Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 17, 2006, Pages 6034-6042

  Smith, Jeffrey A ^a   Maloney, David J ^b   Clark, David E ^a   Xu, Yaming ^b   Hecht, Sidney M ^b   Lannigan, Deborah A ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

3Ac SL0101; Bu SL0101; Kaempferol 3 O (2 ,3 ,4 tri O acetyl l rhamnopyranoside); Kaempferol 3 O (3 ,4 di O butyryl l rhamnopyranoside); Kinase inhibitor; RSK

Indexed keywords

ANTINEOPLASTIC AGENT; KAEMPFEROL 3 O (2'',3'',4'' TRI O ACETYL ALPHA LEVO RHAMNOPYRANOSIDE); KAEMPFEROL 3 O (3'',4'' DI O BUTYRYL ALPHA LEVO RHAMNOPYRANOSIDE); KAEMPFEROL DERIVATIVE; S6 KINASE; SL 0101; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CELL; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; IN VITRO STUDY; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; BENZOPYRANS; BREAST NEOPLASMS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR STRUCTURE; MONOSACCHARIDES; RHAMNOSE; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA;

FORSTERONIA REFRACTA;

EID: 33746097759     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.05.009     Document Type: Article

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