DNA delivery to the mitochondria sites using mito chondrial leader peptide conjugated polyethylenimine

Journal of Drug Targeting

Volumn 15, Issue 2, 2007, Pages 115-122

  Lee, Minhyung ^a   Choi, Joon Sig ^b   Choi, Min Ji ^a   Pak, Youngmi Kim ^c   Rhee, Byoung Doo ^d   Ko, Kyung Soo ^d  

^a Hanyang University   (South Korea)

^b Chungnam National University   (South Korea)

^c University of Ulsan   (South Korea)

^d Inje University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DNA; PLASMID DNA; POLYETHYLENEIMINE; RHODAMINE; SIGNAL PEPTIDE; PEPTIDE;

ANIMAL CELL; ARTICLE; BIOASSAY; CELL FREE SYSTEM; CHEMICAL LABELING; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; GENE TARGETING; IN VITRO STUDY; MITOCHONDRIAL GENE; MITOCHONDRION; MOLECULAR WEIGHT; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; RAT; ANIMAL; CELL LINE; CHEMISTRY; METABOLISM;

ANIMALS; CELL LINE; DNA; MITOCHONDRIA; PEPTIDES; POLYETHYLENEIMINE;

EID: 34249714777     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860600953555     Document Type: Article

References (44)

1. Abdallah, B., Hassan, A., Benoist, C., Goula, D., Behr, JP and Demeneix, BA (1996) A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: Polyethylenimine. Hum Gene Ther, 7, pp.1947-1954.
2. Ballinger, SW, Shoffner, JM, Hedaya, EV, Trounce, I., Polak, MA, Koontz, DA and Wallace, DC (1992) Maternally transmitted diabetes and deafness associated with a 10.4kb mitochondrial DNA deletion. Nat Genet, 1, pp.11-15.
3. Ballinger, SW, Shoffner, JM, Gebhart, S., Koontz, DA and Wallace, DC (1994) Mitochondrial diabetes revisited. Nat Genet, 7, pp.458-459.
4. Brown, MD, Hosseini, S., Steiner, I., Wallace, DC and Korn-Lubetzki, I. (2004) Complete mitochondrial DNA sequence analysis in a family with early-onset dystonia and optic atrophy. Mov Disord, 19, pp.235-237.
5. Brunner, S., Furtbauer, E., Sauer, T., Kursa, M. and Wagner, E. (2002) Overcoming the nuclear barrier: Cell cycle independent nonviral gene transfer with linear polyethylenimine or electroporation. Mol Ther, 5, pp.80-86.
6. Cartier, R. and Reszka, R. (2002) Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems. Gene Ther, 9, pp.157-167.
7. Chan, CK and Jans, DA (1999) Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: Polylysine does not function as a nuclear localization sequence. Hum Gene Ther, 10, pp.1695-1702.
8. Chan, CK, Senden, T. and Jans, DA (2000) Supramolecular structure and nuclear targeting efficiency determine the enhancement of transfection by modified polylysines. Gene Ther, 7, pp.1690-1697.
9. D'Souza, GG and Weissig, V. (2004) Approaches to mitochondrial gene therapy. Curr Gene Ther, 4, pp.317-328.
10. D'Souza, GG, Rammohan, R., Cheng, SM, Torchilin, VP and Weissig, V. (2003) DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells. J Control Release, 92, pp.189-197.
11. D'Souza, GG, Boddapati, SV and Weissig, V. (2005) Mitochondrial leader sequence-plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. Mitochondrion, 5, pp.352-358.
12. Entelis, NS, Kolesnikova, OA, Martin, RP and Tarassov, IA (2001) RNA delivery into mitochondria. Adv Drug Deliv Rev, 49, pp.199-215.
13. Forrest, ML and Pack, DW (2002) On the kinetics of polyplex endocytic trafficking: Implications for gene delivery vector design. Mol Ther, 6, pp.57-66.
14. Godbey, WT, Wu, KK and Mikos, AG (1999) Poly(ethylenimine) and its role in gene delivery. J Control Release, 60, pp.149-160.
15. Godbey, WT, Wu, KK and Mikos, AG (1999) Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. J Biomed Mater Res, 45, pp.268-275.
16. Godbey, WT, Barry, MA, Saggau, P., Wu, KK and Mikos, AG (2000) Poly(ethylenimine)-mediated transfection: A new paradigm for gene delivery. J Biomed Mater Res, 51, pp.321-328.
17. Han, S., Mahato, RI, Sung, YK and Kim, SW (2000) Development of biomaterials for gene therapy. Mol Ther, 2, pp.302-317.
18. Holt, IJ, Harding, AE, Cooper, JM, Schapira, AH, Toscano, A., Clark, JB and Morgan-Hughes, JA (1989) Mitochondrial myopathies: Clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA. Ann Neurol, 26, pp.699-708.
19. Holt, IJ, Harding, AE, Petty, RK and Morgan-Hughes, JA (1990) A new mitochondrial disease associated with mitochondrial DNA heteroplasmy. Am J Hum Genet, 46, pp.428-433.
20. Jensen, KD, Nori, A., Tijerina, M., Kopeckova, P. and Kopecek, J. (2003) Cytoplasmic delivery and nuclear targeting of synthetic macromolecules. J Control Release, 87, pp.89-105.
21. Koh, JJ, Ko, KS, Lee, M., Han, S., Park, JS and Kim, SW (2000) Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice. Gene Ther, 7, pp.2099-2104.
22. Lee, M. and Kim, SW (2002) Polymeric gene carriers. Pharm News, 9, pp.407-415.
23. Lee, M. and Kim, SW (2005) Polyethylene glycol-conjugated copolymers for plasmid DNA delivery. Pharm Res, 22, pp.1-10.
24. Lee, M., Han, SO, Ko, KS, Koh, JJ, Park, JS, Yoon, JW and Kim, SW (2001) Repression of GAD autoantigen expression in pancreas beta-cells by delivery of antisense plasmid/PEG-g-PLL complex. Mol Ther, 4, pp.339-346.
25. Lee, M., Rentz, J., Han, SO, Bull, DA and Kim, SW (2003) Water-soluble lipopolymer as an efficient carrier for gene delivery to myocardium. Gene Ther, 10, pp.585-593.
26. Lemkine, GF, Goula, D., Becker, N., Paleari, L., Levi, G. and Demeneix, BA (1999) Optimisation of polyethylenimine-based gene delivery to mouse brain. J Drug Target, 7, pp.305-312.
27. Lill, R. and Neupert, W. (1996) Mechanisms of protein import across the mitochondrial outer membrane. Trends Cell Biol, 6, pp.56-61.
28. Murphy, MP and Smith, RA (2000) Drug delivery to mitochondria: The key to mitochondrial medicine. Adv Drug Deliv Rev, 41, pp.235-250.
29. Nguyen, HK, Lemieux, P., Vinogradov, SV, Gebhart, CL, Guerin, N., Paradis, G., Bronich, TK, Alakhov, VY and Kabanov, AV (2000) Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Ther, 7, pp.126-138.
30. Nishikawa, M. and Huang, L. (2001) Nonviral vectors in the new millennium: Delivery barriers in gene transfer. Hum Gene Ther, 12, pp.861-870.
31. Pulkes, T. and Hanna, MG (2001) Human mitochondrial DNA diseases. Adv Drug Deliv Rev, 49, pp.27-43.
32. Ruponen, M., Honkakoski, P., Ronkko, S., Pelkonen, J., Tammi, M. and Urtti, A. (2003) Extracellular and intracellular barriers in non-viral gene delivery. J Control Release, 93, pp.213-217.
33. Seibel, P., Trappe, J., Villani, G., Klopstock, T., Papa, S. and Reichmann, H. (1995) Transfection of mitochondria: Strategy towards a gene therapy of mitochondrial DNA diseases. Nucleic Acids Res, 23, pp.10-17.
34. Shoffner, JMt and Wallace, DC (1990) Oxidative phosphorylation diseases. Disorders of two genomes. Adv Hum Genet, 19, pp.267-330.
35. Shoffner, JM and Wallace, DC (1992) Heart disease and mitochondrial DNA mutations. Heart Dis Stroke, 1, pp.235-241.
36. Tang, MX and Szoka, FC (1997) The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther, 4, pp.823-832.
37. Turunen, MP, Hiltunen, MO, Ruponen, M., Virkamaki, L., Szoka Jr., FC, Urtti, A. and Yla-Herttuala, S. (1999) Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes. Gene Ther, 6, pp.6-11.
38. Wallace, DC (2005) The mitochondrial genome in human adaptive radiation and disease: On the road to therapeutics and performance enhancement. Gene, 354, pp.169-180.
39. Wallace, DC, Lott, MT, Shoffner, JM and Brown, MD (1992) Diseases resulting from mitochondrial DNA point mutations. J Inherit Metab Dis, 15, pp.472-479.
40. Wallace, DC, Shoffner, JM, Trounce, I., Brown, MD, Ballinger, SW, Corral-Debrinski, M., Horton, T., Jun, AS and Lott, MT (1995) Mitochondrial DNA mutations in human degenerative diseases and aging. Biochim Biophys Acta, 1271, pp.141-151.
41. Weissig, V. and Torchilin, VP (2001) Cationic bolasomes with delocalized charge centers as mitochondria-specific DNA delivery systems. Adv Drug Deliv Rev, 49, pp.127-149.
42. Weissig, V., D'Souza, GG and Torchilin, VP (2001) DQAsome/DNA complexes release DNA upon contact with isolated mouse liver mitochondria. J Control Release, 75, pp.401-408.
43. Wiethoff, CM and Middaugh, CR (2003) Barriers to nonviral gene delivery. J Pharm Sci, 92, pp.203-217.
44. Wightman, L., Patzelt, E., Wagner, E. and Kircheis, R. (1999) Development of transferrin-polycation/DNA based vectors for gene delivery to melanoma cells. J Drug Target, 7, pp.293-303.