High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome

Blood

Volumn 90, Issue 3, 1997, Pages 1217-1225

  Bergmann, Lothar ^a   Miething, Cornelius ^a   Maurer, Ulrich ^a   Brieger, Jürgen ^a   Karakas, Tunca ^a   Weidmann, Eckhart ^a   Hoelzer, Dieter ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; MESSENGER RNA; ZINC FINGER PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CONTROLLED STUDY; GENE ISOLATION; HUMAN; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

EID: 0030737629     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.3.1217.1217_1217_1225     Document Type: Article

References (49)

1. Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH, Jones C, Housman DE: Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60:509, 1990
2. Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GAP: Homozygous deletion in Wilms' tumors of a zinc-finger gene identified by chromosome jumping. Nature 343:774, 1990
3. Reddy JC, Licht JD: The Wilms' tumor suppressor gene: How much do we really know? Biochem Biophys Acta 1287:1, 1996
4. Brenner B, Wildhardt G, Schneider S, Royer-Pokora B: RNA polymerase chain reaction detects different levels of four alternatively spliced wt-1 transcripts in Wilms' tumors. Oncogene 7:1431, 1992
5. Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE: Alternative splicing and genomic structure of the Wilms' tumor gene wt-1. Proc Natl Acad Sci USA 88:9618, 1991
6. Drummond IA, Madden SL, Rohwer-Nutter P, Bell GI, Sukhatme VP, Rauscher FJ 3rd: Repression of the insulin-like growth factor II gene by the Wilms' tumor suppressor wt-1. Science 257:674, 1992
7. Gashler AL, Bonthron DT, Madden SL, Rauscher FJ III, Collins T, Sukhatme VP: Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1. Proc Natl Acad Sci USA 89:10984, 1992
8. Harrington MA, Konicek B, Song A, Xia X, Fredericks WJ, Rauscher F III: Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus. J Biol Chem 268:21271, 1993
9. Dey BR, Sukhatme VP, Roberts AB, Sporn MB, Rauscher FJ, Kim SJ: Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product. Mol Endocrinol 8:595, 1994
10. Rupprecht HD, Drummond IA, Madden SL, Rauscher FJ, Sukhatme VP: The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J Biol Chem 269:6198, 1994
11. Wang ZY, Qiu QQ, Deuel TF: The Wilms' tumor gene product wt-1 activates or suppresses transcription through separate functional domains. J Biol Chem 268:9172, 1993
12. Madden SL, Cook DM, Morris JF, Gashler A, Sukhatme VP, Rauscher FJ III: Transcriptional repression mediated by the WT-1 Wilms' tumor gene product. Science 253:1550, 1991
13. Joseph LJ, Le Beau MM, Jamieson GA, Acharya S, Shows TB, Rowley JD, Sukhatme VP: Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with 'zinc-binding finger' structure. Proc Natl Acad Sci USA 85:7164, 1988
14. Pritchard-Jones K, Fleming S, Davidson D, Bickmore W, Porteous D, Gosden C, Bard J, Buckler A, Pelletier J, Housman D, Heyningen W, Hastie N: The candidate Wilms' tumor gene is involved in genitourinary development. Nature 346:194, 1990
15. Rackley R, Flenniken A, Kuryan N, Kessler P, Stoler M, Williams G: Expression of the Wilms' tumor suppressor gene wt1 during mouse embryogenesis. Cell Growth Differ 4:1023, 1993
16. Kreidberg J, Sariola H, Loring J, Maeda M, Pelletier J, Housman D, Jaenisch R: WT1 is required for early kidney development. Cell 74:679, 1993
17. Haber DA, Buckler AJ: Wt1: A novel tumor suppressor gene inactivated in Wilms' tumor. New Biol 4:97, 1992
18. Brown KW, Watson JE, Poirier V, Mott MG, Berry PJ, Maitland NJ: Inactivation of the remaining allele of the wt1 gene in a Wilms' tumour from a WAGR patient. Oncogene 7:763, 1992
19. Akasaka Y, Kikuchi H, Nagai T, Hiraoka N, Kato S, Hata J: A point mutation in a sporadic Wilms' tumor without genitoury abnormalities is identical with the most frequent mutations in Denys-Drash syndrome. FEES Lett 317:39, 1993
20. Rodeck U, Bossier A, Kari C, Humphreys CW, Györfi T, Maurer J, Thie E, Menssen HD: Expression of the Wilms' tumor gene by normal and malignant human melanocytes. Int J Cancer 59:78, 1994
21. Viel A, Giannini F, Capozzi E, Canzonieri V, Scarabeli C, Gloghini A, Boiocci M: Molecular mechanisms possibly affecting WT1 functions in human ovarian tumors. Int J Cancer 57:515, 1994
22. Miwa H, Beran M, Saunders GF: Expression of the Wilms' tumor gene (wt-1) in human leukemias. Leukemia 6:405, 1992
23. Miyagi T, Ahuja H, Kubota T, Kubonishi I, Koeffler HP, Miyoshi I: Expression of the candidate Wilms' tumor gene, WT1, in human leukemia cells. Leukemia 7:970, 1993
24. Brieger J, Weidmann E, Fenchel K, Mitrou PS, Hoelzer D, Bergmann L: The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells. Leukemia 8:2138, 1994
25. Menssen HD, Renkl HJ, Maurer J, Notter M, Schwanz S, Reinhardt R, Thiel E: Presence of the Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia 9:1060, 1995
26. Bergmann L, Maurer U, Weidmann E: Wilms tumor gene expression in acute myeloid leukemias. Leuk Lymphoma 1997 (in press)
27. King-Underwood L, Renshaw J, Pritchard-Jones K: Mutations in the Wilms' tumor gene WT1 in leukemias. Blood 87:2171, 1996
28. Phelan SA, Lindberg C, Call KM: Wilms' tumor gene, WT1, mRNA is down-regulated during induction of erythroid and mega-karyocytic differentiation of K562 cells. Cell Growth Differ 5:677, 1994
29. Sekiya M, Adachi M, Hinoda Y, Imai K, Yachi A: Downregulation of Wilms' tumor gene (WT1) during myelomonocytic differentiation in HL60 cells. Blood 83:1876, 1994
30. + progenitors and downregulated early in course of differentiation in vitro. Exp Hematol 1997 (in press)
31. Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Br J Haematol 33:451, 1976
32. Bergmann L, Heil G, Kolbe K, Lengfelder E, Puzicha E, Martin H, Lohmeyer J, Mitrou PS, Hoelzer D: Interleukin-2 bolus infusion as late consolidation therapy in 2nd remission of acute myelocytic leukemia. Leuk Lymphoma 16:271, 1995
33. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
34. Gerard GF: Making effective use of cloned M-MLV reverse transcriptase. Focus (GIBCO BRL) 9:5, 1987
35. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N: Enzymatic amplification of β-Globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350, 1985
36. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA: Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487, 1988
37. Becker-André M, Hahlbrock K: Absolute mRNA quantification using polymerase chain reaction (PCR). A novel approach by a PCR aided transcript titration assy (PATTY). Nucleic Acids Res 17:9437, 1989
38. Southern EM: Detection of specific sequence among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503, 1975
39. Kaplan EM, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457, 1958
40. Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163, 1966
41. Yamagami T, Sugiyama H, Inoue K, Ogawa H, Tatekawa T, Hirata M, Kudoh T, Akiyama T, Murakami A, Maekawa T, Kishimoto T: Growth inhibition of human leukemic cells by wt-1 antisence oligodeoxynucleotides: Implications for the involvement of WT-1 in leukemogenesis. Blood 87:2878, 1996
42. Inoue K, Sugiyama H, Ogawa H, Nakagawa M, Yamagami T, Miwa H, Kita K, Hiraoka A, Nasu K, Kyo T, Dohy H, Nakauchi H, Ishidate T, Akiyama T, Kishimoto T: WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood 84:3071, 1994
43. Hewitt SM, Hamada S, McDonnell TJ, Rauscher FJ III, Saunders GF: Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene wt1. Cancer Res 55:5386, 1995
44. Karakas T, Miething CC, Brieger J, Maurer U, Weidmann E, Mitrou PS, Hoelzer D, Bergmann L: The expression of bcl-2 in AML is associated with a poor outcome and correlated to the expression of wt-1. Br J Haematol 93:144, 1996 (abstr)
45. Hogge DE: Cytogenetics and oncogenes in leukemia. Curr Opin Oncol 6:3, 1995
46. Brieger J, Weidmann E, Maurer U, Hoelzer D, Mitrou PS, Bergmann L: The Wilms' tumor gene is frequently expressd in acute leukemias and may provide a marker for residual blast cells detectable by PCR. Ann Oncol 6:811, 1995
47. Jahn B, Bergmann L, Weidmann E, Brieger J, Fenchel K, Schwulera U, Hoelzer D, Mitrou PS: Bone marrow derived T cell clones of previously untreated acute myelocytic leukemia exhibit blast directed autologous cytotoxicity. Leuk Res 19:73, 1995
48. lnoue K, Ogawa H, Yamagami T, Soma T, Tani Y, Tatekawa T, Oji Y, Tamaki H, Kyo T, Dohy H, Hiraoka A, Masaoka T, Kishimoto T, Sugiyama H: Long-term follow-up of minimal residual disease in leukemic patients by monitoring wt1 (Wilms tumor gene) expression levels. Blood 88:2267, 1996
49. Fraizer GC, Patmasiriwat P, Zhang X, Saunders GF: Expression of the Wilms' tumor gene in both human and mouse bone marrow. Blood 86:4704, 1995 (letter)