Synthesis and initial structure-Activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 16, 2002, Pages 2179-2183

  Wilcoxen, Keith M ^a   Zhu, Yun Fei ^a   Connors Jr , Patrick J ^a   Saunders, John ^a   Gross, Timothy D ^a   Gao, Yinghong ^a   Reinhart, Greg J ^a   Struthers, R Scott ^a   Chen, Chen ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 BUTYROYLAMINOPHENYL) 3 (N BENZYL N METHYLAMINOMETHYL) 6 ETHOXYCARBONYL 8 (2 FLUOROBENZYL)IMIDAZOLO[1,2 A]PYRIMID 5 ONE; 2 (4 METHOXYPHENYL) 3 [N [2 (2 PYRIDYL)ETHYL] N METHYLAMINO]METHYL 6 (3 METHOXYPHENYL) 7 METHYL 8 (2 FLUOROBENZYL)IMIDAZOLO[1,2 A]PYRIMID 5 ONE; 6 ETHOXYCARBONYL 8 (2 FLUOROBENZYL) 2 (4 NITROPHENYL)IMIDAZOLO[1,2 A]PYRIMID 5 ONE; GONADORELIN ANTAGONIST; IMIDAZOLE DERIVATIVE; KETONE DERIVATIVE; UNCLASSIFIED DRUG; GONADORELIN RECEPTOR; PYRIMIDINONE DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; SYNTHESIS;

STAPHYLOCOCCUS PHAGE 3A;

BINDING SITES; HUMANS; MOLECULAR STRUCTURE; PYRIMIDINONES; RECEPTORS, LHRH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037135999     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00370-0     Document Type: Article

References (20)