Gallstone disease

Journal of Internal Medicine

Volumn 261, Issue 6, 2007, Pages 529-542

  Marschall, H U ^a   Einarsson, C ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Gastroenterology; Hepatology

Indexed keywords

ABC TRANSPORTER A1; ACETYLSALICYLIC ACID; BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CLOFIBRATE; CONTRACEPTIVE AGENT; DEOXYCHOLIC ACID; ESTROGEN; FIBRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; OCTREOTIDE; ORGANIC ANION TRANSPORTER; TERT BUTYL METHYL ETHER; URSODEOXYCHOLIC ACID;

ACROMEGALY; AGING; BILE ACID SYNTHESIS; BILE DUCT STONE; CANCER PREVENTION; CHOLANGITIS; CHOLECYSTECTOMY; CHOLECYSTITIS; CHOLESTEROL METABOLISM; CHOLESTEROL STONE; CHOLESTEROL SYNTHESIS; DIAGNOSTIC PROCEDURE; DOG; DYSLIPIDEMIA; ENDOSCOPIC ECHOGRAPHY; ENDOSCOPIC PAPILLOTOMY; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; EXPERIMENTAL MOUSE; GALLBLADDER CANCER; GALLBLADDER CONTRACTION; GALLSTONE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HEREDITY; HUMAN; LIFESTYLE MODIFICATION; LIPID LIVER LEVEL; LIPID METABOLISM; LIPID TRANSPORT; MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY; NONHUMAN; PANCREATITIS; PATHOGENESIS; PATHOPHYSIOLOGY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEX RATIO; SURGICAL TECHNIQUE;

ADULT; CHOLESTASIS; CHOLESTEROL; DIETARY FATS; FEMALE; GALLBLADDER; GALLSTONES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIPID METABOLISM; RISK FACTORS;

EID: 34249701327     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2007.01783.x     Document Type: Review

References (187)

1. Kratzer W, Mason RA, Kachele V. Prevalence of gallstones in sonographic surveys worldwide. J Clin Ultrasound 1999 27 : 1 7.
2. Everhart JE, Khare M, Hill M, Maurer KR. Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterology 1999 117 : 632 9.
3. Sampliner RE, Bennett PH, Comess LJ, Rose FA, Burch TA. Gallbladder disease in pima Indians. Demonstration of high prevalence and early onset by cholecystography. N Engl J Med 1970 283 : 1358 64.
4. Everhart JE, Yeh F, Lee ET et al. Prevalence of gallbladder disease in American Indian populations: findings from the Strong Heart Study. Hepatology 2002 35 : 1507 12.
5. Attili AF, Carulli N, Roda E et al. Epidemiology of gallstone disease in Italy: prevalence data of the Multicenter Italian Study on Cholelithiasis (M.I.COL.). Am J Epidemiol 1995 141 : 158 65.
6. Heaton KW, Braddon FE, Mountford RA, Hughes AO, Emmett PM. Symptomatic and silent gall stones in the community. Gut 1991 32 : 316 20.
7. Friedman GD, Raviola CA, Fireman B. Prognosis of gallstones with mild or no symptoms: 25 years of follow-up in a health maintenance organization. J Clin Epidemiol 1989 42 : 127 36.
8. Russo MW, Wei JT, Thiny MT et al. Digestive and liver diseases statistics, 2004. Gastroenterology 2004 126 : 1448 53.
9. Sandler RS, Everhart JE, Donowitz M et al. The burden of selected digestive diseases in the United States. Gastroenterology 2002 122 : 1500 11.
10. Attili AF, Capocaccia R, Carulli N et al. Factors associated with gallstone disease in the MICOL experience. Multicenter Italian Study on Epidemiology of Cholelithiasis. Hepatology 1997 26 : 809 18.
11. Stampfer MJ, Maclure KM, Colditz GA, Manson JE, Willett WC. Risk of symptomatic gallstones in women with severe obesity. Am J Clin Nutr 1992 55 : 652 8.
12. Amaral JF, Thompson WR. Gallbladder disease in the morbidly obese. Am J Surg 1985 149 : 551 7.
13. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005 365 : 1415 28.
14. Ahlberg J, Angelin B, Einarsson K, Hellstrom K, Leijd B. Prevalence of gallbladder disease in hyperlipoproteinemia. Dig Dis Sci 1979 24 : 459 64.
15. Einarsson K, Hellstrom K, Kallner M. Gallbladder disease in hyperlipoproteinaemia. Lancet 1975 1 : 484 7.
16. Einarsson K, Hellstrom K, Kallner M. Bile acid kinetics in relation to sex, serum lipids, body weights, and gallbladder disease in patients with various types of hyperlipoproteinemia. J Clin Invest 1974 54 : 1301 11.
17. Nervi F, Miquel JF, Alvarez M et al. Gallbladder disease is associated with insulin resistance in a high risk Hispanic population. J Hepatol 2006 45 : 299 305.
18. Scragg RK, Calvert GD, Oliver JR. Plasma lipids and insulin in gall stone disease: a case-control study. Br Med J (Clin Res Ed) 1984 289 : 521 5.
19. Grundy SM. Cholesterol gallstones: a fellow traveler with metabolic syndrome? Am J Clin Nutr 2004 80 : 1 2.
20. Scragg RK, McMichael AJ, Seamark RF. Oral contraceptives, pregnancy, and endogenous oestrogen in gall stone disease-a case-control study. Br Med J (Clin Res Ed) 1984 288 : 1795 9.
21. Henriksson P, Einarsson K, Eriksson A, Kelter U, Angelin B. Estrogen-induced gallstone formation in males. Relation to changes in serum and biliary lipids during hormonal treatment of prostatic carcinoma. J Clin Invest 1989 84 : 811 6.
22. Angelin B, Olivecrona H, Reihner E et al. Hepatic cholesterol metabolism in estrogen-treated men. Gastroenterology 1992 103 : 1657 63.
23. Lee DW, Gilmore CJ, Bonorris G et al. Effect of dietary cholesterol on biliary lipids in patients with gallstones and normal subjects. Am J Clin Nutr 1985 42 : 414 20.
24. Scragg RK, McMichael AJ, Baghurst PA. Diet, alcohol, and relative weight in gall stone disease: a case-control study. Br Med J (Clin Res Ed) 1984 288 : 1113 9.
25. Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Glycemic load, glycemic index, and carbohydrate intake in relation to risk of cholecystectomy in women. Gastroenterology 2005 129 : 105 12.
26. Nervi F, Covarrubias C, Bravo P et al. Influence of legume intake on biliary lipids and cholesterol saturation in young Chilean men. Identification of a dietary risk factor for cholesterol gallstone formation in a highly prevalent area. Gastroenterology 1989 96 : 825 30.
27. Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. The effect of long-term intake of cis unsaturated fats on the risk for gallstone disease in men: a prospective cohort study. Ann Intern Med 2004 141 : 514 22.
28. Leitzmann MF, Willett WC, Rimm EB et al. A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men. JAMA 1999 281 : 2106 12.
29. Leitzmann MF, Giovannucci EL, Stampfer MJ et al. Prospective study of alcohol consumption patterns in relation to symptomatic gallstone disease in men. Alcohol Clin Exp Res 1999 23 : 835 41.
30. Leitzmann MF, Giovannucci EL, Rimm EB et al. The relation of physical activity to risk for symptomatic gallstone disease in men. Ann Intern Med 1998 128 : 417 25.
31. Leitzmann MF, Rimm EB, Willett WC et al. Recreational physical activity and the risk of cholecystectomy in women. N Engl J Med 1999 341 : 777 84.
32. Liddle RA, Goldstein RB, Saxton J. Gallstone formation during weight-reduction dieting. Arch Intern Med 1989 149 : 1750 3.
33. Gustafsson U, Benthin L, Granstrom L, Groen AK, Sahlin S, Einarsson C. Changes in gallbladder bile composition and crystal detection time in morbidly obese subjects after bariatric surgery. Hepatology 2005 41 : 1322 8.
34. Syngal S, Coakley EH, Willett WC, Byers T, Williamson DF, Colditz GA. Long-term weight patterns and risk for cholecystectomy in women. Ann Intern Med 1999 130 : 471 7.
35. Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Weight cycling and risk of gallstone disease in men. Arch Intern Med 2006 166 : 2369 74.
36. Weinsier RL, Wilson LJ, Lee J. Medically safe rate of weight loss for the treatment of obesity: a guideline based on risk of gallstone formation. Am J Med 1995 98 : 115 7.
37. Angelin B, Einarsson K, Leijd B. Clofibrate treatment and bile cholesterol saturation: short-term and long-term effects and influence of combination with chenodeoxycholic acid. Eur J Clin Invest 1981 11 : 185 9.
38. Angelin B, Einarsson K, Leijd B, Biliary lipid composition during treatment with different hypolipidaemic drugs. Eur J Clin Invest 1979 9 : 185 90.
39. Grundy SM, Vega GL. Fibric acids: effects on lipids and lipoprotein metabolism. Am J Med 1987 83 : 9 20.
40. Carey MC, Lamont JT. Cholesterol gallstone formation. 1. Physical-chemistry of bile and biliary lipid secretion. Prog Liver Dis 1992 10 : 139 63.
41. Smit JJ, Schinkel AH, Oude Elferink RP et al. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993 75 : 451 62.
42. de Vree JM, Jacquemin E, Sturm E et al. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci U S A 1998 95 : 282 7.
43. Jacquemin E, De Vree JM, Cresteil D et al. The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood. Gastroenterology 2001 120 : 1448 58.
44. Rosmorduc O, Hermelin B, Poupon R. MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. Gastroenterology 2001 120 : 1459 67.
45. Jacquemin E, Cresteil D, Manouvrier S, Boute O, Hadchouel M. Heterozygous nonsense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. Lancet 1999 353 : 210 1.
46. Wasmuth HE, Glantz A, Keppeler H et al. Intrahepatic cholestasis of pregnancy: the severe form is associated with common variants of the hepatobiliary phospholipid transporter gene ABCB4. Gut 2006 4 Aug; [Epub ahead of print].
47. Gerloff T, Stieger B, Hagenbuch B et al. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 1998 273 : 10046 50.
48. Strautnieks SS, Bull LN, Knisely AS et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet 1998 20 : 233 8.
49. van Mil SW, van der Woerd WL, van der Brugge G et al. Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. Gastroenterology 2004 127 : 379 84.
50. Yu L, Hammer RE, Li-Hawkins J et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A 2002 99 : 16237 42.
51. Berge KE, Tian H, Graf GA et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 2000 290 : 1771 5.
52. Lu TT, Repa JJ, Mangelsdorf DJ. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem 2001 276 : 37735 8.
53. Zollner G, Marschall HU, Wagner M, Trauner M. Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharm 2006 3 : 231 51.
54. Makishima M, Okamoto AY, Repa JJ et al. Identification of a nuclear receptor for bile acids. Science 1999 284 : 1362 5.
55. Parks DJ, Blanchard SG, Bledsoe RK et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 1999 284 : 1365 8.
56. Wang H, Chen J, Hollister K, Sowers LC, Forman BM. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999 3 : 543 53.
57. Lu TT, Makishima M, Repa JJ et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 2000 6 : 507 15.
58. Huang L, Zhao A, Lew JL et al. Farnesoid X receptor activates transcription of the phospholipid pump MDR3. J Biol Chem 2003 278 : 51085 90.
59. Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 2001 276 : 28857 65.
60. Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem 2002 277 : 18793 800.
61. Wang J, Einarsson C, Murphy C et al. Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice. J Lipid Res 2006 47 : 421 30.
62. van Erpecum KJ. Biliary lipids, water and cholesterol gallstones. Biol Cell 2005 97 : 815 22.
63. Hyde SC, Emsley P, Hartshorn MJ et al. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature 1990 346 : 362 5.
64. Cutting GR, Kasch LM, Rosenstein BJ et al. A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein. Nature 1990 346 : 366 9.
65. Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 1996 271 : 518 20.
66. Brown MS, Goldstein JL A receptor-mediated pathway for cholesterol homeostasis. Science 1986 232 : 34 47.
67. Yokoyama C, Wang X, Briggs MR et al. SREBP-1, a basic-helix-loop-helix- leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 1993 75 : 187 97.
68. Beisiegel U, Weber W, Ihrke G, Herz J, Stanley KK. The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature 1989 341 : 162 4.
69. Repa JJ, Turley SD, Lobaccaro JA et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 2000 289 : 1524 9.
70. Altmann SW, Davis HR Jr., Zhu LJ et al. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 2004 303 : 1201 4.
71. Lammert F, Wang DQ. New insights into the genetic regulation of intestinal cholesterol absorption. Gastroenterology 2005 129 : 718 34.
72. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 2003 83 : 633 71.
73. Paumgartner G, Sauerbruch T. Gallstones: pathogenesis. Lancet 1991 338 : 1117 21.
74. Angelico M, Gandin C, Canuzzi P et al. Gallstones in cystic fibrosis: a critical reappraisal. Hepatology 1991 14 : 768 75.
75. Vitek L, Carey MC. Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life. Eur J Clin Invest 2003 33 : 799 810.
76. Lapidus A, Einarsson C. Bile composition in patients with ileal resection due to Crohn's disease. Inflamm Bowel Dis 1998 4 : 89 94.
77. Brink MA, Slors JF, Keulemans YC et al. Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in ileal Crohn's disease. Gastroenterology 1999 116 : 1420 7.
78. Pereira SP, Bain IM, Kumar D, Dowling RH. Bile composition in inflammatory bowel disease: ileal disease and colectomy, but not colitis, induce lithogenic bile. Aliment Pharmacol Ther 2003 17 : 923 33.
79. Lapidus A, Akerlund JE, Einarsson C. Gallbladder bile composition in patients with Crohn's disease. World J Gastroenterol 2006 12 : 70 4.
80. Akerlund JE, Reihner E, Angelin B et al. Hepatic metabolism of cholesterol in Crohn's disease. Effect of partial resection of ileum. Gastroenterology 1991 100 : 1046 53.
81. Ahlberg J, Curstedt T, Einarsson K, Sjovall J, Molecular species of biliary phosphatidylcholines in gallstone patients: the influence of treatment with cholic acid and chenodeoxycholic acid. J Lipid Res 1981 22 : 404 9.
82. Admirand WH, Small DM. The physicochemical basis of cholesterol gallstone formation in man. J Clin Invest 1968 47 : 1043 52.
83. Carey MC. Critical tables for calculating the cholesterol saturation of native bile. J Lipid Res 1978 19 : 945 55.
84. Wang DQ, Carey MC. Characterization of crystallization pathways during cholesterol precipitation from human gallbladder biles: identical pathways to corresponding model biles with three predominating sequences. J Lipid Res 1996 37 : 2539 49.
85. Wang DQ, Carey MC. Complete mapping of crystallization pathways during cholesterol precipitation from model bile: influence of physical-chemical variables of pathophysiologic relevance and identification of a stable liquid crystalline state in cold, dilute and hydrophilic bile salt-containing systems. J Lipid Res 1996 37 : 606 30.
86. Nilsell K, Angelin B, Liljeqvist L, Einarsson K. Biliary lipid output and bile acid kinetics in cholesterol gallstone disease. Evidence for an increased hepatic secretion of cholesterol in Swedish patients. Gastroenterology 1985 89 : 287 93.
87. Einarsson K, Nilsell K, Leijd B, Angelin B. Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N Engl J Med 1985 313 : 277 82.
88. Schwartz CC, Berman M, Vlahcevic ZR, Swell L. Multicompartmental analysis of cholesterol metabolism in man. Quantitative kinetic evaluation of precursor sources and turnover of high density lipoprotein cholesterol esters. J Clin Invest 1982 70 : 863 76.
89. Kern F Jr. Effects of dietary cholesterol on cholesterol and bile acid homeostasis in patients with cholesterol gallstones. J Clin Invest 1994 93 : 1186 94.
90. Carey MC. Homing-in on the origin of biliary steroids. Gut 1997 41 : 721 2.
91. Ahlberg J, Angelin B, Bjorkhem I, Einarsson K, Leijd B. Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones. J Lipid Res 1979 20 : 107 15.
92. Reihner E, Angelin B, Bjorkhem I, Einarsson K. Hepatic cholesterol metabolism in cholesterol gallstone disease. J Lipid Res 1991 32 : 469 75.
93. Stahlberg D, Rudling M, Angelin B et al. Hepatic cholesterol metabolism in human obesity. Hepatology 1997 25 : 1447 50.
94. Rudling M, Angelin B, Stahle L et al. Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver. J Clin Endocrinol Metab 2002 87 : 4307 13.
95. Galman C, Miquel JF, Perez RM et al. Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians. Gastroenterology 2004 126 : 741 8.
96. Heaton KW, Emmett PM, Symes CL, Braddon FE. An explanation for gallstones in normal-weight women: slow intestinal transit. Lancet 1993 341 : 8 10.
97. Shoda J, He BF, Tanaka N et al. Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease and its correlation with de novo syntheses of cholesterol and bile acids in liver, gallbladder emptying, and small intestinal transit. Hepatology 1995 21 : 1291 302.
98. Berr F, Kullak-Ublick GA, Paumgartner G, Munzing W, Hylemon PB. 7 alpha-dehydroxylating bacteria enhance deoxycholic acid input and cholesterol saturation of bile in patients with gallstones. Gastroenterology 1996 111 : 1611 20.
99. Gustafsson U, Sahlin S, Einarsson C. Biliary lipid composition in patients with cholesterol and pigment gallstones and gallstone-free subjects: deoxycholic acid does not contribute to formation of cholesterol gallstones. Eur J Clin Invest 2000 30 : 1099 106.
100. Gustafsson U, Sahlin S, Einarsson C. High level of deoxycholic acid in human bile does not promote cholesterol gallstone formation. World J Gastroenterol 2003 9 : 1576 9.
101. Holzbach RT, Marsh M, Olszewski M, Holan K. Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man. J Clin Invest 1973 52 : 1467 79.
102. Stolk MF, Van Erpecum KJ, Peeters TL et al. Interdigestive gallbladder emptying, antroduodenal motility, and motilin release patterns are altered in cholesterol gallstone patients. Dig Dis Sci 2001 46 : 1328 34.
103. Stolk MF, van Erpecum KJ, Renooij W, Portincasa P, van de Heijning BJ, vanBerge-Henegouwen GP. Gallbladder emptying in vivo, bile composition, and nucleation of cholesterol crystals in patients with cholesterol gallstones. Gastroenterology 1995 108 : 1882 8.
104. van Erpecum KJ, Venneman NG, Portincasa P, Vanberge-Henegouwen GP. Review article: agents affecting gall-bladder motility-role in treatment and prevention of gallstones. Aliment Pharmacol Ther 2000 14 (Suppl. 2 66 70.
105. Colecchia A, Sandri L, Bacchi-Reggiani ML et al. Is it possible to predict the clinical course of gallstone disease? Usefulness of gallbladder motility evaluation in a clinical setting. Am J Gastroenterol 2006 101 : 2576 81.
106. Moschetta A, Stolk MF, Rehfeld JF et al. Severe impairment of postprandial cholecystokinin release and gall-bladder emptying and high risk of gallstone formation in acromegalic patients during Sandostatin LAR. Aliment Pharmacol Ther 2001 15 : 181 5.
107. Thomas LA, Veysey MJ, Bathgate T et al. Mechanism for the transit-induced increase in colonic deoxycholic acid formation in cholesterol cholelithiasis. Gastroenterology 2000 119 : 806 15.
108. Thomas LA, Veysey MJ, Murphy GM et al. Octreotide induced prolongation of colonic transit increases faecal anaerobic bacteria, bile acid metabolising enzymes, and serum deoxycholic acid in patients with acromegaly. Gut 2005 54 : 630 5.
109. Sitzmann JV, Pitt HA, Steinborn PA, Pasha ZR, Sanders RC. Cholecystokinin prevents parenteral nutrition induced biliary sludge in humans. Surg Gynecol Obstet 1990 170 : 25 31.
110. Gebhard RL, Prigge WF, Ansel HJ et al. The role of gallbladder emptying in gallstone formation during diet-induced rapid weight loss. Hepatology 1996 24 : 544 8.
111. Inagaki T, Choi M, Moschetta A et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005 2 : 217 25.
112. Choi M, Moschetta A, Bookout AL et al. Identification of a hormonal basis for gallbladder filling. Nat Med 2006 12 : 1253 5.
113. Lee SP, LaMont JT, Carey MC. Role of gallbladder mucus hypersecretion in the evolution of cholesterol gallstones. J Clin Invest 1981 67 : 1712 23.
114. Lee SP, Nicholls JF. Nature and composition of biliary sludge. Gastroenterology 1986 90 : 677 86.
115. Ko CW, Schulte SJ, Lee SP. Biliary sludge is formed by modification of hepatic bile by the gallbladder mucosa. Clin Gastroenterol Hepatol 2005 3 : 672 8.
116. Holzbach RT, Kibe A, Thiel E, Howell JH, Marsh M, Hermann RE. Biliary proteins. Unique inhibitors of cholesterol crystal nucleation in human gallbladder bile. J Clin Invest 1984 73 : 35 45.
117. Busch N, Lammert F, Marschall HU, Matern S. A new subgroup of lectin-bound biliary proteins binds to cholesterol crystals, modifies crystal morphology, and inhibits cholesterol crystallization. J Clin Invest 1995 96 : 3009 15.
118. Busch N, Lammert F, Matern S. Biliary secretory immunoglobulin A is a major constituent of the new group of cholesterol crystal-binding proteins. Gastroenterology 1998 115 : 129 38.
119. Sahlin S, Danielsson A, Angelin B, Reihner E, Henriksson R, Einarsson K. Mucin in gall bladder bile of gall stone patients: influence of treatment with chenodeoxycholic acid and ursodeoxycholic acid. Gut 1988 29 : 1506 10.
120. Miquel JF, Nunez L, Amigo L et al. Cholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile. Gastroenterology 1998 114 : 1016 23.
121. Sahlin S, Ahlberg J, Einarsson K, Henriksson R, Danielsson A. Quantitative ultrastructural studies of gall bladder epithelium in gall stone free subjects and patients with gall stones. Gut 1990 31 : 100 5.
122. Sahlin S, Glauman H, Danielsson A, Einarsson K. Lysosomal enzyme activities in gallbladder mucosa of gallstone-free subjects and patients with gallstones. J Hepatol 1996 25 : 895 9.
123. Maurer KJ, Ihrig MM, Rogers AB et al. Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation. Gastroenterology 2005 128 : 1023 33.
124. Maurer KJ, Rogers AB, Ge Z, Wiese AJ, Carey MC, Fox JG. Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study. Am J Physiol Gastrointest Liver Physiol 2006 290 : G175 82.
125. Fox JG, Dewhirst FE, Shen Z et al. Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis. Gastroenterology 1998 114 : 755 63.
126. Nilsson I, Shabo I, Svanvik J, Monstein HJ. Multiple displacement amplification of isolated DNA from human gallstones: molecular identification of Helicobacter DNA by means of 16S rDNA-based pyrosequencing analysis. Helicobacter 2005 10 : 592 600.
127. Chen W, Li D, Cannan RJ, Stubbs RS. Common presence of Helicobacter DNA in the gallbladder of patients with gallstone diseases and controls. Dig Liver Dis 2003 35 : 237 43.
128. Fallone CA, Tran S, Semret M, Discepola F, Behr M, Barkun AN. Helicobacter DNA in bile: correlation with hepato-biliary diseases. Aliment Pharmacol Ther 2003 17 : 453 8.
129. Nilsson HO, Pietroiusti A, Gabrielli M, Zocco MA, Gasbarrini G, Gasbarrini A. Helicobacter pylori and extragastric diseases - other Helicobacters. Helicobacter 2005 10 (Suppl. 1 54 65.
130. Lammert F, Matern S. The genetic background of cholesterol gallstone formation: an inventory of human lithogenic genes. Curr Drug Targets Immune Endocr Metabol Disord 2005 5 : 163 70.
131. Gilat T, Feldman C, Halpern Z, Dan M, Bar-Meir S. An increased familial frequency of gallstones. Gastroenterology 1983 84 : 242 6.
132. van der Linden W. Genetic factors in gallstone disease. Clin Gastroenterol 1973 2 : 603 14.
133. van der Linden W, Simonson N. Familial occurrence of gallstone disease. Incidence in parents of young patients. Hum Hered 1973 23 : 123 7.
134. Duggirala R, Mitchell BD, Blangero J, Stern MP. Genetic determinants of variation in gallbladder disease in the Mexican-American population. Genet Epidemiol 1999 16 : 191 204.
135. Nakeeb A, Comuzzie AG, Martin L et al. Gallstones: genetics versus environment. Ann Surg 2002 235 : 842 9.
136. Attili AF, De Santis A, Attili F, Roda E, Festi D, Carulli N. Prevalence of gallstone disease in first-degree relatives of patients with cholelithiasis. World J Gastroenterol 2005 11 : 6508 11.
137. Sarin SK, Negi VS, Dewan R, Sasan S, Saraya A. High familial prevalence of gallstones in the first-degree relatives of gallstone patients. Hepatology 1995 22 : 138 41.
138. Miquel JF, Covarrubias C, Villaroel L et al. Genetic epidemiology of cholesterol cholelithiasis among Chilean Hispanics, Amerindians, and Maoris. Gastroenterology 1998 115 : 937 46.
139. Mendez-Sanchez N, King-Martinez AC, Ramos MH, Pichardo-Bahena R, Uribe M. The Amerindian's genes in the Mexican population are associated with development of gallstone disease. Am J Gastroenterol 2004 99 : 2166 70.
140. Kesaniemi YA, Koskenvuo M, Vuoristo M, Miettinen TA. Biliary lipid composition in monozygotic and dizygotic pairs of twins. Gut 1989 30 : 1750 6.
141. Katsika D, Grjibovski A, Einarsson C, Lammert F, Lichtenstein P, Marschall HU. Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43, 141 twin pairs. Hepatology 2005 41 : 1138 43.
142. Pullinger CR, Eng C, Salen G et al. Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest 2002 110 : 109 17.
143. Rosmorduc O, Hermelin B, Boelle PY, Parc R, Taboury J, Poupon R. ABCB4 gene mutation-associated cholelithiasis in adults. Gastroenterology 2003 125 : 452 9.
144. Lammert F, Wang DQ, Hillebrandt S et al. Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: a model for low phospholipid-associated cholelithiasis. Hepatology 2004 39 : 117 28.
145. Fickert P, Fuchsbichler A, Wagner M et al. Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 2004 127 : 261 74.
146. Fickert P, Zollner G, Fuchsbichler A et al. Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles. Gastroenterology 2002 123 : 1238 51.
147. Khanuja B, Cheah YC, Hunt M et al. Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc Natl Acad Sci U S A 1995 92 : 7729 33.
148. Paigen B, Schork NJ, Svenson KL et al. Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice. Physiol Genomics 2000 4 : 59 65.
149. Wittenburg H, Lyons MA, Paigen B, Carey MC. Mapping cholesterol gallstone susceptibility (Lith) genes in inbred mice. Dig Liver Dis 2003 35 (Suppl. 3 S2 7.
150. Lammert F, Carey MC, Paigen B. Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map. Gastroenterology 2001 120 : 221 38.
151. Wang DQ, Lammert F, Paigen B, Carey MC. Phenotypic characterization of lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice. Pathophysiology Of biliary lipid secretion. J Lipid Res 1999 40 : 2066 79.
152. Wang DQ, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile. J Lipid Res 1997 38 : 1395 411.
153. Lammert F, Wang DQ, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes. J Lipid Res 1999 40 : 2080 90.
154. van Erpecum KJ, Wang DQ, Lammert F, Paigen B, Groen AK, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: soluble pronucleating proteins in gallbladder and hepatic biles. J Hepatol 2001 35 : 444 51.
155. Lammert F, Wang DQ, Wittenburg H et al. Lith genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred mice. Hepatology 2002 36 : 1145 54.
156. Lyons MA, Wittenburg H, Li R et al. Lith6: a new QTL for cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strains. J Lipid Res 2003 44 : 1763 71.
157. Wittenburg H, Lyons MA, Li R, Churchill GA, Carey MC, Paigen B. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology 2003 125 : 868 81.
158. Lyons MA, Wittenburg H. Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human lith genes. Gastroenterology 2006 131 : 1943 70.
159. Lyons MA, Wittenburg H. Susceptibility to cholesterol gallstone formation: evidence that LITH genes also encode immune-related factors. Biochim Biophys Acta 2006 1761 : 1133 47.
160. Lammert F, Sauerbruch T. Mechanisms of disease: the genetic epidemiology of gallbladder stones. Nat Clin Pract Gastroenterol Hepatol 2005 2 : 423 33.
161. Puppala S, Dodd GD, Fowler S et al. A genomewide search finds major susceptibility loci for gallbladder disease on chromosome 1 in Mexican Americans. Am J Hum Genet 2006 78 : 377 92.
162. Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol Clin North Am 1991 20 : 1 19.
163. Leopold GR, Amberg J, Gosink BB, Mittelstaedt C. Gray scale ultrasonic cholecystography: a comparison with conventional radiographic techniques. Radiology 1976 121 : 445 8.
164. A prospective analysis of 1518 laparoscopic cholecystectomies. The Southern Surgeons Club. N Engl J Med 1991 324 : 1073 8.
165. Shea JA, Healey MJ, Berlin JA et al. Mortality and complications associated with laparoscopic cholecystectomy. A meta-analysis. Ann Surg 1996 224 : 609 20.
166. Keus F, de Jong JA, Gooszen HG, van Laarhoven CJ. Laparoscopic versus open cholecystectomy for patients with symptomatic cholecystolithiasis. Cochrane Database Syst Rev 2006 CD006231.
167. Keus F, de Jong JA, Gooszen HG, van Laarhoven CJ. Laparoscopic versus small-incision cholecystectomy for patients with symptomatic cholecystolithiasis. Cochrane Database Syst Rev 2006 CD006229.
168. Keus F, de Jong JA, Gooszen HG, van Laarhoven CJ. Small-incision versus open cholecystectomy for patients with symptomatic cholecystolithiasis. Cochrane Database Syst Rev 2006 CD004788.
169. Danzinger RG, Hofmann AF, Schoenfield LJ, Thistle JL. Dissolution of cholesterol gallstones by chenodeoxycholic acid. N Engl J Med 1972 286 : 1 8.
170. Nakagawa S, Makino I, Ishizaki T, Dohi I. Dissolution of cholesterol gallstones by ursodeoxycholic acid. Lancet 1977 2 : 367 9.
171. Petroni ML, Jazrawi RP, Pazzi P et al. Ursodeoxycholic acid alone or with chenodeoxycholic acid for dissolution of cholesterol gallstones: a randomized multicentre trial. The British-Italian Gallstone Study group. Aliment Pharmacol Ther 2001 15 : 123 8.
172. Villanova N, Bazzoli F, Taroni F et al. Gallstone recurrence after successful oral bile acid treatment. A 12-year follow-up study and evaluation of long-term postdissolution treatment. Gastroenterology 1989 97 : 726 31.
173. Sauerbruch T, Delius M, Paumgartner G et al. Fragmentation of gallstones by extracorporeal shock waves. N Engl J Med 1986 314 : 818 22.
174. Sackmann M, Niller H, Klueppelberg U et al. Gallstone recurrence after shock-wave therapy. Gastroenterology 1994 106 : 225 30.
175. Allen MJ, Borody TJ, Bugliosi TF, May GR, LaRusso NF, Thistle JL. Rapid dissolution of gallstones by methyl tert-butyl ether. Preliminary observations. N Engl J Med 1985 312 : 217 20.
176. Hellstern A, Leuschner U, Benjaminov A et al. Dissolution of gallbladder stones with methyl tert-butyl ether and stone recurrence: a European survey. Dig Dis Sci 1998 43 : 911 20.
177. Gurusamy KS, Samraj K. Early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Cochrane Database Syst Rev 2006 CD005440.
178. Sivak MV Jr. Endoscopic management of bile duct stones. Am J Surg 1989 158 : 228 40.
179. Tewari M. Contribution of silent gallstones in gallbladder cancer. J Surg Oncol 2006 93 : 629 32.
180. Evans WB, Draganov P. Is empiric cholecystectomy a reasonable treatment option for idiopathic acute pancreatitis? Nat Clin Pract Gastroenterol Hepatol 2006 3 : 356 7.
181. Lee SP, Nicholls JF, Park HZ. Biliary sludge as a cause of acute pancreatitis. N Engl J Med 1992 326 : 589 93.
182. Mendez-Sanchez N, Zamora-Valdes D, Chavez-Tapia NC, Uribe M. Role of diet in cholesterol gallstone formation. Clin Chim Acta 2007 376 : 1 8.
183. Broomfield PH, Chopra R, Sheinbaum RC et al. Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and gallstones during loss of weight. N Engl J Med 1988 319 : 1567 72.
184. Sugerman HJ, Brewer WH, Shiffman ML et al. A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss. Am J Surg 1995 169 : 91 6 discussion 6-7.
185. Lee SP, Carey MC, LaMont JT. Aspirin prevention of cholesterol gallstone formation in prairie dogs. Science 1981 211 : 1429 31.
186. Portincasa P, Moschetta A, Palasciano G. Cholesterol gallstone disease. Lancet 2006 368 : 230 9.
187. Moschetta A, Bookout AL, Mangelsdorf DJ. Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med 2004 10 : 1352 8.