Lith genes control mucin accumulation, cholesterol crystallization, and gallstone formation in A/J and AKR/J inbred mice

Hepatology

Volumn 36, Issue 5 5 II, 2002, Pages 1145-1154

  Lammert, Frank ^a   Wang, David Q H ^b   Wittenburg, Henning ^b,c   Bouchard, Guylaine ^c   Hillebrandt, Sonja ^a   Taenzler, Bärbel ^a   Carey, Martin C ^b   Paigen, Beverly ^c  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; MUCIN;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL STONE; CHROMOSOME 15; CHROMOSOME 17; CONTROLLED STUDY; CRYSTALLIZATION; GALLSTONE FORMATION; GENE; GENE CONTROL; GENETIC SUSCEPTIBILITY; GENOTYPE PHENOTYPE CORRELATION; GLYCAM1 GENE; IMMUNOHISTOCHEMISTRY; INBRED STRAIN; LINKAGE ANALYSIS; LITH GENE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

EID: 0036829951     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2002.36821     Document Type: Article

References (38)

1. Lammert F, Carey MC, Paigen B. Chromosomal organization of candidate genes involved in cholesterol gallstone formation: A murine gallstone map. Gastroenterology 2001;120:221-238.
2. Paigen B, Schork NJ, Svenson KL, Cheah YC, Mu JL, Lammert F, Wang DQ-H, et al. Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice. Physiol Genomics 2000;4:59-65.
3. Wang DQ-H, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: Physical-chemistry of gallbladder bile. J Lipid Res 1997;38:1395-1411.
4. Wang DQ-H, Lammert F, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: Pathophysiology of biliary lipid secretion. J Lipid Res 1999;40:2066-2079.
5. Lammert F, Wang DQ-H, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: Integrated activities of hepatic lipid regulatory enzymes. J Lipid Res 1999;40:2080-2090.
6. Lander ES, Schork NJ. Genetic dissection of complex traits [Erratum in Science 1994;266:2353]. Science 1994;265:2037-2048.
7. Darvasi A. Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 1998;18:19-24.
8. Khanuja B, Cheah YC, Hunt M, Nishina PM, Wang DQ-H, Chen HW, Billheimer JT, et al. Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc Natl Acad Sci U S A 1995;92:7729-7733.
9. Carey MC. Critical tables for calculating the cholesterol saturation of native bile. J Lipid Res 1978;19:945-955.
10. Sambrook J, Russell DW. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2001.
11. Mu JL, Naggert JK, Svenson KL, Collin GB, Kim JH, McFarland C, Nishina PM, et al. Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57BLKS/J. J Lipid Res 1999;40:1328-1335.
12. Lander ES, Botstein D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps [Erratum in Genetics 1994;136:1705]. Genetics 1989;121:185-199.
13. Darvasi A, Soller M. Selective genotyping for determination of linkage between a marker locus and a quantitative trait. Theor Appl Genet 1992;85:353-359.
14. Silver LM. Mouse Genetics: Concepts and Applications. Oxford: Oxford University Press, 1995:1-362.
15. Manly KF, Olson JM. Overview of QTL mapping software and introduction to Map Manager QT. Mamm Genome 1999;10:327-334.
16. Haley CS, Knott SA. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 1992;69:315-324.
17. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 1994;138:963-971.
18. Dupuis J, Siegmund D. Statistical methods for mapping quantitative trait loci from a dense set of markers. Genetics 1999;151:373-386.
19. Lasky LA, Singer MS, Dowbenko D, Imai Y, Henzel WJ, Grimley C, Fennie C, et al. An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell 1992;69:927-938.
20. Stewart-Phillips JL, Lough J, Skamene E. Genetically determined susceptibility and resistance to diet-induced atherosclerosis in inbred strains of mice. J Lab Clin Med 1988;112:36-42.
21. Wang DQ-H, Carey MC. Complete mapping of crystallization pathways during cholesterol precipitation from model bile: Influence of physical-chemical variables of pathophysiologic relevance and identification of a stable liquid crystalline state in cold, dilute and hydrophilic bile salt-containing systems. J Lipid Res 1996;37:606-630.
22. Lander ES, Kruglyak L. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-247.
23. Koepsell H. Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol 1998;60:243-266.
24. Green RM, Lo K, Sterritt C, Beier DR. Cloning and functional expression of a mouse liver organic cation transporter. Hepatology 1999;29:1556-1562.
25. Zeisel SH, Da Costa KA, Franklin PD, Alexander EA, LaMont JT, Sheard NF, Beiser A. Choline, an essential nutrient for humans. FASEB J 1991;5:2093-2098.
26. Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA. Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk. J Clin Invest 1993;92:952-960.
27. Bouchard G, Johnson D, Carver T, Tovbina M, Carey MC, Paigen B. Multiple new murine models of cholesterol gallstones: The Jackson Laboratory-Brigham and Women's Hospital strain survey [Abstract]. Gastroenterology 2001;120:A77.
28. Nishina PM, Wang J, Toyofuku W, Kuypers FA, Ishida BY, Paigen B. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 1993;28:599-605.
29. Verhaagh S, Schweifer N, Barlow DP, Zwart R. Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Genomics 1999;55:209-218.
30. Mooslehner KA, Allen ND. Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus. Mamm Genome 1999;10:218-224.
31. LaMont JT, Carey MC. Cholesterol gallstone formation. 2. Pathobiology and pathomechanics. Prog Liver Dis 1992;10:165-191.
32. Ko CW, Lee SP. Gallstone formation. Local factors. Gastroenterol Clin North Am 1999;28:99-115.
33. Klinkspoor JH, Kuver R, Savard CE, Oda D, Azzouz H, Tytgat GN, Groen AK, et al. Model bile and bile salts accelerate mucin secretion by cultured dog gallbladder epithelial cells. Gastroenterology 1995;109:264-274.
34. Van Erpecum KJ, Wang DQ-H, Lammert F, Paigen B, Groen AK, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: Soluble pronucleating proteins in gallbladder and hepatic biles. J Hepatol 2001;35:444-451.
35. Chignard N, Mergey M, Veissire D, Parc R, Capeau J, Poupon R, Paul A, et al. Bile acid transport and regulating functions in the human biliary epithelium. Hepatology 2001;33:496-503.
36. Corfield AP, Myerscough N, Longman R, Sylvester P, Arul S, Pignatelli M. Mucins and mucosal protection in the gastrointestinal tract: New prospects for mucins in the pathology of gastrointestinal disease. Gut 2000;47:589-594.
37. Dowbenko D, Andalibi A, Young PE, Lusis AJ, Lasky LA. Structure and chromosomal localization of the murine gene encoding GLYCAM 1. A mucin-like endothelial ligand for L selectin. J Biol Chem 1993;268:4525-4529.
38. Nishimura T, Takeshita N, Satow H, Kohmoto K. Expression of the mC26 gene encoding GlyCAM-1 in the lactating mouse mammary gland. J Biochem 1993;114:567-569.