Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes

Gene Therapy

Volumn 6, Issue 1, 1999, Pages 6-11

  Turunen, M P ^a   Hiltunen, M O ^a   Ruponen, M ^a   Virkamaki L ^a   Szoka Jr , F C ^b   Urtti, A ^a   Yla Herttuala S ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Carotid artery; Collar model; Fractured dendrimers; Nonviral gene transfer; Polyethylenimine

Indexed keywords

CATION; DENDRIMER; DNA; LIPID; POLYAMIDE; POLYETHYLENE; POLYMER; SILASTIC;

ADVENTITIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAROTID ARTERY; CELL CULTURE; CYTOTOXICITY; DNA ADDUCT; ENDOTHELIUM CELL; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LACTOSE OPERON; MALE; MOLECULAR SIZE; NONHUMAN; PLASMID; POLYMERIZATION; PRIORITY JOURNAL; RABBIT; STAINING;

ANIMALS; BETA-GALACTOSIDASE; CAROTID ARTERIES; CATIONS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENETIC VECTORS; MALE; MUSCLE, SMOOTH, VASCULAR; PLASMIDS; POLYMERS; RABBITS; TRANSFECTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0032953120     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300800     Document Type: Article

References (28)

1. Nabel EG, Nabel GJ. Complex models for the study of gene function in cardiovascular biology. Annu Rev Physiol 1994; 56: 741-761.
2. Simons M et al. Antisense c-myc oligonucleotides inhibit arterial smooth muscle cell accumulation in vivo. Nature 1992; 359: 67-70.
3. Isner JM et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in a patient with ischaemic limb. Lancet 1996; 348: 370-374.
4. Gibbons GH, Dzau VJ. Molecular therapies for vascular diseases. Science 1996; 272: 689-693.
5. Stephan DJ et al. A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo. Hum Gene Ther 1996; 7: 1803-1812.
6. Feldman LJ, Isner JM. Gene therapy for vulnerable plaque. J Am Coll Cardiol 1995; 26: 826-835.
7. Finkel T, Epstein SE. Gene therapy for vascular disease. FASEB J 1995; 9: 843-851.
8. Ylä-Herttuala S. Vascular gene transfer. Curr Opin Lipid 1997; 8: 72-76.
9. Ylä-Herttuala S et al. Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein. J Clin Invest 1995; 95: 2692-2698.
10. Laitinen M et al. Gene transfer into the carotid artery using an adventitial collar: comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses. Hum Gene Ther 1997; 8: 1645-1650.
11. Keogh A-C et al. High efficiency reporter gene transfection of vascular tissue in vitro and in vivo using a cationic lipid-DNA complex. Gene Therapy 1997; 4: 162-171.
12. Barr E et al. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Therapy 1994; 1: 51-58.
13. Laitinen M et al. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. Hum Gene Ther 1997; 8: 1737-1744.
14. Morgan RA, Anderson WF. Human gene therapy. Annu Rev Biochem 1993; 62: 191-217.
15. Haensler J, Szoka FC Jr. Functionalization of polyamidoamine cascade polymers and their use for efficient transfection of cells in culture. Bioconjug Chem 1993; 4: 372-379.
16. Tang MX, Redeman CT, Szoka FC Jr. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 1996; 7: 703-714.
17. Kukowska-Latallo JF et al. Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. Proc Natl Acad Sci USA 1996; 93: 4897-4902.
18. Tang MX, Szoka FC. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Therapy 1997; 4: 823-832.
19. Baker A et al. Polyethylenimine (PEI) is a simple, inexpensive and effective reagent for condensing and linking plasmid DNA to adenovirus for gene delivery. Gene Therapy 1997; 4: 773-782.
20. Boussif O et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-7301.
21. Meunier-Durmort C et al. Adenovirus enhancement of polyethylenimine-mediated transfer of regulated genes in differentiated cells. Gene Therapy 1997; 4: 808-814.
22. Rios CD et al. Adenovirus-mediated gene transfer to normal and atherosclerotic arteries. Arteriosder Thromb Vasc Biol 1995; 15: 2241-2245.
23. Laitinen M et al. Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischaemia. Hum Gene Ther 1998; 9: 1481-1486.
24. Qui L et al. Efficient transfer of genes into murine cardiac grafts by starburst polyamidoamine dendrimers. Hum Gene Ther 1998; 9: 553-560.
25. Roberts JC, Bhalgat MK, Zera RT. Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers. J Biomed Mat Res 1996; 30: 53-65.
26. Plank C, Mechtler K, Szoka FC Jr, Wagner E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum Gene Ther 1996; 7: 1437-1446.
27. Zhu N, Liggit D, Liu Y, Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science 1993; 261: 209-211.
28. Ylä-Herttuala S et al. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc Natl Acad Sci USA 1990; 87: 6959-6963.