Constitutive expression of the Wilms' tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF)

Leukemia Research

Volumn 23, Issue 5, 1999, Pages 499-505

  Tsuboi, Akihiro ^a   Oka, Yoshihiro ^a   Ogawa, Hiroyasu ^a   Elisseeva, Olga A ^a   Tamaki, Hiroya ^a   Oji, Yusuke ^a   Kim, Eui Ho ^a   Soma, Toshihiro ^a   Tatekawa, Toyoshi ^a   Kawakami, Manabu ^a   Kishimoto, Tadamitsu ^a   Sugiyama, Haruo ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Granulocyte colony stimulating factor; Myeloid progenitor cells; The Wilms' tumor gene; WT1

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY FORMING UNIT GM; COLONY FORMING UNIT M; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; GENES, WILMS TUMOR; GENETIC VECTORS; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; RETROVIRIDAE;

EID: 0032944068     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(99)00037-5     Document Type: Article

References (34)

1. Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH, Jones C, Housman DE. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 1990;60:509.
2. Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GAP. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature 1990;343:774.
3. Gashler AL, Bonthron DT, Madden SL, Rauscher FJ III, Collins T, Sukhatme VP. Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1. Proc Natl Acad Sci USA 1992;89:10984.
4. Harrington MA, Konicek B, Song A, Xia X-L, Fredericks WJ, Rauscher FJ III. Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus. J Biol Chem 1993;268:21271.
5. Drummond IA, Madden SL, Rohwer-Nutter P, Bell GI, Sukhatme VP, Rauscher FJ III. Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1. Science 1992;257:674.
6. Werner H, Re GG, Drummond IA, Sukhatme VP, Rauscher FJ III, Sens DA, Garvin AJ, LeRoith D, Roberts CT Jr. Increased expression of the insulin-like growth factor I receptor gene, IGFIR, in Wilms tumor is correlated with modulation of IGFIR promoter activity by the WT1 Wilms tumor gene product. Proc Natl Acad Sci USA 1993;90:5828.
7. Godyer P, Dehbi M, Torban E, Bruening W, Pelletier J. Repression of the retinoic acid receptor-α gene by the Wilms tumor suppressor gene product, wtl. Oncogene 1995;10:1125.
8. Hewitt SM, Hamada S, McDonnell TJ, Rauscher FJIII, Saunders GF. Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 1995;55:5386.
9. Inoue K, Sugiyama H, Ogawa H, Nakagawa M, Yamagami T, Miwa H, Kita K, et al. WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood 1994;84:3071.
10. Inoue K, Ogawa H, Yamagami T, Soma T, Tani Y, Tatekawa T, Oji Y, et al. Long-term follow-up of minimal residual disease in leukemia patients by monitoring WT1 (Wilms tumor gene) expression levels. Blood 1996;88:2267.
11. Inoue K, Ogawa H, Sonoda Y, Kimura T, Sakabe H, Oka Y, Miyake S, Tamaki H, Oji Y, Yamagami T, Tatekawa T, Soma T, Kishimoto T, Sugiyama H. Aberrant overexpression of the Wilms tumor gene (WT1) in humam leukemia. Blood 1997;89:1405.
12. Miwa H, Beran M, Saunders GF. Expression of the Wilms' tumor gene (WT1) in human leukemia. Leukemia 1992;6:405.
13. Miyagi T, Ahuja H, Kubota T, Kubonishi I, Koeffler HP, Miyoshi I. Expression of the candidate Wilms' tumor gene, WT1, in human leukemia cells. Leukemia 1993;7:970.
14. Brieger J, Weidmann E, Fenchel K, Mitrou PS, Hoelzer D, Bergmann L. The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells. Leukemia 1994;8:2138.
15. Menssen HD, Renkl H-J, Rodeck V, Maurer J, Notter M, Schwartz S, Reinhardt R, Thiel E. Presence of Wilm's tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia 1995;9:1060.
16. Tamaki H, Ogawa H, Inoue K, Soma T, Yamagami T, Miyake S, Oka Y, Oji Y, Tatekawa T, Tsuboi A, Tagawa S, Kitani T, Miwa H, Kita K, Aozasa K, Kishimoto T, Sugiyama H. Increased expression of the Wilms tumor gene (WT1) at relapse in acute leukemia. Blood 1996;88:4396.
17. Yamagami T, Sugiyama H, Inoue K, Ogawa H, Tatekawak T, Hirata M, Kudoh T, Akiyama T, Murakami A, Maekawa T, Kishimoto T. Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis. Blood 1996;87:2878.
18. Inoue K, Tamaki H, Ogawa H, Oka Y, Soma T, Tatekawa T, Oji Y, et al. Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells. Blood 1998;91:2969.
19. Lange B, Valtieri M, Santoli D, Caracciolo D, Mavilio F, Gemperlein I, et al. Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines. Blood 1987;70:192.
20. Sachs L. Constitutive uncoupling of the controls for growth and differentiation in myeloid leukemia and the development of cancer. J Nat Cancer Inst 1980;65:675.
21. Park LS, Waldron PE, Friend D, Sassenfeld HM, Price V, Anderson D, et al. Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness. Blood 1989;74:56.
22. Fraizer GC, Patmasiriwat P, Zhang X, Saunders GF. Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow. Blood 1995;86:4704.
23. + hematopoietic progenitors during fetal development and early clonogenic growth. Blood 1997;89:3486.
24. Baird PN, Simmons PJ. Expression of the Wilms' tumor gene (WT1) in normal hemopoiesis. Exp Hematol 1997;25:312.
25. + progenitors and downregulated early in the course of differentiation in vitro. Exp Hematol 1997;25:945.
26. Buckler AJ, Pelletier J, Haber DA, Glasser T, Housman DE. Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol Cell Biol 1991;11:1707.
27. Fukunaga R, Ishizaka-Ikeda E, Nagata S. Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Cell 1993;74:1079.
28. Ziegler SF, Bird TA, Morella KK, Mosley B, Gearing DP, Baumann H. Distinct regions of the human granulocyte colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction. Mol Cell Biol 1993;13: 2384.
29. Dong F, Buitenen C, Pouwels K, Hoefsloot LH, Löwenberg B, Touw IP. Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation. Mol Cell Biol 1993;13:7774.
30. Greenberger JS, Sakakeeny MA, Humphries RK, Eaves CJ, Eckner RJ. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc Natl Acad Sci USA 1983;80:2931.
31. Sekiya M, Adachi M, Hinoda Y, Imai K, Yachi A. Downregulation of Wilms' tumor gene (WT1) during myelomonocytic differentiation in HL60 cells. Blood 1994;83:1876.
32. Phelan SA, Lindberg C, Call KM. Wilms' tumor gene, WT1, mRNA is down-regulated during induction of erythroid and megakaryocytic differentiation of K562 cells. Cell Growth Different 1994;5:677.
33. Maheswaran S, Park S, Bernard A, Morris JF, Rauscher FJ III, Hill DE, Haber DA. Physical and functional interaction between WT1 and p53 proteins. Proc Natl Acad Sci USA 1993;90: 5100.
34. Johnstone RW, See RH, Sells SF, Wang J, Muthukkumar S, Englert C, et al. A novel represser, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. Mol Cell Biol 1996;16:6945.