SCOPUS 정보 검색 플랫폼

Volumn 56, Issue 3, 2000, Pages 761-772

Progress towards the development of non-peptide orally-active gonadotropin-releasing hormone (GnRH) antagonists: Therapeutic implications

(3) Millar, R P a Zhu, Y F b Struthers, R S b

a UNIVERSITY OF EDINBURGH (United Kingdom)

b NEUROCRINE BIOSCIENCES INC (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (N BENZYL N METHYLAMINOMETHYL) 7 (2,6 DIFLUOROBENZYL) 4,7 DIHYDRO 2 (4 ISOBUTYRYLAMINOPHENYL) 4 OXOTHIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID ISOPROPYL ESTER; A 235814; A 75998; ABARELIX; CETRORELIX; GANIRELIX; GONADORELIN; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; GOSERELIN; HISTRELIN; ITURELIX; KETOCONAZOLE; LEUPRORELIN; MCN 4923; NAFARELIN ACETATE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

CLINICAL TRIAL; CRYPTORCHISM; DELAYED PUBERTY; DRUG DESIGN; FEMALE INFERTILITY; HORMONAL CONTRACEPTION; HUMAN; HYPOGONADISM; NONHUMAN; OVULATION INDUCTION; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; REVIEW; SPERMATOGENESIS; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CONTRACEPTIVE AGENTS; FEMALE; FORECASTING; GONADOTROPIN-RELEASING HORMONE; HUMANS; MACACA FASCICULARIS; MODELS, ANIMAL; PROTEIN BINDING; RATS; RECEPTORS, GONADOTROPIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034511980 PISSN: 00071420 EISSN: None Source Type: Journal
DOI: 10.1258/0007142001903346 Document Type: Review

Times cited : (42)

References (36)

1
- 0001169908
- Gonadotropin secretion and its control
- Knobil E, Neill J (Eds) The Physiology of Reproduction. New York: Raven
- (1988) , pp. 1349-1377
- Fink, G.¹

2
- 0023583740
- Gonadotrophin-releasing hormone - Diversity of functions and clinical applications
- (1987) S Afr Med J , vol.72 , pp. 748-755
- Millar, R.P.¹ King, J.A.² Davidson, J.S.³

3
- 0028306250
- Gonadotropin-releasing hormone and its analogs
- (1994) Annu Rev Med , vol.45 , pp. 391-405
- Conn, P.M.¹ Crowley W.F., Jr.²

4
- 0028285865
- Gonadotrophin-releasing hormone agonists. A guide to use and selection
- published erratum appears in Drugs 1994; 48: 326
- (1994) Drugs , vol.48 , pp. 41-58
- Filicori, M.¹

5
- 0028235123
- The use of luteinizing hormone releasing hormone agonists and antagonists in gynaecological cancers
- (1994) Hum Reprod , vol.9 , pp. 1364-1379
- Emons, G.¹ Schally, A.V.²

6
- 0001908765
- Hormonal male contraception: A real chance?
- Nieschlag E, Habenicht U-F (Eds) Spermatogenesis-Fertilization-Contraception. Molecular, Cellular and Endocrine Events in Male Reproduction. Berlin: Springer
- (1992) , pp. 477-501
- Nieschlag, E.¹ Behre, H.M.² Weinbauer, G.E.³

7
- 0027389387
- GnRH analogues for contraception
- (1993) Br Med Bull , vol.49 , pp. 62-72
- Fraser, H.M.¹

8
- 0030937284
- Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor
- (1997) Endocrine Rev , vol.18 , pp. 180-205
- Sealfon, S.C.¹ Weinstein, H.² Millar, R.P.³

9
- 0022665939
- Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: Rationale and perspective
- (1986) Endocrine Rev , vol.7 , pp. 44-66
- Karten, M.J.¹ Rivier, J.E.²

10
- 0001691945
- Endometriosis and the estrogen threshold theory. Relation to surgical and medical treatment
- (1998) J Reprod Med , vol.43 , pp. 287
- Barbieri, R.L.¹

11
- 0026645598
- Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor
- (1992) Mol Endocrinol , vol.6 , pp. 1163-1169
- Tsutsumi, M.¹ Zhou, W.² Millar, R.P.³

12
- 0027475847
- Cloning and characterization of the human GnRH receptor
- (1993) Mol Cell Endocrinol , vol.91
- Chi, L.¹ Zhou, W.² Prikhozhan, A.³

13
- 0027051673
- Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor
- (1992) Biocbem Biopbys Res Commun , vol.189 , pp. 289-295
- Kakar, S.S.¹ Musgrove, L.C.² Devor, D.C.³

14
- 0027506471
- The probable arrangement of the helices in G protein-coupled receptors
- (1993) EMBO J , vol.12 , pp. 1693-1703
- Baldwin, J.M.¹

15
- 0024362248
- An analysis of the periodicity of conserved residues in sequence alignments of G-protein coupled receptors. Implications for the three-dimensional structure
- (1989) FEBS Lett , vol.251 , pp. 109-116
- Donnelly, D.¹ Johnson, M.S.² Blundell, T.L.³

16
- 0006420638
- Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G-protein coupled receptors
- (1975) Methods Neurosci , vol.25 , pp. 345-366
- Ballesteros, J.A.¹ Weinstein, H.²

17
- 0002430661
- Plasticity in the structural and functional evolution of GnRH: A peptide for all seasons
- Proceedings of the Thirteenth International Congress of Comparative Endocrinology. Bologna: Monduzzi
- (1997) , pp. 15-27
- Millar, R.P.¹ Troskie, B.² Sun, Y.M.³

18
- 0028100755
- 8 of mammalian gonadotropin-releasing hormone
- (1994) J Biol Chem , vol.269 , pp. 22636-22641
- Flanagan, C.A.¹ Becker, I.I.² Davidson, J.S.³

19
- 0029666304
- 102 of the gonadotropin-releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamide
- (1996) J Biol Chem , vol.271 , pp. 15510-15514
- Davidson, J.S.¹ McArdle, C.A.² Davies, P.³

20
- 0029135443
- A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites
- (1995) J Biol Chem , vol.270 , pp. 18853-18857
- Zhou, W.¹ Rodic, V.² Kitanovic, S.³

21
- 0000210826
- Role of Asp2.61(198) in agonist complexing with the human gonadotropin-releasing hormone receptor
- (1996) Soc Neurosci Abstr , vol.22 , pp. 1302
- Rodic, V.¹ Flanagan, C.² Millar, R.P.³

22
- 0032820614
- A new photoreactive antagonist cross-links to the N-terminal domain of the gonadotropin-releasing hormone receptor
- (1999) Mol Cell Endocrinol , vol.156 , pp. 179-188
- Assefa, D.¹ Pawson, A.J.² McArdle, C.A.³

23
- 0002994969
- GnRH and GnRH analogues: Structure, actions and clinical applications
- (1998) Horm Frontier Gynecol , vol.5 , pp. 77-83
- Millar, R.P.¹ Assefa, D.² Ott, T.³

24
- 0006493805
- US Patent 4,678,784
- (1987) Method for the Treatment of LHRH Diseases and Conditions
- Ho, C.Y.¹

25
- 0024452507
- LH-RH antagonists: Design and synthesis of a novel series of peptidomimetics
- (1989) J Med Chem , vol.32 , pp. 2036-2038
- De, B.¹ Plattner, J.J.² Bush, E.N.³

26
- 0006462808
- WO 95/2990
- (1995) Condensed Heterocyclic Compounds, Their Production and Use as GnRH Antagonists
- Ohkawa, S.¹ Fujii, N.² Kato, K.³ Miyamoto, M.⁴

27
- 0006462741
- EP 0 712 845 A1
- (1996) Amine Compounds, Their Production and Use as GnRH Antagonists
- Kato, K.¹ Sugiura, Y.² Kato, K.³

28
- 0006490311
- WO 95/28405
- (1995) Bicyclic Thiophene Derivatives and Use as Gonadotropin Releasing Hormone Antagonists
- Furuya, S.¹ Cho, N.² Kato, K.³ Hinuma, S.⁴

29
- 15444355594
- Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor
- (1998) J Med Chem , vol.41 , pp. 4190-4195
- Cho, N.¹

30
- 0006454393
- WO 09950275
- (1999) 3′3′-N-Bis-Substituted Macrolide LHRH Antagonists
- Sauer, D.R.¹

31
- 0033530102
- Identification and initial structure-activity relationships of a novel non-peptide quinolone GnRH receptor antagonist
- (1999) Biomed Chem Lett , vol.9 , pp. 2615-2620
- DeVita, R.J.¹ Hollings, D.D.² Goulet, M.T.³

32
- 0033530138
- Investigation of the 4-O-alkylamine substituent of non-peptide quinolone GnRH receptor antagonist
- (1999) Biomed Chem Lett , vol.9 , pp. 2621-2624
- DeVita, R.J.¹ Goulet, M.² Wyvratt, M.J.³

33
- 0006421682
- WO 97/21435
- (1997) Antagonists of Gonadotropin Releasing Hormone
- Goulet, M.¹ Bugianese, R.L.² Ashton, W.T.³

34
- 0006420477
- WO 994498
- (1999) New Carbonylaminoalkyl Derivatives Are Gonadotropin Modulators - Useful for the Treatment of Sex Steroid-Dependent Disorders and Precocious Puberty
- Anderson, M.¹ Polinsky, A.² Hong, Y.³ Gregor, V.⁴

35
- 0030731863
- Localization of agonist- and antagonist-binding domains of human corticotropin-releasing factor receptors
- (1997) Mol Endocrinol , vol.11 , pp. 2048-2053
- Liaw, C.W.¹ Grigoriadis, D.E.² Lorang, M.T.³ De Souza, E.B.⁴ Maki, R.A.⁵

36
- 0028244827
- Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists
- (1994) J Biol Chem , vol.269 , pp. 14957-14961
- Fong, T.M.¹ Yu, H.² Cascieri, M.A.³ Underwood, D.⁴ Swain, C.J.⁵ Strodm, C.D.⁶

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.