Detection by monoclonal antibodies of the Wilms' tumor (WT1) nuclear protein in patients with acute leukemia

International Journal of Cancer

Volumn 70, Issue 5, 1997, Pages 518-523

  Menssen, Hans D ^a   Renkl, Hans J ^a   Rodeck, Ulrich ^b   Kari, Chaba ^b   Schwartz, Stefan ^a   Thiel, Eckhard ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; NUCLEAR PROTEIN; ONCOPROTEIN; UNCLASSIFIED DRUG; WILMS TUMOR PROTEIN;

ACUTE LEUKEMIA; ADULT; ANTIGEN EXPRESSION; ARTICLE; GENE EXPRESSION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; DNA-BINDING PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L2; LEUKEMIA, MYELOCYTIC, ACUTE; NEOPLASM PROTEINS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; WT1 PROTEINS;

EID: 0030997045     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970304)70:5<518::AID-IJC5>3.0.CO;2-0     Document Type: Article

References (24)

1. ARMSTRONG, J.F., PRITCHARD-JONES. K., BICKMORE, W.A., HASTIE, N.D. and BARD, J.B., The expression of the Wilms' tumor gene, WT1, in the developing mammalian embryo. Mechan. Develop., 40, 85-97 (1993).
2. BICKMORE, W.A., OGHENE, K., LITTEL., M., SEAWRIGHT, A., VAN HEININGEN, V. and HASTIE, N.D., Modulation of DNA binding specificity by alternative splicing of the Wilms' tumor WT1 gene transcript. Science. 257, 235-237 (1992).
3. BRIEGER, J., WEIDMANN, E., FENCHEL, K., MITROU, P.S., HOELZER, D. and BERGMANN, L., The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells. Leukemia, 8, 2138-2143 (1994).
4. BRIEGER, J., WEIDMANN. E., MAURER, U., HOELZER, D., MITROU, P.S. and BERGMANN, L., The Wilms' tumor gene is frequently expressed in acute myeloblastic leukemias and may provide a marker for residual blast cells detectable by PCR. Ann. Oncol., 6, 811-816 (1995).
5. CALL, K.M., GLASER, T., ITO, C.Y., BUCKLER, A.J., PELLETIER, J., HABER, D.A., ROSE, E.A., KRAL. A., YEGER, H., LEWIS, W.H., JONES. C. and HOUSMAN, D.E., Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell, 60, 509-520 (1990).
6. COPPES, M.J., CAMPBELL, C.E. and WILLIAMS, B.R.G., The role of WT1 in Wilms' tumorigenesis. FASEB J., 7, 886-895 (1993).
7. DRUMMOND, I.A., MADDEN, S.L., ROWHER-NUTTER, P., BELL, G.I., SUKHAMATE, V.P. and RAUSCHER, F.J. III, Repression of the insulin-like growth factor-II gene by the Wilms' tumor suppressor WT1. Science, 257, 674-678 (1992).
8. FRAIZER, G.C., PATMASIRIWAT, P., ZHANG, X. and SAUNDERS, G.F., Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow (Letter). Blood, 86, 4704-4706 (1995).
9. GESSLER, M., POUSTKA, A., CAVENEE, W., NEVE, R.L., ORKIN, S.H. and BRUNS, G.A.P., Homozygous deletions in Wilms' tumours of a zinc-finger gene identified by chromosome jumping. Nature (Lond.), 343, 774-778 (1990).
10. HABER, D.A., SOHN, R.L., BUCKLER, A.J., PELLETIER, J., CALL, K.M. and HOUSMAN, D.E., Alternative splicing and genomic structure of the Wilms' tumor gene WT1. Proc. nat. Acad. Sci. (Wash.), 88, 9618-9622 (1991).
11. HARRINGTON, M.A., KONICEK, B., SONG, A., XIA, X.L., FREDERICKS, W.J. and RAUSCHER, F.J. III, Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus. J. biol. Chem., 268, 21271-21275 (1993).
12. INOUE, K. and 15 OTHERS, WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood, 84, 3071-3079 (1994).
13. INOUE, K. and 13 OTHERS, Long-term follow-up of minimal residual disease in leukemia patients by monitoring WT1 (Wilms' tumor gene) expression levels. Blood, 88, 2267-2278 (1996).
14. 1 phase arrest induced by Wilms' tumor protein WT1 is abrogated by cyclin/CDK complexes. Proc. natl. Acad. Sci. (Wash.), 92, 4517-4521 (1995).
15. LARSSON, S.H., CHARLIEU, J.P., MIYAGAWA, K., ENGELKAMP, D., RASSOULZADEGAN, M., Ross, A., CUZI, F., VAN HEYNINGEN, V. and HASTIE, N.D., Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternate splicing. Cell, 81, 391-401 (1995).
16. MAHESWARAN, S., PARK. S., BERNARD, A., MORRIS, J.F., RAUSCHER, F.J. III, HILL, D.E. and HABER, D.A., Physical and functional interaction between WT1 and p53 proteins. Proc. natl. Acad. Sci. (Wash.), 90, 5100-5104 (1993).
17. MENSSEN, H.D., RENKL, H.J., RODECK, U., MAURER, J., NOTTER, M., SCHWARTZ, S., REINHARDT, R. and THIEL, E., Presence of Wilms' tumor gene (WT1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia. 9, 1060-1067 (1995).
18. MUNDLOS, S., PELLETIER, J., DARVEAU, A., BACHMANN, M., WINTERPACHT, A. and ZABEL, B., Nuclear localization of the protein encoded by the Wilms' tumor sene WT1 in embryonic and adult tissues. Development. 119, 1329-1341 (1993).
19. PATMASIRIWAT, P. FRAIZER, G.C., CLAXTON, D. and SAUNDERS, G.F., Expression pattern of WT1 and GATA-1 in AML with chromosome 16q22 abnormalities. Leukemia, 10, 1127-1133 (1996).
20. PRITCHARD-JONES, K., RENSHAW, J. and KING-UNDERWOOD, L., The Wilms' tumour (WT1) gene is mutated in a secondary leukemia in a WAGR patient. Hum. mol. Genet., 3, 1633-1637 (1994).
21. RODECK, U., HERLYN, M., HERLYN, D., MOLTHOFF, C., ATKINSON, B., VARELLO, M., STEPLEWSKI, Z. and KOPROWSKI, H., Tumor growth modulation by a monoclonal antibody to the epidermal growth factor receptor: immunologically mediated and effector cell independent effects. Cancer Res., 47, 3692-3696 (1987).
22. TELERMAN, A., DODEMONT, H., DEGRAEF, C., GALAND, P., BAUWENS, S., VAN OOSTVELDT, P. and AMSON, R.B., Identification of the cellular protein encoded by the human Wilms' tumor (WT1) gene. Oncogene, 7, 2545-2548 (1992).
23. -)-ceIl leukemia and its clinical significance within adult acute lymphoblastic leukemia. Blood, 73, 1247-1255 (1989).
24. WANG, Z.Y., Qiu, Q.Q. and DEUEL, T.F., The Wilms' tumor gene product WT1 activates or suppresses transcription through separate functional domains. J. biol. Chem., 268, 9172-9175 (1993).