Gonadotropin releasing hormone agonist provokes homologous receptor microaggregation: An early event in seven-transmembrane receptor mediated signaling

Endocrinology

Volumn 137, Issue 8, 1996, Pages 3602-3605

  Janovick, Jo Ann ^a   Conn, P Michael ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN AGONIST; GONADORELIN RECEPTOR;

ANIMAL CELL; ARTICLE; BREAST CANCER; ENDOMETRIOSIS; FEMALE; FERTILITY; HORMONE ACTION; HYPOPHYSIS CELL; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DETERMINATION; RAT; SIGNAL TRANSDUCTION;

EID: 0030038090     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.8.8754794     Document Type: Article

References (18)

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2. Smith WA, Conn PM 1984 Microaggregation of the gonadotropin-releasing hormone receptor: relation to gonadotrope desensitization. Endocrinology 114:553-559
3. Conn PM, Rogers DC, Seay SG 1984 Biphasic regulation of the gonadotropin-releasing hormone receptor by receptor microaggregation and intracellular Ca2+ levels. Mol Pharmacol 25:51-55
4. Conn PM, Rogers DC, McNeil R 1982 Potency enhancement of a GnRH agonist: GnRH-receptor microaggregation stimulates gonadotropin release. Endocrinology 111:335-337
5. Blum JJ, Conn PM 1982 Gonadotropin-releasing hormone stimulation of luteinizing hormone: a ligand-receptor-effector model. Proc Nat Acad Sci USA 79:7307-7311
6. Marian J, Conn PM 1979 GnRH stimulation of cultured pituitary cells requires calcium. Mol Pharmacol 16:196-201
7. Gorospe WC, Conn PM 1987 Agents that decrease GnRH-receptor internalization do not inhibit GnRH-mediated gonadotrope desensitization. Endocrinology 120:222-229
8. Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
9. Hazum E, Cuatrecasas P, Marian J, Conn PM 1980 Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes. Proc Nat Acad Sci USA 77:6692-6695
10. Conn PM, Hazum E 1981 Luteinizing hormone release and gonadotropin-releasing hormone (GnRH) receptor internalization: independent actions of GnRH. Endocrinology 109:2040-2045
11. Zhou W, Rodic V, Kitanovic S, Flanagan CA, Chi L, Weinstein H, Maayani S, Millar RP, Sealfon SC 1995 A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites. J Biol Chem 270(32):18853-7
12. Flanagan CA, Becker II, Davidson JS, Wakefield IK, Zhou W, Sealfon SC, Millar RP 1994 Glutamate 301 of the mouse gonadotropin-releasing hormone receptor confers specificity for arginine 8 of mammalian gonadotropin-releasing hormone. J Biol Chem 269:22636-22641
13. Kirschner MW, Schachman HK 1973 Local and gross conformational changes in aspartate transcarbamylase. Biochem 12:2997-3004
14. Kaiser UB, Zhao D, Cardona GR, Chin WW 1992 Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptor. Biochem Biophys Res Commun 189:1645-1652
15. Conn PM, Morrell DV, Dufau ML, Catt KJ 1979 Gonadotropin-releasing hormone action in cultured pituicytes: Independence of luteinizing hormone release and adenosine 3', 5'-monophosphate production. Endocrinology 104:448-453
16. Clapper D, Conn PM 1985 Gonadotropin-releasing hormone stimulation of pituitary gonadotrope cells produces an increase in intracellular calcium. Biol Reprod 32:269-278
17. Jennes L, Conn PM, Stumpf WE 1986 Synthesis and use of colloidal gold-coupled receptor ligands. In: Methods in Enzymology, P.M. Conn, ed. Vol. 124, (Academic Press, Orlando, Florida), pp. 36-47
18. Janovick JA, Haviv F, Fitzpatrick TD, Conn PM 1993 Differential orientation of a GnRH agonist and antagonist in the pituitary GnRH receptor. Endocrinology 133:942-945