메뉴 건너뛰기




Volumn 4, Issue 3, 2007, Pages 211-222

Molecular targets in metastasis: Lessons from genomic approaches

Author keywords

Collagen; CSF 1; CXCR4; Host; Microarray; Osteopontin; Profile; Review; rhoC

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); CHEMOKINE RECEPTOR CXCR4; COLLAGEN TYPE 1; COLONY STIMULATING FACTOR 1; OSTEOPONTIN; PROTEIN RHOC; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 34249333868     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (28)

References (108)
  • 1
    • 0037708932 scopus 로고    scopus 로고
    • Metastatic potential: Generic predisposition of the primary tumor or rare, metastatic variants-or both?
    • Hynes RO: Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both? Cell 113: 821-823, 2003.
    • (2003) Cell , vol.113 , pp. 821-823
    • Hynes, R.O.1
  • 2
    • 0037158692 scopus 로고    scopus 로고
    • A progression puzzle
    • Bernards R and Weinberg RA: A progression puzzle. Nature 418: 823, 2002.
    • (2002) Nature , vol.418 , pp. 823
    • Bernards, R.1    Weinberg, R.A.2
  • 5
    • 27144488136 scopus 로고    scopus 로고
    • Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer
    • Weigelt B, Hu Z, He X, Livasy C, Carey LA, Ewend MG, Glas AM, Perou CM and Van't Veer LJ: Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. Cancer Res 65: 9155-9158, 2005.
    • (2005) Cancer Res , vol.65 , pp. 9155-9158
    • Weigelt, B.1    Hu, Z.2    He, X.3    Livasy, C.4    Carey, L.A.5    Ewend, M.G.6    Glas, A.M.7    Perou, C.M.8    Van't Veer, L.J.9
  • 7
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy S, Ross KN, Lander ES and Golub TR: A molecular signature of metastasis in primary solid tumors. Nat Genet 33: 49-54, 2003.
    • (2003) Nat Genet , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 11
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • Fidler IJ: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3: 453-458, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 12
    • 32944479186 scopus 로고    scopus 로고
    • Germ line polymorphism in metastatic progression
    • Hunter KW, Crawford NP: Germ line polymorphism in metastatic progression. Cancer Res 66: 1251-1254, 2006.
    • (2006) Cancer Res , vol.66 , pp. 1251-1254
    • Hunter, K.W.1    Crawford, N.P.2
  • 13
    • 0026587657 scopus 로고    scopus 로고
    • Guy CT, Cardiff RD and Muller WJ: Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Molec Cell Biol 12: 954-961, 1992.
    • Guy CT, Cardiff RD and Muller WJ: Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Molec Cell Biol 12: 954-961, 1992.
  • 14
    • 0031823908 scopus 로고    scopus 로고
    • Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression
    • Lifsted T, Le Voyer T, Williams M, Muller W, Klein-Szanto A, Buetow KH and Hunter KW: Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression. Int J Cancer 77: 640-644, 1998.
    • (1998) Int J Cancer , vol.77 , pp. 640-644
    • Lifsted, T.1    Le Voyer, T.2    Williams, M.3    Muller, W.4    Klein-Szanto, A.5    Buetow, K.H.6    Hunter, K.W.7
  • 15
    • 18944394908 scopus 로고    scopus 로고
    • Modifiers of mammary tumor progression and metastasis on mouse chromosomes 7, 9, and 17
    • Lancaster M, Rouse J and Hunter KW: Modifiers of mammary tumor progression and metastasis on mouse chromosomes 7, 9, and 17. Mamm Genome 16: 120-126, 2005.
    • (2005) Mamm Genome , vol.16 , pp. 120-126
    • Lancaster, M.1    Rouse, J.2    Hunter, K.W.3
  • 17
    • 0142244181 scopus 로고    scopus 로고
    • Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
    • Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ and Pollard JW: Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 163: 2113-2126, 2003.
    • (2003) Am J Pathol , vol.163 , pp. 2113-2126
    • Lin, E.Y.1    Jones, J.G.2    Li, P.3    Zhu, L.4    Whitney, K.D.5    Muller, W.J.6    Pollard, J.W.7
  • 19
    • 4344688268 scopus 로고    scopus 로고
    • Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: Correlation to human disease
    • Qiu TH, Chandramouli GV, Hunter KW, Alkharouf NW, Green JE and Liu ET: Global expression profiling identifies signatures of tumor virulence in MMTV-PyMT-transgenic mice: correlation to human disease. Cancer Res 64: 5973-5981, 2004.
    • (2004) Cancer Res , vol.64 , pp. 5973-5981
    • Qiu, T.H.1    Chandramouli, G.V.2    Hunter, K.W.3    Alkharouf, N.W.4    Green, J.E.5    Liu, E.T.6
  • 20
    • 33746506286 scopus 로고    scopus 로고
    • Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer
    • Crawford NP, Ziogas A, Peel DJ, Hess J, Anton-Culver H and Hunter KW: Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Res 8: R16, 2006.
    • (2006) Breast Cancer Res , vol.8
    • Crawford, N.P.1    Ziogas, A.2    Peel, D.J.3    Hess, J.4    Anton-Culver, H.5    Hunter, K.W.6
  • 22
    • 33750296975 scopus 로고    scopus 로고
    • Molecular pathogenesis of hepatocellular carcinoma
    • McKillop IH, Moran DM, Jin X and Koniaris LG: Molecular pathogenesis of hepatocellular carcinoma. J Surg Res 136: 125-135, 2006.
    • (2006) J Surg Res , vol.136 , pp. 125-135
    • McKillop, I.H.1    Moran, D.M.2    Jin, X.3    Koniaris, L.G.4
  • 23
    • 85041325246 scopus 로고    scopus 로고
    • American Cancer Society. What are the key statistics about liver cancer? http: //www.cancer.org/docroot/CRI/content/ CRI_2_4_1X_What_are_the_key_statistics_for_liver_cancer_25.asp?sitearea=. Accessed 1.12.07.
    • American Cancer Society. What are the key statistics about liver cancer? http: //www.cancer.org/docroot/CRI/content/ CRI_2_4_1X_What_are_the_key_statistics_for_liver_cancer_25.asp?sitearea=. Accessed 1.12.07.
  • 24
    • 26444496469 scopus 로고    scopus 로고
    • The molecular signature of metastases of human hepatocellular carcinoma
    • Budhu AS, Zipser B, Forgues M, Ye QH, Sun Z and Wang XW: The molecular signature of metastases of human hepatocellular carcinoma. Oncology 69(Suppl 1): 23-27, 2005.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 1 , pp. 23-27
    • Budhu, A.S.1    Zipser, B.2    Forgues, M.3    Ye, Q.H.4    Sun, Z.5    Wang, X.W.6
  • 26
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • Budhu A, Forgues M, Ye QH, Jia HL, He P, Zanetti KA, Kammula US, Chen Y, Qin LX, Tang ZY and Wang XW: Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10: 99-111, 2006.
    • (2006) Cancer Cell , vol.10 , pp. 99-111
    • Budhu, A.1    Forgues, M.2    Ye, Q.H.3    Jia, H.L.4    He, P.5    Zanetti, K.A.6    Kammula, U.S.7    Chen, Y.8    Qin, L.X.9    Tang, Z.Y.10    Wang, X.W.11
  • 27
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RhoC
    • Clark EA, Golub TR, Lander ES and Hynes RO: Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406: 532-535, 2000.
    • (2000) Nature , vol.406 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3    Hynes, R.O.4
  • 28
    • 0031465588 scopus 로고    scopus 로고
    • The GTP-binding protein Rho
    • Ridley AJ: The GTP-binding protein Rho. Int J Biochem Cell Biol 29: 1225-1229, 1997.
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 1225-1229
    • Ridley, A.J.1
  • 29
    • 33748038365 scopus 로고    scopus 로고
    • RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck
    • Kleer CG, Teknos TN, Islam M, Marcus B, Lee JS, Pan Q and Merajver SD: RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res 12: 4485-4490, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 4485-4490
    • Kleer, C.G.1    Teknos, T.N.2    Islam, M.3    Marcus, B.4    Lee, J.S.5    Pan, Q.6    Merajver, S.D.7
  • 30
    • 33745171133 scopus 로고    scopus 로고
    • RhoA and RhoC proteins promote both cell proliferation and cell invasion of human oesophageal squamous cell carcinoma cell lines in vitro and in vivo
    • Faried A, Faried LS, Kimura H, Nakajima M, Sohda M, Miyazaki T, Kato H, Usman N and Kuwano H: RhoA and RhoC proteins promote both cell proliferation and cell invasion of human oesophageal squamous cell carcinoma cell lines in vitro and in vivo. Eur J Cancer 42: 1455-1465, 2006.
    • (2006) Eur J Cancer , vol.42 , pp. 1455-1465
    • Faried, A.1    Faried, L.S.2    Kimura, H.3    Nakajima, M.4    Sohda, M.5    Miyazaki, T.6    Kato, H.7    Usman, N.8    Kuwano, H.9
  • 31
    • 33746648699 scopus 로고    scopus 로고
    • Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis
    • Kusama T, Mukai M, Endo H, Ishikawa O, Tatsuta M, Nakamura H and Inoue M: Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis. Cancer Sci 97: 848-853, 2006.
    • (2006) Cancer Sci , vol.97 , pp. 848-853
    • Kusama, T.1    Mukai, M.2    Endo, H.3    Ishikawa, O.4    Tatsuta, M.5    Nakamura, H.6    Inoue, M.7
  • 32
    • 33646149996 scopus 로고    scopus 로고
    • RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility
    • Yao H, Dashner EJ, van Golen CM and van Golen KL: RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility. Oncogene 25: 2285-2296, 2006.
    • (2006) Oncogene , vol.25 , pp. 2285-2296
    • Yao, H.1    Dashner, E.J.2    van Golen, C.M.3    van Golen, K.L.4
  • 34
    • 9244237677 scopus 로고    scopus 로고
    • Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma
    • Simpson KJ, Dugan AS and Mercurio AM: Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res 64: 8694-8701, 2004.
    • (2004) Cancer Res , vol.64 , pp. 8694-8701
    • Simpson, K.J.1    Dugan, A.S.2    Mercurio, A.M.3
  • 35
    • 3042739357 scopus 로고    scopus 로고
    • Genomic analysis reveals RhoC as a potential marker in hepatocellular carcinoma with poor prognosis
    • Wang W, Yang LY, Huang GW, Lu WQ, Yang ZL, Yang JQ and Liu HL: Genomic analysis reveals RhoC as a potential marker in hepatocellular carcinoma with poor prognosis. Br J Cancer 90: 2349-2355, 2004.
    • (2004) Br J Cancer , vol.90 , pp. 2349-2355
    • Wang, W.1    Yang, L.Y.2    Huang, G.W.3    Lu, W.Q.4    Yang, Z.L.5    Yang, J.Q.6    Liu, H.L.7
  • 36
    • 33750594388 scopus 로고    scopus 로고
    • Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma
    • Bellovin DI, Simpson KJ, Danilov T, Maynard E, Rimm DL, Oettgen P and Mercurio AM: Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene 25: 6959-6967, 2006.
    • (2006) Oncogene , vol.25 , pp. 6959-6967
    • Bellovin, D.I.1    Simpson, K.J.2    Danilov, T.3    Maynard, E.4    Rimm, D.L.5    Oettgen, P.6    Mercurio, A.M.7
  • 40
    • 0027131418 scopus 로고
    • Osteopontin: A protein with diverse functions
    • Denhardt DT and Guo X: Osteopontin: a protein with diverse functions. FASEB J 7: 1475-1482, 1993.
    • (1993) FASEB J , vol.7 , pp. 1475-1482
    • Denhardt, D.T.1    Guo, X.2
  • 42
    • 23944445440 scopus 로고    scopus 로고
    • Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway
    • Al-Shami R, Sorensen ES, Ek-Rylander B, Andersson G, Carson DD and Farach-Carson MC: Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway. J Cell Biochem 94: 1218-1233, 2005.
    • (2005) J Cell Biochem , vol.94 , pp. 1218-1233
    • Al-Shami, R.1    Sorensen, E.S.2    Ek-Rylander, B.3    Andersson, G.4    Carson, D.D.5    Farach-Carson, M.C.6
  • 43
    • 1642565264 scopus 로고    scopus 로고
    • Osteopontin induces AP-1-mediated secretion of urokinase-type plasminogen activator through c-Src-dependent epidermal growth factor receptor transactivation in breast cancer cells
    • Das R, Mahabeleshwar GH and Kundu GC: Osteopontin induces AP-1-mediated secretion of urokinase-type plasminogen activator through c-Src-dependent epidermal growth factor receptor transactivation in breast cancer cells. J Biol Chem 279: 11051-11064, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 11051-11064
    • Das, R.1    Mahabeleshwar, G.H.2    Kundu, G.C.3
  • 44
    • 0037468265 scopus 로고    scopus 로고
    • Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways
    • Tuck AB, Hota C, Wilson SM and Chambers AF: Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways. Oncogene 22: 1198-1205, 2003.
    • (2003) Oncogene , vol.22 , pp. 1198-1205
    • Tuck, A.B.1    Hota, C.2    Wilson, S.M.3    Chambers, A.F.4
  • 47
    • 2942511574 scopus 로고    scopus 로고
    • Role of osteopontin in tumour progression
    • Rittling SR and Chambers AF: Role of osteopontin in tumour progression. Br J Cancer 90: 1877-1881, 2004.
    • (2004) Br J Cancer , vol.90 , pp. 1877-1881
    • Rittling, S.R.1    Chambers, A.F.2
  • 48
    • 33847000174 scopus 로고    scopus 로고
    • Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer
    • Ramankulov A, Lein M, Kristiansen G, Loening SA and Jung K: Plasma osteopontin in comparison with bone markers as indicator of bone metastasis and survival outcome in patients with prostate cancer. Prostate 67: 330-340, 2007.
    • (2007) Prostate , vol.67 , pp. 330-340
    • Ramankulov, A.1    Lein, M.2    Kristiansen, G.3    Loening, S.A.4    Jung, K.5
  • 50
    • 33644764887 scopus 로고    scopus 로고
    • An inducible short-hairpin RNA vector against osteopontin reduces metastatic potential of human esophageal squamous cell carcinoma in vitro and in vivo
    • Ito T, Hashimoto Y, Tanaka E, Kan T, Tsunoda S, Sato F, Higashiyama M, Okumura T and Shimada Y: An inducible short-hairpin RNA vector against osteopontin reduces metastatic potential of human esophageal squamous cell carcinoma in vitro and in vivo. Clin Cancer Res 12: 1308-1316, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 1308-1316
    • Ito, T.1    Hashimoto, Y.2    Tanaka, E.3    Kan, T.4    Tsunoda, S.5    Sato, F.6    Higashiyama, M.7    Okumura, T.8    Shimada, Y.9
  • 51
    • 33748286729 scopus 로고    scopus 로고
    • Osteopontin expression correlates with prognostic variables and survival in clear cell renal cell carcinoma
    • Matusan K, Dordevic G, Stipic D, Mozetic V and Lucin K: Osteopontin expression correlates with prognostic variables and survival in clear cell renal cell carcinoma. J Surg Oncol 94: 325-331, 2006.
    • (2006) J Surg Oncol , vol.94 , pp. 325-331
    • Matusan, K.1    Dordevic, G.2    Stipic, D.3    Mozetic, V.4    Lucin, K.5
  • 52
    • 33845643114 scopus 로고    scopus 로고
    • Clinical implications of osteopontin in metastatic lesions of uterine cervical cancers
    • Sakaguchi H, Fujimoto J, Hong BL and Tamaya T: Clinical implications of osteopontin in metastatic lesions of uterine cervical cancers. Cancer Lett 247: 98-102, 2007.
    • (2007) Cancer Lett , vol.247 , pp. 98-102
    • Sakaguchi, H.1    Fujimoto, J.2    Hong, B.L.3    Tamaya, T.4
  • 56
    • 0038340658 scopus 로고    scopus 로고
    • Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma
    • Pan HW, Ou YH, Peng SY, Liu SH, Lai PL, Lee PH, Sheu JC, Chen CL and Hsu HC: Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma. Cancer 98: 119-127, 2003.
    • (2003) Cancer , vol.98 , pp. 119-127
    • Pan, H.W.1    Ou, Y.H.2    Peng, S.Y.3    Liu, S.H.4    Lai, P.L.5    Lee, P.H.6    Sheu, J.C.7    Chen, C.L.8    Hsu, H.C.9
  • 61
    • 0028057251 scopus 로고
    • Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis
    • Scholl SM, Pallud C, Beuvon F, Hacene K, Stanley ER, Rohrschneider L, Tang R, Pouillart P and Lidereau R: Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J Natl Cancer Inst 86: 120-126, 1994.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 120-126
    • Scholl, S.M.1    Pallud, C.2    Beuvon, F.3    Hacene, K.4    Stanley, E.R.5    Rohrschneider, L.6    Tang, R.7    Pouillart, P.8    Lidereau, R.9
  • 63
    • 0035135492 scopus 로고    scopus 로고
    • The activated macrophage colony-stimulating factor (CSF-1) receptor as a predictor of poor outcome in advanced epithelial ovarian carcinoma
    • Toy EP, Chambers JT, Kacinski BM, Flick MB and Chambers SK: The activated macrophage colony-stimulating factor (CSF-1) receptor as a predictor of poor outcome in advanced epithelial ovarian carcinoma. Gynecol Oncol 80: 194-200, 2001.
    • (2001) Gynecol Oncol , vol.80 , pp. 194-200
    • Toy, E.P.1    Chambers, J.T.2    Kacinski, B.M.3    Flick, M.B.4    Chambers, S.K.5
  • 64
    • 0030953238 scopus 로고    scopus 로고
    • Overexpression of epithelial macrophage colony-stimulating factor (CSF-1) and CSF-1 receptor: A poor prognostic factor in epithelial ovarian cancer, contrasted with a protective effect of stromal CSF-1
    • Chambers SK, Kacinski BM, Ivins CM and Carcangiu ML: Overexpression of epithelial macrophage colony-stimulating factor (CSF-1) and CSF-1 receptor: a poor prognostic factor in epithelial ovarian cancer, contrasted with a protective effect of stromal CSF-1. Clin Cancer Res 3: 999-1007, 1997.
    • (1997) Clin Cancer Res , vol.3 , pp. 999-1007
    • Chambers, S.K.1    Kacinski, B.M.2    Ivins, C.M.3    Carcangiu, M.L.4
  • 65
    • 0017227228 scopus 로고
    • Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse
    • Marks SC Jr and Lane PW: Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse. J Hered 67: 11-18, 1976.
    • (1976) J Hered , vol.67 , pp. 11-18
    • Marks Jr, S.C.1    Lane, P.W.2
  • 67
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin EY, Nguyen AV, Russell RG and Pollard JW: Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 193: 727-740, 2001.
    • (2001) J Exp Med , vol.193 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 69
    • 3442901908 scopus 로고    scopus 로고
    • Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice
    • Aharinejad S, Paulus P, Sioud M, Hofmann M, Zins K, Schafer R, Stanley ER and Abraham D: Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. Cancer Res 64: 5378-5384, 2004.
    • (2004) Cancer Res , vol.64 , pp. 5378-5384
    • Aharinejad, S.1    Paulus, P.2    Sioud, M.3    Hofmann, M.4    Zins, K.5    Schafer, R.6    Stanley, E.R.7    Abraham, D.8
  • 70
    • 20444422949 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor induces vascular endothelial growth factor production in skeletal muscle and promotes tumor angiogenesis
    • Okazaki T, Ebihara S, Takahashi H, Asada M, Kanda A and Sasaki H: Macrophage colony-stimulating factor induces vascular endothelial growth factor production in skeletal muscle and promotes tumor angiogenesis. J Immunol 174: 7531-7538, 2005.
    • (2005) J Immunol , vol.174 , pp. 7531-7538
    • Okazaki, T.1    Ebihara, S.2    Takahashi, H.3    Asada, M.4    Kanda, A.5    Sasaki, H.6
  • 72
    • 33748635840 scopus 로고    scopus 로고
    • The chemokine receptor CXCR4 as a therapeutic target for several diseases
    • Tamamura H, Tsutsumi H and Fujii N: The chemokine receptor CXCR4 as a therapeutic target for several diseases. Mini Rev Med Chem 6: 989-995, 2006.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 989-995
    • Tamamura, H.1    Tsutsumi, H.2    Fujii, N.3
  • 73
    • 33750455077 scopus 로고    scopus 로고
    • Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases
    • Lee CH, Kakinuma T, Wang J, Zhang H, Palmer DC, Restifo NP and Hwang ST: Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases. Mol Cancer Ther 5: 2592-2599, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2592-2599
    • Lee, C.H.1    Kakinuma, T.2    Wang, J.3    Zhang, H.4    Palmer, D.C.5    Restifo, N.P.6    Hwang, S.T.7
  • 78
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL and Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121: 335-348, 2005.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 79
    • 33645458005 scopus 로고    scopus 로고
    • Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma
    • Ohira S, Sasaki M, Harada K, Sato Y, Zen Y, Isse K, Kozaka K, Ishikawa A, Oda K, Nimura Y and Nakanuma Y: Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma. Am J Pathol 168: 1155-1168, 2006.
    • (2006) Am J Pathol , vol.168 , pp. 1155-1168
    • Ohira, S.1    Sasaki, M.2    Harada, K.3    Sato, Y.4    Zen, Y.5    Isse, K.6    Kozaka, K.7    Ishikawa, A.8    Oda, K.9    Nimura, Y.10    Nakanuma, Y.11
  • 84
    • 28544440733 scopus 로고    scopus 로고
    • Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells
    • Su L, Zhang J, Xu H, Wang Y, Chu Y, Liu R and Xiong S: Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells. Clin Cancer Res 11: 8273-8280, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 8273-8280
    • Su, L.1    Zhang, J.2    Xu, H.3    Wang, Y.4    Chu, Y.5    Liu, R.6    Xiong, S.7
  • 89
    • 27144457455 scopus 로고    scopus 로고
    • The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancer
    • Kang H, Watkins G, Douglas-Jones A, Mansel RE and Jiang WG: The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancer. Breast 14: 360-367, 2005.
    • (2005) Breast , vol.14 , pp. 360-367
    • Kang, H.1    Watkins, G.2    Douglas-Jones, A.3    Mansel, R.E.4    Jiang, W.G.5
  • 90
    • 33646734034 scopus 로고    scopus 로고
    • Ottaiano A, Franco R, Aiello Talamanca A, Liguori G, Tatangelo F, Delrio P, Nasti G, Barletta E, Facchini G, Daniele B, Di Blasi A, Napolitano M, Ierano C, Calemma R, Leonardi E, Albino V, De Angelis V, Falanga M, Boccia V, Capuozzo M, Parisi V, Botti G, Castello G, Vincenzo Iaffaioli R and Scala S: Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients. Clin Cancer Res 12: 2795-2803, 2006.
    • Ottaiano A, Franco R, Aiello Talamanca A, Liguori G, Tatangelo F, Delrio P, Nasti G, Barletta E, Facchini G, Daniele B, Di Blasi A, Napolitano M, Ierano C, Calemma R, Leonardi E, Albino V, De Angelis V, Falanga M, Boccia V, Capuozzo M, Parisi V, Botti G, Castello G, Vincenzo Iaffaioli R and Scala S: Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients. Clin Cancer Res 12: 2795-2803, 2006.
  • 91
    • 33645848942 scopus 로고    scopus 로고
    • Regulation of hepatocyte cell cycle progression and differentiation by type I collagen structure
    • Hansen LK, Wilhelm J and Fassett JT: Regulation of hepatocyte cell cycle progression and differentiation by type I collagen structure. Curr Top Dev Biol 72: 205-236, 2006.
    • (2006) Curr Top Dev Biol , vol.72 , pp. 205-236
    • Hansen, L.K.1    Wilhelm, J.2    Fassett, J.T.3
  • 93
    • 33646341752 scopus 로고    scopus 로고
    • Sensing extracellular matrix: An update on discoidin domain receptor function
    • Vogel WF, Abdulhussein R and Ford CE: Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal 18: 1108-1116, 2006.
    • (2006) Cell Signal , vol.18 , pp. 1108-1116
    • Vogel, W.F.1    Abdulhussein, R.2    Ford, C.E.3
  • 94
    • 33744488545 scopus 로고    scopus 로고
    • Cellular mechanotransduction: Putting all the pieces together again
    • Ingber DE: Cellular mechanotransduction: putting all the pieces together again. FASEB J 20: 811-827, 2006.
    • (2006) FASEB J , vol.20 , pp. 811-827
    • Ingber, D.E.1
  • 96
    • 33749000912 scopus 로고    scopus 로고
    • Type I Collagen Receptor ({alpha}2{beta}1) Signaling Promotes the Growth of Human Prostate Cancer Cells within the Bone
    • Hall CL, Dai J, van Golen KL, Keller ET and Long MW: Type I Collagen Receptor ({alpha}2{beta}1) Signaling Promotes the Growth of Human Prostate Cancer Cells within the Bone. Cancer Res 66: 8648-8654, 2006.
    • (2006) Cancer Res , vol.66 , pp. 8648-8654
    • Hall, C.L.1    Dai, J.2    van Golen, K.L.3    Keller, E.T.4    Long, M.W.5
  • 97
    • 0036934057 scopus 로고    scopus 로고
    • TGFbeta-induced fibrogenesis of the pancreas
    • Menke A and Adler G: TGFbeta-induced fibrogenesis of the pancreas. Int J Gastrointest Cancer 31: 41-46, 2002.
    • (2002) Int J Gastrointest Cancer , vol.31 , pp. 41-46
    • Menke, A.1    Adler, G.2
  • 98
    • 33646428351 scopus 로고    scopus 로고
    • Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells
    • Koenig A, Mueller C, Hasel C, Adler G and Menke A: Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells. Cancer Res 66: 4662-4671, 2006.
    • (2006) Cancer Res , vol.66 , pp. 4662-4671
    • Koenig, A.1    Mueller, C.2    Hasel, C.3    Adler, G.4    Menke, A.5
  • 100
    • 33846263431 scopus 로고    scopus 로고
    • Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression
    • Shintani Y, Hollingsworth MA, Wheelock MJ and Johnson KR: Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res 66: 11745-11753, 2006.
    • (2006) Cancer Res , vol.66 , pp. 11745-11753
    • Shintani, Y.1    Hollingsworth, M.A.2    Wheelock, M.J.3    Johnson, K.R.4
  • 101
    • 0032054482 scopus 로고    scopus 로고
    • Halofuginone: A novel antifibrotic therapy
    • Pines M and Nagler A: Halofuginone: a novel antifibrotic therapy. Gen Pharmacol 30: 445-450, 1998.
    • (1998) Gen Pharmacol , vol.30 , pp. 445-450
    • Pines, M.1    Nagler, A.2
  • 104
    • 33646414772 scopus 로고    scopus 로고
    • Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition
    • Taras D, Blanc JF, Rullier A, Dugot-Senant N, Laurendeau I, Bieche I, Pines M and Rosenbaum J: Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition. Neoplasia 8: 312-318, 2006.
    • (2006) Neoplasia , vol.8 , pp. 312-318
    • Taras, D.1    Blanc, J.F.2    Rullier, A.3    Dugot-Senant, N.4    Laurendeau, I.5    Bieche, I.6    Pines, M.7    Rosenbaum, J.8
  • 105
    • 0033205228 scopus 로고    scopus 로고
    • Inhibition of neovascularization and tumor growth, and facilitation of wound repair, by halofuginone, an inhibitor of collagen type I synthesis
    • Abramovitch R, Dafni H, Neeman M, Nagler A and Pines M: Inhibition of neovascularization and tumor growth, and facilitation of wound repair, by halofuginone, an inhibitor of collagen type I synthesis. Neoplasia 1: 321-329, 1999.
    • (1999) Neoplasia , vol.1 , pp. 321-329
    • Abramovitch, R.1    Dafni, H.2    Neeman, M.3    Nagler, A.4    Pines, M.5
  • 107
    • 6944224022 scopus 로고    scopus 로고
    • Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model - an MRI study
    • Abramovitch R, Itzik A, Harel H, Nagler A, Vlodavsky I and Siegal T: Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model - an MRI study. Neoplasia 6: 480-489, 2004.
    • (2004) Neoplasia , vol.6 , pp. 480-489
    • Abramovitch, R.1    Itzik, A.2    Harel, H.3    Nagler, A.4    Vlodavsky, I.5    Siegal, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.