Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: Implications for the involvement of WT1 in leukemogenesis

Blood

Volumn 87, Issue 7, 1996, Pages 2878-2884

  Yamagami, Tamotsu ^b   Sugiyama, Haruo ^a   Inoue, Kazushi ^b   Ogawa, Hiroyasu ^b   Tatekawa, Toyoshi ^b   Hirata, Moritoshi ^b   Kudoh, Tetsuhiro ^b   Akiyama, Tetsu ^b   Murakami, Akira ^b   Maekawa, Taira ^b   Kishimoto, Tadamitsu ^b  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; OLIGOMER; ONCOPROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BLAST CELL CRISIS; CELL GROWTH; CHRONIC MYELOID LEUKEMIA; COLONY FORMING UNIT GM; CONTROLLED STUDY; ERYTHROLEUKEMIA CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMOGENESIS; NEPHROBLASTOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 9244237089     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.7.2878.bloodjournal8772878     Document Type: Article

References (35)

1. Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH, Jones C, Housman DE: Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60:509, 1990
2. Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GAP: Homozygous deletion in Wilms tumours of a zing-finger gene identified by chromosome jumping. Nature 343:774, 1990
3. Haber DA, Buckler AJ, Glaser T, Call KM, Pelletier J, Sohn RL, Douglass EC, Housman DE: An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor. Cell 61:1257, 1990
4. Little MH, Prosser J, Condie A, Smith PJ, Van Heyningen V, Hastie ND: Zinc finger point mutations within the WT1 gene in Wilms tumor patients. Proc Natl Acad Sci USA 89:4791, 1992
5. Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE: Alternative splicing and genomic structure of the Wilms' tumor gene WT1. Proc Natl Acad Sci USA 88:9618, 1991
6. Madden SL, Cook DM, Morris JF, Gashler A, Sukhatme VP, Rauscher III FJ: Transcriptional repression mediated by the WT1 Wilms tumor gene product. Science 253:1550, 1991
7. Drummond IA, Madden SL, Rohwer-Nutter P, Bell GI, Sukhatme VP, Rauscher III FJ: Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1. Science 257:674, 1992
8. Pritchard-Jones K, Fleming S, Davidson D, Bickmore W, Porteus D, Gosden C, Bard J, Buckler A, Pelletier J, Housman DE, van Heyningen V, Hastie N: The candidate Wilms' tumor gene is involved in genitourinary development. Nature 346:194, 1990
9. Buckler AJ, Pelletier J, Haber DA, Glaser T, Housman DE: Isolation characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol Cell Biol 11:1707, 1991
10. Inoue K, Sugiyama H, Ogawa H, Nakagawa M, Yamagami T, Miwa H, Kita K, Hiraoka A, Masaoka T, Nasu K, Kyo T, Dohy H, Nakauchi H, Ishidate T, Akiyama T and Kishimoto T: WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood 84:3071, 1994
11. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposed revised criteria for the classificatin of acute myeloid leukemia: A report of the French-American-British Cooperative Group. Ann Intern Med 103:626, 1985
12. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7): A report of the French-American-British Cooperative Group. Ann Intern Med 103:460, 1985
13. Inoue K, Wongsasant B, Akiyama T, Toyoshima K: Human c-fgr induces a monocyte-specific enzyme in NIH 3T3 cells. Mol Cell Biol 11:6279, 1991
14. Reed JC, Stein C, Subasinghe C, Haldar S, Croce CM, Yum S, Cohen J: Antisense-mediated inhibitin of BCL2 protooncogene expression and leukemic cell growth and survival: Comparison of phosphodiester and phosphorothioate oligodeoxynucleotides. Cancer Res 50:6565, 1990
15. Higgins KA, Perez JR, Coleman TA, Dorshkind K, McComas WA, Sarmiento UM, Rosen CA, Narayanan R: Antisense inhibition of the p65 subunit of NF-κB blocks tumorigenicity and causes tumor regression. Proc Natl Acad Sci USA 90:9901, 1993
16. Sakakura C, Yamaguchi-Iwai Y, Satake M, Bae S-C, Takahashi A, Ogawa E, Hagiwara A, Takahashi T, Murakami A, Makino K, Nakagawa T, Kamada N, Ito Y: Growth inhibition and induction of differentialion of t(8;21) acute myeloid leukemia cells by the DNA-binding domain of PEBP2 and the AML1/MTG8(ETO)-specific antisense oligonucleotide. Proc Natl Acad Sci USA 91:11723, 1994
17. Kimura S, Maekawa T, Hirakawa K, Murakami A, Abe T: Alterations of c-myc expression by antisense oligonucleotides enhance the induction of apoptosis in HL-60 cells. Cancer Res 55:1379, 1995
18. Huang A, Campbell CE, Bonetta L, McAndrews-Hill MS, Chilton-MacNeill S, Coppes MJ, Law DJ, Feinberg AP, Yeger H, Williams BRG: Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. Science 250:991, 1990
19. Gessler M, Bruns GAP: Sequence of the WT1 upstream region including the wit-1 gene. Oncogene 9:2059, 1994
20. Hofmann W, Royer H-D, Drechsler M, Schneider S, Royer-Pokora B: Characterization of the transcriptional regulatory region of the human WT1 gene. Oncogene 8:3123, 1993
21. Eccles MR, Grubb G, Ogawa O, Szeto J, Reeve AE: Cloning of novel Wilms tumor gene (WT1) cDNAs; evidence for antisense transcription of WT1. Oncogene 9:2059, 1994
22. Yeger H, Cullinane C, Flenniken A, Huang A, Chilton-McNeil S, Bonetta L, Campbell C, McGrews-Hill M, Coopes M, Greenberg M, Thorner P, Williams BRG: Coordinate expression of Wilms tumor genes correlates with Wilms tumor phenotypes. Cell Growth Differ 3:855, 1992
23. Campbell CE, Huang A, Gurney AL, Kessler PM, Hewitt JA, Williams BRG: Antisense Transcripts and protein binding motifs within the Wilms tumour (WT1) locus. Oncogene 9:583, 1993
24. Phelan SA, Lindberg C, Call KM: Wilms' tumor gene. WT1, mRNA is down-regulated during induction of erythroid and megakaryocytic differentiation of K562 cells. Cell Growth Differ 5:677, 1994
25. Sekiya M, Adachi M, Hinoda Y, Imai K, Yachi A: Downregulation of Wilms' tumor gene (WT1) during myelomonocytic differentiation in HL60 cells. Blood 83:1876, 1994
26. Gewirtz AM, Calabretta B: A c-myb antisense oligodeoxynucleolide inhibits normal human hematopoiesis in vitro. Science 242:1303, 1988
27. Anfossi G, Gewirtz AM, Calabretta B: An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines. Proc Natl Acad Sci USA 86:3379, 1989
28. Calabretta B, Sims RB, Valtieri M, Caracciolo D, Szczylik C, Venturelli D, Ratajczak M, Beran M, Gewirtz AM: Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: An in vitro study relevant to bone marrow purging. Proc Natl Acad Sci USA 88:2351, 1991
29. Ratajczak MZ, Hijiya N, Catani L, DeRiel K, Luger SM, McGlave P, Gewirtz AM: Acute- and chronic-phase chronic myelogenous leukemia colony-forming units are highly sensitive to the growth inhibitory effects of c-myb antisense oligodeoxynucleotides. Blood 79:1956, 1992
30. Arsura M, Introna M, Passerini F, Mantovani A, Golay J: B-myb antisense oligonucleotides inhibit proliferation of human hematopoietic cell lines. Blood 79:2708, 1992
31. Holt JT, Redner RL, Nienhuis AW: An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation. Mol Cell Biol 8:963, 1988
32. Wickstrom EL, Bacon TA, Gonzalez A, Freeman DL, Lyman GH, Wickstrom E: Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA. Proc Natl Acad Sci USA 85:1028, 1988
33. Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B: Selective inhibition of leukemia cell proliferation by bcr-abl antisense oligodeoxynuleotides. Science 253:562, 1991
34. Maekawa T, Kimura S, Hirakawa K, Murakami A, Zon G, Abe T: Sequence specificity on the grwoth suppression and induction of apoptosis of chronic myeloid leukemia cells by BCR-ABL antisense oligodeoxynucleoside phosphorothioates. Int J Cancer 62:63, 1995
35. Maheswaran S, Park S, Bernard A, Morris JF, Rauscer III FJ, Hill DE, Haber DA. Physical and functional interactin between WT1 and p53 proteins. Proc Natl Acad Sci USA, 90:5100, 1993