메뉴 건너뛰기




Volumn 115, Issue 3, 2005, Pages 664-672

Essential role of RSK2 in c-Fos-dependent osteosarcoma development

Author keywords

[No Author keywords available]

Indexed keywords

RSK2; S6 KINASE; UNCLASSIFIED DRUG;

EID: 20044390185     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200522877     Document Type: Article
Times cited : (90)

References (42)
  • 1
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty, G., and Wagner, E.F. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev. Cell. 2:389-406.
    • (2002) Dev. Cell. , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 2
    • 0035971432 scopus 로고    scopus 로고
    • AP-1 in mouse development and tumorigenesis
    • Jochum, W., Passegue, E., and Wagner, E.F. 2001. AP-1 in mouse development and tumorigenesis. Oncogene. 20:2401-2412.
    • (2001) Oncogene , vol.20 , pp. 2401-2412
    • Jochum, W.1    Passegue, E.2    Wagner, E.F.3
  • 3
    • 0242691046 scopus 로고    scopus 로고
    • AP-1: A double-edged sword in tumorigenesis
    • Eferl, R., and Wagner, E.F. 2003. AP-1: a double-edged sword in tumorigenesis. Nat. Rev. Cancer. 3:859-868.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 859-868
    • Eferl, R.1    Wagner, E.F.2
  • 4
    • 0027070472 scopus 로고
    • Bone and haematopoietic defects in mice lacking c-fos
    • Wang, Z.Q., et al. 1992. Bone and haematopoietic defects in mice lacking c-fos. Nature. 360:741-745.
    • (1992) Nature , vol.360 , pp. 741-745
    • Wang, Z.Q.1
  • 5
    • 0026486816 scopus 로고
    • Pleiotropic effects of a null mutation in the c-fos proto-oncogene
    • Johnson, R.S., Spiegelman, B.M., and Papaioannou, V. 1992. Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell. 71:577-586.
    • (1992) Cell , vol.71 , pp. 577-586
    • Johnson, R.S.1    Spiegelman, B.M.2    Papaioannou, V.3
  • 6
    • 0027236534 scopus 로고
    • Osteoblasts are target cells for transformation in c-fos transgenic mice
    • Grigoriadis, A.E., Schellander, K., Wang, Z.Q., and Wagner, E.F. 1993. Osteoblasts are target cells for transformation in c-fos transgenic mice. J. Cell Biol. 122:685-701.
    • (1993) J. Cell Biol. , vol.122 , pp. 685-701
    • Grigoriadis, A.E.1    Schellander, K.2    Wang, Z.Q.3    Wagner, E.F.4
  • 7
    • 10144227763 scopus 로고    scopus 로고
    • Parathyroid hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element (CRE)-binding protein binding to the major CRE
    • Pearman, A.T., Chou, W.Y., Bergman, K.D., Pulumati, M.R., and Partridge, N.C. 1996. Parathyroid hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element (CRE)-binding protein binding to the major CRE. J. Biol. Chem. 271:25715-25721.
    • (1996) J. Biol. Chem. , vol.271 , pp. 25715-25721
    • Pearman, A.T.1    Chou, W.Y.2    Bergman, K.D.3    Pulumati, M.R.4    Partridge, N.C.5
  • 8
    • 0030665760 scopus 로고    scopus 로고
    • Proto-oncogene c-fos is transcriptionally regulated by parathyroid hormone (PTH) and PTH-related protein in a cyclic adenosine monophosphate- dependent manner in osteoblastic cells
    • McCauley, L.K., Koh, A.J., Beecher, C.A., and Rosol, T.J. 1997. Proto-oncogene c-fos is transcriptionally regulated by parathyroid hormone (PTH) and PTH-related protein in a cyclic adenosine monophosphate-dependent manner in osteoblastic cells. Endocrinology. 138:5427-5433.
    • (1997) Endocrinology , vol.138 , pp. 5427-5433
    • McCauley, L.K.1    Koh, A.J.2    Beecher, C.A.3    Rosol, T.J.4
  • 9
    • 0028144846 scopus 로고
    • c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK
    • Deng, T., and Karin, M. 1994. c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature. 371:171-175.
    • (1994) Nature , vol.371 , pp. 171-175
    • Deng, T.1    Karin, M.2
  • 10
    • 0029937701 scopus 로고    scopus 로고
    • Phosphorylation of c-Fos at rhe C-rerminus enhances its transforming activity
    • Chen, R.H., Juo, P.C., Curran, T., and Blenis, J. 1996. Phosphorylation of c-Fos at rhe C-rerminus enhances its transforming activity. Oncogene. 12:1493-1502.
    • (1996) Oncogene , vol.12 , pp. 1493-1502
    • Chen, R.H.1    Juo, P.C.2    Curran, T.3    Blenis, J.4
  • 11
    • 0028787249 scopus 로고
    • The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells
    • Okazaki, K., and Sagata, N. 1995. The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. EMBO J. 14:5048-5059.
    • (1995) EMBO J. , vol.14 , pp. 5048-5059
    • Okazaki, K.1    Sagata, N.2
  • 12
    • 0036051342 scopus 로고    scopus 로고
    • Molecular interpretation of ERK signal duration byimmediate early gene products
    • Murphy, L.O., Smith, S., Chen, R.H., Fingar, D.C., and Blenis, J. 2002. Molecular interpretation of ERK signal duration byimmediate early gene products. Nat. Cell Biol. 4:556-564.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 556-564
    • Murphy, L.O.1    Smith, S.2    Chen, R.H.3    Fingar, D.C.4    Blenis, J.5
  • 13
    • 0037129205 scopus 로고    scopus 로고
    • RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta
    • Takayanagi, H., et al. 2002. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature. 416:744-749.
    • (2002) Nature , vol.416 , pp. 744-749
    • Takayanagi, H.1
  • 14
    • 0033550142 scopus 로고    scopus 로고
    • Perspectives: Signal transduction. Cell survival demands some Rsk
    • Nebreda, A.R., and Gavin, A.C. 1999. Perspectives: signal transduction. Cell survival demands some Rsk. Science. 286:1309-1310.
    • (1999) Science , vol.286 , pp. 1309-1310
    • Nebreda, A.R.1    Gavin, A.C.2
  • 15
    • 0032514734 scopus 로고    scopus 로고
    • Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene
    • De Cesare, D., Jacquot, S., Hanauer, A., and Sassone-Corsi, P. 1998. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. Proc. Natl. Acad. Sci. U. S. A. 95:12202-12207.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 12202-12207
    • De Cesare, D.1    Jacquot, S.2    Hanauer, A.3    Sassone-Corsi, P.4
  • 16
    • 12944293128 scopus 로고    scopus 로고
    • Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene
    • Bruning, J.C., et al. 2000. Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene. Proc. Natl. Acid. Sci. U. S. A. 97:2462-2467.
    • (2000) Proc. Natl. Acid. Sci. U. S. A. , vol.97 , pp. 2462-2467
    • Bruning, J.C.1
  • 17
    • 0033636595 scopus 로고    scopus 로고
    • Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation
    • Cheung, P., et al. 2000. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol. Cell. 5:905-915.
    • (2000) Mol. Cell. , vol.5 , pp. 905-915
    • Cheung, P.1
  • 18
    • 0036793859 scopus 로고    scopus 로고
    • Coffin-Lowry syndrome: Clinical and molecular features
    • Hanauer, A., and Young, I.D. 2002. Coffin-Lowry syndrome: clinical and molecular features. J. Med. Genet. 39:705-713.
    • (2002) J. Med. Genet. , vol.39 , pp. 705-713
    • Hanauer, A.1    Young, I.D.2
  • 19
    • 0034747717 scopus 로고    scopus 로고
    • Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice
    • Dufresne, S.D., et al. 2001. Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice. Mol. Cell. Biol. 21:81-87.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 81-87
    • Dufresne, S.D.1
  • 20
    • 11144357428 scopus 로고    scopus 로고
    • ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: Implication for Coffin-Lowry Syndrome
    • Yang, X., et al. 2004. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: implication for Coffin-Lowry Syndrome. Cell. 117:387-398.
    • (2004) Cell , vol.117 , pp. 387-398
    • Yang, X.1
  • 21
    • 0029160578 scopus 로고
    • A gene (PEX) with homologies to endopeptidases is mutated in patients with X-Linked hypophosphatemic rickets
    • The HYP Consortium
    • Anonymous. 1995. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-Linked hypophosphatemic rickets. The HYP Consortium. Nat. Genet. 11:130-136.
    • (1995) Nat. Genet. , vol.11 , pp. 130-136
  • 22
    • 15644373713 scopus 로고    scopus 로고
    • A PHEX gene mutation is responsible for adult-onset vitamin D-resistant hypophosphatemic osteomalacia: Evidence that the disorder is not a distinct entity from X-linked hypophosphatemic rickets
    • Econs, M.J., et al. 1998. A PHEX gene mutation is responsible for adult-onset vitamin D-resistant hypophosphatemic osteomalacia: evidence that the disorder is not a distinct entity from X-linked hypophosphatemic rickets. J. Clin. Endocrinol. Metab. 83:3459-3462.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 3459-3462
    • Econs, M.J.1
  • 23
    • 0030615069 scopus 로고    scopus 로고
    • Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia
    • Strom, T.M., et al. 1997. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum. Mol. Genet. 6:165-171.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 165-171
    • Strom, T.M.1
  • 24
    • 0028787357 scopus 로고
    • c-fos-induced osteosarcoma formation in transgenic mice: Cooperativity with c-jun and the role of endogenous c-fos
    • Wang, Z.Q., Liang, J., Schellander, K., Wagner, E.F., and Grigoriadis, A.E. 1995. c-fos-induced osteosarcoma formation in transgenic mice: cooperativity with c-jun and the role of endogenous c-fos. Cancer Res. 55:6244-6251.
    • (1995) Cancer Res. , vol.55 , pp. 6244-6251
    • Wang, Z.Q.1    Liang, J.2    Schellander, K.3    Wagner, E.F.4    Grigoriadis, A.E.5
  • 25
    • 0036001310 scopus 로고    scopus 로고
    • Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety
    • Vahle, J.L., et al. 2002. Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety. Toxicol. Pathol. 30:312-321.
    • (2002) Toxicol. Pathol. , vol.30 , pp. 312-321
    • Vahle, J.L.1
  • 26
    • 0031052014 scopus 로고    scopus 로고
    • The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase
    • Alessi, D.R. 1997. The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase. FEBS Lett. 402:121-123.
    • (1997) FEBS Lett. , vol.402 , pp. 121-123
    • Alessi, D.R.1
  • 27
    • 0141988724 scopus 로고    scopus 로고
    • Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS
    • Fleischmann, A., et al. 2003. Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J. Neurosci. 23:9116-9122.
    • (2003) J. Neurosci. , vol.23 , pp. 9116-9122
    • Fleischmann, A.1
  • 28
    • 0038678168 scopus 로고    scopus 로고
    • FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeleral mineralization
    • Quarles, L.D. 2003. FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeleral mineralization. Am. J. Physiol. Endocrinol. Metab. 285:E1-E9.
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285
    • Quarles, L.D.1
  • 29
    • 0035107364 scopus 로고    scopus 로고
    • Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition
    • Miao, D., et al. 2001. Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition. Endocrinology. 142:926-939.
    • (2001) Endocrinology , vol.142 , pp. 926-939
    • Miao, D.1
  • 31
    • 0033915030 scopus 로고    scopus 로고
    • Developmental expression and tissue distribution of Phex protein: Effect of the Hyp mutation and relationship to bone markers
    • Ruchon, A.F., et al. 2000. Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers. J. Bone Miner. Res. 15:1440-1450.
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 1440-1450
    • Ruchon, A.F.1
  • 32
    • 0024359778 scopus 로고
    • c-fos expression induces bone tumors in transgenic mice
    • Ruther, U., Komitowski, D., Schubert, F.R., and Wagner, E.F. 1989. c-fos expression induces bone tumors in transgenic mice. Oncogene. 4:861-865.
    • (1989) Oncogene , vol.4 , pp. 861-865
    • Ruther, U.1    Komitowski, D.2    Schubert, F.R.3    Wagner, E.F.4
  • 33
    • 0037385030 scopus 로고    scopus 로고
    • Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas
    • Papachristou, D.J., Batistatou, A., Sykiotis, G.P., Varakis, I., and Papavassiliou, A.G. 2003. Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. Bone. 32:364-371.
    • (2003) Bone , vol.32 , pp. 364-371
    • Papachristou, D.J.1    Batistatou, A.2    Sykiotis, G.P.3    Varakis, I.4    Papavassiliou, A.G.5
  • 34
    • 0028173214 scopus 로고
    • c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling
    • Grigoriadis, A.E., et al. 1994. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science. 266:443-448.
    • (1994) Science , vol.266 , pp. 443-448
    • Grigoriadis, A.E.1
  • 35
    • 0035829738 scopus 로고    scopus 로고
    • Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos protooncoprotein during the G(0)-to-S phase transition
    • Acquaviva, C., et al. 2001. Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos protooncoprotein during the G(0)-to-S phase transition. Oncogene. 20:7563-7572.
    • (2001) Oncogene , vol.20 , pp. 7563-7572
    • Acquaviva, C.1
  • 36
    • 0037435037 scopus 로고    scopus 로고
    • The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression
    • Ferrara, P., et al. 2003. The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression. Oncogene. 22:1461-1474.
    • (2003) Oncogene , vol.22 , pp. 1461-1474
    • Ferrara, P.1
  • 37
    • 0029150852 scopus 로고
    • c-fos is required for malignant progression of skin tumors
    • Saez, E., et al. 1995. c-fos is required for malignant progression of skin tumors. Cell. 82:721-732.
    • (1995) Cell , vol.82 , pp. 721-732
    • Saez, E.1
  • 38
    • 0033835880 scopus 로고    scopus 로고
    • Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1
    • Jochum, W., et al. 2000. Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat. Med. 6:980-984.
    • (2000) Nat. Med. , vol.6 , pp. 980-984
    • Jochum, W.1
  • 39
    • 0037113034 scopus 로고    scopus 로고
    • JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation- dependent and -independent mechanisms
    • David, J.P., Sabapathy, K., Hoffmann, O., Idarraga, M.H., and Wagner, E.F. 2002. JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms. J. Cell Sci. 115:4317-4325.
    • (2002) J. Cell Sci. , vol.115 , pp. 4317-4325
    • David, J.P.1    Sabapathy, K.2    Hoffmann, O.3    Idarraga, M.H.4    Wagner, E.F.5
  • 40
    • 0034595423 scopus 로고    scopus 로고
    • Cell cycle-dependent variations in c-Jun and JunB phosphorylation: A role in the control of cyclin D1 expression
    • Bakiri, L., Lallemand, D., Bossy-Wetzel, E., and Yaniv, M. 2000. Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression. EMBO J. 19:2056-2068.
    • (2000) EMBO J. , vol.19 , pp. 2056-2068
    • Bakiri, L.1    Lallemand, D.2    Bossy-Wetzel, E.3    Yaniv, M.4
  • 41
    • 0033303655 scopus 로고    scopus 로고
    • Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses
    • Amling, M., et al. 1999. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology. 140:4982-4987.
    • (1999) Endocrinology , vol.140 , pp. 4982-4987
    • Amling, M.1
  • 42
    • 0023488581 scopus 로고
    • Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt, A.M., et al. 1987. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2:595-610.
    • (1987) J. Bone Miner. Res. , vol.2 , pp. 595-610
    • Parfitt, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.