Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease

Oncology Reports

Volumn 16, Issue 6, 2006, Pages 1159-1164

  Wehler, Thomas ^a   Wolfert, Felix ^a   Schimanski, Carl C ^a   Gockel, Ines ^a   Herr, Wolfgang ^a   Biesterfeld, Stefan ^a   Seifert, Joachim K ^a   Adwan, Hassan ^b   Berger, Martin R ^b   Junginger, Theodor ^a   Galle, Peter R ^a   Moehler, Markus ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Cancer; Chemokine receptor; Metastases; Pancreas

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; TUMOR MARKER;

ADENOCARCINOMA; AGED; ARTICLE; BIOSYNTHESIS; CANCER STAGING; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; PANCREAS TUMOR; PATHOLOGY; RETROSPECTIVE STUDY; WESTERN BLOTTING;

ADENOCARCINOMA; AGED; BLOTTING, WESTERN; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM STAGING; PANCREATIC NEOPLASMS; RECEPTORS, CXCR4; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL;

EID: 34249318872     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.16.6.1159     Document Type: Article

References (33)

1. Parkin DM, Bray FI and Devesa SS: Cancer burden in the year 2000. The global picture. Eur J Cancer 37 (Suppl 8): S4-S66, 2001.
2. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E and Thun MJ: Cancer statistics, 2003. CA Cancer J Clin 2003 53: 5-26, 2003. (Pubitemid 36163619)
3. Lankisch PG, Assmus C, Maisonneuve P and Lowenfels AB: Epidemiology of pancreatic diseases in Luneburg County. A study in a defined German population. Pancreatology 2: 469-477, 2002. (Pubitemid 36151343)
4. Sener SF, Fremgen A, Menck HR and Winchester DP: Pancreatic cancer: a report of treatment and survival trends for 100313 patients diagnosed from 1985-1995, using the National Cancer Database. J Am Coll Surg 189: 1-7, 1999. (Pubitemid 29307735)
5. Hedberg M, Borgstromm A, Genell S and Janzon L: Survival following pancreatic carcinoma: a follow-up study of all cases recorded in Malmo, Sweden 1977-1991. Br J Surg 85: 1641-1644, 1998. (Pubitemid 28548339)
6. Bramhall SR, Allum WH, Jones AG, Allwood A, Cummins C and Neoptolemos JP: Treatment and survival in 13560 patients with pancreatic cancer and incidence of the disease in the West Midlands. An epidemiological study. Br J Surg 82: 111-115, 1995.
7. Solcia E, Capella C and Kloppel G: Tumors of the Pancreas. Armed Forces Institute of Pathology, Washington DC, 1997.
8. Arya M, Patel HR and Williamson M: Chemokines: key players in cancer. Curr Med Res Opin 19: 557-564, 2003. (Pubitemid 37122049)
9. Zlotnik A and Yoshie O: Chemokines: a new classification system and their role in immunity. Immunity 12: 121-127, 2000. (Pubitemid 30398626)
10. Murdoch C: CXCR4: chemokine receptor extraordinaire. Immunol Rev 177: 175-184, 2000.
11. Phillips RJ, Burdick MD, Lutz M, Belperio JA, Keane MP and Strieter RM: The stromal derived factor-1/CXCL 12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am J Respir Crit Care Med 167: 1676-1686, 2003. (Pubitemid 36760683)
12. Terada R, Yamamoto K, Hakoda T, Shimada N, Okano N, Baba N, Ninomiya Y, Gershwin ME and Shiratori Y: Stromal cell-derived factor-1 from biliary epithelial cells recruits CXCR4-positive cells: implications for inflammatory liver diseases. Lab Invest 83: 665-672, 2003. (Pubitemid 36618045)
13. Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E and Peled A: Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. Eur J Immunol 34: 1164-1174, 2004. (Pubitemid 39255996)
14. Schimanski CC, Schwald S, Simiantonaki N, Jayasinghe C, Gonner U, Wilsberg V, Junginger T, Berger MR, Galle PR and Moehler M: Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin Cancer Res 11: 1743-1750, 2005. (Pubitemid 40471835)
15. Kato M, Kitayama J, Kazama S and Nagawa H: Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma. Breast Cancer Res 5: R144-R150, 2003.
16. Uchida D, Begum NM, Almofti A, Nakashiro K, Kawamata H, Tateishi Y, Hamakawa H, Yoshida H and Sato M: Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma. Exp Cell Res 290: 289-302, 2003. (Pubitemid 37272173)
17. Mori T, Doi R, Koizumi M, Toyoda E, Ito D, Kami K, Masui T, Fujimoto K, Tamamura H, Hiramatsu K, Fujii N and Imamura M: CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther 3: 29-37, 2004. (Pubitemid 39193676)
18. Chen Y, Stamatoyannopoulos G and Song CZ: Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res 63: 4801-4804, 2003. (Pubitemid 37022609)
19. Marchesi F, Monti P, Leone BE, Zerbi A, Vecchi A, Piemonti L, Mantovani A and Allavena P: Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. Cancer Res 64: 8420-8427, 2004. (Pubitemid 39491782)
20. Saur D, Seidler B, Schneider G, Algul H, Beck R, Senekowitsch-Schmidtke R, Schwaiger M and Schmid RM: CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer. Gastroenterology 129: 1344-1347, 2005.
21. Laverdiere C, Hoang BH, Yang R, Sowers R, Qin J, Meyers PA, Huvos AG, Healey JH and Gorlick R: Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. Clin Cancer Res 11: 2561-2567, 2005. (Pubitemid 40569454)
22. Oonakahara KI, Matsuyama W, Higashimoto I, Kawabata M, Arimura K and Osame M: Stromal-derived factor-1(alpha)/CXCL12-CXCR 4 axis is involved in the dissemination of NSCLC cells into pleural space. Am J Respir Cell Mol Biol 30: 671-677, 2004. (Pubitemid 38591218)
23. Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, Kieran MW, Luster AD and Segal RA: A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci USA 100: 13513-13518, 2003. (Pubitemid 37444773)
24. Helbig G, Christopherson KW II, Bhat-Nakshatri P, Kumar S, Kishimoto H, Miller KD, Broxmeyer HE and Nakshatri H: NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 278: 21631-21638, 2003. (Pubitemid 36792563)
25. Schioppa T, Uranchimeg B, Saccani A, Biswas SK, Doni A, Rapisarda A, Bernasconi S, Saccani S, Nebuloni M, Vago L, Mantovani A, Melillo G and Sica A: Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med 198: 1391-1402, 2003. (Pubitemid 37392484)
26. Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ and Krek W: Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 425: 307-311, 2003. (Pubitemid 37158407)
27. Stetler-Stevenson WG and Kleiner DE: Molecular Biology of Cancer: Invasion and Metastases. Lippincott & Wilkins, 2001.
28. Weiss L, Grundmann E, Torhorst J, Hartveit F, Moberg I, Eder M, Fenoglio-Preiser CM, Napier J, Horne CH and Lopez MJ: Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J Pathol 150: 195-203, 1986. (Pubitemid 17181753)
29. Nicolson GL: Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis. Cancer Metastasis Rev 12: 325-343, 1993.
30. Burger M, Glodek A, Hartmann T, Schmitt-Graff A, Silberstein LE, Fujii N, Kipps TJ and Burger JA: Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. Oncogene 22: 8093-8101, 2003. (Pubitemid 37487300)
31. Cardones AR, Murakami T and Hwang ST: CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. Cancer Res 63: 6751-6757, 2003. (Pubitemid 37322955)
32. Balkwill F and Mantovani A: Inflammation and cancer: back to Virchow? Lancet 357: 539-545, 2001. (Pubitemid 32173595)
33. Brigati C, Noonan DM, Albini A and Benelli R: Tumors and inflammatory infiltrates: friends or foes? Clin Exp Metastasis 19: 247-258, 2002. (Pubitemid 34553525)