Synthesis and evaluation of homo-bivalent GnRHR ligands

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 14, 2007, Pages 4841-4856

  Bonger, Kimberly M ^a   van den Berg, Richard J B H N ^a   Heitman, Laura H ^a   IJzerman, Ad P ^a   Oosterom, Julia ^b   Timmers, Cornelis M ^b   Overkleeft, Herman S ^a   van der Marel, Gijsbert A ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NV ORGANON   (Netherlands)

Author keywords

Bivalent ligands; G protein coupled receptors; Gonadotropin releasing hormone receptor; Huisgen 1,3 cycloaddition; Imidazopyrimidinone

Indexed keywords

8 (2,6 DIFLUOROBENZYL) 5,8 DIHYDRO 2 (4 ETHYLAMINOCARBONYLAMINOPHENYL) 3 (N METHYL N BENZYLAMINOMETHYL) 5 OXOIMIDAZO[1,2 A]PYRIMIDINE 6 CARBOXYLIC ACID ETHYL ESTER; 8 (2,6 DIFLUOROBENZYL) 5,8 DIHYDRO 2 (4 ETHYLAMINOCARBONYLAMINOPHENYL) 3 (N METHYL N BENZYLAMINOMETHYL) 5 OXOIMIDAZO[1,2 A]PYRIMIDINE 6 CARBOXYLIC ACID PROPARGYL ESTER; 8 (2,6 DIFLUOROBENZYL) 5,8 DIHYDRO 2 (4 ETHYLAMINOCARBONYLAMINOPHENYL)3 (N PROPARGYLAMIDOMETHYL N BENZYLAMINOMETHYL) 5 OXOIMIDAZO[1,2 A]PYRIMIDINE 6 CARBOXYLIC ACID ETHYL ESTER; 8 (2,6 DIFLUOROBENZYL) 5,8 DIHYDRO 2 (4 PROPARGYLAMINOCARBONYLAMINOPHENYL) 3 (N METHYL N BENZYLAMINOMETHYL) 5 OXOIMIDAZO[1,2 A]PYRIMIDINE 6 CARBOXYLIC ACID ETHYL ESTER; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYCLOADDITION; DIMERIZATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; NONHUMAN;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; LIGANDS; MOLECULAR STRUCTURE; RECEPTORS, LHRH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34249685481     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.04.065     Document Type: Article

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