Expression of the Wilms' tumor gene product WT1 in glioblastomas and medulloblastomas

Brain Tumor Pathology

Volumn 21, Issue 3, 2004, Pages 113-116

  Nakahara, Yukiko ^a   Okamoto, Hiroaki ^a   Mineta, Toshihiro ^a   Tabuchi, Kazuo ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

Glioblastoma; Medulloblastoma; WT1

Indexed keywords

GENE PRODUCT; MESSENGER RNA; TRANSCRIPTION FACTOR; WT1 PROTEIN; ZINC FINGER PROTEIN;

ARTICLE; CANCER IMMUNOTHERAPY; CHILDHOOD CANCER; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; GLIOBLASTOMA; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY TUMOR; MAJOR CLINICAL STUDY; MEDULLOBLASTOMA; NEPHROBLASTOMA; SOLID TUMOR; STAINING; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

CEREBELLAR NEOPLASMS; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MEDULLOBLASTOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL; WT1 PROTEINS;

EID: 13244292434     PISSN: 14337398     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02482185     Document Type: Article

References (25)

1. Call KM, Glaser T, Ito CY, et al (1990) Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60:509-520
2. Gessler M, Poustka A, Cavenee W, et al (1990) Homozygous deletion in Wilms' tumours of a zinc-finger gene identified by chromosome jumping. Nature 343:774-778
3. Haber DA, Englert C, Maheswaran S (1996) Functional properties of WT1. Med Pediatr Oncol 27:453-455
4. Hewitt SM, Hamada S, McDonnell TJ, et al (1995) Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 55:5386-5389
5. Menke AL, Schedl A (2003) WT1 and glomerular function. Semin Cell Dev Biol 14:233-240
6. Inoue K, Ogawa H, Sonoda Y, et al (1997) Aberrant overexpression of the Wilms tumor gene (WT1) in human leukemia. Blood 89:1405-1412
7. Silberstein GB, Van Horn K, Strickland P, et al (1997) Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer. Proc Natl Acad Sci U S A 94:8132-8137
8. Park S, Schalling M, Bernard A, et al (1993) The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma. Nat Genet 4:415-420
9. Campbell CE, Kuriyan NP, Rackley RR, et al (1998) Constitutive expression of the Wilms tumor suppressor gene (WT1) in renal cell carcinoma. Int J Cancer 78:182-188
10. Yamagami T, Sugiyama H, Inoue K, et al (1996) Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis. Blood 87:2878-2884
11. Sugiyama H (2002) Cancer immunotherapy targeting WT1 protein. Int J Hematol 76:127-132
12. Kleihues P, Cavenee WK (2000) Pathology and genetics of tumours of the nervous system. IARC, Lyon
13. Haber DA, Sohn RL, Buckler AJ, et al (1991) Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc Natl Acad Sci U S A 88:9618-9622
14. Oji Y, Ogawa H, Tamaki H, et al (1999) Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growth. Jpn J Cancer Res 90:194-204
15. Loeb DM, Sukumar S (2002) The role of WT1 in oncogenesis: tumor suppressor or oncogene? Int J Hematol 76:117-126
16. Loeb DM, Korz D, Katsnelson M, et al (2002) Cyclin E is a target of WT1 transcriptional repression. J Biol Chem 277:19627-19632
17. Liu XW, Gong LJ, Guo LY, et al (2001) The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells. J Biol Chem 276:5068-5073
18. Ellisen L (2002) Regulation of gene expression by WT1 in development and tumorigenesis. Int J Hematol 76:110-116
19. Oji Y, Yamamoto H, Nomura M, et al (2003) Overexpression of the Wilms' tumor gene WT1 in colorectal adenocarcinoma. Cancer Sci 94:712-717
20. Niksic M, Slight J, Sanford JR et al (2004) The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysemes. Hum Mol Genet 13:463-471
21. Gaiger A, Reese V, Disis ML, et al (2000) Immunity to WT1 in the animal model and in patients with acute myeloid leukemia. Blood 96:1480-1489
22. Oka Y, Udaka K, Tsuboi A, et al (2000) Cancer immunotherapy targeting Wilms' tumor gene WT1 product. J Immunol 164:1873-1880
23. Elisseeva OA, Oka Y, Tsuboi A, et al (2002) Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies. Blood 99:3272-3279
24. Ohminami H, Yasukawa M, Fujita S (2000) HLA class I-restricted lysis of leukemia cells by a CD8( + ) cytotoxic T-lymphocyte clone specific for WT1 peptide. Blood 95:286-293
25. Tsuboi A, Oka Y, Osaki T, et al (2004) WT1 peptide-based immunotherapy for patients with lung cancer: report of two cases. Microbiol Immunol 48:175-184