Polymeric gene carriers

Pharmaceutical News

Volumn 9, Issue 6, 2002, Pages 407-415

  Lee, Minhyung ^a   Kim, Sung Wan ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Local delivery; Non viral gene therapy; Polymeric gene carrier; Site specific delivery; Systemic delivery

Indexed keywords

DEXTRAN; GLYCOLIC ACID DERIVATIVE; HYBRID PROTEIN; MACROGOL; METHYLGLYCOLATE; PLASMA PROTEIN; POLY[ALPHA (4 AMINOBUTYL) LEVO GLYCOLIC ACID]; POLYETHYLENEIMINE; POLYLYSINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

BIODEGRADATION; CARCINOMA; CELL MEMBRANE; CELL NUCLEUS; CYTOTOXICITY; DIABETES MELLITUS; DRUG DEGRADATION; DRUG MECHANISM; DRUG SYNTHESIS; ENDOSOME; GENE DELIVERY SYSTEM; GENE INTERACTION; GENE LOCATION; GENE TARGETING; GENE THERAPY; GENETIC TRAIT; HEART DISEASE; HETEROZYGOTE; MEMBRANE FUSION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; POLYMERIZATION; REVIEW; VIRUS GENE;

EID: 0042694402     PISSN: 1071894X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (70)

1. Temin, H.M. (1990). Safety considerations in somatic gene therapy of human disease with retroviral vectors. Hum Gene Ther 1, 111-23.
2. Kabanov, A.V., Kabanov, V.A. (1995). DNA complexes with polycations for the delivery of genetic material into cells. Bioconjug Chem 6, 7-20.
3. Han, S., Mahato, R.I., Sung, Y.K., Kim, S.W. Development of biomaterials for gene therapy. Mol Ther 2, 302-17.
4. Trubetskoy, V.S., Loomis, A., Hagstrom, J.E., Budker, V.G., Wolff, J.A. (1999). Layer-by-layer deposition of oppositely charge polyelectrolytes on the surface of condensed DNA particles. Nucleic Acids Res 27, 3090-95.
5. Haensler, J., Szoka, F.C.J. (1993). Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 4, 372-9.
6. Pouton, C.W., Lucas, P., Thomas, B.J., Uduehi, A.N., Milroy, D.A., Moss, S.H. (1998). Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids. J Control Release 53, 289-99.
7. Tang, M.X., Szoka, F.C.J. (1997). The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther 4, 823-32.
8. Wagner, E., Cotton, M., Foisner, R., Bimstiel, M.L. (1991). Transferrin-Polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proc Natl Acad Sci USA 88, 4255-9.
9. Kim, J-S., Maruyama, A., Akaike, T., Kim, S.W. (1997). In vitro gene expression on smooth muscle cells using a Terplex delivery system. J Control Release 47, 51-9.
10. Ahn, C-H., Chae, S.Y., Bae, Y.H., Kim, S.W. (2002). Biodegradable poly(ethylenimine) for plasmid DNA delivery. J Control Release 80, 273-82.
11. Lee, M., Rentz, J., Han, S., Bull, D.A., Kim, S.W. (2003). Water soluble lipopolymers as an efficient carrier for gene delivery to myocardium. Gene Ther 10, 585-93.
12. Barry, M.E., Pinto-gonzales, D., Orson, F.M., Mckenzie, G.L., Petry, G.R., Barry, M.A. (1999). Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection. Hum Gene Ther 10, 2461-80.
13. Lee, M., Nahm J-W., Kwon, Y., Kohm J.J., Ko, K.S., Kim, S.W. (2001). Water-soluble and low molecular weight chitosan-based plasmid DNA delivery. Pharm Res, 18, 427-31.
14. Koh, J.J., Ko, K.S., Lee, M., Han, S., Park, J.S., Kim, S.W. (2000). Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice. Gene Ther 7, 2099-105.
15. Lee, M., Han, S., Ko, K.S., Kim, S.W. (2001). Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymers. J Control Release 75, 421-9.
16. Lee, M., Han, S., Ko, K.S., Koh, J.J., Park, J.S., Yoon, J-W., et al. (2001). Repression of GAD autoantigen in pancreas β cell by delivery of antisense plasmid/PEG-g-PLL complex. Mol Ther 4, 339-46.
17. Maruyama, A., Watanabe, H., Ferdous, A., Katoh, M., Ishihara, T., Akaike, T. (1998). Characterization of interpolyelectrolyte complexes between double-strand DNA and polylysine comb-type copolymers having hydrophilic side chains. Bioconjug Chem 9, 292-9.
18. Boussif, O., Delair, T., Brua, C., Veron, L., Pavirani, A., Kolbe, H.V. (1999). Synthesis of polyallylamine derivatives and their use as gene transfer vectors in vitro. Bioconjug Chem 10, 877-83.
19. Choi, Y.H., Liu, F., Kim, J-S., Choi, Y.K., Park, J-S., Kim, S.W. (1998). Polyethylene glycol-grafted poly-l-lysine as polymeric gene carrier. J Control Release 54, 39-48.
20. Boussif, O., Lezoualc' H.F., Zanta, M.A., Mergny, M.D., Scherman, D., Demeneix, B., et al. (1995). A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine. Proc Natl Acad Sci USA 92, 7297-301.
21. Boussif, O., Zanta, M.A., Behr, J-P. (1996). Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold. Gene Ther 3, 1074-80.
22. Dunlap, D.D., Maggi, A., Soria, M.R., Monaco, L. (1997). Nanoscopic structure of DNA condensed for gene delivery. Nucleic Acids Res 25, 3095-101.
23. Godbey, W.T., Wu, K.K., Mikos, A.G. (1999). Poly(ethylenimine) and its role in gene therapy. J Control Release 60, 149-60.
24. Godbey, W.T., Barry, M.A., Saggau, P., Wu, K.K., Mikos, A.G. (2000). Poly(ethylenimine)-mediated transfection: a new paradigm for gene therapy. J Biomed Mater Res 51, 321-8.
25. Behr, J-P., Demeneix, B.A. (1998). Gene delivery with polycationic amphiphiles and polymers. Curr Res Mol Ther 1, 5-11.
26. Mechtler, K., Wagner, E. (1997). Gene transfer mediated by influenza virus peptides: The role of peptide sequences. N J Chem 21, 105-11.
27. Parente, R.A., Nir, S., Szoka, F.C.J. (1990). Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry 29, 8720-8.
28. Ishiguro, R., Matsumoto, M., Takahashi, S. (1996). Interaction of fusogenic synthetic peptide with phospholipid bilayers: orientation of the peptide α-helix and binding isotherm. Biochemistry 35, 4976-83.
29. Benns, J.M., Choi, J-S., Mahato, R.I., Park, J-S., Kim, S.W. (2000). pH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb-shaped polymer. Bioconjug Chem 11, 637-45.
30. Murthy, N., Robichaud, J.R., Tirrell, D.A., Stayton, P.S., Hoffman, A.S. (1999). The design and synthesis of polymers for eukaryotic membrane disruption. J Control Release 61, 137-43.
31. Chan, C.K., Jans, D.A. (1999). Enhancement of polylysine-mediated transfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence. Hum Gene Ther 10, 1695-702.
32. Ciolina, C., Byk, G., Blanche, F., Thuillier, V., Scherman, D., Wils, P. (1999). Coupling of nuclear localization signals to plasmid DNA and specific interaction of the conjugates with importin α. Bioconjug Chem 10, 49-4.
33. Rebuffat, A., Bernasconi, A., Ceppi, M., Wehrli, H., Verca, S.B., Ibrahim, M., et al. (2001). Selective enhancement of gene transfer by steroid-mediated gene delivery. Nature Biotech 19, 1155-61.
34. Lim, Y.B., Han, S., Kong, H.U., Lee, Y., Park, J-S., Jeong, B., et al. (2000). Biodegradable polyester, poly[α-(4-aminobutyl)-L-glycolic acid], as a non-toxic gene carrier. Pharm Res 17, 811-6.
35. Lee, M., Koh, J.J., Han, S., Ko, K.S., Kim, S.W. (2002). Prevention of autoimmune insulitis by delivery of interleukin-4 plasmid using a soluble and biodegradable polymeric carrier. Pharm Res 19, 246-9.
36. Ko, K.S., Lee, M., Koh, J.J., Kim, S.W. (2001). Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice. Mol Ther 4, 313-6.
37. Furgeson, D.Y., Cohen, R.N., Mahato, R.I., Kim, S.W. (2002). Novel water insoluble lipoparticulates for gene delivery. Pharm Res 19, 382-90.
38. Westlin, W.F. (2001). Integrins as targets of angiogenesis inhibition. Cancer J 7, S 139-43.
39. Suh, W.H., Kim, S.W. (2002). RGD peptide-poly(ethylene glycol)-grafted-poly(ethylenimine) as a tumor targeting gene carrier. Mol Ther submitted.
40. Zanta, M.A., Boussif, O., Adib, A., Behr, J.P. (1997). In vitro gene delivery to hepatocytes with galactosylated poly-ethylenimine. Bioconjug Chem 8, 839-44.
41. Nishikawa, M., Takemura, S., Takakura, Y., Hashida, M. (1998). Targeted delivery of plasmid DNA to hepatocytes in vivo: optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(l-lysine) complexes by controlling their physicochemical properties. J Pharmacol Exp Ther 287, 408-15.
42. Bettinger, T., Remy, J.S., Erbacher, P. (1999). Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes. Bioconjug Chem 10, 558-61.
43. Biessen, E.A., Beuting, D.M., Roelen, H.C.P.F., van de Marel, G.A., van Boom, J.H., van Berkel, T.J.C. (1995). Synthesis of cluster galactosides with high affinity for the hepatic asialoglycoprotein receptor. J Med Chem 38, 1538-46.
44. Sagara, K., Kim, S.W. (2002). A new synthesis of galactose-poly(ethylene glycol)-polyethylenimine for gene delivery to hepatocytes. J Control Release 79, 271-81.
45. Nah, J.W., Yu, L., Han, S., Ahn, C-H., Kim, S.W. (2002). Artery wall binding peptide-poly(ethylene glycol)-grafted-poly(L-lysine)-based gene delivery to artery wall cells. J Control Release 78, 273-84.
46. Kim, J-S., Kim, B.I., Maruyama, A., Akaike, T., Kim, S.W. (1998). A new non-viral DNA delivery vector: the Terplex system. J Control Release 30, 175-82.
47. Kim, J-S., Maruama, A., Akaike, T., Kim, S.W. (1998). Terplex DNA delivery system as a gene carrier. Pharm Res 15, 116-21.
48. Yu, L., Nielsen, M., Han, S., Kim, S.W. (2001). TerplexDNA gene carrier system targeting to artery wall cells. J Control Release 72, 179-89.
49. Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., et al. (1997). An endothelial receptor for oxidized low-density lipoprotein. Nature 386, 73-7.
50. Shih, I.L., Lees, R.S., Chang, M.Y., Lees, A.M. (1990). Focal accumulation of an apolipoprotein B-based synthetic oligopeptide in the healing rabbit arterial wall. Proc Natl Acad Sci USA 87, 1436-40.
51. Hein, M., Ernst, M., Moller, F., Regensburger, D. (1998). Gene transfer into rat heart-derived endothelial cells. Eur J Cardiothor Surg 13, 460-6.
52. Havel, R.J. (1998). Receptor and non-receptor mediated uptake of chylomicron remnants by the liver. Atherosclerosis 141, S1-7.
53. Yu, L., Suh, H., Koh, J.J., Kim, S.W. (2001). Systemic administration of TerplexDNA system: pharmacokinetics and gene expression. Pharm Res 18, 1277-83.
54. Affleck, D.G., Yu, L., Bull, D.A., Bailey, S.H., Kim, S.W. (2001). Augmentation of myocardial transfection using TerplexDNA: a novel gene delivery system. Gene Ther 8, 349-53.
55. Han, S., Mahato, R.I., Kim, S.W. (2001). Water-soluble lipopolymer for gene delivery. Bioconjug Chem 12, 337-45.
56. Simons, K., Ikonen, E. (2000). How cells handle cholesterol. Science 290, 1721-6.
57. Gao, X., Huang, L. (1991). A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem Biophys Res Commun 179, 280-5.
58. Nabel, G.J., Nabel, E.G., Yang, Z,Y., Fox, B.A., Plautz, G.E, Gao, X., et al. (1993). Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci USA 90, 11307-11.
59. Gill, D.R., Southern, K.W., Mofford, K.A., Seddon, T., Huang, L., Sorgi, F., et al. (1997). A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis. Gene Ther 4, 199-209.
60. Lee, E.R., Marshall, J., Siegel, C.S., Jiang, C., Yew, N.S., Nichols, M.R., et al. (1996). Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung. Hum Gene Ther 7, 1701-17.
61. Mahato, R.I., Lee, M., Han, S., Maheshwari,A., Kim, S.W. (2001). Intratumoral delivery of p2CMVmIL-12 using water-soluble lipopolymers. Mol Ther 4, 130-8.
62. Katayose, S., Kataoka, K. (1997). Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer. Bioconjug Chem 8, 702-7.
63. Lee, H., Jeong, J.H., Park, T.G. (2002). PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low cytotoxicity. J Control Release 79, 283-91.
64. Hashida, M., Takemura, S., Nishikawa, M., Takakura, Y. (1998). Targeted delivery of plasmid DNA complexes with galactosylated poly(L-lysine). J Control Release 53, 301-10.
65. Wagner, E., Zenke, M., Cotton, M., Beug, H., Birnstiel, M.L. (1990). Trasferrin-polycation conjugates as carriers for DNA uptake into cells. Proc Natl Acad Sci USA 87, 3410-4.
66. Xu, B., Wiehie, S., Roth, J.A., Cristiano, R.J. (1998). The contribution of poly-L-lysine, epidermal growth factor and streptavidin to EGF/PLL/DNA polyplex formation. Gene Ther 5, 1235-43
67. Vinogradov, S.V., Bronich, T.K., Kabanov, A.V. (1998). Self-assembly of polyamine-poly(ethylene glycol) copolymers with phosphorothioate oligonucleotides. Bioconjug Chem 9, 805-12.
68. Wojda, U., Goldsmith, P., Miller, J.L. (1999). Surface membrane biotinylation efficiently mediates the endocytosis of avidin bioconjugates into nucleated cells. Bioconjug Chem 10, 1044-50.
69. Erbacher, P., Remy, J.S., Behr, J.P. (1999). Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther 6, 138-45.
70. Kircheis, R., Schuller, S., Brunner, S., Ogris, M., Heider, K.H., Zauner, W., Wagner, E. (1999). Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. J Gene Med 1, 111-20.