MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis

Gastroenterology

Volumn 120, Issue 6, 2001, Pages 1459-1467

  Rosmorduc, Olivier ^a   Hermelin, Brigitte ^a   Poupon, Raoul ^a  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MULTIDRUG RESISTANCE PROTEIN; RNA; URSODEOXYCHOLIC ACID;

ADULT; ARTICLE; BILIARY COLIC; CHOLANGITIS; CHOLECYSTECTOMY; CHOLELITHIASIS; CHOLESTASIS; CHOLESTEROL STONE; CLINICAL ARTICLE; CLINICAL FEATURE; DISEASE ASSOCIATION; FEMALE; GALLSTONE; GENE SEQUENCE; HUMAN; MALE; PANCREATITIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0035053975     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.23947     Document Type: Article

References (38)

1. Cholesterol gallstone formation. 2. Pathobiology and pathomechanics
2. Nature and composition of biliary sludge
3. Phosphatidylcholine translocase: A physiological role for the mdr2 gene
4. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
5. Uncoupling of biliary phospholipid and cholesterol secretion in mice with reduced expression of mdr2 P-glycoprotein
6. Biliary sludge: Curiosity or culprit?
7. Prognosis of gallstones with mild or no symptoms: 25 Years of follow-up in a health maintenance organization
8. The natural history of silent gallstones: The innocent gallstone is not a myth
9. Natural history of asymptomatic and symptomatic gallstones
10. What is the risk of biliary pancreatitis in patients with gallstones?
11. Rapid formation of cholesterol crystals in gallbladder bile is associated with stone recurrence after laparoscopic cholecystotomy
12. Gallstone recurrence after shock-wave therapy
13. Acute suppurative cholangitis associated with choledochal sludge
14. Biliary sludge as a cause of acute pancreatitis
15. Occult microlithiasis in "idiopathic" acute pancreatitis: Prevention of relapses by cholecystectomy or ursodeoxycholic acid therapy
16. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
17. Critical tables for calculating the cholesterol saturation of native bile
18. Alagille syndrome is caused by mutations in human Jagged 1, which encodes a ligand for Notch 1
19. Mutational analysis of the P-glycoprotein first intracellular loop and flanking transmembrane domains
20. Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning
21. Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: Evidence for a defect in protein trafficking
22. Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy
23. Genetic basis of progressive familial intrahepatic cholestasis
24. Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis
25. MDR3 deficiency in patients with progressive familial intrahepatic cholestasis with high serum gamma-glutamyl transferase
26. Ursodoxycholic acid therapy in pediatric patients with progressive familial intrahepatic chotestasis
27. Role of biliary phosphatidylcholine in bile acid protection and NSAID injury of the ileal mucosa in rats
28. The liver in pregnancy
29. Biliary secretion of bile acids and lipids in primary sclerosing cholangitis. Influence of cholestasis and effect of ursodeoxycholic acid treatment
30. Ursodeoxycholic acid therapy of chronic cholestasic conditions in adults and children
31. Ursodeoxycholic acid in cholestasis: Potential mechanisms of action and therapeutic applications
32. Effects of ursodesoxycholic acid in patients with intrahepatic cholestasis of pregnancy
33. Lithotripsy plus ursodiol is superior to ursodiol alone for cholesterol gallstones
34. Long-term ursodeoxychotic acid therapy is associated with reduced risk of biliary pain and acute cholecystitis in patients with gallbladder stones: A cohort analysis
35. High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1
36. In the genetic locus containing the second cholesterol gallstone gene Lith2, an Mrp2 polymorphism is linked to heightened secretion of organic anions
37. Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice
38. Phenotypic characterization of lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice. Pathophysiology of biliary lipid secretion