Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer

Annals of Oncology

Volumn 17, Issue 6, 2006, Pages 945-951

  Andre, F ^a   Cabioglu, N ^c   Assi, H ^a   Sabourin, J C ^a   Delaloge, S ^a   Sahin, A ^c   Broglio, K ^c   Spano, J P ^b   Combadiere, C ^b   Bucana, C ^c   Soria, J C ^a   Cristofanilli, M ^c  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Breast cancer; Chemokine receptors; Metastases

Indexed keywords

BIOLOGICAL MARKER; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR4; DOUBLE STRANDED RNA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AXILLARY LYMPH NODE; BRAIN METASTASIS; BREAST CANCER; CANCER GRADING; CANCER RELAPSE; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MAJOR CLINICAL STUDY; MANTEL HAENSZEL TEST; METASTASIS POTENTIAL; OVERALL SURVIVAL; PATHOPHYSIOLOGY; PLEURA METASTASIS; POSTOPERATIVE CARE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RISK ASSESSMENT; SKIN METASTASIS; STATISTICAL ANALYSIS; TREATMENT OUTCOME; TUMOR VOLUME;

EID: 33646867374     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdl053     Document Type: Article

References (31)

1. Paget S. The distribution of secondary growths in cancer of the breast. Lancet 1889; 1: 99-101.
2. Moser B, Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001; 2: 123-128.
3. Muller A, Homey B, Soto H et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001; 410: 50-56.
4. Zlotnik A. Chemokines in neoplastic progression. Semin Cancer Biol 2004; 14: 181-185.
5. Wiley HE, Gonzalez EB, Maki W et al. Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. J Natl Cancer Inst 2001; 93:1638-1643.
6. Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004; 4: 540-550.
7. Kleeff J, Kusama T, Rossi DL et al. Detection and localization of Mip-3alpha/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer. Int J Cancer 1999; 81: 650-657.
8. Shulby SA, Dolloff NG, Stearns ME, Meucci O, Fatatis A. CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells. Cancer Res 2004; 64: 4693-4698.
9. Mashino K, Sadanaga N, Yamaguchi H et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res 2002; 62: 2937-2941.
10. Takanami I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int J Cancer 2003; 105:186-189.
11. Lacour J, Lacour F, Spira A et al. Adjuvant treatment with polyadenylic-polyuridylic acid (Polya.Polyu) in operable breast cancer. Lancet 1980; 2: 161-164.
12. Cabioglu N, Yazici MS, Arun B et al. CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer. Clin Cancer Res 2005; 11: 5686-5693.
13. Li YM, Pan Y, Wei Y et al. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 2004; 6: 459-469.
14. Spano JP, Andre F, Morat L et al. Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: Pattern of expression and correlation with outcome. Ann Oncol 2004; 15: 613-617.
15. Ohl L, Mohaupt M, Czeloth N et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 2004; 21: 279-288.
16. Zeelenberg IS, Ruuls-Van Stalle L, Roos E. The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res 2003; 63: 3833-3839.
17. Murakami T, Maki W, Cardones AR et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. Cancer Res 2002; 62: 7328-7334.
18. Lapteva N, Yang A-G, Sanders DE et al. CXCR4 knockdown by small interfering RNA abrogates breast tumor in vivo. Cancer Gene Ther 2005; 12: 84-89.
19. Perissinotto E, Fonsato V, Cavalloni G et al. Tumor progression in osteosarcoma: Role of the CXCR4/SDF-1 system. Proc Am Soc Clin Oncol 2004; 23: 819 (Abstr 9021).
20. Hall JM, Korach KS. Stromal cell-derived factor 1, a novel target for estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Molecular Endocr 2005; 17: 792-803.
21. Hatori K, Nagai A, Heisel R et al. Fractalkine and fractalkine receptors in human neurons and glial cells. J Neurosci Res 2002; 69: 418-426.
22. Kimsey TF, Campbell AS, Albo D, Wang TN. Co-localization of macrophage inflammatory protein-3alpha (Mip-3alpha) and its receptor, CCR6, promotes pancreatic cancer cell invasion. Cancer J 2004; 10: 374-380.
23. Campbell AS, Albo D, Kimsey TF et al. Macrophage inflammatory protein-3alpha promotes pancreatic cancer cell invasion. J Surg Res 2005; 123: 96-101.
24. Schutyser E, Struyf S, Van Damme J. The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev 2003; 14: 409-426.
25. Dellacasagrande J, Schreurs OJ, Hofgaard PO et al. Liver metastasis of cancer facilitated by chemokine receptor CCR6. Scand J Immunol 2003; 57:534-544.
26. Takanami I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int J Cancer. 2003; 105(2): 186-189.
27. Ding Y, Shimada Y, Maeda M et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin Cancer Res 2003; 9: 3406-3412
28. Günther K, Leier J, Golo Henning G et al. Prediction of lymph node metastasis in colorectal carcinoma by expression of chemokine receptor CCR7. Int J Cancer 2005; 116: 726-733.
29. Wiley HE, Gonzalez EB, Wusi Maki W et al. Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. J Natl Cancer Inst 2001; 93: 1638-1643.
30. Quénel N, Wafflart J, Bonichon F et al. The prognostic value of c-erbB2 in primary breast carcinomas: A study on 942 cases. Breast Cancer Res Treat 1995; 35: 283-291.
31. Smith MC, Luker KE, Garbow JR et al. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004; 64: 8604-8612.