakatsuka, S., Sasaki, A., Udaka, K., Dohy, H., Aozasa, K., Noguchi, S., Kawase, I., and Sugiyama, H. (2004) Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc. Natl. Acad. Sci. U. S. A. 101, 13885-13890.
  • 61
    • 0018758172 scopus 로고
    • Adjuvant immunotherapy of lung cancer with BCG cell wall skeleton (BCG-CWS)
    • Yamamura, Y., Sakatani, M., Ogura, T., and Azuma, I. (1979) Adjuvant immunotherapy of lung cancer with BCG cell wall skeleton (BCG-CWS). Cancer 43, 1314-1319.
    • (1979) Cancer , vol.43 , pp. 1314-1319
    • Yamamura, Y.1    Sakatani, M.2    Ogura, T.3    Azuma, I.4
  • 62
    • 0020526158 scopus 로고
    • Postoperative adjuvant immunotherapy of gastric cancer with BCG-cell wall skeleton. 3- to 6-year follow up of a randomized clinical trial
    • Ochiai, T., Sato, H., Hayashi, R., Asano, T., Sato, H., and Yamamura, Y. (1983) Postoperative adjuvant immunotherapy of gastric cancer with BCG-cell wall skeleton. 3- to 6-year follow up of a randomized clinical trial. Cancer Immunol. Immunother. 14, 167-171.
    • (1983) Cancer Immunol. Immunother , vol.14 , pp. 167-171
    • Ochiai, T.1    Sato, H.2    Hayashi, R.3    Asano, T.4    Sato, H.5    Yamamura, Y.6
  • 63
    • 0030160412 scopus 로고    scopus 로고
    • Does the cell wall skeleton from Bacille Calmette-Guerin directly induce interferongamma, independent of interleukin-12?
    • Hayashi, A. and Noda, A. (1996) Does the cell wall skeleton from Bacille Calmette-Guerin directly induce interferongamma, independent of interleukin-12? Jpn. J. Clin. Oncol. 26, 124-127.
    • (1996) Jpn. J. Clin. Oncol , vol.26 , pp. 124-127
    • Hayashi, A.1    Noda, A.2
  • 66
    • 0032724112 scopus 로고    scopus 로고
    • Phase I trial of a MART-1 peptide vaccine with incomplete Freund's adjuvant for resected high-risk melanoma
    • Wang, F., Bade, E., Kuniyoshi, C., Spears, L., Jeffery, G., Marty, V., Groshen, S., and Weber, J. (1999) Phase I trial of a MART-1 peptide vaccine with incomplete Freund's adjuvant for resected high-risk melanoma. Clin. Cancer Res. 5, 2756-2765.
    • (1999) Clin. Cancer Res , vol.5 , pp. 2756-2765
    • Wang, F.1    Bade, E.2    Kuniyoshi, C.3    Spears, L.4    Jeffery, G.5    Marty, V.6    Groshen, S.7    Weber, J.8
  • 68
    • 0034665776 scopus 로고    scopus 로고
    • Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: Evidence for involvement at the hematopoietic stem cell level
    • Nilsson, L., Astrand-Grundstrom, I., Arvidsson, I., Jacobsson, B., Hellstrom-Lindberg, E., Hast, R., and Jacobsen, S.E. (2000) Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level. Blood 96, 2012-2021.
    • (2000) Blood , vol.96 , pp. 2012-2021
    • Nilsson, L.1    Astrand-Grundstrom, I.2    Arvidsson, I.3    Jacobsson, B.4    Hellstrom-Lindberg, E.5    Hast, R.6    Jacobsen, S.E.7
  • 69
    • 0742324477 scopus 로고    scopus 로고
    • Complete remission in a patient with recurrent acute myeloid leukemia induced by vaccination with WT1 peptide in the absence of hematological or renal toxicity
    • Mailaender, V., Scheibenbogen, C., Thiel, E., Letsch, A., Blau, I. W., and Keilholz, U. (2004) Complete remission in a patient with recurrent acute myeloid leukemia induced by vaccination with WT1 peptide in the absence of hematological or renal toxicity. Leukemia 18, 165-166.
    • (2004) Leukemia , vol.18 , pp. 165-166
    • Mailaender, V.1    Scheibenbogen, C.2    Thiel, E.3    Letsch, A.4    Blau, I.W.5    Keilholz, U.6
  • 72
    • 8444224189 scopus 로고    scopus 로고
    • Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes
    • Azuma, T., Otsuki, T., Kuzushima, K., Froelich, C.J., Fujita, S., and Yasukawa, M. (2004) Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes. Clin. Cancer Res. 10, 7402-7412.
    • (2004) Clin. Cancer Res , vol.10 , pp. 7402-7412
    • Azuma, T.1    Otsuki, T.2    Kuzushima, K.3    Froelich, C.J.4    Fujita, S.5    Yasukawa, M.6
  • 73
    • 0036322632 scopus 로고    scopus 로고
    • Prediction of an HLA-DR-binding peptide derived from Wilms' tumour 1 protein and demonstration of in vitro immunogenicity of WT1(124-138)-pulsed dendritic cells generated according to an optimised protocol
    • Knights, A.J., Zaniou, A., Rees, R.C., Pawelec, G., and Muller, L. (2002) Prediction of an HLA-DR-binding peptide derived from Wilms' tumour 1 protein and demonstration of in vitro immunogenicity of WT1(124-138)-pulsed dendritic cells generated according to an optimised protocol. Cancer Immunol. Immunother. 51, 271-281.
    • (2002) Cancer Immunol. Immunother , vol.51 , pp. 271-281
    • Knights, A.J.1    Zaniou, A.2    Rees, R.C.3    Pawelec, G.4    Muller, L.5
  • 74
    • 15244341442 scopus 로고    scopus 로고
    • Synthetic peptides derived from the Wilms' tumor 1 protein sensitize human T lymphocytes to recognize chronic myelogenous leukemia cells
    • Muller, L., Knights, A., and Pawelec, G. (2003) Synthetic peptides derived from the Wilms' tumor 1 protein sensitize human T lymphocytes to recognize chronic myelogenous leukemia cells. Hematol J. 4, 57-66.
    • (2003) Hematol J , vol.4 , pp. 57-66
    • Muller, L.1    Knights, A.2    Pawelec, G.3
  • 76
    • 34247174293 scopus 로고    scopus 로고
    • Fujiki, F., Oka, Y., Tsuboi, A., Kawakami, M., Kawakatsu, M., Nakajima, H., Elisseeva, O.A., Harada, Y., Ito, K., Li, Z., Tatsumi, N., Sakaguchi, N., Fujioka, T., Masuda, T., Yasukawa, M., Udaka, K., Kawase, I., Oji, Y., and Sugiyama, H. (2007) Identification and characterization of a WT1 (Wilms tumor hene) protein-derived HLADRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes. J. Immunother. 30(3), 282-293.
    • Fujiki, F., Oka, Y., Tsuboi, A., Kawakami, M., Kawakatsu, M., Nakajima, H., Elisseeva, O.A., Harada, Y., Ito, K., Li, Z., Tatsumi, N., Sakaguchi, N., Fujioka, T., Masuda, T., Yasukawa, M., Udaka, K., Kawase, I., Oji, Y., and Sugiyama, H. (2007) Identification and characterization of a WT1 (Wilms tumor hene) protein-derived HLADRB1*0405-restricted 16-mer helper peptide that promotes the induction and activation of WT1-specific cytotoxic T lymphocytes. J. Immunother. 30(3), 282-293.
  • 77
    • 1142275255 scopus 로고    scopus 로고
    • Phase I trial of patient-oriented vaccination in HLA-A2-positive patients with metastatic hormone-refractory prostate cancer
    • Noguchi, M., Itoh, K., Suekane, S., Yao, A., Suetsugu, N., Katagiri, K., Yamada, A., Yamana, H., and Noda, S. (2004) Phase I trial of patient-oriented vaccination in HLA-A2-positive patients with metastatic hormone-refractory prostate cancer. Cancer Sci. 95, 77-84.
    • (2004) Cancer Sci , vol.95 , pp. 77-84
    • Noguchi, M.1    Itoh, K.2    Suekane, S.3    Yao, A.4    Suetsugu, N.5    Katagiri, K.6    Yamada, A.7    Yamana, H.8    Noda, S.9
  • 78
    • 13844312036 scopus 로고    scopus 로고
    • Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: A multicentre observational trial
    • Bocchia, M., Gentili, S., Abruzzese, E., Fanelli, A., Iiuliano, F., Tabilio, A., Amabile, M., Forconi, F., Gozzetti, A., Raspadori, D., Amadori, S., and Lauria, F. (2005) Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial. Lancet 365, 657-662.
    • (2005) Lancet , vol.365 , pp. 657-662
    • Bocchia, M.1    Gentili, S.2    Abruzzese, E.3    Fanelli, A.4    Iiuliano, F.5    Tabilio, A.6    Amabile, M.7    Forconi, F.8    Gozzetti, A.9    Raspadori, D.10    Amadori, S.11    Lauria, F.12
  • 80
    • 29444433283 scopus 로고    scopus 로고
    • Combining cancer vaccines with chemotherapy
    • Chong, G. and Mors, M.A. (2005) Combining cancer vaccines with chemotherapy. Expert Opin. Pharmacother. 6, 2813-2820.
    • (2005) Expert Opin. Pharmacother , vol.6 , pp. 2813-2820
    • Chong, G.1    Mors, M.A.2
  • 81
    • 25144466458 scopus 로고    scopus 로고
    • Gemcitabine selectively eliminates slpenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • Suzuki, K., Kapoor, V., Jassar, A.S., Kaiser, L.R., and Albelda, S.M. (2005) Gemcitabine selectively eliminates slpenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin. Cancer Res. 11, 6713-6721.
    • (2005) Clin. Cancer Res , vol.11 , pp. 6713-6721
    • Suzuki, K.1    Kapoor, V.2    Jassar, A.S.3    Kaiser, L.R.4    Albelda, S.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.