Cancer immunotherapy targeting WT1 protein

International Journal of Hematology

Volumn 76, Issue 2, 2002, Pages 127-132

  Sugiyama, Haruo ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Cancer immunotherapy; CTL; Wilms tumor gene; WT1

Indexed keywords

WT1 PROTEIN; TUMOR ANTIGEN;

ARTICLE; CANCER IMMUNOTHERAPY; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMORAL IMMUNITY; LEUKEMIA CELL; MONONUCLEAR CELL; MYELODYSPLASTIC SYNDROME; MYELOID LEUKEMIA; NONHUMAN; ANIMAL; ANTIBODY PRODUCTION; IMMUNOLOGY; IMMUNOTHERAPY; METHODOLOGY; NEOPLASM; REVIEW;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, NEOPLASM; HUMANS; IMMUNOTHERAPY; NEOPLASMS; T-LYMPHOCYTES, CYTOTOXIC; WT1 PROTEINS;

EID: 0012727860     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02982574     Document Type: Article

References (64)

1. Call KM, Glaser T, Ito CY, et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms tumor locus. Cell. 1990;60:509-520.
2. Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GAP. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature. 1990;343:774-778.
3. Gashler AL, Bonthron DT, Madden SL, Rauscher FJI, Collins T, Sukhatme VP. Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1. Proc Natl Acad Sci U S A. 1992;89:10984-10988.
4. Harrington MA, Konicek B, Song A, Xia X-L, Fredericks WJ, Rauscher FJI. Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms tumor locus. J Biol Chem. 1993;268:21271-21275.
5. Drummond IA, Madden SL, Rohwer-Nutter P, Bell GI, Sukhatme VP, Rauscher FJI. Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1. Science. 1992;257: 674-678.
6. Werner H, Re GG, Drummond IA, et al. Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product. Proc Natl Acad Sci U S A. 1993;9:5828-5832.
7. Englert C, Hou X, Maheswaran S, et al. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J. 1995;14:4662-4675.
8. Godyer P, Dehbi M, Torban E, Bruening W, Pelletier J. Repression of the retinoic acid receptor-α gene by the Wilms tumor suppressor gene product, wt1. Oncogene. 1995;10:1125-1129.
9. McCann S, Sullivan J, Guerra J, Arcinas M, Boxer LM. Repression of the c-myb gene by WT1 protein in T and B cell lines. J Biol Chem. 1995;270:23785-23789.
10. Hewitt SM, Hamada S, McDonnel TJ, Rauscher FJI, Saunders GF. Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms tumor suppressor gene WT1. Cancer Res. 1995;55:5386-5389.
11. Li RS, Law GL, Seifert RA, Romaniuk PJ, Morris DR. Ornithine decarboxylase is a transcriptional target of tumor suppressor WT1. Exp Cell Res. 1999;247:257-266.
12. Zhang X, Xing G, Saunders GF. Proto-oncogene N-myc promoter is down regulated by the Wilms' tumor suppressor gene WT1. Anti-Cancer Res. 1999;19:1641-1648.
13. Guan LS, Rauchman M, Wang ZY. Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition. J Biol Chem. 1998;273:27047-27050.
14. Kim J, Prawitt D, Bardeesy N, et al. The Wilms' tumor suppressor gene (WT1) product regulates Dax-1 gene expression during gonadal differentiation. Mol Cell Biol. 1999;19:2289-2299.
15. Mayo MW, Wang CY, Drouin SS, et al. WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene. EMBO J. 1999;18:3990-4003.
16. Buckler AJ, Pelletier J, Haber DA, Glaser T, Housman DE. Isolation, characterization, and expression of the murine Wilms tumor gene (WT1) during kidney development. Mol Cell Biol. 1991;11: 1707-1712.
17. Park S, Schalling M, Bernard A, et al. The Wilms tumor gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma. Nature Genet. 1993;4:415-420.
18. Davies R, Moore A, Schedl A, et al. Multiple roles for the Wilms' tumor suppressor, WT1. Cancer Res. 1999;59(suppl 7):1747s-1750s [discussion, 1751s].
19. Moore AW, McInnes L, Kreidberg J, Hastie ND, Schedl A. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development. 1999;126:1845-1857.
20. Miwa H, Beran M, Aunders GF. Expression of the Wilms tumor gene (WT1) in human leukemias. Leukemia. 1992;6:405-409.
21. Miyagi T, Ahuja H, Kubota T, Kubonishi I, Koeffler HP, Miyoshi I. Expression of the candidate Wilms tumor gene, WT1, in human leukemia cells. Leukemia. 1993;7:970-977.
22. Inoue K, Sugiyama H, Ogawa H, et al. WT1 as new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood. 1994;84:3071-3079.
23. Bergmann L, Miething C, Maurer U, et al. High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome. Blood. 1997;90:1217-1225.
24. Brieger J, Weidmann E, Fenchel K, Mitrou PS, Hoelzer D, Bergmann L. The expression of the Wilms tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells. Leukemia. 1994;8:2138-2143.
25. Menssen HD, Renkl H-J, Rodeck U, et al. Presence of Wilms tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia. 1995;9:1060-1067.
26. Menssen HD, Renkl HJ, Rodeck U, Kari C, Schwartz S, Thiel E. Detection by monoclonal antibodies of the Wilms' tumor (WT1) nuclear protein in patients with acute leukemia. Int J Cancer. 1997; 70:518-523.
27. Tamaki H, Ogawa H, Ohyashiki K, et al. The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes. Leukemia. 1999;13:393-399.
28. Shichishima T, Okamoto M, Ikeda K, et al. HLA class II haplotype and quantitation of the WT1 gene in Japanese patients with paroxysmal nocturnal hemoglobinuria (PNH). Blood. In press.
29. Bruening W, Gros P, Sato T, et al. Analysis of the 11p13 Wilms' tumor suppressor gene (WT1) in ovarian tumors. Cancer Invest. 1993;11:393-399.
30. Viel A, Giannini F, Capozzi E, et al. Molecular mechanisms possibly affecting WT1 function in human ovarian tumors. Int J Cancer. 1994;57:515-521.
31. Campbell CE, Kuriyan NP, Rackley RR, et al. Constitutive expression of the Wilms' tumor suppressor gene (WT1) in renal cell carcinoma. Int J Cancer. 1998;78:182-188.
32. Walker C, Rutten F, Yuan X, Pass H, Mew DM, Everitt J. Wilms' tumor suppressor gene expression in rat and human mesothelioma. Cancer Res. 1994;54:3101-3106.
33. Amin KM, Litzky LA, Smythe WR, et al. Wilms' tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma Am J Pathol. 1995;146:344-356.
34. Langerak AW, Williamson KA, Miyagawa K, Hagemeijer A, Versnel MA, Hastie ND. Expression of the Wilms' tumor gene WT1 in human malignant mesothelioma cell lines and relationship to platelet-derived growth factor A and insulin-like growth factor 2 expression. Genes Chromosomes Cancer. 1995;12:87-96.
35. Rodeck U, Bossier A, Kari C, et al. Expression of the wt1 Wilms' tumor gene by normal and malignant human melanocytes. Int J Cancer. 1994;59:78-82.
36. Ladanyi M, Gerald W. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res. 1994;54: 2837-2840.
37. Silberstein GB, Van Horn K, Strickland P, Roberts CTJ, Daniel CW. Altered expression of the WT1 wilms tumor suppressor gene in human breast cancer. Proc Natl Acad Sci U S A. 1997;94:8132-8137.
38. Loeb DM, Evron E, Patel CB, et al. Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation. Cancer Res. 2001;61:921-925.
39. Miyoshi Y, Ando A, Egawa C, et al. High expression of Wilms' tumor suppressor gene predicts poor prognosis in breast cancer patients. Clin Cancer Res. 2002;8:1167-1171.
40. Oji Y, Ogawa H, Tamaki H, et al. Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growth. Jpn J Cancer Res. 1999;90:194-204.
41. Menssen HD, Bertelmann E, Bartelt S, et al. Wilms' tumor gene (WT1) expression in lung cancer, colon cancer and glioblastoma cell lines compared to freshly isolated tumor specimens. J Cancer Res Clin Oncol. 2000;126:226-332.
42. Oji Y, Miyoshi, S, Maeda H, et al. Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers. Int J Cancer. In press.
43. Coppes MJ, Campbell CE, Williams BRG. The role of WT1 in Wilms tumorigenesis. FASEB J. 1993;7:886-895.
44. Rauscher FJI. The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. FASEB J. 1993;7:896-903.
45. Haber DA, Park S, Maheswaran S, et al. WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant. Science. 1993;262:2057-2059.
46. Algar EM, Kenney MT, Simms LA, Smith SI, Kida Y, Smith PJ. Homozygous intragenic deletion in the WT1 gene in a sporadic Wilms' tumour associated with high levels of expression of a truncated transcript. Hum Mutat. 1995;5:221-227.
47. Little M, Wells C. A clinical overview of WT1 gene mutations. Hum Mutat. 1997;9:209-225.
48. Sugiyama H. Wilms' tumor gene WT1: its oncogenic function and clinical application. Int J Hematol. 2001;73:177-187.
49. Inoue K, Ogawa H, Sonoda Y, et al. Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia. Blood. 1997;89: 1405-1412.
50. Yamagami T, Sugiyama H, Inoue K, et al. Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis. Blood. 1996;87:2878-2884.
51. Inoue K, Tamaki H, Ogawa H, et al. Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells. Blood. 1998;91:2969-2976.
52. Tsuboi A, Oka Y, Ogawa H, et al. Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF). Leuk Res. 1999;23: 499-505.
53. Osaka M, Koami K, Sugiyama T. WT1 contributes to leukemogenesis: expression patterns in 7, 12-dimthylbenz[a]anthracence (DMBA)-induced leukemia. Int J Cancer. 1997;72:696-699.
54. Oka Y, Tsuboi A, Elisseeva OA, Udaka K, Sugiyama H. WT1 as a novel target antigen for cancer immunotherapy. Curr Cancer Drug Targets. 2001;2:45-54.
55. Oka Y, Udaka K, Tsuboi A, et al. Cancer immunotherapy targeting Wilms tumor gene WT1 product. J Immunol. 2000;164: 1873-1880.
56. Tsuboi A, Oka Y, Ogawa H, et al. Cytotoxic T-lymphocyte responses elicited to Wilms' tumor gene WT1 product by DNA vaccination. J Clin Immunol. 2000;20:195-202.
57. Gaiger A, Reese V, Disis ML, Cheever MA. Immunity to WT1 in the animal model and in patients with acute myeloid leukemia. Blood. 2000;96:1480-1489.
58. Oka Y, Elisseeva OA, Tsuboi A, et al. Human cytotoxic T lymphocyte responses specific for peptides of wild-type Wilms tumor gene WT1 product. Immunogenetics. 2000;51:99-107.
59. Gao L, Bellantuono I, Elsasser A, et al. Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood. 2000;95:2198-2203.
60. Yasukawa M. Immunotherapy for leukemia targeting the Wilms' tumor gene. Leuk Lymph. 2001;42:267-273.
61. Ohminami H, Yasukawa M, Fujita S. HLA class I-restricted lysis of leukemia cells by a CD8+ cytotoxic T-lymphocyte clone specific for WT1 peptide. Blood. 2000;95:286-293.
62. Azuma T, Makita M, Ninomiya K, Fujita S, Harada M, Yasukawa M. Identification of a novel WT1-derived peptide which induces human leucocyte antigen-A24-restricted anti-leukaemia cytotoxic T lymphocytes. Br J Haematol. 2002;116:601-603.
63. Elisseeva OA, Oka Y, Tsuboi A, et al. Humoral immune responses against Wilms' tumor gene WT1 product in patients with hematopoietic malignancies. Blood. 2002;99:3272-3279.
64. Gaiger A, Carter L, Greinix H, et al. WT1-specific serum antibodies in patients with leukemia. Clin Cancer Res. 2001;7:761s-765s.