Role of P-Glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge

Current Drug Metabolism

Volumn 8, Issue 4, 2007, Pages 325-340

  Yu, Xi Yong ^a   Lin, Shu Guang ^a   Zhou, Zhi Wei ^b   Chen, Xiao ^c   Liang, Jun ^d   Liu, Pei Qing ^c   Duan, Wei ^e   Chowbay, Balram ^f   Wen, Jing Yuan ^g   Li, Chun Guang ^h   Zhou, Shu Feng ⁱ  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b NANCHANG UNIVERSITY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d UNIVERSITY OF SYDNEY   (Australia)

^e DEAKIN UNIVERSITY   (Australia)

^f DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^g THE UNIVERSITY OF AUCKLAND   (New Zealand)

^h RMIT UNIVERSITY   (Australia)

ⁱ QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Bioavailability; Intestinal absorption; P glycoprotein; Tanshinone IIA

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CELECOXIB; DIGOXIN; GLYCOPROTEIN P; NIFEDIPINE; PROBENECID; QUINIDINE; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE; TANSHINONE IIA; UNCLASSIFIED DRUG; VERAPAMIL; VERLUKAST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TRANSPORT; ENZYME ACTIVITY; FIRST PASS EFFECT; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE PERFUSION; LIVER MICROSOME; MALE; MONOLAYER CULTURE; NONHUMAN; PLANT ROOT; RAT; REVIEW;

ADENOSINE TRIPHOSPHATE; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; DIGOXIN; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; INTESTINES; MALE; MICROSOMES, LIVER; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PHENANTHRENES; PLANT ROOTS; PROBENECID; PROPIONATES; QUINIDINE; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; TEMPERATURE; TRANSFECTION; VERAPAMIL;

EID: 34249093067     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007780655450     Document Type: Review

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